日度归档：2024年10月14日

O-Desmethyl Midostaurin(Synonyms: CGP62221; O-Desmethyl PKC412)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

O-Desmethyl Midostaurin (Synonyms: CGP62221; O-Desmethyl PKC412) 纯度: 95.48%

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) 是 Midostaurin (HY-10230) 的活性代谢物，通过细胞色素 P450 肝酶代谢产生，可以作为 Midostaurin 在体内代谢的指标之一。Midostaurin 是一种多靶点蛋白激酶 (kinase) 抑制剂，IC50 范围为 22-500 nM。

O-Desmethyl Midostaurin(Synonyms: CGP62221; O-Desmethyl PKC412)

O-Desmethyl Midostaurin Chemical Structure

CAS No. : 740816-86-8

规格 价格 是否有货 数量
5 mg ￥18500 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

IC50 & Target

IC50: active metabolite of Midostaurin[1]
分子量

556.61

Formula

C34H28N4O4
CAS 号

740816-86-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.

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英国Stuart数控水浴SWB24D/SWB15D/SWB6D

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【简单介绍】

品牌 其他品牌

英国Stuart数控水浴SWB24D/SWB15D/SWB6D是三种结实且可靠的水浴系统，都带有容易清洁的不锈钢水槽和坚硬的金属外壳。每个水浴都配有标准水浴盖以减少热量流失和减少蒸发。水浴盖由坚硬的聚碳酸酯制成，可以清晰地观察水浴中的情况。
不同规格可选: 6L, 15L和24L
英国进口
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【详细说明】

英国Stuart数控水浴SWB24D/SWB15D/SWB6D

产品描述：

    英国Stuart数控水浴SWB24D/SWB15D/SWB6D是三种结实且可靠的水浴系统，都带有容易清洁的不锈钢水槽和坚硬的金属外壳。

数字式水浴，带有简易使用的温度控制器和清晰易读的LED水温显示。并带有过温保护系统，能够追踪设定温度并控制加热器以防产生错误。

加热器安装在水槽的下面，使清洗简单。包括低水位感应器，能够在水位过低时切断电源，以防止干烧。集成排水管用于将水简单地排出。

每个水浴都配有标准水浴盖以减少热量流失和减少蒸发。水浴盖由坚硬的聚碳酸酯制成，可以清晰地观察水浴中的情况。

主要特点：

  1. 不同规格可选: 6L, 15L和24L
  2. 数字式恒温槽温度设定和显示
  3. 低水位感应器
  4. 集成排水管
  5. 提供坚硬的聚碳酸酯盖

技术参数

型号 SWB6D SWB15D SWB24D
容量 6L 15L 24L
温度范围 室温+5℃-99.9℃ 室温+5℃-99.9℃ 室温+5℃-99.9℃
温度稳定性 ± 0.5℃ ± 0.5℃ ± 0.5℃
内部尺寸(w x d x h),mm 300×150×200 300×325×200 300×500×200
外形尺寸(w x d x h), mm 335×230×280 335×408×280 335×584×280
净重, kg 6.5kg 9.0kg 12.8kg
加热功率 500W 1000W 1700W
电源 230V, 50Hz, 500W 230V, 50Hz, 1000W 230V, 50Hz, 1700W
IP等级 31 31 31

订货信息

型号 描述
SWB6D 数字式水浴锅6L
SWB15D 数字式水浴锅15L
SWB24D 数字式水浴锅24L
SWB6D/ 1 聚碳酸酯盖，适用于6L水浴
SWB15D/ 1 聚碳酸酯盖，适用于15L水浴
SWB24D/ 1 聚碳酸酯盖，适用于24L水浴
SWB1/ 1 山形盖，不锈钢，适用于6L水浴
SWB2/ 1 山形盖，不锈钢，适用于15L水浴
SWB3/ 1 山形盖，不锈钢，适用于24L水浴

 

桌上型自动分析装置|生命科学/临床检验药|关东化学株式会社

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血液化验，病人的组织和内脏器官的状态把握的有效手段的事，病的诊断和治疗效果确认等被广泛使用。但是，所谓通用生化学自动分析装置，这本身就是一个大型，而且昂贵，所以医院和诊所之类的小规模设施导入难，检查委托外部的情况几乎。桌上型血液化学检查装置ビオリス12 i及ビオリス15 i新是各种各样的特长，具备了，小规模医疗设施和检查专职工作人员没有面向设施作为最适合。

