Nifuroxazide
JAK / STAT信号抑制剂。硝基呋喃抗生素。
10mM in DMSO
有货
基本信息
| 产品名称 | Nifuroxazide |
|---|---|
| 英文名称 | Nifuroxazide |
| 别名 | 硝呋齐特 |
| 英文别名 | 5-Nitro-2-furaldehyde p-hydroxybenzoylhydrazone;p-Hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide |
| 规格或纯度 | 10mM in DMSO |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Nifuroxazide is a nitrofuran compound inhibitor of STAT transcription factor signaling. Nifuroxazide is described to block constitutive phosphorylation of STAT3 by reducing Jak kinase autophosphorylation, decreasing the viability of myeloma cells depending on constitutive STAT3 activity for survival while not affecting normal peripheral blood mononuclear cells. Nifuroxazide produces decreases in tyrosine phosphorylation of Jak2 and Tyk2, and showed no effects on EGF receptor tyrosine kinase or Src kinase, indicating a relative specificity of Nifuroxazide for Jak2 and Tyk2. Nifuroxazide shows no inhibition of Akt or MAPK phosphorylation.JAK/STAT signaling inhibitor. Nitrofuran antibiotic. Inhibits JAK2 and Tyk2 phosphorylation and subsequent downstream STAT3 inhibition (EC 50 = 3 μM). Antidiarrheal. Shows little effect on Akt, NF-κB, JAK1, MAPK and Src signaling. |
一般描述
An inhibitor of STAT activation and signaling activity
An inhibitor of STAT activation and signaling activity
相关属性
| CAS编号 | 965-52-6 |
|---|---|
| 敏感性 | 对光敏感、对空气敏感、对热敏感 |
| 熔点 | 281-283°C |
| 储存温度 | -80℃储存 |
| 分子量 | 275.22 |
| 分子式 | C12H9N3O5 |
| 品牌 | Jinpan |
| PubChem CID | 5337997 |