奎奴普丁
基本信息
| 产品名称 | 奎奴普丁 |
|---|---|
| 英文名称 | Quinupristin |
| 英文别名 | AC1LAKMS |
| 规格或纯度 | 97% |
| 运输条件 | 超低温冰袋运输 |
一般描述
奎奴普丁是通过曼尼希缩合和消除生成4-哌啶酮酮的环外亚甲基α形成的维吉尼亚霉素B（ostreogyrcin B，ristristinacin IA，链霉菌素B）的半合成类似物。将奎尼丁基硫醇加到亚甲基上得到奎奴普丁。结构上的变化为疏水性更高的化合物提供了易于电离的基团，用于生成盐。奎奴普丁与达福普汀（30:70）协同组合用于商业用途。关于奎奴普丁单独的合成，生物学或抗生素活性的公开数据很少，但是该组合产品非常有效，包括针对抗生素抗性菌株的活性。
Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, Streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
相关属性
| CAS编号 | 120138-50-3 |
|---|---|
| 折光率 | n20D1.66 |
| 溶解性 | Soluble in alcohol, water (slightly), and DMSO. |
| 储存温度 | -20°C储存 |
| 密度 | 1.39 g/cm3 |
| 分子量 | 1022.2 |
| 分子式 | C53H67N9O10S |
| 品牌 | Jinpan |
| Smiles | CCC1C(=O)N2CCC[C@H]2C(=O)N([C@H](C(=O)N3C[C@H](C(=O)CC3C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CS[C@ |
| PubChem CID | 470126 |