硫酸多粘菌素B
基本信息
| 产品名称 | 硫酸多粘菌素B |
|---|---|
| 英文名称 | Polymyxin B sulfate |
| 别名 | 多粘菌素B硫酸盐 |
| 英文别名 | Polymyxin B sulfate salt;Aerosporin;Mastimyxin |
| 规格或纯度 | 10mM in Water |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae. Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.Cationic surfactant antibiotic agent. Mixture of polymyxins B1 and B2. Increases the permeability of the cell membrane. Shows bactericidal effects against Gram-negative bacteria in vivo. |
一般描述
易溶于40％的乙醇水溶液中，溶于水。在醚、酮、酯、烃等有机溶剂中几乎不溶解。
多粘菌素B为抗革兰阴性杆菌多肽类抗生素, 可以改变膜结构使小分子物质泄漏而抑制革兰氏阴性菌的生长。对大肠杆菌具有杀菌作用。结合到细菌脂多糖类的脂质A部分。在外皮细胞膜诱发小孔。
作用模式: 结合并干涉细胞质膜的渗透性。
抗菌谱: 革兰式阴性细菌。
Chemical structure: peptide
Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Polymyxin B sulfate salt has been used:
• in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin
• in the analysis of the isolates
• in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)
相关属性
| CAS编号 | 1405-20-5 |
|---|---|
| 敏感性 | 对光、热敏感 |
| 比旋光度 | -80 ° (C=2, H2O) |
| 储存温度 | 避光,-80℃储存 |
| RTECS | TR1150000 |
| 品牌 | Jinpan |