Enoxacin-d8

发表于2024年11月1日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enoxacin-d8

Enoxacin-d8 是 Enoxacin 的氘代物。Enoxacin (AT 2266) 是一种氟喹诺酮，可以干扰 DNA 复制，抑制细菌 DNA 促旋酶 (IC₅₀=126 µg/ml) 和拓扑异构酶 IV (IC₅₀=26.5 µg/ml)。Enoxacin 是一种 miRNA 加工激活剂，可增强 siRNA 介导的 mRNA 降解并促进内源性 miRNA 的生物发生，也可增强 TAR RNA 结合蛋白 2 (TRBP) 介导的 microRNA 加工。Enoxacin 有效抑制革兰氏阳性和阴性细菌，是一种特异性的癌症生长抑制剂。

Enoxacin-d8 Chemical Structure

CAS No. : 1329642-60-5

规格		是否有货
2.5 mg		Check price and availability
25 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	Enoxacin-d8 (AT 2266-d8) is the deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 µg/ml) and topoisomerase IV (IC₅₀=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing^[1]^[2]^[3]^[4].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	328.37
Formula	C₁₅H₉D₈FN₄O₃
CAS 号	1329642-60-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Sonia Melo, et al.Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9. [3]. M Takei, et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7. [4]. Ge Shan, et al. A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol. 2008 Aug;26(8):933-40. [5]. Rengen Fan, et al. Small molecules with big roles in microRNA chemical biology and microRNA-targeted therapeutics. RNA Biol. 2019 Jun;16(6):707-718. [6]. Chin, N.-X. and H.C. Neu, In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. Antimicrobial agents and chemotherapy, 1983. 24(5): p. 754-763.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Minodronic acid-d4(Synonyms: YM-529-d4)

发表于2024年11月1日由上海金畔生物科技有限公司

Minodronic acid-d4 (Synonyms: YM-529-d4)

Minodronic acid-d4 是 Minodronic acid 氘代物。Minodronic acid (YM-529) 是第三代二磷酸盐，直接或间接地阻止增殖，诱导细胞凋亡，并抑制各种类型的癌细胞的转移。Minodronic acid (YM-529) 是一种参与疼痛的嘌呤 P2X2/3 受体拮抗剂。

Minodronic acid-d4 Chemical Structure

CAS No. : 1807367-80-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Minodronic acid-d4 is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	326.17
Formula	C₉H₈D₄N₂O₇P₂
CAS 号	1807367-80-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61. [3]. Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lucanthone-d4 hydrochloride

发表于2024年11月1日由上海金畔生物科技有限公司

Lucanthone-d4 hydrochloride

Lucanthone-d4 hydrochloride 是 Lucanthone 的氘代物。Lucanthone 是 Apurinic 内切核酸酶-1 (APE-1) 的内切核酸酶抑制剂。

Lucanthone-d4 hydrochloride Chemical Structure

CAS No. : 1329613-40-2

规格		是否有货
1 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	Lucanthone-d4 hydrochloride is the deuterium labeled Lucanthone. Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1)^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	380.97
Formula	C₂₀H₂₁D₄ClN₂OS
CAS 号	1329613-40-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18. [3]. Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

