Mc-​Val-​Ala-​PAB

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Mc-​Val-​Ala-​PAB 

Mc-​Val-​Ala-​PAB 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

Mc-​Val-​Ala-​PAB

Mc-​Val-​Ala-​PAB Chemical Structure

CAS No. : 1870916-87-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Mc-​Val-​Ala-​PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

486.56

Formula

C25H34N4O6

CAS 号

1870916-87-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

头孢克洛

头孢克洛

有货

头孢克洛

CAS编号 53994-73-3 | 品牌:Jinpan
Cefaclor

MSDS

质检证书(CoA)

相似产品

  • 分子式 C15H14ClN3O4S
  • 分子量367.81
  • Beilstein号 8176092
  • EC号 258-909-5
  • MDL号 MFCD00151471
  • PubChem编号 40958

货号 (SKU) 包装规格 是否现货 价格 数量
C487132-100mg 100mg 期货 头孢克洛  
C487132-1g 1g 期货 头孢克洛  

基本信息

产品名称 头孢克洛
英文名称 Cefaclor

一般描述

Description

Chemical structure: ß-lactamCefaclor has been used in the heterologous expression of AaOr7 and AaOr8 inXenopus laevisoocytes. It has also been used in cultures of isolated trigeminal ganglion (TG) and dorsal root ganglion (DRG) neurons.Cefaclor is used to study urinary tract, intra-abdominal, and Haemophilus influenzae infections . It is used to study the mechanism of human renal organic anion and peptide transporters such as hOAT1, hPEPT1, and hPEPT2 and to study the effects of inhibition of penicillin-binding proteins on bacterial cell wall mucopeptide synthesis .

Description

Chemical structure: ß-lactamCefaclor has been used in the heterologous expression of AaOr7 and AaOr8 inXenopus laevisoocytes. It has also been used in cultures of isolated trigeminal ganglion (TG) and dorsal root ganglion (DRG) neurons.Cefaclor is used to study urinary tract, intra-abdominal, and Haemophilus influenzae infections . It is used to study the mechanism of human renal organic anion and peptide transporters such as hOAT1, hPEPT1, and hPEPT2 and to study the effects of inhibition of penicillin-binding proteins on bacterial cell wall mucopeptide synthesis .

相关属性

CAS编号 53994-73-3
比旋光度 α20/D +112.2°
折光率 n20D1.72 (Predicted)
熔点 327.66° C (Predicted)
沸点 713.40° C at 760 mmHg (Predicted)
pKa值 pKa: 1.95 (Predicted), pKa: 6.84 (Predicted)
溶解性 可溶(微溶于水,几乎不溶于甲醇、乙醇)
RTECS XI0363000
MDL号 MFCD00151471
分子量 367.81
分子式 C15H14ClN3O4S
EC号 258-909-5
品牌 Jinpan
Smiles C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl
PubChem CID 40958
Ki Data PEPT2: Ki= 28.84 μM (human)

m-PEG25-Propargyl

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG25-Propargyl 

m-PEG25-Propargyl 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

m-PEG25-Propargyl

m-PEG25-Propargyl Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

m-PEG25-Propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1127.35

Formula

C52H102O25

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG37-Propargyl

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG37-Propargyl 

m-PEG37-Propargyl 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

m-PEG37-Propargyl

m-PEG37-Propargyl Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG37-Propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1655.98

Formula

C76H150O37

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

RET-IN-11

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

RET-IN-11 

RET-IN-11 是一种有效的选择性 RET 抑制剂,RETRETV804MIC50s 分别为 6.20 nM 和 18.68 nM。RET-IN-11 在 LC-2/ad 细胞中显示出抗增殖和迁移活性。RET-IN-11 诱导细胞凋亡 (apoptosis)。

RET-IN-11

RET-IN-11 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

RET-IN-11 is a potent and selective RET inhibitor with IC50s of 6.20 nM, 18.68 nM for RET and RETV804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis[1].

