Inotodiol

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Inotodiol 

Inotodiol (compound 3) 是一种羊毛甾烷型三萜类化合物,从Inonotus obliquus 的菌核中分离得到。Inotodiol 在体内致癌试验中表现出有效的抗肿瘤促进活性。

Inotodiol

Inotodiol Chemical Structure

CAS No. : 35963-37-2

规格 是否有货
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250 mg   询价  
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生物活性

Inotodiol (compound 3) is a lanostane-type triterpenoid compound isolated from the sclerotia of Inonotus obliquus. Inotodiol exhibits the potent anti-tumor promoting activity in the in vivo carcinogenesis test[1].

分子量

442.72

Formula

C30H50O2

CAS 号

35963-37-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Nakata T, et al. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem. 2007;15(1):257-264.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

KIRGEN科进KG8231培养箱除菌剂Incubator Cleaner(500ml/瓶)

【简单介绍】

KIRGEN科进KG8231培养箱除菌剂Incubator Cleaner(500ml/瓶),用于细胞房和细胞培养箱中细菌、真菌的清除。

【详细说明】

KIRGEN科进KG8231培养箱除菌剂Incubator Cleaner(500ml/瓶)

产品描述

   KIRGEN科进KG8231培养箱除菌剂Incubator Cleaner(500ml/瓶)用于细胞房和细胞培养箱中细菌、真菌的清除。 
产品特点: 
安全,绿色、高效 
可以取代84,甲醛等毒性处理方法 
产品无挥发性,对人体安全 
*创新产品,市场同类产品少 
对于真菌的污染效果明显,尤其适用于梅雨季节


产品特点

1、KIRGEN酵母浸粉以纯培养的酿酒酵母为原料,经过酶解、 过滤、浓缩、喷粉等工艺生产而成,产品呈浅黄色粉状, 富含肽类、游离氨基酸、核苷酸、维生素、微量元素等营 养成分。
2、KIRGEN琼脂糖是高纯度低电渗(Low EEO)多用途琼脂糖, 适用于凝胶电泳,采用绿色环保的原创工艺,生产过程中不 使用有机溶剂,从而减少环境污染,同时也减少对操作者和 样品影响。 
3、KIRGEN胰蛋白胨采用优质乳酪蛋白,进行胰酶酶解生成的蛋白胨产物。 
4、水浴锅除菌剂:用于清除和抑制水浴锅中/培养箱的水盘中的细菌、真菌。 
5、培养箱/细胞房除菌剂:用于细胞房和细胞培养箱中细菌、真菌的清除。

技术规格

产品型号 产品描述 包装规格
KG8216 酵母粉 Yeast Extrat(搭配KG8217) 500g/瓶
KG8217 蛋白胨 Peptone(搭配KG8216) 500g/瓶
KG8218 超滤级酵母粉 Yeast Extrat(搭配KG8219) 500g/瓶
KG8219 超滤级胰蛋白胨 Tryptone(搭配KG8218) 500g/瓶
KG8220 琼脂糖 Agarose 100g/瓶
KG8221 琼脂糖 Agarose 500g/瓶
KG8230 Bath Cleaner 水浴锅除菌剂 100ml/瓶
KG8231 Incubator Cleaner 培养箱除菌剂 500ml/瓶
KG8232 Room Cleaner 细胞房除菌剂 500ml/瓶

 

m-PEG16-NH2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG16-NH2 

m-PEG16-NH2 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

m-PEG16-NH2

m-PEG16-NH2 Chemical Structure

CAS No. : 907577-50-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG16-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