上海衡平微波消解仪TITAN12B

发表于2024年11月1日由上海金畔生物科技有限公司

上海衡平微波消解仪TITAN12B

品牌衡平|CNSHP

型号 TITAN12B

商品详情

技术参数

电源	220VAC士10%, 50Hz
微博频率	2450MHz
微波炉腔	316L不锈钢腔体，整体喷涂8层PFA特氟龙防腐涂层
温度控制系统	高精度、高灵敏度铀电阻温度传感器，测温范围：-40~500℃ ，控制精度：士0.1℃，测温控制范围：0～300℃
压力控制系统	压电晶体压力传感器，控压市围： 0-20MPa，控制精度：士0.0lMPa，显示精度：士0.1MPa
压力监控系统	弓形弹性模块和防爆膜双重结构，超压自动泄压，定量控制
终端面板灯监控	终端面板门体灯监控，智能门锁自检系统，防止门体随意打开，最高的防护水准！终端面板微波灯监控，微波发射状态监控，微波是否正常工作一目了然。终端面板转盘灯监控，转子运行状态监控，一旦异常即刻报警并终止仪器运行。终端面板按键订监控，按键状态检测，任何一步操作都指示明确。
整机物理尺寸	480550630mrn （长＊宽＊高>
整机净重	57kg
工作环境温度	RT-50℃
工作环境湿度	15-80%RH

MGH-CP1

发表于2024年11月1日由上海金畔生物科技有限公司

MGH-CP1

MGH-CP1 是一种有效且具有口服活性的 TEAD2 和 TEAD4 自棕榈酰化抑制剂， IC₅₀ 分别为 710 nM 和 672 nM。MGH-CP1 可降低细胞内源性或异位表达的 TEAD 蛋白棕榈酰化水平。MGH-CP1 与 Lats1/2 缺失，可抑制 Myc 表达，抑制上皮细胞过度增殖，诱导细胞凋亡 (apoptosis)。

MGH-CP1 Chemical Structure

CAS No. : 896657-58-2

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC₅₀s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion^[1].

IC₅₀ & Target

IC₅₀: 710 nM (TEAD2), 672 nM (TEAD4) ^[1]

体外研究
(In Vitro)

MGH-CP1 (0-100 μM) inhibits auto-palmitoylation of recombinant TEAD2 and TEAD4 in a dose-dependent manner^[1].
MGH-CP1 (0-2 μM) inhibits TEAD-binding sites (TBS)-Luc reporter activity in a dose-dependent manner in YAP-expressing HEK293 cells^[1].
MGH-CP1 does not affect YAP nuclear localization or protein levels but potently inhibits TEAD-mediated transcription in a dose-dependent manner and effectively blocks cell over-proliferation^[1].
MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

MGH-CP1 (75mg/kg; PO; daily, for 2 weeks) inhibits the palmitoylation of TEAD proteins in the intestinal epithelium in wild-type mice, but inhibits upregulation of the TEAD target genes, CTGF and ANKRD1, in Lats1/2 KO mice intestine^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice (induced high-dose Cre recombination by intraperitoneal injection of 120mg/kg Tamoxifen for two consecutive days)^[1]
Dosage:	75 mg/kg
Administration:	PO; daily, for 2 weeks
Result:	Effectively inhibited the palmitoylation of TEAD proteins in the intestinal epithelium in wild-type mice, but effectively inhibited upregulation of the TEAD target genes, CTGF and ANKRD1, in Lats1/2 KO mice intestine.

分子量

368.50

Formula

C₂₀H₂₄N₄OS

CAS 号

896657-58-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Li Q, Sun Y, Jarugumilli GK, et al. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell. 2020;26(5):675-692.e8. doi:10.1016/j.stem.2020.03.002

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Trofosfamide-d4

发表于2024年11月1日由上海金畔生物科技有限公司

Trofosfamide-d4

Trofosfamide-d4 是 Trofosfamide 的氘代物。Trofosfamide 是一种有口服生物活性的氧氮磷环类衍生物，具有抗癌活性。

Trofosfamide-d4 Chemical Structure

CAS No. : 1189884-36-3

规格		是否有货
2.5 mg		Check price and availability
25 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	Trofosfamide-d4 is the deuterium labeled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	327.61
Formula	C₉H₁₄D₄Cl₃N₂O₂P
CAS 号	1189884-36-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145(1):129-136. [3]. Görn M, et al. A pilot study of docetaxel and trofosfamide as second-line ‘metronomic’ chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC). Onkologie. 2008 Apr;31(4):185-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

多肽定制Z-A-A-L-pNA 编码 [61043-33-2]

