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LY3295668 (Synonyms: AK-01) 纯度: 98.36%
LY3295668 (AK-01) 是高度特异性的 Aurora-A kinase 的抑制剂,其对 AurA 和 AurB 的Ki 值分别为 0.8 nM 和 1038 nM。
![LY3295668 Chemical Structure LY3295668(Synonyms: AK-01)](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-114258.gif)
LY3295668 Chemical Structure
CAS No. : 1919888-06-4
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥3900 | In-stock | |
10 mg | ¥6800 | In-stock | |
50 mg | ¥20400 | In-stock | |
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200 mg | 询价 |
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生物活性 |
LY3295668 (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nm)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
489.95 |
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Formula |
C24H26ClF2N5O2 |
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CAS 号 |
1919888-06-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (204.10 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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