735.90

Formula

C33H69NO16

CAS 号

907577-50-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

多肽定制Tyr-Leptin (26-39) (human) 编码

上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

名称 Tyr-Leptin (26-39) (human)
编码
别名 Tyr-Leptin (26-39) (human)
纯度 80%,90%,95%,98%,99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列(单字母缩写) YKVQDDTKTLIKTIV-OH
序列(三字母缩写) Tyr-Lys-Val-Gln-Asp-Asp-Thr-Lys-Thr-Leu-Ile-Lys-Thr-Ile-Val
基本描述
溶解度
分子量 0
化学式
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Tyr-Leptin (26-39) (human)          编码
Figures Tyr-Leptin (26-39) (human)          编码
Reference
C端
N端
化学桥

m-PEG16-SH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG16-SH 

m-PEG16-SH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

m-PEG16-SH

m-PEG16-SH Chemical Structure

CAS No. : 874820-38-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG16-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

752.95

Formula

C33H68O16S

CAS 号

874820-38-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG8-O-alkyne

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG8-O-alkyne 

m-PEG8-O-alkyne 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

m-PEG8-O-alkyne

m-PEG8-O-alkyne Chemical Structure

CAS No. : 880081-81-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

422.51

Formula

C20H38O9

CAS 号

880081-81-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Thiol-PEG4-alcohol(Synonyms: HS-PEG4-OH)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Thiol-PEG4-alcohol (Synonyms: HS-PEG4-OH)

Thiol-PEG4-alcohol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Thiol-PEG4-alcohol(Synonyms: HS-PEG4-OH)

Thiol-PEG4-alcohol Chemical Structure

CAS No. : 90952-27-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

210.29

Formula

C8H18O4S

CAS 号

90952-27-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG8-O-alkyne

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG8-O-alkyne 

m-PEG8-O-alkyne 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

m-PEG8-O-alkyne

m-PEG8-O-alkyne Chemical Structure

CAS No. : 880081-81-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

422.51

Formula

C20H38O9

CAS 号

880081-81-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

上海博迅手动门脉动真空灭菌器BXW-1.2SDM(双门)(医用型)

上海博迅手动门脉动真空灭菌器BXW-1.2SDM(双门)(医用型)

  • 品牌 博迅|Boxun
  • 型号 BXW-1.2SDM
  • 商品详情

    品名:手动门脉动真空灭菌器
    型号:BXW系列

    性能特点:

    ☆灭菌器内室采用S30408不锈钢,夹套采用锅炉压力容器专用钢板,主体的制造采用先进的焊接工艺和检测手段,保证灭菌器主体的质量可靠、经久耐用。
    ☆灭菌全过程采用微电脑自动控制,自动化程度高,彩色触摸屏可动态显示工作温度、压力、时间、灭菌阶段等参数,操作更直观、方便。
    ☆设备配备了多套灭菌程序(织物、器械、液体等),也可根据用户实际情况设定工作参数。
      同时设有真空检测、BD测试程序,真空泄漏率小于0.13Kpa/min。
    ☆密封门采用符合法规要求的安全联锁装置
    (1)门未关闭锁紧时,灭菌程序不能启动。
    (2)内室有压力时,锁紧装置保证不能转动手轮,保证用户安全。
    ☆密封圈采用机械压紧式结构设计,具有密封效果好,使用寿命长的特点。
    ☆PID控温功能,通过选择可以自动修正加热控制参数,防止温度过冲发生。
    注:自产蒸汽的灭菌器:
    备有蒸汽发生器和加水泵,该装置具有以下功能:
    (1)加水泵自动进水、补水功能,使蒸汽发生器中的水位控制在合理范围内。
    (2)蒸汽发生器内的水位达到水位最低值时,能够切断电热管电源,并报警提示。
    (3)采用压力控制器控制蒸汽发生器内的压力,超压后有安全阀进行保护。

    1.用户可以根据需要进行单门双门、外接蒸气或自产蒸汽等要求的选择。
    2.可以根据用户需要进行符合卫生级要求的特殊定制。

  • m-PEG16-NH2

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    m-PEG16-NH2 

    m-PEG16-NH2 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    m-PEG16-NH2

    m-PEG16-NH2 Chemical Structure

    CAS No. : 907577-50-8

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    m-PEG16-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    735.90