发表于2024年11月1日由上海金畔生物科技有限公司

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称	Z-A-A-L-pNA
编码	[61043-33-2]
别名	Z-A-A-L-pNA
纯度	80%，90%，95%，98%，99%
重量	1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写）	ZAALPNA
序列（三字母缩写）	Z-Ala-Ala-Leu-pNA
基本描述
溶解度
分子量	527.6
化学式	C26H33N5O7
存储条件	Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference
C端
N端
化学桥

Tezosentan-d4

发表于2024年11月1日由上海金畔生物科技有限公司

Tezosentan-d4

Tezosentan-d4 (RO 610612-d4) 是 Tezosentan 的氘代物。Tezosentan (RO 610612) 是内皮素 (ET) 受体的一个拮抗剂，其对 ET_A 和 ET_B 受体的 pA₂ 值分别为 9.5, 7.7。

Tezosentan-d4 Chemical Structure

CAS No. : 1794707-10-0

规格		是否有货
1 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	Tezosentan-d4 (RO 610612-d4) is the deuterium labeled Tezosentan. Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA₂s of 9.5, 7.7 for ET_A and ET_B receptors, respectively^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	609.65
Formula	C₂₇H₂₃D₄N₉O₆S
CAS 号	1794707-10-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Clozel M, et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther. 1999 Aug;290(2):840-6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Teludipine-d6

发表于2024年11月1日由上海金畔生物科技有限公司

Teludipine-d6

Teludipine-d6 (GR53992B-d6) 是 Teludipine hydrochloride 的氘代物。Teludipine 是一种亲脂性的钙通道 (Calcium channel) 抑制剂。

Teludipine-d6 Chemical Structure

CAS No. : 1246833-02-2

规格		是否有货
2.5 mg		Check price and availability
25 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	Teludipine-d6 (GR53992B-d6) is the deuterium labeled Teludipine hydrochloride. Teludipine is a lipophilic calcium channel blocker^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	504.65
Formula	C₂₈H₃₂D₆N₂O₆
CAS 号	1246833-02-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tolomeo M, et al. Effects of R-enantiomer (GR66234A) and L-enantiomer (GR66235A) of telupidine, a new dihydropyridine derivative, on cell lines displaying the multidrug resistant phenotype. Haematologica. 1994 Jul-Aug;79(4):328-33.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ent-Tadalafil-d3(Synonyms: ent-IC-351-d3)

发表于2024年11月1日由上海金畔生物科技有限公司

ent-Tadalafil-d3 (Synonyms: ent-IC-351-d3)

ent-Tadalafil-d3 (ent-IC-351-d3) 是 ent-Tadalafil 的氘代物。ent-Tadalafil (ent-IC-351)，化合物 (6S,12aS) ，是化合物 (6R,12aS) 的无活性顺式对映异构体。化合物 (6R,12aS) 是有效的 PDE5 抑制剂，IC₅₀ 为0.090 μM，而ent-Tadalafil 在高浓度 10 µM 时仍然没有活性。

ent-Tadalafil-d3 Chemical Structure

CAS No. : 1329568-92-4

规格		是否有货
1 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	ent-Tadalafil-d3 (ent-IC-351-d3) is the deuterium labeled ent-Tadalafil. ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC₅₀ of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	392.42
Formula	C₂₂H₁₆D₃N₃O₄
CAS 号	1329568-92-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione analogues.J Med Chem. 2003 Oct 9;46(21):4533-42.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Tizanidine-d4

发表于2024年11月1日由上海金畔生物科技有限公司

Tizanidine-d4

Tizanidine-d4 是 Tizanidine 的氘代物。Tizanidine 是 α2-肾上腺素受体激动剂，能抑制神经递质从CNS去甲肾上腺素激活的神经元中释放。

Tizanidine-d4 Chemical Structure

CAS No. : 1188331-19-2

规格	价格	是否有货
1 mg	￥1400	询问价格 & 货期
5 mg	￥6500	询问价格 & 货期
10 mg	￥10500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Tizanidine-d4 is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	257.74
Formula	C₉H₄D₄ClN₅S
CAS 号	1188331-19-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