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生化学检查

生命科学/临床检验药的咨询

信息查询

电话: 03 – 6214 – 1091

传真: 03 – 3241 – 1049

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Spautin-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Spautin-1  纯度: 99.26%

Spautin-1是一种特异性和有效的自噬抑制剂，可抑制泛素特异性肽酶USP10和 USP13，IC50s 约为0.6-0.7 μM。

Spautin-1

Spautin-1 Chemical Structure

CAS No. : 1262888-28-7

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥610 In-stock
5 mg ￥550 In-stock
10 mg ￥700 In-stock
50 mg ￥2500 In-stock
100 mg ￥4500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Spautin-1 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Anti-Cancer Compound Library
  • Autophagy Compound Library

生物活性

Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC50s of 0.6-0.7 μM.

体外研究
(In Vitro)

Spautin-1 enhances imatinib mesylate (IM)-induced CmL cell apoptosis by reducing the expression of the anti-apoptotic proteins Mcl-1 and Bcl-2. The pro-apoptotic activity of spautin-1 is associated with activation of GSK3β, an important downstream effector of PI3K/AKT. Spautin-1 enhances IM-induced cytotoxicity in CmL cell line K562, decreasing the IC50 from 1 to 0.5 μM[1]. The mechanism of spautin-1 acting on acute pancreatitis is associated with impaired autophagy inhibition[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Spautin-1 ameliorates the pathogenesis of acute pancreatitis induced by cerulein or L-arginine. Spautin-1 pretreatment significantly diminishes the elevation of serum amylase and lipase levels, which are indicative of trypsin activity. Increasing levels of serum TNFα caused by cerulein are inhibited in the presence of spautin-1. Spautin-1 treatment can ameliorate the inflammation damage induced by cerulein, such as edema, degeneration, coagulative necrosis and infiltration of inflammatory cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

271.26

Formula

C15H11F2N3
CAS 号

1262888-28-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (184.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6865 mL 18.4325 mL 36.8650 mL
5 mM 0.7373 mL 3.6865 mL 7.3730 mL
10 mM 0.3687 mL 1.8433 mL 3.6865 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.22 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.22 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.22 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.22 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Shao S, et al. Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int J Oncol. 2014 May;44(5):1661-1668.

    [2]. Xiao J, et al. Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload. Mol Med. 2016 Aug 18;22.
Cell Assay
[1]

Spautin-1 is dissolved in DMSO. Cell proliferation is evaluated using CCK-8 kit. K562 cells (1×105/mL) are seeded into 96-well plates in triplicate and then treated with 125 to 4,000 nM IM alone or in combi¬nation with spautin-1 (10 μM). After 48 h of incubation, 10 μL of CCK-8 reagent is added to each well. Four hours later, the absorbance is read at 450 nm using a microplate reader[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Mice: In this study, mice models with acute pancreatitis, including cerulein- and L-arginine-induced models, are constructed. For the cerulein-induced model, four intraperitoneal injections of cerulein (50 μg/kg body weight) are given consecutively at hourly intervals; The L-arginine-induced model received hourly intraperitoneal injections of 1.4 g/kg (optimal dosage for this study) L-arginine three times[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Shao S, et al. Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int J Oncol. 2014 May;44(5):1661-1668.

    [2]. Xiao J, et al. Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload. Mol Med. 2016 Aug 18;22.

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Bavachin(Synonyms: 补骨脂二氢黄酮; Corylifolin)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Bavachin (Synonyms: 补骨脂二氢黄酮; Corylifolin) 纯度: 99.94%

Bavachin 是从补骨脂种子中分离到的黄酮类物质，作为植物雌激素激活雌性激素受体 ERα 和 ERβ，EC50 值分别为 320 和 680 nM。

Bavachin(Synonyms: 补骨脂二氢黄酮; Corylifolin)

Bavachin Chemical Structure

CAS No. : 19879-32-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥880 In-stock
5 mg ￥800 In-stock
10 mg ￥1400 In-stock
25 mg ￥2900 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Bavachin 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Lipid Compound Library
  • Phenols Library
  • Flavonoids Library

生物活性

Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively.

