Hexadimethrine bromide(Synonyms: 聚凝胺; Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide)

发表于2024年10月20日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Hexadimethrine bromide (Synonyms: 聚凝胺; Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide) 纯度: ≥95.0%

Hexadimethrine bromide (Polybrene) 是一种阳离子聚合物，通常用于提高逆转录病毒载体介导的基因转移效率。

Hexadimethrine bromide Chemical Structure

CAS No. : 28728-55-4

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200 mg		询价

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Hexadimethrine bromide 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Anti-Cancer Compound Library
FDA Approved & Pharmacopeial Drug Library

生物活性	Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer^[1]^[2].
体外研究 (In Vitro)	Hexadimethrine bromide inhibits human mesenchymal stem cell proliferation during lentiviral transduction. Hexadimethrine bromide is considered non-toxic at low concentrations, but has been found to negatively affect cell proliferation in some cell types at concentrations greater than 10 µg/mL. Trypsinized cells exposed to Hexadimethrine bromide are visibly larger in size when viewed under the microscope^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Formula	C₁₅H₃₆Br₂N₂
CAS 号	28728-55-4
中文名称	海(地)美溴铵
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
溶解性数据	In Vitro: H₂O : ≥ 125 mg/mL DMSO : 5 mg/mL (Need ultrasonic and warming) * “≥” means soluble, but saturation unknown. In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂： ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶 1. 请依序添加每种溶剂： PBS Solubility: 100 mg/mL (Infinity mM); Clear solution; Need ultrasonic 2. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: ≥ 0.5 mg/mL (Infinity mM); Clear solution 此方案可获得 ≥ 0.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液 3. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline) Solubility: ≥ 0.5 mg/mL (Infinity mM); Clear solution 此方案可获得 ≥ 0.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明 4. 请依序添加每种溶剂： 10% DMSO 90% corn oil Solubility: 0.5 mg/mL (Infinity mM); Clear solution; Need warming 此方案可获得 0.5 mg/mL (Infinity mM) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。 *以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。
参考文献	[1]. Lin P, et al. Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction. PLoS One. 2011;6(8):e23891. [2]. Abe A, et al. Polybrene increases the efficiency of gene transfer by lipofection. Gene Ther. 1998;5(5):708-711.

Cell Assay ^[1]	Trypsinized cells are washed and resuspended in medium at 2×10⁴ cells/mL with or without rhFGF-2 (final concentration=10 ng/mL, PeproTech) and with or without Hexadimethrine bromide at a final Hexadimethrine bromide concentration of 1, 4, or 8 µg/mL. The different conditions are seeded in 96-well plates at 1×10³ cells in 50 µL per well in triplicate and cultured at 37°C, 5% CO₂. After 6, 9, or 24 hr, the medium is changed and subsequent medium changes occurred every 3-4 days with 50 µL of ± FGF-2 medium (10 ng/mL). Plates are harvested on day 4, 7, 14, and 21 by removing the medium and placing the plates in the -80°C freezer until the day of analysis. The CyQUANT assay is then performed on the wells^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Lin P, et al. Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction. PLoS One. 2011;6(8):e23891. [2]. Abe A, et al. Polybrene increases the efficiency of gene transfer by lipofection. Gene Ther. 1998;5(5):708-711.

Cell Assay
^[1]

Trypsinized cells are washed and resuspended in medium at 2×10⁴ cells/mL with or without rhFGF-2 (final concentration=10 ng/mL, PeproTech) and with or without Hexadimethrine bromide at a final Hexadimethrine bromide concentration of 1, 4, or 8 µg/mL. The different conditions are seeded in 96-well plates at 1×10³ cells in 50 µL per well in triplicate and cultured at 37°C, 5% CO₂. After 6, 9, or 24 hr, the medium is changed and subsequent medium changes occurred every 3-4 days with 50 µL of ± FGF-2 medium (10 ng/mL). Plates are harvested on day 4, 7, 14, and 21 by removing the medium and placing the plates in the -80°C freezer until the day of analysis. The CyQUANT assay is then performed on the wells^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Lin P, et al. Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction. PLoS One. 2011;6(8):e23891.

[2]. Abe A, et al. Polybrene increases the efficiency of gene transfer by lipofection. Gene Ther. 1998;5(5):708-711.

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Isoviolanthin(Synonyms: 异佛来心苷)

发表于2024年10月20日由上海金畔生物科技有限公司

Isoviolanthin (Synonyms: 异佛来心苷) 纯度: 99.66%

Isoviolanthin 是一种黄酮糖苷，在 HCC 细胞中，可通过调控 TGF-β/Smad 和 PI3K/Akt/mTOR 通路抑制上皮间质转化 (EMT)，从而显着抑制 TGF-β1 介导的迁移和侵袭。 Isoviolanthin 对正常肝 LO2 细胞没有细胞毒性作用。

Isoviolanthin Chemical Structure

CAS No. : 40788-84-9

规格	价格	是否有货
5 mg	￥2300	In-stock
10 mg	￥3900	In-stock
50 mg		询价
100 mg		询价

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Isoviolanthin 相关产品

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Natural Product Library Plus
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TGF-beta/Smad Compound Library
Wnt/Hedgehog/Notch Compound Library
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Anti-Aging Compound Library
Phenols Library
Traditional Chinese Medicine Monomer Library
Flavonoids Library
Angiogenesis Related Compound Library
Transcription Factor Targeted Library
Anti-Liver Cancer Compound Library
Anti-Colorectal Cancer Compound Library

生物活性

Isoviolanthin, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells^[1].

分子量

578.52

Formula

C₂₇H₃₀O₁₄

CAS 号

40788-84-9

中文名称

异佛来心苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 250 mg/mL (432.14 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7285 mL	8.6427 mL	17.2855 mL
5 mM	0.3457 mL	1.7285 mL	3.4571 mL
10 mM	0.1729 mL	0.8643 mL	1.7285 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (3.60 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.60 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.60 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (3.60 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Xing S, et al. Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. Int J Mol Sci. 2018 May 23;19(6).

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美国Crystal精骐试管旋转混匀器HYQ-2231/HYQ-2230

发表于2024年10月20日由上海金畔生物科技有限公司

【简单介绍】

美国Crystal精骐试管旋转混匀器HYQ-2231/HYQ-2230是一款设计*的产品，旋转速度温和，通过对试管板的调节，使样品处于任意角度旋转，广泛应用于分子生物学、化学、临床应用等各种需求混合的场合。可同时安装不同的试管板，并可调整不同的角度，以提高实验效率。

【详细说明】

美国Crystal精骐试管旋转混匀器HYQ-2231/HYQ-2230

产品简述：

美国Crystal精骐试管旋转混匀器HYQ-2231/HYQ-2230是一款设计*的产品，旋转速度温和，通过对试管板的调节，使样品处于任意角度旋转，广泛应用于分子生物学、化学、临床应用等各种需求混合的场合。可同时安装不同的试管板，并可调整不同的角度，以提高实验效率。

The Tube Revolver can be used in a variety of laboratory fields such as Molecular Biology, Biochemistry,
Clinical and Histochemistry. The rotisseries are interchangeable so that the unit works with a variety of tube
sizes. The four rotisserie??paddles?can?be?mixed for?a combination of different?tubes. Each paddle?direction??
can??be ?independently adjusted from 0-90 degrees.
In addition to the speed adjustability and digital display, Model HYQ-1131 can be programmed to operate in an
oscillating mode, simulating the mixing process by hand. Oscillation occurs at every 40 degrees in the rotation.
The combination of rotation and oscillation mixes liquid more effectively. ??