香豆素A1

发表于2024年11月1日由上海金畔生物科技有限公司

香豆素A1

有货

CAS编号 4434-05-3 | 品牌：Jinpan

Coumermycin A1

MSDS

质检证书(CoA)

相似产品

分子式 C₅₅H₅₉N₅O₂₀
分子量1110.08
Beilstein号 470805
MDL号 MFCD00057312
PubChem编号 54678496

货号 (SKU)	包装规格	是否现货
C487093-50mg	50mg	期货
C487093-5mg	5mg	期货
C487093-10mg	10mg	期货

基本信息

产品名称	香豆素A1
英文名称	Coumermycin A1

一般描述

Description

Chemical structure: coumarin-glycosideCoumermycin A1 is an aminocoumarin antibiotic used to study processes such as DNA replication, transcription, and recombination that involve DNA topoisomerase II activity. It has been used to treatStaphylococcus aureusendocarditis in the rat model and to study the effect of coumermycin A1 on the expression of 67 fusions inSalmonella typhimurium. .

Description

CAS编号	4434-05-3
折光率	n20D1.68
溶解性	DMSO：50mg/mL
RTECS	UX9375000
MDL号	MFCD00057312
分子量	1110.08
分子式	C₅₅H₅₉N₅O₂₀
品牌	Jinpan
Smiles	CC1=CC=C(N1)C(=O)OC2C(C(OC(C2OC)(C)C)OC3=C(C4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CNC(=C5C)C(=O)NC6=C(C7=C(C(=C(C=C7)OC8C(C(C(C(O8)(C)C)OC)OC(=O)C9=CC=C(N9)C)O)C)OC6=O)O)O)C)O
PubChem CID	54678496

上海衡平微波消解仪TITAN10

发表于2024年11月1日由上海金畔生物科技有限公司

上海衡平微波消解仪TITAN10

品牌衡平|CNSHP

型号 TITAN10

商品详情

技术参数：

电源	220VAC士10%, 50Hz
微博频率	2450MHz
微波炉腔	316L不锈钢腔体，整体喷涂8层PFA特氟龙防腐涂层
温度控制系统	高精度、高灵敏度铀电阻温度传感器，测温范围：-40~500℃ ，控制精度：士0.1℃，测温控制范围：0～300℃
压力控制系统	压电晶体压力传感器，控压市围： 0-20MPa，控制精度：士0.0lMPa，显示精度：士0.1MPa
压力监控系统	弓形弹性模块和防爆膜双重结构，超压自动泄压，定量控制
终端面板灯监控	终端面板门体灯监控，智能门锁自检系统，防止门体随意打开，最高的防护水准！终端面板微波灯监控，微波发射状态监控，微波是否正常工作一目了然。终端面板转盘灯监控，转子运行状态监控，一旦异常即刻报警并终止仪器运行。终端面板按键订监控，按键状态检测，任何一步操作都指示明确。
整机物理尺寸	480550630mrn （长＊宽＊高>
整机净重	57kg
工作环境温度	RT-50℃
工作环境湿度	15-80%RH

RPR132595A-d3

发表于2024年11月1日由上海金畔生物科技有限公司

RPR132595A-d3

RPR132595A-d3 是 RPR132595A 的氘代物。RPR132595A 是 CPT-11 的活性代谢产物，它是由细胞色素 P-450 3A4 (CYP3A4) 产生并最终通过尿排出。

RPR132595A-d3 Chemical Structure

CAS No. : 1217625-98-3

规格		是否有货
1 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	RPR132595A-d3 is the deuterium labeled RPR132595A. RPR132595A is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	521.58
Formula	C₂₈H₂₇D₃N₄O₆
CAS 号	1217625-98-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Alvau MD, et al. Enzyme-Based Electrochemical Biosensor for Therapeutic Drug Monitoring of Anticancer Drug Irinotecan.Anal Chem. 2018 May 15;90(10):6012-6019.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