IC50 & Target

IC50: 320 nM (ERα), 680 nM (ERβ)
体外研究
(In Vitro)

Bavachin significantly inhibits melanin synthesis and TYR activity. Bavachin (10 µM) inhibits the expression of TYR and JNK proteins, and the expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2 mRNA in A375 cells. ICI182780 and U0126 cAN significantly reverse the bavachin treatment on the protein expression levels and the mRNA expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2[1]. Bavachin accumulates lipid in a dose dependent manner in ORO staining experiments. Bavachin significantly increases the growth of preadipoctye at 10 µM compared with the control cells in MTT assay. Bavachin also increases BrdU incorporation into newly synthesized DNA during pre-adipocyte proliferation. BrdU incorporation is enhanced by insulin and further enhanced by co-treatment with insulin and bavachin at 2 and 10 µM. Bavachin activates adipogenic factors and increases PPARγ transcriptional activity in differentiated adipocytes. Bavachin enhances insulin-stimulated glucose uptake through GLUT4 translocation via Akt and AMPK pathway[2]. BVN significantly increases both hMAO-A and hMAO-B activities[3]. Bavachin shows ER ligand binding activity in competitive displacement of [3H] E2 from recombinant ER. The estrogenic activity of bavachin is characterized in a transient transfection system using ERα or ERβ and estrogen-responsive luciferase plasmids in CV-1 cells with an EC50 of 320 nM and 680 nM, respectively. Bavachin increases the mRNA levels of estrogen-responsive genes such as pS2 and PR, and decreases the protein level of ERα by proteasomal pathway[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

324.37

Formula

C20H20O4
CAS 号

19879-32-4
中文名称

补骨脂甲素；补骨脂二氢黄酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (308.29 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0829 mL 15.4145 mL 30.8290 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL
10 mM 0.3083 mL 1.5414 mL 3.0829 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.41 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.41 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.41 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.41 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.41 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.41 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Wang JH, et al. Effects of bavachin and its regulation of melanin synthesis in A375 cells. Biomed Rep. 2016 Jul;5(1):87-92. Epub 2016 May 20.

    [2]. Lee H, et al. Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes. Int J Mol Sci. 2016 Apr 8;17(4):527.

    [3]. Zarmouh NO, et al. Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B. Evid Based Complement Alternat Med. 2015;2015:852194.

    [4]. Park J, et al. Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia. Biomol Ther (Seoul). 2012 Mar;20(2):183-8.

Kinase Assay
[3]

The chemiluminescent assay is used to confirm PCSEE MAO-A and MAO-B inhibitory effects and to test BNN and BVN hMAO-A and hMAO-B inhibition using MAO-Glo kit. Each enzyme’s Arbitrary Light Unit (ALU) is measured in the presence of PCSEE, BNN, BVN, and standard DEP as an MAO-BI positive control. Briefly, hMAO-A and hMAO-B isozymes are diluted to 2× with reaction buffer (pH 7.4) and preincubated with 4× PCSEE, BNN, BVN, or DEP working solutions at RT for 30 min in white opaque 96-well plates. For determining activity inhibition, final 8.5 μg/mL concentrations of PCSEE, BNN, BVN, and DEP are used. For IC50 determination, 8× PCSEE and BNN working solutions are serially diluted using reaction buffers (pH 7.4) to make a 4× concentration. Ten points’ range of PCSEE (1.0 to 250.0 μg/mL) and BNN (up to 400 μM (135.4 μg/mL)) final concentrations is used. Controls used are with and without ethanol. Ethanol solvent in controls is kept to a maximum final (volume) of ≤2%. Each isozyme is substituted with the reaction buffer for the blank. Based on our preliminary optimizations and Valley’s method, the reaction is initiated by adding 4× luciferin derivative substrate (LDS) for a final (concentration) of 40 and 4 μM for hMAO-A and hMAO-B reactions, respectively. The final volume per well of each reaction is 50 μL. The reaction is optimized for the amount of A and B enzyme used to be incubated for less than 3.5 h at RT. To stop the reaction and produce the luminescence signal RLDR is added to all wells, 50 μL to each well, and incubated for a further 30 min.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay
[1]

MTT solution (20 µL) is added to each well of the 96-well plates, the cells are cultured for 4 h, the solution is discarded, and the purple crystal is dissolved in the wells with 150 µL DMSO solution, agitated in a 37°C incubator shaker for 10 min, and the optical density (OD) is measured at 490 nm by the microplate reader.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Wang JH, et al. Effects of bavachin and its regulation of melanin synthesis in A375 cells. Biomed Rep. 2016 Jul;5(1):87-92. Epub 2016 May 20.