IC50 & Target

IC50: 6.20 nM (RET); 18.68 nM (RETV804M)[1]

体外研究
(In Vitro)

RET-IN-11 (compound 20) (72 h) shows inhibition activity with an IC50 of 18.68 nM for RETV804M, and shows anti-proliferation activities in CCDC6-RET-driven LC-2/ad cells[1].
RET-IN-11 (0-200 000 nM) shows selectivity with IC50s of 6.20, 96.38, 87.57, 1421.75, >200 000, 100.17, 112.95 nM for RET, Aurora A, CSF-1R, MAP4K4, NEK2, TRKA, FLT3, respectively[1].
RET-IN-11 (500, 1000 nM) induces cell apoptosis in LC-2/ad Cells[1].
RET-IN-11 (1, 2 µM; 48 h) inhibits the migration with the wound healing percentages of 43% and 27% at 1 µM and 2 µM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: LC-2/ad Cells
Concentration:
Incubation Time: 72 h
Result: Showed anti-proliferation activities with an IC50 of 100.26 nM.

Western Blot Analysis[1]

Cell Line: RAT1 (RETC634R), NCOA4-RET/NCOA4-RETV804M/NCOA4-RETG810R transfected HEK293T cells
Concentration: 100, 500, 2500 nM
Incubation Time: 2 h
Result: Significantly inhibits the auto-phosphorylation of RETC634R and NCOA4-RET on Y905 and Y1062 at 100 nM and 500 nM.

Apoptosis Analysis[1]

Cell Line: LC-2/ad Cells
Concentration: 500, 1000 nM
Incubation Time: 48 h
Result: Increased the fraction of apoptotic cell for 500 nM (31% increase) and 1 µM (36% increase), respectively.

分子量

515.59

Formula

C27H30FN9O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhang L, et al. Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose. J Med Chem. 2022 Jan 27;65(2):1536-1551.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

上海一恒微型高速离心机BLF-15K

上海一恒微型高速离心机BLF-15K

  • 品牌 一恒|yiheng
  • 型号 BLF-15K
  • 商品详情

     

    BLF-15K 微型高速离心机是一款实用、小巧、可靠的实验室工作助手,最高转速可达14,500 rpm。人性化的设计,简约小巧的外型,特殊处理的低噪音设计为您创造安静、舒畅的实验环境;效的速度控制,加速至最高转速仅需15s,从最高速减速也仅需15s;另外,便于操作的数字显示屏,简单上手的操作键以及Short-Spin瞬时离心键、rpm和rcf转换等功能使您得心应手于各种实验阶段。

    产品特点 

    ■漂亮造型和简洁外观,背光LCD显示;

    ■最大容量:12×1.5ml或2.0ml离心管;

    ■采用无刷免维护高速电机,超静音运行;

    ■独特的气流导向,保持样品低温,最高转速运行30分温度升高仅为10℃;

    ■灵敏高效的速度控制,加速至最高转速仅需15s,从最高速减速仅需15s;

    ■单独的Short-spin按键,操作简单,方便瞬时离心;

    ■铝合金转子,无使用寿命限制,转子可高温高压灭菌;

    ■多重安全保护功能,符合CE安全标准,安全可靠;

    转子及附件:

    可选购适配器配件

       –0.2ml PCR管的适配器 

       –0.5ml PCR管的适配器  

    技术参数

    型号

    BLF-15K

    电源

    100~120V/200~240V 50/60Hz

    电源功率

    100W

    最高转速(rpm)

    14,500 rpm

    最大相对离心力(rcf)

    14,000xg

    计时器设置范围

    20 sec~99min

    加速至最高转速的时间

    15sec

    从最高转速减速的时间

    15sec

    尺寸(长x宽x高)cm

    27x23x15.5 cm

    重量(包括转子)

    4.8kg

    订货信息

    产品描述

    订货号

    BLF-15K微型高速离心机

    AS-08110-00

    0.5ml离心管适配器

    AS-08041-01

    0.2ml离心管适配器

    AS-08041-02

  • Mc-​Val-​Ala-​PAB

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Mc-​Val-​Ala-​PAB 

    Mc-​Val-​Ala-​PAB 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

    Mc-​Val-​Ala-​PAB

    Mc-​Val-​Ala-​PAB Chemical Structure

    CAS No. : 1870916-87-2

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Mc-​Val-​Ala-​PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

