上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
SC75741 纯度: 99.51%
SC75741 是一种广泛,有效的 NF-κB 抑制剂,对 p65 的 IC50 为 200 nM。SC75741 可阻断 influenza viruses 复制。SC75741 通过损害 NF-κB 亚基 p65 的 DNA 结合,导致细胞因子,趋化因子和促凋亡因子的表达降低,抑制 caspase 活化和阻断 caspase 介导的病毒核糖核蛋白 (viralribonucleoproteins) 的核输出。
SC75741 Chemical Structure
CAS No. : 913822-46-5
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1120 | In-stock | |
5 mg | ¥900 | In-stock | |
10 mg | ¥1600 | In-stock | |
25 mg | ¥3100 | In-stock | |
50 mg | ¥5600 | In-stock | |
100 mg | ¥9900 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
SC75741 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
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- NF-κB Signaling Compound Library
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- Transcription Factor Targeted Library
- Anti-Liver Cancer Compound Library
生物活性 |
SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65[1]. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins[2]. |
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IC50 & Target |
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体外研究 (In Vitro) |
SC75741 (5 μM; 24-96 hours) inhibits long-term A549 cells proliferation[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Cell Viability Assay[2]
Western Blot Analysis[2]
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体内研究 (In Vivo) |
SC75741 (intraperitoneal injection; 15 mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
565.67 |
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Formula |
C29H23N7O2S2 |
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CAS 号 |
913822-46-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 83.33 mg/mL (147.31 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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