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GC7 Sulfate 纯度: ≥98.0%
GC7 Sulfate 是一种脱氧嘌呤合成酶 (DHPS) 抑制剂。
GC7 Sulfate Chemical Structure
CAS No. : 150417-90-6
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in Water | ¥1640 | In-stock | |
1 mg | ¥550 | In-stock | |
5 mg | ¥1650 | In-stock | |
10 mg | ¥2600 | In-stock | |
25 mg | ¥5200 | In-stock | |
50 mg | ¥8300 | In-stock | |
100 mg | ¥13200 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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GC7 Sulfate 相关产品
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生物活性 |
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. |
IC50 & Target |
DHPS[1] |
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体外研究 (In Vitro) |
The treatment of MYCN2 (±Dox) and BE(2)-C cells with GC7 Sulfate for 72 h at various concentrations (0.1 to 100 μM) significantly reduces the number of viable cells in a dose-dependent manner. In MYCN2 cells, 5 μM of GC7 Sulfate inhibits cell viability by ~40 and ~60 %, respectively, compare to untreated control cells. BE(2)-C cells require 25 μM of GC7 Sulfate to reduce cell viability by ~50 %. Exposure to 10 and 100 μM GC7 for 72 h clearly decreases the levels of total retinoblastoma (Rb) and phosphorylated Rb as well as of Cdk4 protein, and increases the levels of p21 protein[1]. Between 0 and 20 μM, GC7 Sulfate induces little cytotoxicity in HCC cells, while higher concentrations of GC7 Sulfate (50 to 100 μM) significantly inhibit the viability of all five HCC cell lines tested. Newly synthesized 3H-labeled hypusine of eIF5A1/eIF5A2 is rarely detected after 20 μM GC7 Sulfate treatment, compare to untreated control. The activity of [3H]-spermidine incorporated into HCC cells is significantly decreased by 20 μM GC7 Sulfate or higher concentration[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
270.35 |
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Formula |
C8H22N4O4S |
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CAS 号 |
150417-90-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
H2O : 3 mg/mL (11.10 mM; Need ultrasonic and warming) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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Cell Assay [1] |
Cell viability is analyzed with the MTS assay kit in accordance with the manufacturer’s protocols. Briefly, after treatment with GC7 Sulfate for 72 h at various concentrations (0.1 to 100 μM) in 96-well plates, cells are directly incubated with the MTS dye reagent for 1 h at 37°C in a 5 % CO2 atmosphere. The absorbance is read at 490 nm using a reader[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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