    IC50 & Target

    Cleavable

     

    体外研究
    (In Vitro)

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    486.56

    Formula

    C25H34N4O6

    CAS 号

    1870916-87-2

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Alectinib-d6(Synonyms: CH5424802-d6; RO5424802-d6; AF802-d6)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Alectinib-d6 (Synonyms: CH5424802-d6; RO5424802-d6; AF802-d6)

    Alectinib-d6 是 Alectinib 氘代物。Alectinib (CH5424802) 是一种有效、选择性、具有口服活性的 ALK 抑制剂,其 IC50 为 1.9 nM,Kd 值为 2.4 nM (以 ATP 竞争方式),并且还抑制 ALK F1174LALK R1275Q,其 IC50 分别为 1 nM 和 3.5 nM。Alectinib 还具有有效的中枢神经系统 (CNS) 渗透能力。

    Alectinib-d6(Synonyms: CH5424802-d6;  RO5424802-d6;  AF802-d6)

    Alectinib-d6 Chemical Structure

    CAS No. : 1616374-19-6

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Alectinib-d6 is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].

    体外研究
    (In Vitro)

    Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    488.65

    Formula

    C30H28D6N4O2

    CAS 号

    1616374-19-6

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

      [2]. Sakamoto H, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011, 19(5), 679-690.

      [3]. Gadgeel S, et al. Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study. Ann Oncol. 2018 Nov 1;29(11):2214-2222.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    BCN-PEG1-Val-Cit-OH

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    BCN-PEG1-Val-Cit-OH 

    BCN-PEG1-Val-Cit-OH 是一种可降解 (cleavable) 的含 1 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

    BCN-PEG1-Val-Cit-OH

    BCN-PEG1-Val-Cit-OH Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    BCN-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

    IC50 & Target

    Cleavable

     

    体外研究
    (In Vitro)

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    565.66

    Formula

    C27H43N5O8

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    m-PEG37-Propargyl

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    m-PEG37-Propargyl 

    m-PEG37-Propargyl 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    m-PEG37-Propargyl

    m-PEG37-Propargyl Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    m-PEG37-Propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    1655.98

    Formula

    C76H150O37

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Tetrazine-Ph-OPSS

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Tetrazine-Ph-OPSS 

    Tetrazine-Ph-OPSS 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

    Tetrazine-Ph-OPSS

    Tetrazine-Ph-OPSS Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

    IC50 & Target

    Cleavable

     

    体外研究
    (In Vitro)

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    384.48

    Formula

    C17H16N6OS2

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    上海一恒微孔板迷你离心机BLF-P25

    上海一恒微孔板迷你离心机BLF-P25

  • 品牌 一恒|yiheng
  • 型号 BLF-P25
  • 商品详情

    迷你型微孔板离心机BLF-P25为国内首款专门为96孔板设计的离心机,方便离下挂壁液滴。当前市面上大多数微孔板离心机都体积庞大,占据了大量的实验室空间,该微孔板离心机设计独特、精小,仅23x20cm。微孔板由离心机顶部插槽垂直装入离心机转子内,液体在表面张力作用下保持在微孔板底部,因此不会漏液。

    产品特点: 

    ■快速离心挂壁液滴;

    ■PCR实验前使用,显著提高扩增效果;

    ■适用带裙边,不带裙边及各种标准PCR微孔板;

    技术参数

    型号

    BLF-P25

    相对离心力

    500xg

    样品处理量

    2×96孔 PCR板

    转速(rpm)

    2,500 rpm

    尺寸(长x宽x高)cm

    23x20x19.3 cm

    重量

    3.0kg

    电压

    AC 120V/220V, 50~60Hz

  • 头孢哌酮钠盐

    头孢哌酮钠盐

    870-1015μg/mg(无水级 )

    有货

    头孢哌酮钠盐

    CAS编号 62893-20-3 | 品牌:Jinpan
    Cefoperazone sodium salt

    MSDS

    质检证书(CoA)

    相似产品

    • 分子式 C25H26N9NaO8S2
    • 分子量667.65
    • Beilstein号 4902135
    • EC号 263-751-5
    • MDL号 MFCD07793331
    • PubChem编号 23663974

    货号 (SKU) 包装规格 是否现货 价格 数量
    C466850-5g 5g 期货 头孢哌酮钠盐  
    C466850-1g 1g 期货 头孢哌酮钠盐  

    基本信息

    产品名称 头孢哌酮钠盐
    英文名称 Cefoperazone sodium salt
    规格或纯度 870-1015μg/mg(无水级 )
    运输条件 冰袋运输

    一般描述

    Description

    Chemical structure: ß-lactamCefoperazone is used to study drug-protein binding, expression and inhibition of penicillin-binding proteins (PBPs) during cell wall synthesis.