技术参数

型号	HYQ-2230	HYQ-2231
产品名称	固定转速试管混匀器	数显转速可调试管混匀器
转速	18rpm	10~40rpm
容量	42×0.5ml 试管, 50×1.5ml/2.0ml 试管, 14×5ml/7ml 试管, 14×10ml 试管, 6×50ml 试管
标配	试管支架：2个HYQF-8、2个HYQF-9、2个HYQF-10、2个HYQF-11、1个HYQF-12
环境温度	4℃~60℃
外形尺寸	225×154×195mm
大功率	4W	6W
重量	0.8kg	1.2kg
电源	AC220±22V 50±1Hz	AC100~240V/50~60Hz

特点

1、体积小巧，操作简便；

2、标配五种试管板，满足客户多种需求；

3、开启状态下，轻按试管板，可反方向旋转；

4、噪音低，运转平稳；

5、高性能马达，使用寿命长。

Small footprint and “Plug and Play” operation;
Includes five different interchangeable rotisseries;
Rotation direction can be changed by slightly touching the rotisseries;
Paddle angle?is?adjustable?for?different mixing purposes
High quality, maintenance-free motor with quiet operation.

附件

名称	10ml/15ml试管板	5ml/7ml试管板	1.5ml/2ml试管板	0.5ml/0.8ml试管板	50ml试管板	磁板附件
型号	HYQF-8	HYQF-9	HYQF-10	HYQF-11	HYQF-12	TBA2A
个/包	2	2	2	2	1	1
图片

Nelarabine(Synonyms: 奈拉滨; 506U78; GW 506U78; Nelzarabine)

发表于2024年10月20日由上海金畔生物科技有限公司

Nelarabine (Synonyms: 奈拉滨; 506U78; GW 506U78; Nelzarabine) 纯度: 99.88%

Nelarabine (Arranon, 506U78)是嘌呤核苷酸类似物，为DNA合成抑制剂，对肿瘤细胞的IC50为0.067-2.15 μM，可作用于T细胞急性淋巴细胞白血病。

Nelarabine Chemical Structure

CAS No. : 121032-29-9

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Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥1377	In-stock
5 mg	￥1252	In-stock
10 mg	￥2358	In-stock
50 mg	￥7149	In-stock
100 mg	￥10114	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

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Drug Repurposing Compound Library Plus
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FDA-Approved Drug Library Mini
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Anti-Aging Compound Library
Drug Repurposing Compound Library
Reprogramming Compound Library
Nucleotide Compound Library
Anti-COVID-19 Compound Library
FDA Approved & Pharmacopeial Drug Library
Anti-Lung Cancer Compound Library
Drug-Induced Liver Injury (DILI) Compound Library
Anti-Blood Cancer Compound Library
Anti-Cancer Metabolism Compound Library
Rare Diseases Drug Library

生物活性

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. Nelarabine is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. IC50 Value: 0.44 uM (HSB2 cell lines); 1.24 μM(ALL-SIL cell lines); 2.15 μM(JURKAT cell lines); 0.067 uM (PER-255 cell lines) [1] Target: Nucleoside antimetabolite/analog in vitro: The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively [1]. in vivo: The median age was 34 years (range, 16-66 years); 32 (82%) patients were male. The rate of complete remission was 31% (95% confidence interval [CI], 17%, 48%) and the overall response rate was 41% (95% CI, 26%, 58%). The principal toxicity was grade 3 or 4 neutropenia and thrombocytopenia, occurring in 37% and 26% of patients, respectively [2]. Nelarabine has activity in T-cell malignancies, as evaluated in 2 Phase I and 5 Phase II studies. It received accelerated approval from the FDA based on the resuits of 2 Phase II trials, one in pediatric patients (PGAA 2001) and the other in adults (CALGB 19801) Toxicity: The principal toxicity was grade 3 or 4 neutropenia and thrombocytopenia, occurring in 37% and 26% of patients, respectively [2]. Clinical trial: Drug Use Investigation for Arranon G (Nelarabine) Injection 250 mg.

Clinical Trial

分子量

297.27

Formula

C₁₁H₁₅N₅O₅

CAS 号

121032-29-9

中文名称

奈拉滨

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (336.39 mM; Need ultrasonic)

H₂O : 10 mg/mL (33.64 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3639 mL	16.8197 mL	33.6395 mL
5 mM	0.6728 mL	3.3639 mL	6.7279 mL
10 mM	0.3364 mL	1.6820 mL	3.3639 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.41 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.41 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.41 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Beesley AH, et al. In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia. Br J Haematol. 2007 Apr;137(2):109-16.

[2]. DeAngelo DJ, et al. Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801. Blood. 2007 Jun 15;109(12):5136-42.

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(S)-(−)-Perillyl alcohol

发表于2024年10月20日由上海金畔生物科技有限公司

(S)-(−)-Perillyl alcohol 纯度: ≥98.0%

(S)-(−)-Perillyl alcohol 是薰衣草中的单萜类物质，抑制 Ras 的法尼基化，上调 6-磷酸甘露糖受体，诱导凋亡 (apoptosis)。具有抗癌作用。

(S)-(−)-Perillyl alcohol Chemical Structure

CAS No. : 18457-55-1

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥550	In-stock
100 mg	￥500	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

(S)-(−)-Perillyl alcohol 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Metabolism/Protease Compound Library
Natural Product Library
Anti-Cancer Compound Library
Human Endogenous Metabolite Compound Library
Terpenoids Library
Traditional Chinese Medicine Monomer Library

生物活性

(S)-(−)-Perillyl alcohol is a monoterpene found in lavender, inhibits farnesylation of Ras, upregulates the mannose-6-phosphate receptor and induces apoptosis. Anti-cancer activity^[1].

IC₅₀ & Target

Human Endogenous Metabolite

分子量

152.23

Formula

C₁₀H₁₆O

CAS 号

18457-55-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : ≥ 250 mg/mL (1642.25 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.5690 mL	32.8450 mL	65.6901 mL
5 mM	1.3138 mL	6.5690 mL	13.1380 mL
10 mM	0.6569 mL	3.2845 mL	6.5690 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (13.66 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (13.66 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (13.66 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (13.66 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (13.66 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (13.66 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Liston BW, et al. Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. Cancer Res. 2003 May 15;63(10):2399-403.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

大龙加热震荡恒温金属浴HM100-PRO

发表于2024年10月20日由上海金畔生物科技有限公司

大龙加热震荡恒温金属浴HM100-PRO

品牌大龙|DLAB

型号 HM100-PRO

货号 5032104100

商品详情

产品介绍：

出色的温度控制系统。室温下，能够对15-100℃的温度范围进行精准控制；

20-45℃ 最大温度精准度为±0.5℃；

最高转速1500 rpm(不同模块会有变动)；

多种承载模块选择；

支持程序编辑和存储。

磁体吸附技术，无需工具，模块即可自动与机器吸附；

配置保温功能模块罩，防止热量散失。

技术参数：

技术参数	HM100-Pro
功能	加热,混匀
温度控制范围[℃ ]	最低：高于室温5℃
温度控制范围[℃ ]	最高：100℃
	最高：100℃
温度可设定范围 [℃ ]	15℃~100℃
温度控制精度[20–45℃ ]	± 0.5℃
温度均一性[20–45℃ ]	± 0.5℃
最大加热速率 [℃/分]	5.5
调速范围 [rpm]	200–1500
混匀直径 [mm]	3
显示屏规格	LCD
最大编程数量	9
输入电压	100-240V, 50Hz/60Hz
功率	200 W
时间设置范围	1min~99h59min
尺寸[长?宽?高 mm]	200×235×120
工作环境温度	5~40℃
工作环境湿度	80%

产品编号	型号	产品名称
5032104100	HM100-PRO	加热震荡恒温金属浴 200-240V/50Hz/60Hz

加热块附件
产品编号	型号	产品名称
18900238		适用 0.5mL离心管, 24孔
18900237		适用于1.5mL离心管, 24孔
18900239		适用于2mL离心管, 24孔
18900240		适用于5mL离心管, 8孔
18900241		适用于15mL离心管, 8孔
18900242		适用于50mL 离心管, 4孔
18900243		适用0.2mL PCR管
18900244		适用96/384孔板