    Formula

    C33H69NO16

    CAS 号

    907577-50-8

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    来自链霉菌的硫酸卷曲霉素

    来自链霉菌的硫酸卷曲霉素

    抗菌肽

    有货

    来自链霉菌的硫酸卷曲霉素

    CAS编号 1405-37-4 | 品牌:Jinpan
    Capreomycin sulfate from Streptomyces capreolus

    MSDS

    质检证书(CoA)

    相似产品

    • 分子式 C25H44N14O7.H2SO4
    • 分子量750.78
    • EC号 215-776-8
    • MDL号 MFCD00079032
    • PubChem编号 22836615

    货号 (SKU) 包装规格 是否现货 价格 数量
    C477559-5g 5g 期货 来自链霉菌的硫酸卷曲霉素  
    C477559-1g 1g 期货 来自链霉菌的硫酸卷曲霉素  

    基本信息

    产品名称 来自链霉菌的硫酸卷曲霉素
    英文名称 Capreomycin sulfate from Streptomyces capreolus
    规格或纯度 抗菌肽
    运输条件 超低温冰袋运输

    一般描述

    Description

    Capreomycin is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis.

    Preparation instructions

    Sparingly soluble in water.

    相关属性

    CAS编号 1405-37-4
    沸点 1377℃
    溶解性  水:50 毫克/毫升
    储存温度 -20°C储存
    RTECS EX8930000
    MDL号 MFCD00079032
    分子量 750.78
    分子式 C25H44N14O7.H2SO4
    EC号 215-776-8
    品牌 Jinpan
    PubChem CID 22836615

    Hydroxy-PEG2-acid

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Hydroxy-PEG2-acid 

    Hydroxy-PEG2-acid 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    Hydroxy-PEG2-acid

    Hydroxy-PEG2-acid Chemical Structure

    CAS No. : 1334286-77-9

    规格 价格 是否有货 数量
    100 mg ¥1200 In-stock
    250 mg ¥2100 In-stock
    500 mg ¥3300 In-stock
    1 g   询价  
    5 g   询价  

    * Please select Quantity before adding items.

    生物活性

    Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    178.18

    Formula

    C7H14O5

    CAS 号

    1334286-77-9

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Thiol-PEG4-alcohol(Synonyms: HS-PEG4-OH)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Thiol-PEG4-alcohol (Synonyms: HS-PEG4-OH)

    Thiol-PEG4-alcohol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    Thiol-PEG4-alcohol(Synonyms: HS-PEG4-OH)

    Thiol-PEG4-alcohol Chemical Structure

    CAS No. : 90952-27-5

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    210.29

    Formula

    C8H18O4S

    CAS 号

    90952-27-5

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    HS-1793

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    HS-1793 

    HS-1793 是一种 resveratrol 类似物,在多种癌细胞中具有抗肿瘤 (antitumor) 活性。HS-1793 诱导细胞凋亡 (apoptosis)。

    HS-1793

    HS-1793 Chemical Structure

    CAS No. : 927885-00-5

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    HS-1793 is a resveratrol analogue with antitumor activities in a variety of cancer cell lines[1]. HS-1793 induces cell apoptosis[2].

    体外研究
    (In Vitro)

    HS-1793 (0-100 µM, 24 h) suppresses proliferation of MCF-7, MDA-MB-231 and HCT116 cells[1][2].
    HS-1793 (0-50 µM, 4 h) inhibits hypoxia-induced HIF-1α protein in MCF-7 and MDA-MB-231 cells unrelated to cell death, downregulates hypoxia-induced VEGF expression, and suppresses hypoxia-induced mRNA expression of VEGF at the transcriptional level[1].
    HS-1793 (0-100 µM, 24 h) induces apoptosis, promotes G2/M cell cycle arrest, and inhibits Akt and ERK phosphorylation in HCT116 cells[2].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[1]

    Cell Line: MCF-7, MDA-MB-231 and MCF-10A
    Concentration: 0-100 μM
    Incubation Time: 24 h
    Result: Showed antiproliferation activity with IC50 values of 26.3±3.2, 48.2±4.2 and >100 μM against MCF-7, MDA-MB-231 and MCF-10A, respectively.