    Description

    Chemical structure: ß-lactamCefoperazone is used to study drug-protein binding, expression and inhibition of penicillin-binding proteins (PBPs) during cell wall synthesis.

    相关属性

    CAS编号 62893-20-3
    储存温度 2-8°C储存
    MDL号 MFCD07793331
    分子量 667.65
    分子式 C25H26N9NaO8S2
    EC号 263-751-5
    品牌 Jinpan
    PubChem CID 23663974

    DSPE-PEG46-N3

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    DSPE-PEG46-N3 

    DSPE-PEG46-N3 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    DSPE-PEG46-N3

    DSPE-PEG46-N3 Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    DSPE-PEG46-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    2843.51

    Formula

    C134H265N4O55P

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Edi-Q10/Edi-Q10UT去离子纯水机

    【简单介绍】

    产地 国产

    Edi-Q10/Edi-Q10UT去离子纯水机,Edi系列以城市自来水为水源,可方便快速的制造RO反渗透水、EDI去离子水和UP超纯水,以中国实验室纯水系统的产品、2017/2018年科学仪器行业受关注仪器、连续2届国产好仪器-Master为基础,采用Ionpure EDI技术及模块,连续生产10MΩ.cm(25℃)以上且TOC<30ppb的Ⅱ级纯水、18.2MΩ.cm(25℃)的超纯水。

    【详细说明】

    Edi-Q10/Edi-Q10UT去离子纯水机(自来水为水源)

    产品简述:

       Edi系列以城市自来水为水源,可方便快速的制造RO反渗透水、EDI去离子水和UP超纯水,以中国实验室纯水系统的产品、2017/2018年科学仪器行业受关注仪器、连续2届国产好仪器-Master为基础,采用Ionpure EDI技术及模块,连续生产10MΩ.cm(25℃)以上且TOC<30ppb的Ⅱ级纯水、18.2MΩ.cm(25℃)的超纯水。

    现有Edi-Q/S 2个子产品系列,系统产水量:10升/小时,每天纯水产量可达240升。出水水质完全符合GB/T 6682-2008、GB/T33087-2016、ASTM、CAP、CLSI、EP和USP制定的Ⅰ级水质标准。

    特点与优势:

    • 每天纯水产量可达240升
    • 全自动微电脑控制系统,多级菜单式操作
    • 国内du有的上班、下班两种工作模式,保证供水量充足
    • 全自动RO 膜防垢冲洗程序,延长RO膜使用寿命
    • 预处理、RO膜、UV灯和超纯化柱的寿命可设定,显示耗材已用和剩余时间,耗材到期更换自动提醒,避免水质下降
    • 预处理、RO、EDI 模块、超纯化组件,采用模块式独立结构,系统维护、滤芯更换更加便捷,符合GLP规范
    • 纯水管路、接头均获NSF认证

    Edi-Q10/Edi-Q10UT去离子纯水机(自来水为水源)

    主要技术参数:

    产品型号 Edi-Q10 Edi-Q10UT
    进水要求 城市自来水:TDS<200 ppm,5-45℃,1.0-4.0Kgf/cm2 ( 进水TDS>200ppm 时,建议选配外置软化器)
    EDI 去离子水指标:  
    电阻率 >5MΩ.cm
    总有机碳(TOC) <30 ppb
    硅截留率 >99.9%
    细菌 N/A <0.1 cfu/ml
    颗粒物(>0.2μm) N/A <1/ml
    RO 反渗透水指标  
    离子截留率 96%-99%(使用新RO 膜时)
    有机物截留率 >99%,当MW>200 道尔顿
    颗粒和细菌截留率 >99%
    产水量(25℃) 10 升/ 小时
    RO 瞬间出水量 2.0 升/ 分钟( 需配压力水桶)
    出水口( 触摸按键) 2 个:RO 反渗透水;EDI 高纯水
    外形尺寸/ 重量 长× 宽× 高:50×36×54cm/ 约25Kg
    电源/ 功率 220V、50Hz/120W
    标准配置 主机( 含1 套纯化柱)+20升水箱+ 附件包

