EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC50 of 4.85 and 4.74 for EGFR and HER-2, respectively[1].
IC50 & Target[1]
EGFR
4.85 (pIC50)
HER2
4.74 (pIC50)
分子量
265.26
Formula
C16H11NO3
CAS 号
133550-22-8
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Kamath S, et al. Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors. J Med Chem. 2003;46(22):4657-4668.
Salvianolic acid Y 是一种酚酸，与 Salvianolic acid B 具有相同的平面结构。Salvianolic acid Y 可以挽救 H2O2 造成的细胞损伤。
Salvianolic acid Y Chemical Structure
CAS No. : 1638738-76-7
规格
价格
是否有货
数量
5 mg
￥9300
In-stock
10 mg
询价
50 mg
询价
* Please select Quantity before adding items.
Salvianolic acid Y 相关产品
•相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
生物活性
Salvianolic acid Y is a phenolic acid with the same planar structure as Salvianolic acid B. Salvianolic acid Y rescues cell injury by H2O2[1].
体外研究 (In Vitro)
Salvianolic acid Y has protection activityon hydrogen peroxide (H2O2)-induced cell lesion. The protection rates of Salvianolic acid Y is 54.2% in rat pheochromocytoma line PC12[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
718.61
Formula
C36H30O16
CAS 号
1638738-76-7
中文名称
丹酚酸Y
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Jun Gong, et al. Salvianolic acid Y: a new protector of PC12 cells against hydrogen peroxide-induced injury from Salvia officinalis. Molecules. 2015 Jan 6;20(1):683-92.
Oenothein B 是一种二聚体大环鞣花单宁，具有广泛的药理活性，包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。
Oenothein B Chemical Structure
CAS No. : 104987-36-2
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].
体外研究 (In Vitro)
Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1]. Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1]. Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1]. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Effectively inhibited the proliferation of A549 cells.
Apoptosis Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Induced apoptosis in A549 cells.
Cell Cycle Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Arrested cells in the G1 phase.
Western Blot Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
体内研究 (In Vivo)
Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1571.10
Formula
C68H50O44
CAS 号
104987-36-2
中文名称
月见草素B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120.
[3]. Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14(5):9767-78.
Yadanziolide C 是一种苦木素类化合物，在 HL-60 细胞中具有抗增殖和诱导分化特性。
Yadanziolide C Chemical Structure
CAS No. : 95258-12-1
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Yadanziolide C is a quassinoid with antiproliferative and differentiation-inducing properties in promyelocytic HL-60 cells[1].
分子量
410.42
Formula
C20H26O9
CAS 号
95258-12-1
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. L Luyengi, et al. A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells. Phytochemistry. 1996 Sep;43(2):409-12.
[2]. E Mata-Greenwood, et al. Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture. Nat Prod. 2001 Dec;64(12):1509-13.
Malvidin-3-galactoside chloride Chemical Structure
CAS No. : 30113-37-2
规格
价格
是否有货
1 mg
￥3360
询问价格 & 货期
5 mg
￥10000
询问价格 & 货期
10 mg
￥15840
询问价格 & 货期
* Please select Quantity before adding items.
生物活性
Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor function[1].
体外研究 (In Vitro)
Malvidin-3-galactoside chloride (50, 100, 200 μg/mL; for 24, 48, 72 h) displays obvious cytotoxicity on Huh-7 cells and has no significant effect with 50 and 100 μg/mL for 48 h. Malvidin-3-galactoside chloride has a notable cytotoxic effect against Huh-7 cells at 72 h[1]. Malvidin-3-galactoside chloride (50-200 μg/mL) arrests the cells in the S phase, accompanied by the cells in the G1 phase decreased, and the cells in the S phase increased[1]. Malvidin-3-galactoside chloride (50-200 μg/mL; for 72 h) induces cell apoptosis in Huh-7 cells[1]. Malvidin-3-galactoside chloride (50-200 μg/mL; for 72 h) markedly increased the levels of caspase-3, cleaved-caspase-3 and cleaved-PARP in a dose-dependent manner[1]. Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) inhibits the production and accumulation of ROS[1]. Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) dramatically reduces the level of phosphorylation ERK (p-ERK) in a dose-dependent manner. Malvidin-3-galactoside chloride with 200 μg/mL markedly increases the phosphorylation level of p38 and JNK (p-p38 and p-JNK)[1]. Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) inhibits the migration and invasion in Huh-7 cells[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
528.89
Formula
C23H25ClO12
CAS 号
30113-37-2
中文名称
氯化锦葵色素-3-O-半乳糖苷
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Jie Lin, et al. Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways. Food Science and Human Wellness, Volume 9, Issue 2, June 2020, Pages 136-145.
Prosaikogenin F is a monoglycoside with anticancer and hemolytic properties[1][2].
体外研究 (In Vitro)
Prosaikogenin F inhibits A549 proliferation with inhibition rates of 40.53%, 92.62% and 93.07% at concentrations of 20, 40 and 60 μg/mL, respectively[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
In mice, intraperitoneal administration of Saikosaponin A and its intestinal metabolite, Prosaikogenin F, show corticosterone secretion-inducing activity at a dose of 0.1 mmol/kg, and maximally increase it at a dose of 0.4 mmol/kg[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
618.84
Formula
C36H58O8
CAS 号
99365-20-5
中文名称
前柴胡皂苷F
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Lu Shi, et al. A Potential Anti-cancer Compound Separated from the Chloroform Extract of the Chinese Medicine Formula Shenqi San. Curr Med Sci. 2020 Feb;40(1):138-144.
[2]. M Nose, S Amagaya, et al. Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane. Chem Pharm Bull (Tokyo). 1989 Dec;37(12):3306-10.
[3]. M Nose, et al. Corticosterone secretion-inducing activity of saikosaponin metabolites formed in the alimentary tract. Chem Pharm Bull (Tokyo). 1989 Oct;37(10):2736-40.
Oenothein B 是一种二聚体大环鞣花单宁，具有广泛的药理活性，包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。
Oenothein B Chemical Structure
CAS No. : 104987-36-2
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].
体外研究 (In Vitro)
Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1]. Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1]. Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1]. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Effectively inhibited the proliferation of A549 cells.
Apoptosis Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Induced apoptosis in A549 cells.
Cell Cycle Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Arrested cells in the G1 phase.
Western Blot Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
体内研究 (In Vivo)
Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1571.10
Formula
C68H50O44
CAS 号
104987-36-2
中文名称
月见草素B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120.
[3]. Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14(5):9767-78.