英国Grant数字式超声波清洗器XUB5/XUB18/XUB10/XUB12/XUB25

发表于2024年11月1日由上海金畔生物科技有限公司

【简单介绍】

英国Grant数字式超声波清洗器XUB5/XUB18/XUB10/XUB12/XUB25，室温+5℃ to 70℃，标配 ABS盖，不锈钢篮子，SD卡，排水孔和一瓶M2超声波清洗液。

【详细说明】

英国Grant数字式超声波清洗器XUB5/XUB18/XUB10/XUB12/XUB25

产品简述：

英国Grant数字式超声波清洗器XUB5/XUB18/XUB10/XUB12/XUB25，室温+5℃ to 70℃，标配 ABS盖，不锈钢篮子，SD卡，排水孔和一瓶M2超声波清洗液。本系列超声波水浴所提供的数字型台式超声波水浴适用于众多领域例如实验室，科学领域和医学领域等。的性能，的变频功能，确保了超声波频率的稳定性。各种改进的技术很大程度地提高了工作效率。

产品特点：

变频技术使水浴槽中的超声过程更均匀，减少死角和驻波
加热范围：室温+ 5?C to 70?C
数字认证的SD卡能够记录并分析每个循环的数据
LCD显示屏, 菜单驱动控制
精确控制时间，温度，超声波强度，排气及功率
现代设计，标配含不锈钢篮子、ABS浴槽盖和排水阀
5种型号供选择

结构特色：

技术参数:

应用领域：

医疗保健/临床- 用于外科（包括牙科，足科和普通全科所有用的仪器）可重复使用的仪器的初步去污
基本用途-瓶子，设备，零部件的清洗；血细胞计数器，喷嘴的超声处理，分散和增容作用
实验室——零部件清洗，液体脱气，液体和组分混合，细胞消化，液体溶解
工业——轻工制造业
生物制药——样品溶解

可选配件
			数字式					模拟式
			XUB5	XUB10	XUB12	XUB18	XUB25	XUBA1	XUBA3
可替换ABS盖子
减少运行噪音，避免悬浮颗粒的溢出			XAL5	XAL10	XAL12	XAL18	XAL25	XAL1	XAL3
篮子
用于盛放容器，与盖子一起使用可作为废液收集器（作为水浴标配附件）			XAB5	XAB10	XAB12	XAB18	XAB25	XAB1	XAB3
篮子尺寸	w/d/h	mm	273×125×90	460×110×90	265×215×140	285×260×140	470×270×140	120×96×55	220×125×40
超声波清洁液
通用型超声波水浴清洁剂。1L/瓶，6瓶/包			M2 Sol	M2 Sol	M2 Sol	M2 Sol	M2 Sol	M2 Sol	M2 Sol

9-cis-Retinoic acid-d5

发表于2024年11月1日由上海金畔生物科技有限公司

9-cis-Retinoic acid-d5

9-cis-Retinoic acid-d5 (ALRT1057-d5) 是 9-cis-Retinoic acid 的氘代物。9-cis-Retinoic acid (ALRT1057)，维生素 A 的衍生物，是一种有效的 RAR/RXR 激动剂。9-cis-Retinoic acid 可诱导细胞凋亡 (apoptosis)，调节细胞周期并具有抗癌，抗炎和神经保护活性。