    [2]. Lee H, et al. Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes. Int J Mol Sci. 2016 Apr 8;17(4):527.

    [3]. Zarmouh NO, et al. Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B. Evid Based Complement Alternat Med. 2015;2015:852194.

    [4]. Park J, et al. Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia. Biomol Ther (Seoul). 2012 Mar;20(2):183-8.

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SNT-207858

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SNT-207858 

SNT-207858 是一种选择性，可渗透血脑屏障的，有口服活性的黑皮质素 (melanocortin; MC-4) 受体拮抗剂，SNT-207858 抑制与 MC-4 受体结合，IC50 为 22 nM。SNT-207858 抑制 MC-4 活性，IC50 为 11 nM。

SNT-207858

SNT-207858 Chemical Structure

CAS No. : 1104080-42-3

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* Please select Quantity before adding items.

SNT-207858 的其他形式现货产品:

SNT-207858 free base

生物活性

SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].

IC50 & Target

IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1]
体外研究
(In Vitro)

SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with C26 adenocarcinoma-induced cachexia model[1]
Dosage: 30 mg/kg
Administration: Oral administration; once daily; 15 days
Result: Significantly reduced the tumor induced weight loss.

分子量

689.54

Formula

C32H45Cl4N5O3
CAS 号

1104080-42-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774.

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交叉耦合触媒一览|交叉偶联触媒|有机合成纯试剂|试剂|关东化学株式会社

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Buchwald配位体Buchwald Ligands

Massachusetts学院明确Technology（MIT）的Buchwald等开发的ビアリールモノホスフィン类新发售。本膦电子丰富，且嵩高的结构具有。

Amphos

[ 4 -(N您N-二甲胺基苯基] -）页tert –ブチルホスフィン（Amphos）新发售。书配位是电子供给性高tBu基础的内容为高活性的同时，高稳定性并存，被关注。

直接交叉偶联反应用镍触媒（Ni – dcype）Nickel Catalyst在Cross – coupling Reactions

名古屋大学变形金刚成法生命分子研究所（WPI – ITbM）的伊丹健一郎教授，山口川润一郎准教授所开发的镍触媒（Ni – dcype）新发售了。本触媒异质芳香族化合物和酚衍生物，芳香族酯，エノール衍生物，或不饱和酯开始对应耦合化合物中高效给予。

偶联反应试剂Coupling reagents

铃木-宮浦耦合反应用于硼酸化合物是医药品，生理活性物质，功能性材料的碳骨骼形成的重要的化合物。硼酸化合物，Buchwald配位，Amphos，Ni – dcype，碳酸钾、碳酸钠、金属食腐动物等，耦合反应的必要的试剂一册归结了。

试剂的咨询

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抗GAPDH抗体[ epr16891 ]（ab181602）

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种属反应性

与反应：小鼠、大鼠、兔、鸡、人、鱼、猴、斑马鱼、Xenopus酵母
  • 应用 AB评论 说明 WB 1 / 10000。检测到的频带的约36 kDa（预测分子量：36 kDa）。 ihc-p 2000 / 1。进行热三/ EDTA缓冲液pH 9开始前的免疫组化染色协议介导抗原修复。 国际商会/如果 1 / 500。 流式细胞 1 / 180。