适配 eppendorf 管的新模块
18900353		加热模块, 适用于 5mL 离心管, 8 孔
18900354		加热模块, 适用于 5mL 离心管, 8 孔, 锥形低, 只适用于新机器
18900355		加热模块, 适用于 15mL 离心管, 8 孔
18900356		加热模块, 适用于 50mL 离心管, 4 孔

离心机MLX-204/MLX-206/MLX-210/MLX-200F

发表于2024年10月20日由上海金畔生物科技有限公司

【简单介绍】

品牌	HETTICH	加工定制	否
结构类型	台式	布局形式	其他

美国Crystal迷你离心机MLX-204/MLX-206/MLX-210/MLX-200F是临床、环保、工业等众多科研领域的常规实验室仪器，是应用于快速旋转分离、样品过滤、细胞分离等实验的理想选择。
1、流线型设计，美观大方；
2、高强度透明上盖，观察清晰；
3、高品质复合材料和现代生产工艺，运转平稳；
4、翻盖开关设计，开盖即可自动停止运转；

【详细说明】

美国Crystal迷你离心机MLX-204/MLX-206/MLX-210/MLX-200F

产品简述：

美国Crystal迷你离心机是临床、环保、工业等众多科研领域的常规实验室仪器，是应用于快速旋转分离、样品过滤、细胞分离等实验的理想选择。

技术参数

型号	MLX-204	MLX-206	MLX-210
转速	4000rpm	6000rpm	10000rpm
相对离心力	900g	2000g	5000g
噪音	≤65dB	≤65dB	≤75dB
外壳颜色	粉色	米白色	蓝色
标配转子头	八连管转子：16×0.2ml 标准转子：6×1.5ml
安全保护模式	开盖即停
环境温度	5℃~40℃
相对湿度	≤80%
外形尺寸	155×140×115mm
电源	AC100~240V
重量	≤1kg

迷你离心机MLX-204/MLX-206/MLX-210/MLX-200F

特点

1、流线型设计，美观大方；

2、高强度透明上盖，观察清晰；

3、高品质复合材料和现代生产工艺，运转平稳；

4、翻盖开关设计，开盖即可自动停止运转；

5、采用世界的宽频电源技术（85V-264V），保证运行品质；

6、整机配有可互换的转子头，一机多用，灵活方便。

附件

名称	型号	图片
0.5ml离心管适配器具	MLXF-1
0.2ml离心管适配器具	MLXF-2
0.2ml条形转头	MLXF-3
1.5ml标准转子头	MLXF-7

—————————————————————————————————————————

迷你离心机MLX-200F

描述

迷你离心机MLX-200F具有3个可选择转头和双速度选择。可以运行于3种不同的工作模式下（定时运行，点动和连续运行）。LED灯带指示运行状态，其红、蓝、绿的发光颜色及不发光状态可通过底座的拨动开关而选择。

技术参数

型号	MLX-200F
转速	6000rpm		9200rpm
相对离心力（转子头）	5ml	2414g	5677g
	1.5ml	2012g	4731g
	0.2ml	1509g	3549g
运行模式	点动、连续、定时（0~15分钟）
LED发光选择	关、绿色、蓝色、红色
标配转子头	4×5ml 8×1.5ml 16×0.2ml
安全保护模式	开盖即停
噪音	<65dB
环境温度	5℃~ 40℃
相对湿度	≤80%
外形尺寸	240×187×139mm
电源	AC100~240V
重量	1.6Kg

1、设计精巧，造型美观；

2、转速可选：有6000rpm/9200rpm；

3、工作模式：点动、连续、定时；

4、标准转头配置：4×5ml、8×1.5ml、16×0.2ml；

5、转头转换方便、可靠，采用抱夹装置，安全性高，操作简便；

6、安全锁定，松盖即停；

7、三色LED发光选择，指示运行状态；

8、宽幅电源（100~240V），通用。

ICG-001

发表于2024年10月20日由上海金畔生物科技有限公司

ICG-001 纯度: 99.83%

ICG-001 是 β-catenin/TCF 介导的转录抑制剂。 ICG-001 特异性结合 CREB 蛋白起作用，IC₅₀ 为3 μM。ICG-001 选择性地阻断 β-catenin/CBP 相互作用而不干扰 β-catenin/p300 相互作用。

ICG-001 Chemical Structure

CAS No. : 780757-88-2

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥1112	In-stock
5 mg	￥921	In-stock
10 mg	￥1200	In-stock
50 mg	￥4500	In-stock
100 mg	￥8184	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

ICG-001 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Apoptosis Compound Library
Stem Cell Signaling Compound Library
Wnt/Hedgehog/Notch Compound Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Differentiation Inducing Compound Library
Cytoskeleton Compound Library
Neuroprotective Compound Library
Anti-Breast Cancer Compound Library
Transcription Factor Targeted Library
Anti-Liver Cancer Compound Library
Anti-Colorectal Cancer Compound Library

生物活性

ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC₅₀ of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction.

IC₅₀ & Target

IC50: 3 μM (CBP)

体外研究
(In Vitro)

ICG-001 (5μM) inhibits leptin-induced EMT, invasion and tumorsphere formation in MCF7 cells^[1]. ICG-001 can phenotypically rescue normal nerve growth factor (NGF)-induced neuronal differentiation and neurite outgrowth in the presenilin-1 mutant cells, emphasizing the importance of the TCF/β-catenin signaling pathway on neurite outgrowth and neuronal differentiation^[2]. ICG-001 (25μM) treatment reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein in SW480 cells, both of which can be up-regulated by β-catenin. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, and reduces in vitro growth of colon carcinoma cells^[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

ICG-001 (5 mg/kg per day) significantly inhibits beta-catenin signaling in mice, while concurrently preserving the epithelium^[2]. Administration of a water-soluble analog of ICG-001 for 9 weeks reduces the formation of colon and small intestinal polyps by 42% as effectively as the nonsteroidal antiinflammatory agent MK-231, which has consistently demonstrated efficacy in this model. ICG-001 (150 mg/kg, i.v.) demonstrates a dramatic reduction in tumor volume over the 19-day course of treatment, with no mortality or weight loss in the SW620 nude mouse xenograft model of tumor regression^[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

548.63

Formula

C₃₃H₃₂N₄O₄

CAS 号

780757-88-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 50 mg/mL (91.14 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8227 mL	9.1136 mL	18.2272 mL
5 mM	0.3645 mL	1.8227 mL	3.6454 mL
10 mM	0.1823 mL	0.9114 mL	1.8227 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.56 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (4.56 mM); Suspended solution; Need ultrasonic and warming

此方案可获得 2.5 mg/mL (4.56 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.56 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Yan D, et al, Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem, 2012, 287(11), 8598-8612.

[2]. Henderson WR Jr, et al, Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA, 2010, 107(32), 14309-14314.

[3]. Emami KH, et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687.

[4]. Liu Y, et al. ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population. J Exp Clin Cancer Res. 2017 Sep 11;36(1):125.

Cell Assay ^[2]	To evaluate effects of ICG-001 on α-SMA and collagen type 1 expression, RLE-6TN cells are treated with TGF-β1 (0.25 ng/mL) in the presence or absence of ICG-001 (5.0 μM). After 24 h, cells are harvested and mRNA isolated for analysis by qPCR. RNA is reverse-transcribed using SuperScript reverse transcriptase. Quantitative PCR is performed with SYBR-Green PCR using Real-Time PCR System HT7900. The amplification protocol is set as follows: 95°C denaturation for 10 min followed by 40 cycles of 15-s denaturation at 95°C, 1 min of annealing/extension, and data collection at 60°C. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[3]	Seven-week-old male C57BL/6J-Apc^Min/+and WT C57BL/6J mice are treated orally for 9 weeks with ICG-001a (300 mg/kg per day) or vehicle (1% carboxymethylcellulose), once daily, six times per week. MK-231 is administered in drinking water (160 ppm, dissolved in 8 mM Na₂PO₄ buffer, pH 7.6). At 16 weeks, the polyp number is counted manually by using a dissecting microscope. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Yan D, et al, Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem, 2012, 287(11), 8598-8612. [2]. Henderson WR Jr, et al, Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA, 2010, 107(32), 14309-14314. [3]. Emami KH, et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687. [4]. Liu Y, et al. ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population. J Exp Clin Cancer Res. 2017 Sep 11;36(1):125.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SJB2-043

发表于2024年10月20日由上海金畔生物科技有限公司

SJB2-043 纯度: 99.25%

SJB2-043 抑制 USP1/UAF1 复合体，IC₅₀ 为 544 nM。

SJB2-043 Chemical Structure

CAS No. : 63388-44-3

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥2384	In-stock
5 mg	￥2167	In-stock
10 mg	￥3302	In-stock
50 mg	￥7821	In-stock
100 mg	￥13020	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

SJB2-043 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Cell Cycle/DNA Damage Compound Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Ubiquitination Compound Library
Targeted Diversity Library

生物活性

SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC₅₀ of 544 nM.

