盐酸脱氧甘露霉素
抑制哺乳动物高尔基-α-甘露糖苷酶I的甘露糖类似物
≥98%
有货
基本信息
| 产品名称 | 盐酸脱氧甘露霉素 |
|---|---|
| 英文名称 | Deoxymannojirimycin hydrochloride |
| 英文别名 | DMJ |
| 规格或纯度 | ≥98% |
| 运输条件 | 超低温冰袋运输 |
一般描述
盐酸脱氧甘露糖霉素是一种甘露糖类似物，可在活性位点抑制哺乳动物MAN1A2（高尔基-α-甘露糖苷酶I）。已知会阻止复杂寡糖的生物合成。但是，它不会阻止内质网α-甘露糖苷酶。观察到诱导细胞外基质纤连蛋白装配体的混乱。同样，在肝癌H7721细胞中处理的脱氧甘露糖霉素也导致内质网应激和细胞凋亡。
Deoxymannojirimycin HCl is a mannose analog that inhibits mammalian MAN1A2 (Golgi-alpha-mannosidase I) at the active site. Known to block the biosynthesis of complex oligosaccharides. However, it does not block endoplasmic reticulum alpha-mannosidase. Observed to induce disorganization of the extracellular matrix fibronectin assembly. Also, deoxymannojirimycin treated in hepatocarcinoma H7721 cells resulted in ER stress and apoptosis.
相关属性
| CAS编号 | 84444-90-6 |
|---|---|
| 折光率 | n20D1.58 |
| 熔点 | 197.5-198.7° C |
| 沸点 | 361.1° C at 760 mmHg |
| 溶解性 | Soluble in water (50 mM), methanol (warm), and DMSO. |
| 储存温度 | -20°C储存,充氩 |
| 分子量 | 199.6 |
| 分子式 | C6H13NO4・HCl |
| 品牌 | Jinpan |
| Smiles | C1C(C(C(C(N1)CO)O)O)O.Cl |
| PubChem CID | 11390018 |