    ab172730兔单克隆抗体，适用于该抗体的同型对照。

    IP 1 / 60。

    • 靶标

    • 功能具有3-磷酸甘油醛脱氢酶和nitrosylase活动，从而在糖酵解和核函数的作用，分别。参与包括转录，核事件RNA运输、DNA复制和细胞凋亡。核函数是可能的nitrosylase活性介导的半胱氨酸巯基亚硝基化核靶蛋白如SIRT1，HDAC2和PRKDC（相似性）。3-磷酸甘油醛脱氢酶是一种糖酵解过程中的关键酶，催化该途径的第一步将D-甘油醛3-磷酸（G3P）为3-phospho-d-glyceroyl磷酸盐。
    • 通路碳水化合物的降解；糖酵解；从D-甘油醛3-磷酸丙酮酸：步骤1 / 5。
    • 序列相似性属于3-磷酸甘油醛脱氢酶家族。
    • 翻译后修饰S-亚硝基化的Cys-152导致交互Siah1，随后转运到细胞核。isgylated。
    • 细胞定位细胞质细胞质>。核。细胞质核周区>。膜。转位后的S-亚硝基化和交互Siah1的核心，它包含一个核定位信号（相似性）。后核周区。

    • 以上信息来自：UniProt加入目标p04406UniProt协会通用蛋白质资源（UniProt）2010
      核酸研究38（2010）：d142-d148。

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    英国斯图尔特Stuart振荡水浴摇床SBS40

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    【简单介绍】

    英国斯图尔特Stuart振荡水浴摇床SBS40集合了振荡功能和可选择的平板，可以为您提供线性往复式或轨道式振荡方式的需要。平板的替换不需要要特别的安装而是使用连接到不锈钢水槽下面的驱动装置的强大磁力。容器通过一些高压的弹簧被牢固地固定在不锈钢板上，能够用于任意的容器或容器组合。
    英国进口，！

    【详细说明】

    英国斯图尔特Stuart振荡水浴摇床SBS40

    产品描述：

         英国斯图尔特Stuart振荡水浴摇床SBS40集合了振荡功能和可选择的平板，可以为您提供线性往复式或轨道式振荡方式的需要。平板的替换不需要要特别的安装而是使用连接到不锈钢水槽下面的驱动装置的强大磁力。容器通过一些高压的弹簧被牢固地固定在不锈钢板上，能够用于任意的容器或容器组合。加热器安装在水槽的下面，清洗简单方便。当水浴中水位很低时，仪器的低水位感应器会发出警报，显示盘上警报灯闪烁，并切断加热器的电源以防止烧干。集成排水管用于将水简单地排出。平板能适用于以下锥形瓶: 8 x 250ml, 6 x 500, 或4 x 1000ml。

    速度和温度控制器使用简单。振荡速度可调，电子反馈控制能确保准确的速度保持。能通过简单易读的LED显示器设定并监控水浴温度。另外，还包含一个过温保护系统，能够追踪设定温度并控制加热器以防产生错误。

    一系列不锈钢附件可用，设计适用于通用的样品管型号，从1.5ml微管到高达50ml离心管。可用的可选择盖，设计用于减少热量流失和防止蒸发，有不锈钢和塑料材质的可选。依据工作环境和个人喜好，聚碳酸酯盖可以通过铰链安装在水浴的四周。

    主要特点：

    可选择线性往复式或轨道式振荡方式
    数字式显示和设定温度
    低水位感应器
    集成排水管
    一系列的附件可用

    技术参数

    容量 24L
    温度范围 室温+5°C – 99.9°C
    温度稳定性 ±0.25°C
    振荡速度 20-200rpm
    振动轨道/振幅 20mm
    内部尺寸(w x d x h) 300 x 500 x 200 mm
    外形尺寸(w x d x h) 335 x 580 x 330 mm
    净重 17kg
    电源 230V, 50hz 1400W


    订货信息

    型号 描述
    SBS40 振荡水浴，(不包含平板)
    SBS40/1 平板，适用于线性振荡方式
    SBS40/2 平板，适用于轨道振荡方式
    SBS40/3 平板, 有孔的
    SBS40/4 聚碳酸酯盖，铰链式
    SWB3/1 不锈钢盖
    SBS40/5 试管架, 143 x 1.5ml微管
    SBS40/6 试管架, 120 x 13mm培养管
    SBS40/7 试管架, 72 x 16mm培养管
    SBS40/8 试管架, 56 x 15ml离心管
    SBS40/9 试管架, 30 x 26mm培养管
    SBS40/10 试管架, 25 x 50ml离心管

    ABBV-744

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    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    ABBV-744  纯度: 99.97%