IC₅₀ & Target

IC50: 544 nM (USP1/UAF1)^[1]

体外研究
(In Vitro)

SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC₅₀ of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

275.26

Formula

C₁₇H₉NO₃

CAS 号

63388-44-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 3.33 mg/mL (12.10 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6329 mL	18.1646 mL	36.3293 mL
5 mM	0.7266 mL	3.6329 mL	7.2659 mL
10 mM	0.3633 mL	1.8165 mL	3.6329 mL

参考文献

[1]. Mistry H, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther. 2013 Dec;12(12):2651-62.

Kinase Assay ^[1]	The in vitro enzymatic assays are performed using ubiquitin-AMC (Ub-7-amido-4methylcoumarin) as a substrate in a reaction buffer containing 20 mM HEPES-KOH (pH 7.8), 20 mM NaCl, 0.1 mg/mL ovalbumin, 0.5 mM EDTA and 10 mM dithiothreitol. The fluorescence is measured by FluoStar Galaxy Fluorometer. For the Ub-vinylsulfone (VS) assay, the proteins are incubated with Ub-VS at 0.5 μM final concentration for 45 min at 30°C, followed by the immunoblotting analysis^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay ^[1]	Leukemic cell lines are grown in RPMI 1640 medium supplemented with 10% fetal bovine serum and penicillin/streptomycin. Hela cells and U2OS cells are grown in DMEM supplemented with 10% fetal bovine serum and penicillin/streptomycin. USP1 inhibitor C527 and its derivatives (e.g., SJB2-043) are synthesized and the purity is validated by high-performance liquid chromatography. Primary human AML patient samples are collected from DFCI leukemia program under the approval of appropriate protocols. Cells are treated with DMSO or USP1 inhibitors (e.g., SJB2-043) in appropriate medium for 24-72 hrs. The viable cell counts are determined using Trypan blue staining, Cell TiterGlo reagent or MTT assay. The apoptotic cells are detected using AnnexinV and 7AAD staining using flow cytometry. For Benzidine staining, the cells are washed twice with PBS and resuspended in 45 μL of PBS + 5 μL of Benzidine stain solution (0.2% in 0.5 M glacial acetic acid, 3% H₂O₂). After 45 min incubation at room temperature, the Benzidine positive cells are detected by light microscopy^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Mistry H, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther. 2013 Dec;12(12):2651-62.

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迷你离心机MLX-200F（双速度选择）

发表于2024年10月20日由上海金畔生物科技有限公司

【简单介绍】

加工定制	否	结构类型	台式
布局形式	其他

美国Crystal迷你离心机MLX-200F（双速度选择）具有3个可选择转头和双速度选择。可以运行于3种不同的工作模式下（定时运行，点动和连续运行）。LED灯带指示运行状态，其红、蓝、绿的发光颜色及不发光状态可通过底座的拨动开关而选择。是临床、环保、工业等众多科研领域的常规实验室仪器，是应用于快速旋转分离、样品过滤、细胞分离等实验的理想选择。

【详细说明】

美国Crystal迷你离心机MLX-200F（双速度选择）

描述

美国Crystal进口迷你离心机(LED)MLX-200F（双速度选择）是临床、环保、工业等众多科研领域的常规实验室仪器，是应用于快速旋转分离、样品过滤、细胞分离等实验的理想选择。

本机具有3个可选择转头和双速度选择。可以运行于3种不同的工作模式下（定时运行，点动和连续运行）。LED灯带指示运行状态，其红、蓝、绿的发光颜色及不发光状态可通过底座的拨动开关而选择。

美国Crystal迷你离心机MLX-200F（双速度选择）

技术参数

型号	MLX-200F
转速	6000rpm		9200rpm
相对离心力（转子头）	5ml	2414g	5677g
	1.5ml	2012g	4731g
	0.2ml	1509g	3549g
运行模式	点动、连续、定时（0~15分钟）
LED发光选择	关、绿色、蓝色、红色
标配转子头	4×5ml 8×1.5ml 16×0.2ml
安全保护模式	开盖即停
噪音	<65dB
环境温度	5℃~ 40℃
相对湿度	≤80%
外形尺寸	187×240×139mm
电源	AC100~240V
重量	1.8Kg

特点

1、设计精巧，造型美观；2、转速可选：有6000rpm/9200rpm；3、工作模式：点动、连续、定时；4、标准转头配置：4×5ml、8×1.5ml、16×0.2ml；5、转头转换方便、可靠，采用抱夹装置，安全性高，操作简便；6、安全锁定，松盖即停；7、三色LED发光选择，指示运行状态；8、宽幅电源（100~240V），通用

产品附件

名称	型号	图片	离心管外径
8×1.5ml 转头	MLXF-4		/
4×5ml转头	MLXF-5		Φ14.5mm~Φ15.5mm
4×5ml转头	MLXF-8		Φ16.3mm~Φ16.7mm
0.2ml条形转头	MLXF-6		/

LY2109761

发表于2024年10月20日由上海金畔生物科技有限公司

LY2109761 纯度: 99.88%

LY2109761是可口服，选择性的 TGF-β receptor type I/II 抑制剂，K_i分别为38 nM 和 300 nM。

LY2109761 Chemical Structure

CAS No. : 700874-71-1

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥880	In-stock
5 mg	￥800	In-stock
10 mg	￥1400	In-stock
50 mg	￥4300	In-stock
100 mg	￥6500	In-stock
200 mg	￥9500	In-stock
500 mg		询价
1 g		询价

* Please select Quantity before adding items.

LY2109761 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Kinase Inhibitor Library
TGF-beta/Smad Compound Library
Anti-Cancer Compound Library
Autophagy Compound Library
Reprogramming Compound Library
Orally Active Compound Library
Anti-Pancreatic Cancer Compound Library
Angiogenesis Related Compound Library
Targeted Diversity Library
Anti-Colorectal Cancer Compound Library

生物活性

LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with K_is of 38 nM and 300 nM, respectively.

IC₅₀ & Target

Ki: 38 nM (TβRI), 300 nM (TβRII)

体外研究
(In Vitro)

LY2109761 significantly inhibits the growth of L3.6pl/GLT soft agar colonies in a dose-dependent manner, and results in appr 33% inhibition at 2 μM and 73% inhibition at 20 μM. Targeting TβRI/II kinase activity with LY2109761 (5 μM) almost completely suppresses both the basal and TGF-β1-stimulated migration of L3.6pl/GLT cells^[1]. LY2109761 induces a dose-dependent reduction in phosphorylation of Smad-2. HLE endogenous phosphorylation of Smad-2 is inhibited by LY2109761. LY2109761 blocks migration on different ECM proteins and invasion of both HLE and HLF through a 3-dimensional structure. LY2109761 increases E-cadherin mRNA expression after 24 hours and protein levels after 48 hours^[2]. LY2109761 pretreatment reduces clonogenic survival in cell cultures of U87MG and T98 following radiation, resulting in an increase in the radiosensitivity with a DEF0.1 of 1.30 and 1.37, respectively^[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

LY2109761 (50 mg/kg, p.o.) greatly reduces the tumor volume and increases the median survival duration of the mice to 45.0 days. The mice treated with LY2109761 develop significantly fewer metastatic lesions and, in some of them, no metastatic lesion, as indicated by the GFP signal, can be identified in the abdomen^[1]. LY2109761 enhances radiation-induced tumor growth delay in a U87MG subcutaneous xenograft tumor model in BALB/c nude mice. LY2109761 increases survival in an orthotopical CSLC glioblastoma model and enhanced antitumor activity of radiation^[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

441.52

Formula

C₂₆H₂₇N₅O₂

CAS 号

700874-71-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 25 mg/mL (56.62 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2649 mL	11.3245 mL	22.6490 mL
5 mM	0.4530 mL	2.2649 mL	4.5298 mL
10 mM	0.2265 mL	1.1325 mL	2.2649 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 0.5% CMC-Na 0.5% Tween-80

Solubility: 10 mg/mL (22.65 mM); Suspened solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (4.71 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.71 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.71 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.71 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.71 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.71 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。
5.