     

     

    货号/型号 品名 使用寿命/根(估值)
    PC-M-PP 5μmPP深层滤芯 约2-6个月
    PC-M-KDF KDF复合滤芯 约1年
    PC-M-AC-G 精密活性炭滤芯 约6个月
    RO-150GPD 150GPDRO膜 约1-2年
    PTC-SF 软化柱 约2-6个月
    PTC-EDI10-IP EDI模块 约1-3年
    PTC-AC-HZB1 有机物纯化柱 约9000升纯水
    PTC-UPPR-M 超纯化柱(进口树脂) 约1000升纯水/柱
    PTC-UPPR-M4 4柱式超纯化柱(进口树脂) 约4000升纯水/组,由4根单体超纯化柱组成
    TF-(0.45+0.1)μm-S (0.45+0.1)μm进口PES终端滤器
    UF-5000D MWCO5000DUF超滤组件(进口)
    UV-(185nm&254nm)-10W-M 双波长(185nm&254nm)UV紫外灯组件(进口)
    LAMP-(185nm&254nm)-10W-M 双波长(185&254nm)紫外灯管(进口) 约9000小时
    UV-254-10W-M 254nmUV紫外灯组件(进口灯管)
    LAMP-254-10W-M 254nm紫外灯管(进口) 约9000小时

     

    BCN-PEG1-Val-Cit-OH

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    BCN-PEG1-Val-Cit-OH 

    BCN-PEG1-Val-Cit-OH 是一种可降解 (cleavable) 的含 1 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

    BCN-PEG1-Val-Cit-OH

    BCN-PEG1-Val-Cit-OH Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    BCN-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

    IC50 & Target

    Cleavable

     

    体外研究
    (In Vitro)

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    565.66

    Formula

    C27H43N5O8

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Tetrazine-Ph-OPSS

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Tetrazine-Ph-OPSS 

    Tetrazine-Ph-OPSS 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

    Tetrazine-Ph-OPSS

    Tetrazine-Ph-OPSS Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

    IC50 & Target

    Cleavable

     

    体外研究
    (In Vitro)

    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    384.48

    Formula

    C17H16N6OS2

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    多肽定制Vasoactive Intestinal Peptide (1-12), human, porcine, rat 编码 [120928-03-2]

    上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

    名称 Vasoactive Intestinal Peptide (1-12), human, porcine, rat
    编码 [120928-03-2]
    别名 Vasoactive Intestinal Peptide (1-12), human, porcine, rat
    纯度 80%,90%,95%,98%,99%
    重量 1mg,5mg,10mg,50mg,100mg,1g
    序列(单字母缩写) HSDAVFTDNYTR
    序列(三字母缩写) His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg
    基本描述
    溶解度
    分子量 1425.49
    化学式 C61H88N18O22
    存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
    注释
    Documents Vasoactive Intestinal Peptide (1-12), human, porcine, rat           编码     [120928-03-2]
    Figures Vasoactive Intestinal Peptide (1-12), human, porcine, rat           编码     [120928-03-2]
    Reference
    C端
    N端
    化学桥

    Propargyl-PEG25-acid

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Propargyl-PEG25-acid 

    Propargyl-PEG25-acid 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    Propargyl-PEG25-acid

    Propargyl-PEG25-acid Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Propargyl-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    1185.39

    Formula

    C54H104O27

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    DSPE-PEG46-N3

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    DSPE-PEG46-N3 

    DSPE-PEG46-N3 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    DSPE-PEG46-N3

    DSPE-PEG46-N3 Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    DSPE-PEG46-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    2843.51

    Formula

    C134H265N4O55P

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务