    ABBV-744 是一种首创，具有口服活性和选择性的 BET 家族蛋白 BDII 结构域 (BDII domain)，对 BRD2、BRD3、BRD4 和 BRDT 的 IC50 值为 4~18 nM。ABBV-744 主要由 CYP3A4 代谢，具有类似药物的特性，可用于研究其抗肿瘤功效和耐受性。

    ABBV-744

    ABBV-744 Chemical Structure

    CAS No. : 2138861-99-9

    规格 价格 是否有货 数量
    Free Sample (0.1-0.5 mg)   Apply now  
    10 mM * 1 mL in DMSO ￥1650 In-stock
    2 mg ￥900 In-stock
    5 mg ￥1600 In-stock
    10 mg ￥2600 In-stock
    25 mg ￥5200 In-stock
    50 mg ￥8400 In-stock
    100 mg ￥13280 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    ABBV-744 相关产品

    •相关化合物库:

    • Clinical Compound Library Plus
    • Bioactive Compound Library Plus
    • Anti-Infection Compound Library
    • Epigenetics Compound Library
    • Immunology/Inflammation Compound Library
    • Histone Modification Research Compound Library
    • Anti-Cancer Compound Library
    • Clinical Compound Library
    • Antiviral Compound Library
    • Reprogramming Compound Library
    • Orally Active Compound Library
    • Chemical Probe Library
    • Anti-Blood Cancer Compound Library

    生物活性

    ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values ranging from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT. ABBV-744 is primarily metabolized by CYP3A4 with drug-like properties enable the investigation of its antitumor efficacy and tolerability[1].

    IC50 & Target[1]

    BRD2 (BD2)

    8 nM (IC50)

    BRD3 (BD2)

    13 nM (IC50)

    BRDT (BD2)

    18 nM (IC50)

    BRD4 (BD2)

    4 nM (IC50)

    BRD4 (BD2)

    3 nM (Kd)

    体外研究
    (In Vitro)

    ABBV-744 (90 nM; 0~24 h; LNCaP cells) downregulates the expression of KLK2 and MYC genes[1].
    ABBV-744 (90 nM; 0~72 h; LNCaP cells) induces cell cycle arrest in G1 followed by senescence[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[1]

    Cell Line: LNCaP cells
    Concentration: 90 nM
    Incubation Time: 0~24 hours
    Result: Downregulated the expression of KLK2 and MYC genes.

    Cell Cycle Analysis[1]

    Cell Line: LNCaP cells
    Concentration: 90 nM
    Incubation Time: 0~72 hours
    Result: Induced cell cycle arrest in G1 followed by senescence.

    体内研究
    (In Vivo)

    ABBV-744 (4.7 mg/kg; oral gavage; 28 days) causes a delay in tumor growth and displays equivalent or better antitumor activity compared with ABBV-075[1].
    ABBV-744 (30 mg/kg; 14 days) is able to produce significant antitumor activity. ABBV-744 (30 mg/kg) triggers a reduction in platelets of only 20 %[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mice
    Dosage: 4.7 mg/kg (Pharmacokinetic Analysis)
    Administration: Oral gavage; 28 days
    Result: Caused a delay in tumor growth and displayed equivalent or better antitumor activity compared with ABBV-075.
    Animal Model: Sprague-Dawley rats
    Dosage: 30 mg/kg (Pharmacokinetic Analysis)
    Administration: 14 days
    Result: Produced significant antitumor activity.

    Clinical Trial

    分子量

    491.55

    Formula

    C28H30FN3O4
    CAS 号

    2138861-99-9
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (203.44 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.0344 mL 10.1719 mL 20.3438 mL
    5 mM 0.4069 mL 2.0344 mL 4.0688 mL
    10 mM 0.2034 mL 1.0172 mL 2.0344 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (5.09 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (5.09 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
    • 3.

      请依序添加每种溶剂： 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (5.09 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

    • 4.

      请依序添加每种溶剂： 50% PEG300    50% saline

      Solubility: 2.5 mg/mL (5.09 mM); Suspended solution; Need ultrasonic

    • 5.

      请依序添加每种溶剂： 5% DMSO    40% PEG300    5% Tween-80    50% saline

      Solubility: ≥ 2 mg/mL (4.07 mM); Clear solution

    • 6.