请依序添加每种溶剂： 5% DMSO 40% PEG300 5% Tween-80 50% saline

Solubility: ≥ 1.25 mg/mL (2.83 mM); Clear solution

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Melisi D, et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther, 2008, 7(4), 829-840.

[2]. Fransvea E, et al. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology, 2008, 47(5), 1557-1566.

[3]. Zhang M, et al. Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res, 2011, 71(23), 7155-7167.

Cell Assay ^[1]	L3.6pl/GLT cells are washed twice with cold PBS and lysed at 4°C into RIPA buffer (50 mM Tris HCl [pH 8], 150 mM NaCl, 1% NP-40, 0.5% sodium deoxycolate, and 0.1% SDS). Tumor and liver specimens are homogenized into RIPA buffer with an electric homogenizer and then maintained in constant agitation for two hours at 4°C. The lysates are cleared by centrifugation. Each lysate (20 µg of protein) is separated by 8% SDS-PAGE and probed with polyclonal rabbit antibodies against total ERK1/2, TβRI, and TβRII or with monoclonal mouse antibodies against phosphorylated Smad2, total Smad2, phosphorylated ERK1/2, and phosphorylated and total JNK. Immunoreactive proteins are visualized with Lumi-Light Western blotting substrate according to the manufacturer’s instructions. phosphorylated Smad2/Smad2 band density ratios are calculated using the ImageQuant software. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	Fifty mice are randomLy allocated into five groups (n=5 mice per group) to receive p.o. vehicle for 50 μL of LY2109761 or 50 mg/kg LY2109761 twice a day p.o. On day 0, mice are anesthetized with 1.5% isofluorane-air mixture, a small left abdominal flank incision is created, and the spleen is carefully exteriorized. L3.6pl/GLT or C5LM2/GLT cells (1.0×10⁵ cells/50 μL of HBSS), cultured in the presence of LY2109761 (5 μM) or DMSO from day −5 to day 0, are inoculated into the spleen with a 30-gauge needle. A visible paling of the spleen is the criterion for successful inoculation. After 10 min, the spleen is removed using a high-temperature cautery to avoid the possibility that the ectopic growth of pancreatic tumor cells in the spleen could be a confounding source of hematogenous liver metastatic cells. The abdominal wall is closed in one layer with wound clips. Treatment with 50 mg/kg LY2109761 twice a day p.o. (days 1-5 of each week after inoculation) is continued for one group of untreated mice inoculated with untreated cells. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Melisi D, et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther, 2008, 7(4), 829-840. [2]. Fransvea E, et al. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology, 2008, 47(5), 1557-1566. [3]. Zhang M, et al. Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res, 2011, 71(23), 7155-7167.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sophocarpine monohydrate(Synonyms: 槐果碱水合物)

发表于2024年10月20日由上海金畔生物科技有限公司

Sophocarpine monohydrate (Synonyms: 槐果碱水合物) 纯度: 99.15%

Sophocarpine (monohydrate) 是从传统草药苦参 (Sophora flavescens) 中提取的重要生物碱之一，苦参具有抗病毒，抗肿瘤，抗炎等多种药理作用。Sophocarpine (monohydrate) 通过多种机制显着抑制胃癌细胞的生长，例如诱导自噬 (autophagy)，激活细胞凋亡 (apoptosis) 和下调细胞存活 PI3K/AKT 信号通路。Sophocarpine (monohydrate) 已被证明在各种癌细胞中具有抗肿瘤活性，包括肝细胞癌，前列腺癌和结肠直肠癌。

Sophocarpine monohydrate Chemical Structure

CAS No. : 145572-44-7

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
5 mg	￥500	In-stock
10 mg	￥800	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

Sophocarpine monohydrate 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Anti-Infection Compound Library
Apoptosis Compound Library
Immunology/Inflammation Compound Library
Kinase Inhibitor Library
PI3K/Akt/mTOR Compound Library
Stem Cell Signaling Compound Library
Natural Product Library
Anti-Cancer Compound Library
Antiviral Compound Library
Autophagy Compound Library
Anti-Aging Compound Library
Differentiation Inducing Compound Library
Oxygen Sensing Compound Library
Medicine Food Homology Compound Library
Glycolysis Compound Library
Cytoskeleton Compound Library
Glutamine Metabolism Compound Library
Traditional Chinese Medicine Monomer Library
Alkaloids Library
Anti-Breast Cancer Compound Library
Anti-Lung Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Blood Cancer Compound Library
Anti-Cancer Metabolism Compound Library
Anti-Obesity Compound Library
Angiogenesis Related Compound Library
Glucose Metabolism Compound Library
Anti-Liver Cancer Compound Library
Anti-Colorectal Cancer Compound Library

生物活性

Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer^[1].

IC₅₀ & Target^[1]

PI3K

Akt

分子量

264.36

Formula

C₁₅H₂₄N₂O₂

CAS 号

145572-44-7

中文名称

槐果碱水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (378.27 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7827 mL	18.9136 mL	37.8272 mL
5 mM	0.7565 mL	3.7827 mL	7.5654 mL
10 mM	0.3783 mL	1.8914 mL	3.7827 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.46 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.46 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.46 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Huang Y, et al. Sophocarpine inhibits the growth of gastric cancer cells via autophagy and apoptosis. Front Biosci (Landmark Ed). 2019 Mar 1;24:616-627.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NVP 231

发表于2024年10月20日由上海金畔生物科技有限公司

NVP 231 纯度: 98.91%

NVP 231 是一种强效、特异、可逆的神经酰胺激酶 (CerK) 抑制剂 (IC₅₀=12 nM)，可竞争性地抑制神经酰胺与 CerK 的结合。NVP 231 通过增加 DNA 片段和 caspase-3 和 caspase-9 的裂解来诱导细胞凋亡 (apoptosis)。

NVP 231 Chemical Structure

CAS No. : 362003-83-6

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥610	In-stock
10 mg	￥550	In-stock
50 mg	￥1500	In-stock
100 mg	￥2500	In-stock
500 mg	￥9500	In-stock
1 g		询价
5 g		询价

* Please select Quantity before adding items.

NVP 231 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Apoptosis Compound Library
Kinase Inhibitor Library
Anti-Cancer Compound Library
Lipid Metabolism Compound Library

生物活性

NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC₅₀=12 nM) that competitively inhibits binding of ceramide to CerK^[1]. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage^[2].