9-cis-Retinoic acid-d5 Chemical Structure

CAS No. : 78996-15-3

规格		是否有货
1 mg		Check price and availability
5 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	9-cis-Retinoic acid-d5 (ALRT1057-d5) is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities^[1]^[2]^[3]^[4]^[5]^[6].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	305.47
Formula	C₂₀H₂₃D₅O₂
CAS 号	78996-15-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080. [3]. Hua Yang, et al. Effects of 9-cis-retinoic Acid on the Proliferation and Apoptosis of Cutaneous T-cell Lymphoma Cells. Anticancer Drugs. 2019 Jan;30(1):56-64. [4]. Zhiqing Yuan, et al. 9-cis-retinoic Acid Elevates MRP3 Expression by Inhibiting Sumoylation of RXRα to Alleviate Cholestatic Liver Injury. Biochem Biophys Res Commun. 2018 Sep 3;503(1):188-194. [5]. V M Manzano, et al. Human Renal Mesangial Cells Are a Target for the Anti-Inflammatory Action of 9-cis Retinoic Acid. Br J Pharmacol. 2000 Dec;131(8):1673-83. [6]. Gro H Mathisen, et al. Delayed Translocation of NGFI-B/RXR in Glutamate Stimulated Neurons Allows Late Protection by 9-cis Retinoic Acid. Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PLX-4720-d7

发表于2024年11月1日由上海金畔生物科技有限公司

PLX-4720-d7

PLX-4720-d7 是 PLX-4720 的氘代物。PLX-4720 是一种有效的，选择性的 B-Raf^V600E 抑制剂，IC₅₀ 值为 13 nM；与对 c-Raf-1 的选择性相同，是野生型 B-Raf 选择性的 10 倍。

PLX-4720-d7 Chemical Structure

CAS No. : 1304096-50-1

规格		是否有货
1 mg		Check price and availability
5 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	PLX-4720-d7 is the deuterium labeled PLX-4720. PLX-4720 is a potent and selective inhibitor of B-Raf^V600E with an IC₅₀ of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-Raf^V600E than wild-type B-Raf^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	420.87
Formula	C₁₇H₇D₇ClF₂N₃O₃S
CAS 号	1304096-50-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tsai J, et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A, 2008, 105(8), 3041-3046. [3]. Paraiso KH, et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res, 2011, 71(7), 2750-2760. [4]. Nucera C, et al. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A, 2010, 107(23), 10649-10654. [5]. Rizzolio S, et al. Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies. J Clin Invest. 2018 Aug 31;128(9):3976-3990.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

c-Met/HDAC-IN-2

发表于2024年11月1日由上海金畔生物科技有限公司

c-Met/HDAC-IN-2

c-Met/HDAC-IN-2 是一种高效的 c-Met 和 HDAC 双重抑制剂，对 HDAC1 与 c-Met 的 IC₅₀ 分别为 18.49 nM 和 5.40 nM。c-Met/HDAC-IN-2 对几种癌细胞具有抗增殖活性。c-Met/HDAC-IN-2 能将 HCT-116 细胞周期阻滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。c-Met/HDAC-IN-2 可用于抗癌耐药研究。

c-Met/HDAC-IN-2 Chemical Structure

CAS No. : 2740495-53-6

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC₅₀s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance^[1].

IC₅₀ & Target^[1]

HDAC1

18.49 nM (IC₅₀)

c-Met

5.4 nM (IC₅₀)

体外研究
(In Vitro)

c-Met/HDAC-IN-2 (compound 14X) (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549^[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) induces of cancer cell apoptosis in a dose-dependent manner^[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) significantly causes G2/M-phase arrest in HCT-116 cells in a dose dependent manner^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	HCT-116, MCF-7 and A549^[1]
Concentration:	0-20 μM
Incubation Time:	72 hours
Result:	Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC₅₀s of 0.22 ± 0.09 μM, 1.59 ± 0.06 μM and 0.22 ± 0.04 μM, respectively.

Apoptosis Analysis

Cell Line:	HTC-116^[1]
Concentration:	0.2, 1 and 5 μM
Incubation Time:	48 hours
Result:	The percentage of apoptotic cells was 4.19%, 11.53% and 21.48% at 0.2 μM, 1.0 μM and 5.0 μM, respectively.