      请依序添加每种溶剂： 5% DMSO    95% (20% SBE-β-CD in saline)

      Solubility: ≥ 2 mg/mL (4.07 mM); Clear solution

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献

    • [1]. Faivre EJ, et al. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. Nature. 2020;578(7794):306-310.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Imisopasem manganese(Synonyms: M40403; GC4403)

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    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Imisopasem manganese (Synonyms: M40403; GC4403) 纯度: ≥96.0%

    Imisopasem manganese (M40403) 是稳定的 MnSOD 的非肽基模拟物。

    Imisopasem manganese(Synonyms: M40403; GC4403)

    Imisopasem manganese Chemical Structure

    CAS No. : 218791-21-0

    规格 价格 是否有货 数量
    10 mM * 1 mL in Water ￥1793 In-stock
    2 mg ￥990 In-stock
    5 mg ￥1700 In-stock
    10 mg ￥2700 In-stock
    25 mg ￥5400 In-stock
    50 mg ￥8500 In-stock
    100 mg ￥11500 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    Imisopasem manganese 相关产品

    •相关化合物库:

    • Drug Repurposing Compound Library Plus
    • Clinical Compound Library Plus
    • Bioactive Compound Library Plus
    • Anti-Cancer Compound Library
    • Clinical Compound Library
    • Drug Repurposing Compound Library

    生物活性

    Imisopasem manganese (M40403) is a stable non-peptidyl mimetic of manganese superoxide MnSOD.

    体外研究
    (In Vitro)

    Imisopasem manganese is a small molecule, synthetic manganese containing superoxide dismutase mimetic (SODm) that removes superoxide anions without interfering with other reactive species known to be involved in inflammatory responses (e.g. nitric oxide, NO and peroxynitrite, ONOO-)[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    体内研究
    (In Vivo)

    Imisopasem manganese is a small-molecule superoxide dismutase mimetic that has shown efficacy in animal model disease states in which superoxide anions are thought to play a key role. Imisopasem manganese inhibits the inflammatory response following the intrapleural injection of carrageenan in rats. All parameters of inflammation are attenuated by Imisopasem manganese except for NOx, PGE2 and IL-10 which remains unaltered[1]. Decreased apoptosis of the large and particularly the small bowel and marked recovery of both lymphoid and hematopoietic tissues occurs in the Imisopasem manganese pre-treated mice. Imisopasem manganese is effective in reducing TBI-induced tissue destruction and has potential as a new radioprotective agent[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial

    分子量

    479.35

    Formula

    C21H31Cl2MnN5
    CAS 号

    218791-21-0
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    H2O : 16 mg/mL (33.38 mM; Need ultrasonic and warming)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.0862 mL 10.4308 mL 20.8616 mL
    5 mM 0.4172 mL 2.0862 mL 4.1723 mL
    10 mM 0.2086 mL 1.0431 mL 2.0862 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
    参考文献

    • [1]. Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27.

      [2]. Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17.
    Animal Administration
    [1][2]

    Rats: Male Sprague-Dawley rats are used in the study. M40403 (5-20 mg kg-1), or an equivalent volume (0.3 mL) of vehicle (26 mm sodium bicarbonate buffer, pH 8.1-8.3), is injected intraperitoneally (i.p.) 15 min before carrageenan. At 4 h after the injection of carrageenan, the animals are killed by inhalation of CO2[1].

    Mice: 30 mg dry powder M40403 is dissolved in 6.0 ml SBC adjusted to pH 8.3 with 1 M NaOH. This stock solution is diluted to 1.25 mg/mL in SBC. Two experimental models are tested. In one, the dose of IR is held constant at 8.5 Gy total body irradiation (TBI). The mice are injected i.p. with a single dose of 40 mg/kg, 30 mg/kg, 20 mg/kg or 10 mg/kg M40403. Thirty minutes later the mice receives 8.5 Gy total body irradiation (TBI). Control animals receives 0.1 ml of SBC buffer prior to TBI. In the other model, groups of 20 mice receives either 6.5 or 7.5 Gy TBI. One half of each group is treated with 2.0 mg/kg M40403 i.p. and the other with SBC 30 min before TBI. All are followed for survival[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    • [1]. Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27.

      [2]. Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17.

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