IC₅₀ & Target

IC50: 12 nM (CerK); apoptosis^[1]^[3]

体外研究
(In Vitro)

NVP-231 (0-500 nM; 24 hours) gradually reduces the cellular CerK activity, as measured by NBD-C1P formation, demonstrating that NVP-231 active in transfected cells. The IC₅₀ for CerK in this cellular system is 59.70 ± 12 nM^[3].
NVP-231 (0-1000 nM; 48 hours) decreases cell viability as a dose-dependent manner. This compound shows IC₅₀ values of 1 μM in MCF-7 cells and 500 nM in NCI-H358 cells^[3].
NVP-231 (1 μM; 24-72 hours) induces caspase-3 and caspase-9 cleavage in both cell lines. However, the highest caspase-3 and caspase-9 cleavage and activation occurred at 24 hours in MCF-7 cells, then decreases again. In NCI-H358 cells, caspase-3 and caspase-9 cleavage occurrs continuously over 72 hours^[3].
NVP-231 (0-500 nM; 24 hours) causes a concentration-dependent up-regulation of cyclin B1 phosphorylation at Ser133 and a reduction of CDK1 phosphorylation at Tyr15. The total CDK1 expression also declined upon CerK inhibition^[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	MCF-7 cells; NCI-H358 cells
Concentration:	0 nM, 10 nM, 100 nM, 300 nM, 500 nM, 1000 nM
Incubation Time:	48 hours
Result:	Reduced MCF-7 cells and NCI-H358 cells in a concentration manner.

Apoptosis Analysis^[3]

Cell Line:	MCF-7 cells; NCI-H358 cells
Concentration:	1000 nM
Incubation Time:	24-72 hours
Result:	Increases caspase-3 and caspase-9 cleavage in MCF-7 and NCI-H358 cells.

Western Blot Analysis^[3]

Cell Line:	MCF-7 cells; NCI-H358 cells
Concentration:	0 nM, 100 nM, 300 nM, 500 nM
Incubation Time:	24 hours
Result:	Decreased p-cyclin B1, p-CDK1 as a concentration manner.

分子量

431.55

Formula

C₂₅H₂₅N₃O₂S

CAS 号

362003-83-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 41 mg/mL (95.01 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3172 mL	11.5861 mL	23.1723 mL
5 mM	0.4634 mL	2.3172 mL	4.6345 mL
10 mM	0.2317 mL	1.1586 mL	2.3172 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (5.79 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.79 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.79 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.79 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.79 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.79 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Graf C, et al. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol Pharmacol. 2008 Oct;74(4):925-32.

[2]. Graf C, et al. A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal Biochem. 2009 Jan 1;384(1):166-9.

[3]. Pastukhov O,et al. The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death.Br J Pharmacol. 2014 Dec;171(24):5829-44.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

恒温数控超声波清洗器KQ-300GDV/KQ-500GDV

发表于2024年10月20日由上海金畔生物科技有限公司

【简单介绍】

台式恒温数控超声波清洗器KQ-300GDV/KQ-500GDV/KQ-600GDV/KQ-700GDV主要适用于商业、轻工、大专院校、科研单位的小批量清洗、脱气、消泡、乳化、混匀、置换、提取、粉料粉碎及细胞粉碎.
三频系列台式数控超声波清洗器

现货常备，！

【详细说明】

台式恒温数控超声波清洗器KQ-300GDV/KQ-500GDV/KQ-600GDV/KQ-700GDV

产品简述：

台式恒温系列超声波清洗机，采用进口封闭型无氟压缩机，清洗机在工作中，加热与制冷两种设备自动交替工作，从而使清洗槽内溶液温度恒定，能满足有恒温超声需求的用户群体。洗系列产品可适用于某些中药提取、特种材料的清洗及需要恒温超声的各种实验项目等。

系列产品可用于：超声波清洗、乳化、混匀、提取、分散、消泡、脱气、置换、溶解等。

主要性能及特点

清洗机采用单片机软件操作
清洗机降音盖、清洗槽均采用优质不锈钢
恒温系列清洗机密封性好，并具有隔音、隔热效果
数显超温度、超电压、超电流、低水位、无溶液保护指示
数显记忆、设定显示超声工作时间、超声功率、进液液位（及实际液位）、加热温度（及实际温度）
数显记忆、设定显示清洗机槽内恒定温度，±2℃
清洗机电路具有自动扫频功能，能产生连续脉冲射流，使清洗效果更明显，工作更稳定
清洗机电路及器件升级并匹配，电功转换率高、无功损耗低
可选单种超声频率有20KHz、25KHz、28KHz、33KHz、40KHz。

恒温数控超声波清洗器KQ-300GDV/KQ-500GDV/KQ-600GDV/KQ-700GDV

技术参数：

型号：KQ-300GDV	外形尺寸：640490540mm	内槽尺寸：300240180mm	容量：13L
标准超声频率：40KHz	超声频率可选择替换	频率转换时间可调：—	超声功率：300W
超声功率可调范围：40-	水位显示：80-130mm	加热功率：500W
制冷功率：350W	温度设定范围：0-80℃	工作时间可调：1-480min	溶液过滤：—
其他配置：清洗网篮、降音盖、电控进排水、220V/50Hz电源

型号：KQ-500GDV	外形尺寸：910490540mm	内槽尺寸：500300180mm	容量：27L
标准超声频率：40KHz	超声频率可选择替换	频率转换时间可调：—	超声功率：500W
超声功率可调范围：40-	水位显示：80-130mm	加热功率：1000W
制冷功率：350W	温度设定范围：0-80℃	工作时间可调：1-480min	溶液过滤：—
其他配置：清洗网篮、降音盖、电控进排水、220V/50Hz电源

型号：KQ-600GDV	外形尺寸：910490540mm	内槽尺寸：500300180mm	容量：27L
标准超声频率：40KHz	超声频率可选择替换	频率转换时间可调：—	超声功率：600W
超声功率可调范围：40-	水位显示：80-130mm	加热功率：1000W
制冷功率：350W	温度设定范围：0-80℃	工作时间可调：1-480min	溶液过滤：—
其他配置：清洗网篮、降音盖、电控进排水、220V/50Hz电源

型号：KQ-700GDV	外形尺寸：910490540mm	内槽尺寸：500300180mm	容量：27L
标准超声频率：40KHz	超声频率可选择替换	频率转换时间可调：—	超声功率：700W
超声功率可调范围：40-	水位显示：80-130mm	加热功率：1000W
制冷功率：350	温度设定范围：0-80℃	工作时间可调：1-480min	溶液过滤：—
其他配置：清洗网篮、降音盖、电控进排水、220V/50Hz电源

台式/KQ-600GDV/KQ-700GDV

台式恒温数控超声波清洗器 20KHZ、25KHZ、28KHZ、33KHz.40KHZ，
型号	仪器尺寸	清洗槽内尺寸	容量 L	超声频率 KHz	超声功率 W	功率可调 %	加热功率 W	制冷功率 W	恒温可调℃	时间可调 min
型号	长×宽×高（mm）		容量 L	超声频率 KHz	超声功率 W	功率可调 %	加热功率 W	制冷功率 W	恒温可调℃	时间可调 min
KQ-300GDV	640×350×400	300×240×180	13	40	300	40-100	600	50	0-80	1-480
KQ-500GDV	840×410×400	500×300×180	27	40	500	40-100	1000	90	0-80	1-480
KQ-600GDV	840×410×400	500×300×180	27	40	600	40-100	1000	90	0-80	1-480
KQ-700GDV	840×410×400	500×300×180	27	40	700	40-100	1000	90	0-80	1-480

台式/KQ-600GDV/KQ-700GDV

大龙加热制冷震荡恒温金属浴HCM100-PRO

发表于2024年10月20日由上海金畔生物科技有限公司

大龙加热制冷震荡恒温金属浴HCM100-PRO

品牌大龙|DLAB

型号 HCM100-PRO

货号 5032103100

商品详情

产品介绍：

出色的温度控制系统。室温下，能够对15-100℃的温度范围进行精准控制；

20-45℃ 最大温度精准度为±0.5℃；

最高转速1500 rpm(不同模块会有变动)；

多种承载模块选择；

支持程序编辑和存储。

磁体吸附技术，无需工具，模块即可自动与机器吸附；

配置保温功能模块罩，防止热量散失。

技术参数:

技术参数	HCM100-Pro
功能	加热,制冷,混匀
温度控制范围[℃ ]	最低：低于室温15℃ 最高：100 ℃
温度可设定范围 [℃ ]	0.1℃~100℃
温度控制精度[20–45℃ ]	± 0.5℃
温度均一性[20–45℃ ]	± 0.5℃
最大加热速率 [℃/分]	5.5
最大制冷速率 [℃/分]	5℃（100℃至室温）0.5℃（至低于室温）
调速范围 [rpm]	200–1500
混匀直径 [mm]	3
显示屏规格	LCD
最大编程数量	9
输入电压	100-240V, 50Hz/60Hz
功率	200 W
时间设置范围	1min~99h59min
尺寸[长?宽?高 mm]	200×235×120
工作环境温度	5~40℃
工作环境湿度	80%

产品编号	型号	产品名称
5032103100	HCM100-PRO	加热制冷震荡恒温金属浴 200-240V/50Hz/60Hz

加热块附件
产品编号	型号	产品名称
18900238		适用 0.5mL离心管, 24孔
18900237		适用于1.5mL离心管, 24孔
18900239		适用于2mL离心管, 24孔
18900240		适用于5mL离心管, 8孔
18900241		适用于15mL离心管, 8孔
18900242		适用于50mL 离心管, 4孔
18900243		适用0.2mL PCR管
18900244		适用96/384孔板
适配 eppendorf 管的新模块
18900353		加热模块, 适用于 5mL 离心管, 8 孔
18900354		加热模块, 适用于 5mL 离心管, 8 孔, 锥形低, 只适用于新机器
18900355		加热模块, 适用于 15mL 离心管, 8 孔
18900356		加热模块, 适用于 50mL 离心管, 4 孔

Kushenol A(Synonyms: Leachianone E)

发表于2024年10月20日由上海金畔生物科技有限公司

Kushenol A (Synonyms: Leachianone E)

Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，可阻止 L-tyrosinase 转化为 L-DOPA，IC₅₀ 和 K_i 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) (IC₅₀: 45 μM; K_i: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。

Kushenol A Chemical Structure

CAS No. : 99217-63-7

规格	价格	是否有货
5 mg	￥8500	询问价格 & 货期
10 mg	￥15000	询问价格 & 货期

* Please select Quantity before adding items.

Kushenol A 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Natural Product Library
Anti-Cancer Compound Library
Phenols Library
Traditional Chinese Medicine Monomer Library
Flavonoids Library
Anti-Lung Cancer Compound Library
Anti-Obesity Compound Library
Glucose Metabolism Compound Library

生物活性

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively^[1]. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase^[2]. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging^[1].

IC₅₀ & Target

IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)^[1]^[2]

体外研究
(In Vitro)

Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC₅₀ value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM^[1].
Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC₅₀ values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC₅₀ value of 57.2 μg/ml for BEAS-2B cells^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	NSCLC cell lines, A549 and NCI-H226 Normal human lung epithelial: BEAS-2B
Concentration:	0-60 μg/ml
Incubation Time:	24 hours
Result:	Exhibited considerable cytotoxic effects against NSCLC cells.

分子量

408.49

Formula

C₂₅H₂₈O₅

CAS 号

99217-63-7

中文名称

苦参新醇A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054.

[2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.

[3]. Chen H, et al. A Novel Flavonoid Kushenol Z from Sophora flavescens Mediates mTOR Pathway by Inhibiting Phosphodiesterase and Akt Activity to Induce Apoptosis in Non-Small-Cell Lung Cancer Cells.Molecules. 2019 Dec 4;24(24). pii: E4425.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

T0901317

发表于2024年10月20日由上海金畔生物科技有限公司

T0901317 纯度: 99.91%

T0901317 是口服有效且高度选择性的 LXR 激动剂，对 LXRα 的 EC₅₀ 为 20 nM。T0901317 激活 FXR，EC₅₀ 为 5 μM。T0901317 是 RORα 和 RORγ 双重反向激动剂，K_i 值分别为 132 nM 和 51 nM。T0901317 诱导细胞凋亡 (apoptosis)，并抑制低密度脂蛋白 (LDL) 受体缺失小鼠动脉粥样硬化的发展。

T0901317 Chemical Structure

CAS No. : 293754-55-9

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥660	In-stock
10 mg	￥600	In-stock
50 mg	￥1200	In-stock
100 mg	￥1950	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

T0901317 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Apoptosis Compound Library
Metabolism/Protease Compound Library
Anti-Cancer Compound Library
Small Molecule Immuno-Oncology Compound Library
Anti-Cardiovascular Disease Compound Library
Orally Active Compound Library
Chemical Probe Library
Transcription Factor Targeted Library
Lipid Metabolism Compound Library

生物活性

T0901317 is an orally active and highly selective LXR agonist with an EC₅₀ of 20 nM for LXRα^[1]. T0901317 activates FXR with an EC₅₀ of 5 μM^[2]. T0901317 is RORα and RORγ dual inverse agonist with K_i values of 132 nM and 51 nM, respectively^[3]. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice^[4]^[5].

IC₅₀ & Target

EC50: 20 nM (LXRα) and 5 μM (FXR)^[1]^[2]
Ki: 132 nM (RORα) and 51 nM (RORγ)^[3]

体外研究
(In Vitro)

T0901317 (5-50 μM; 72 hours) significantly inhibits cellular proliferation in CaOV3, SKOV3, A2780 (human ovarian carcinoma cell lines) in a dose-dependent and time-dependent manner^[5].
T0901317 (10 μM; 24-72 hours) decreases the percentage of cells in S phase and increases the percentage of cells in the G0/G1 phase, indicating a cell cycle arrest at the G1-S checkpoint. The percentage of cells in G0/G1 phase increases in a time-dependent manner^[5].
T0901317 (10-40 μM; 24 hours ) results in a significant increase of cells in early apoptosis^[5].
T0901317 (5-40 μM; 48 hours) results in an increase of p21 and p27 protein expression in a dose-dependent manner after 48 hours^[5].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[5]

Cell Line:	A2780, CaOV3 and SKOV3 ovarian cancer cell lines
Concentration:	5, 10, 20, 40 or 50 μM
Incubation Time:	72 hours
Result:	Inhibited cellular proliferation in all cell lines in a dose-dependent and time-dependent manner.

Cell Cycle Analysis^[5]

Cell Line:	A2780, CaOV3 and SKOV3 cells
Concentration:	10 μM
Incubation Time:	24, 48 or 72 hours
Result:	Decreased the percentage of cells in S phase and increased the percentage of cells in the G0/G1 phase.

Apoptosis Analysis^[5]

Cell Line:	CaOV3 cells
Concentration:	10 to 40 μM
Incubation Time:	24 hours
Result:	Resulted in a significant increase of cells in early apoptosis.

Western Blot Analysis^[5]

Cell Line:	CaOV3 cells
Concentration:	5 to 40 μM
Incubation Time:	48 hours
Result:	Resulted in an increase of p21 and p27 protein expression in a dose-dependent manner.

体内研究
(In Vivo)

T0901317 (10 mg/kg/day; orally; for 12 weeks) inhibits the progression of atherosclerosis^[5].
T0901317 (i.p.; 50 mg/kg; twice weekly for 7 days) can protect male C57BL/6 mice from high fat diet-induced obesity and insulin resistance^[6].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8- to 10-week-old LDL receptor null mice^[5]
Dosage:	10 mg/kg
Administration:	Orally; daily; for 12 weeks
Result:	Inhibited the progression of atherosclerosis.

分子量

481.33

Formula

C₁₇H₁₂F₉NO₃S

CAS 号

293754-55-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (207.76 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0776 mL	10.3879 mL	20.7758 mL
5 mM	0.4155 mL	2.0776 mL	4.1552 mL
10 mM	0.2078 mL	1.0388 mL	2.0776 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 3 mg/mL (6.23 mM); Clear solution

此方案可获得 ≥ 3 mg/mL (6.23 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 3 mg/mL (6.23 mM); Clear solution

此方案可获得 ≥ 3 mg/mL (6.23 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 3 mg/mL (6.23 mM); Clear solution

此方案可获得 ≥ 3 mg/mL (6.23 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。
4.

请依序添加每种溶剂： 5% DMSO 40% PEG300 5% Tween-80 50% saline

Solubility: 2.5 mg/mL (5.19 mM); Suspended solution; Need ultrasonic
5.

