庆大霉素C

庆大霉素C 是从真菌培养液中分离出的庆大霉素抗生素的成员，具有抗菌和抗增殖特性。庆大霉素显示出对耐甲氧西林的金黄色葡萄球菌菌株的生长抑制，对革兰氏阳性菌有活性，而对革兰氏阴性菌则无活性。庆大霉素C和其他庆大霉素在营养缺乏的情况下表现出对PANC-1胰腺癌细胞的细胞毒性，与在营养丰富的条件下相比，庆大霉素在抑制营养缺乏的条件下抑制PANC-1细胞生长所需的浓度显着降低（约100倍）情况。有人提出，该庆大霉素响应于营养剥夺状态而阻断了PANC-1细胞信号传导的PKB / Akt的激活，从而扰乱了抗癌性的潜在机

Kigamicin C is a member of the kigamicin antibiotics isolated from|Amycolatopsis|culture broths, with antimicrobial and antiproliferative properties. The kigamicins demonstrate growth inhibition of methicillin-resistant|Staphylococcus aureus|strains, are active against gram-positive bacteria, and inactive against gram-negative bacteria. Kigamicin C and other kigamicins demonstrate cytotoxicity against PANC-1 pancreatic cancer cells under nutrient starved conditions, requiring a markedly lower concentration (~100-fold) of kigamicin to inhibit growth of PANC-1 cells under nutrient-starved conditions than under nutrient-rich conditions. It is proposed that the kigamicins block the activation of PKB/Akt signaled by PANC-1 cells in response to a nutrient-deprived state, disturbing a potential mechanism of cancer starvation resistance. Extending these observations, Kigamicin D (representing the kigamicin family) is specifically show to suppress an activating phosphorylation of Akt presented by cells in response to a nutrient-starved growth medium. Kigamicin C and the kigamicins (named for kiga, a japanese word for starvation) present a novel intervention upon the resistance to nutrient starvation characteristic of oncogenesis.