Cell Cycle Analysis

Cell Line:	HTC-116^[1]
Concentration:	0.2, 1 and 5 μM
Incubation Time:	48 hours
Result:	Significantly caused G2/M-phase arrest in HCT-116 cells in a dose dependent manner.

分子量

623.66

Formula

C₃₄H₃₃N₅O₇

CAS 号

2740495-53-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Hu H, Chen F, Dong Y, et al. Discovery of Novel c-Mesenchymal-Epithelia transition factor and histone deacetylase dual inhibitors. Eur J Med Chem. 2020;204:112651.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Relugolix-d6(Synonyms: TAK-385-d6)

发表于2024年11月1日由上海金畔生物科技有限公司

Relugolix-d6 (Synonyms: TAK-385-d6)

Relugolix-d6 是 Relugolix 氘代物。Relugolix (TAK-385) 是一种有效的，具有口服活性，非肽性促性腺激素释放激素(GnRH) 的拮抗剂。与 TAK-013 (HY-100209 ) 相比，Relugolix 对人 (IC₅₀=0.33 nM) 和猴子 (IC₅₀=0.32 nM) 的受体具有高亲和力和强拮抗活性。Relugolix 用于性激素依赖性疾病的研究，如子宫内膜异位症、子宫肌瘤、前列腺癌等。

Relugolix-d6 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Relugolix-d6 is deuterium labeled Relugolix. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209)^[1]. Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	629.67
Formula	C₂₉H₂₁D₆F₂N₇O₅S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kazuhiro Miwa, et al. Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor. doi/10.1021/jm200216q [3]. Daisuke Nakata, et al. Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice. Eur J Pharmacol. 2014 Jan 15;723:167-74.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Promestriene-d3

发表于2024年11月1日由上海金畔生物科技有限公司

Promestriene-d3

Promestriene-d3 是 Promestriene 的氘代物。Promestriene 是一种合成的雌二醇二乙醚，是一种局部有效的雌激素。Promestriene 对阴道萎缩有作用，但吸收量小。

Promestriene-d3 Chemical Structure

CAS No. : 1316849-37-2

规格		是否有货
2.5 mg		Check price and availability
25 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	Promestriene-d3 is the deuterium labeled Promestriene. Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	331.51
Formula	C₂₂H₂₉D₃O₂
CAS 号	1316849-37-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Isabel Santos, et al. Urogenital Disorders Associated With Oestrogen Deficiency: The Role of Promestriene as Topical Oestrogen Therapy. Gynecol Endocrinol. 2010 Sep;26(9):644-51. [3]. Lino Del Pup, et al. Promestriene, a Specific Topic Estrogen. Review of 40 Years of Vaginal Atrophy Treatment: Is It Safe Even in Cancer Patients. Anticancer Drugs. 2013 Nov;24(10):989-98. [4]. AJO Almodovar, et al. Abstract P5-05-07: Promestriene effects on estrogen-sensitive breast cancer cell proliferation in vitro. Cancer Res 2013;73(24 Suppl): Abstract nr P5-05-07.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

whatman (沃特曼)

英国沃特曼 Millipore PALL中国代理商金畔官网

月度归档：2024年11月

Enoxacin-d8

Minodronic acid-d4(Synonyms: YM-529-d4)

Lucanthone-d4 hydrochloride

上海衡平微波消解仪TITAN12B

MGH-CP1

Trofosfamide-d4

多肽定制Z-A-A-L-pNA 编码 [61043-33-2]

Tezosentan-d4

Teludipine-d6

ent-Tadalafil-d3(Synonyms: ent-IC-351-d3)

Tizanidine-d4

香豆素A1

香豆素A1

基本信息

一般描述

相关属性

上海衡平微波消解仪TITAN10

RPR132595A-d3

英国Grant数字式超声波清洗器XUB5/XUB18/XUB10/XUB12/XUB25

9-cis-Retinoic acid-d5

PLX-4720-d7

c-Met/HDAC-IN-2

Relugolix-d6(Synonyms: TAK-385-d6)

Promestriene-d3