请依序添加每种溶剂： 5% DMSO 95% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. J R Schultz, et al. Role of LXRs in Control of Lipogenesis. Genes Dev. 2000 Nov 15;14(22):2831-8.

[2]. Keith A Houck, et al. T0901317 Is a Dual LXR/FXR Agonist. Mol Genet Metab. Sep-Oct 2004;83(1-2):184-7.

[3]. Naresh Kumar, et al. The Benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor-Alpha/Gamma Inverse Agonist. Mol Pharmacol. 2010 Feb;77(2):228-36.

[4]. Rough JJ, et al. Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells. J Ovarian Res. 2010 May 26;3:13.

[5]. Todd G Kirchgessner, et al. Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils. Cell Metab. 2016 Aug 9;24(2):223-33.

[6]. Mingming Gao, et al. The Liver X Receptor Agonist T0901317 Protects Mice From High Fat Diet-Induced Obesity and Insulin Resistance. AAPS J. 2013 Jan;15(1):258-66.

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Gossypol(Synonyms: 棉酚; BL 193)

发表于2024年10月20日由上海金畔生物科技有限公司

Gossypol (Synonyms: 棉酚; BL 193) 纯度: 99.56%

Gossypol 分别与 Bcl-xL 蛋白和 Bcl-2 蛋白结合，K_i 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。

Gossypol Chemical Structure

CAS No. : 303-45-7

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥1650	In-stock
100 mg	￥1500	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Gossypol 相关产品

•相关化合物库:

Covalent Screening Library Plus
Natural Product Library Plus
Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Natural Product Library
FDA-Approved Drug Library
Anti-Cancer Compound Library
Drug Repurposing Compound Library
Covalent Screening Library
NMPA-Approved Drug Library
Phenols Library
Traditional Chinese Medicine Monomer Library
FDA Approved & Pharmacopeial Drug Library
Food-Sourced Compound Library
Rare Diseases Drug Library

生物活性

Gossypol binds to Bcl-xL protein and Bcl-2 protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

IC₅₀ & Target^[1]

Bcl-xL

0.5-0.6 μM (Ki)

Bcl-2

0.2-0.3 mM (Ki)

体外研究
(In Vitro)

Gossypol, a natural product isolated from cottonseeds and roots that has been studied as an anticancer agent. The racemic form of Gossypol [(±)-Gossypol] is tested in several clinical trials and is well tolerated. The racemic form Gossypol ((±)-Gossypol) binds to Bcl-xL protein with a K_i of 0.5 to 0.6 μM. (±)-Gossypol also potently binds to Bcl-2 protein with a K_i value of 0.2-0.3 mM. The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (+)-Gossypol enantiomers. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001)^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

518.55

Formula

C₃₀H₃₀O₈

CAS 号

303-45-7

中文名称

棉酚；棉籽酚；棉子酚；棉子醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 33.33 mg/mL (64.28 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9285 mL	9.6423 mL	19.2845 mL
5 mM	0.3857 mL	1.9285 mL	3.8569 mL
10 mM	0.1928 mL	0.9642 mL	1.9285 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (4.01 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.01 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.

Cell Assay ^[1]	Two representative UM-SCC cell lines, UM-SCC-6 and UM-SCC-14A, are continuously exposed to 0 (vehicle control), 5 or 10 μM (±)-Gossypol, (-)-Gossypol or (+)-Gossypol in a 6-day MTT cell survival assay^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.

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Chelerythrine(Synonyms: 白屈菜红碱)

发表于2024年10月20日由上海金畔生物科技有限公司

Chelerythrine (Synonyms: 白屈菜红碱)

Chelerythrine 是一种天然生物碱，为有效、选择性的 Ca²⁺/磷脂依赖性 PKC 拮抗剂，IC₅₀ 值为 0.7 μM。Chelerythrine 具有抗肿瘤、抗糖尿病、抗炎的活性。Chelerythrine 抑制 BclXL-Bak BH3 肽结合，IC₅₀ 为 1.5 μM，并从 BclXL 取代了 Bax。 Chelerythrine 诱导细胞凋亡和自噬。

Chelerythrine Chemical Structure

CAS No. : 34316-15-9

规格	价格	是否有货
5 mg	￥500	询问价格 & 货期
10 mg	￥900	询问价格 & 货期
20 mg	￥1500	询问价格 & 货期

* Please select Quantity before adding items.

Chelerythrine 的其他形式现货产品:

Chelerythrine chloride

生物活性

Chelerythrine is a natural alkaloid, acts as a potent and selective Ca²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM^[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity^[2]. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy^[3]^[4].

IC₅₀ & Target^[1]

PKC

0.7 μM (IC₅₀)

分子量

348.37

Formula

C₂₁H₁₈NO₄⁺

CAS 号

34316-15-9

中文名称

白屈菜红碱；白屈菜赤碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.

[2]. Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91.

[3]. Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6.

[4]. Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

超声波清洗机KQ-600VDE/KQ-600VDV

发表于2024年10月20日由上海金畔生物科技有限公司

【简单介绍】

台式数控三频超声波清洗机KQ-600VDE/KQ-600VDV/KQ-600VDB，其特性为一台设备拥有三种不同的超声频率，进行合理交替转换工作，能让清洗物件在清洗机中完成粗洗、清洗、精细的全部过程，对不同性质的污垢进行*的清洗，成功克服清洗中的死角与盲区；此清洗机并可针对不同的清洗物或污物选择不同的频率清洗，达到一机多用的特性，广泛运用于各个行业、各级实验室的清洗等需求。

【详细说明】

台式数控三频超声波清洗机KQ-600VDE/KQ-600VDV/KQ-600VDB

主要性能特点

采用单片机软件操作
清洗机降音盖、外壳、清洗槽均采用优质不锈钢
数显超温度、超电压、超电流、低水位、无溶液保护指示
数显记忆、设定显示超声工作时间、超声功率、超声频率、超声频率自动转换时间、进液液位（及实际液位）、加热温度（及实际温度）
清洗机电路具有自动扫频功能，能产生连续脉冲射流，使清洗效果更明显，工作更稳定
清洗机电路及器件升级并匹配，电功转换率高、无功损耗低
可选三种组合超声频率有20/40/60KHz、28/45/80KHz、28/45/100KHz、45/80/100KHz

台式数控三频超声波清洗机KQ-600VDE/KQ-600VDV/KQ-600VDB

产品参数：

型号：KQ-600VDB	外形尺寸：530320365mm	内槽尺寸：500300150mm	容量：22.5L
标准超声频率：45/80/100KHz	超声频率可选择替换	频率转换时间可调：1-999S	超声功率：600W
超声功率可调范围：40-	水位显示：30-120mm	加热功率：1000W
制冷功率：—	温度设定范围：室温-80℃	工作时间可调：1-480min	溶液过滤：—
其他配置：清洗网篮、手控进排水、220V/50Hz电源

型号：KQ-600VDE	外形尺寸：530320380mm	内槽尺寸：500300150mm	容量：22.5L
标准超声频率：45/80/100KHz	超声频率可选择替换	频率转换时间可调：1-999S	超声功率：600W
超声功率可调范围：40-	水位显示：30-120mm	加热功率：1000W
制冷功率：—	温度设定范围：室温-80℃	工作时间可调：1-480min	溶液过滤：—
其他配置：清洗网篮、降音盖、手控进排水、220V/50Hz电源

型号：KQ-600VDV	外形尺寸：638460500mm	内槽尺寸：500300180mm	容量：27L
标准超声频率：45/80/100KHz	超声频率可选择替换	频率转换时间可调：1-999S	超声功率：600W
超声功率可调范围：40-	水位显示：30-120mm	加热功率：1000W
制冷功率：—	温度设定范围：室温-80℃	工作时间可调：1-480min	溶液过滤：—
其他配置：清洗网篮、降音盖、电控进排水、220V/50Hz电源

台式数控三频/KQ-600VDB