    Western Blot Analysis[1]

    Cell Line: MCF-7, MDA-MB-231
    Concentration: 12.5, 25 and 50 μM
    Incubation Time: 4 h
    Result: Downregulated HIF-1α expression in a concentration-dependent manner in both cell lines.

    RT-PCR[1]

    Cell Line: MCF-7, MDA-MB-231
    Concentration: 12.5, 25 and 50 μM
    Incubation Time: 4 h
    Result: Downregulated the expression of VEGF mRNA, with the more marked results observed in MDA-MB-231 cells.

    Cell Proliferation Assay[2]

    Cell Line: HCT116
    Concentration: 12.5, 25, 50 and 100 µM
    Incubation Time: 1, 2 and 4 days
    Result: Significantly reduced the cell viability concentration- and time-dependently. Significantly suppressed proliferation of colon cancer cell line HCT116.

    Apoptosis Analysis[2]

    Cell Line: HCT116
    Concentration: 12.5, 25, 50 and 100 µM
    Incubation Time: 24 h
    Result: Induced cell apoptosis in a dose-dependent manner. Caused chromatin condensation and fragmentation.

    Western Blot Analysis[2]

    Cell Line: HCT116
    Concentration: 12.5, 25, 50 and 100 µM
    Incubation Time: 24 h
    Result: Effectively induced the reduction of pro-caspase-8 and pro-caspase-3 at 100 µM. Activated caspase-8 and caspase-3. Caused the PARP cleavage. Slightly downregulated the level of antiapoptotic protein Bcl-2 at 100 µM. Promoted an increase in the release of cytochrome c from the mitochondria into the cytosol. Decreased the expression of G2/M cell cycle regulatory protein cyclin B1, Cdc2 and Cdc25C. Decreased the level of CDK4 and CDK6. Decreased Akt phosphorylation and reduced total Akt at high-concentration. Decreased the phosphorylation of ERK1/2 without affecting the protein level.

    Cell Cycle Analysis[2]

    Cell Line: HCT116
    Concentration: 12.5, 25 and 50 µM
    Incubation Time: 24 h
    Result: Induced the accumulation of cells in the G2/M phase in a concentration-dependent manner.

    体内研究
    (In Vivo)

    HS-1793 (5 and 10 mg/kg; i.p.; twice a week, 4 weeks) significantly inhibits MDA-MB-231 xenograft tumor growth and in a dose-dependent manner and relatively hampers angiogenesis with non-toxicity[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Five-week-old female BALB/c nude mice injected with MDA-MB-231 cells[1]
    Dosage: 5 mg/kg and 10 mg/kg (dissolved in PBS containing 0.1% v/v dimethyl sulfoxide (DMSO))
    Administration: Intraperitoneal injection, twice a week, 4 weeks
    Result: Significantly inhibited MDA-MB-231 xenograft tumor growth in a dose-dependent manner with non-toxicity. Significantly lowered Ki-67 (a proliferation marker) and CD31 expression. Successfully suppressed the expression of HIF-1α and VEGF in tumor tissues.

    分子量

    252.26

    Formula

    C16H12O3

    CAS 号

    927885-00-5

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Kim DH, et al. HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model. Int J Oncol. 2017 Aug;51(2):715-723.

      [2]. Kim DH, et al. Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncol Rep. 2017 Jan;37(1):281-288.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    多肽定制Tyr-Leptin (26-39), human 编码

    上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

    名称 Tyr-Leptin (26-39), human
    编码
    别名 Tyr-Leptin (26-39), human
    纯度 80%,90%,95%,98%,99%
    重量 1mg,5mg,10mg,50mg,100mg,1g
    序列(单字母缩写) YKVQDDTKTLIKTIV
    序列(三字母缩写) H-Tyr-Lys-Val-Gln-Asp-Asp-Thr-Lys-Thr-Leu-Ile-Lys-Thr-Ile-Val-OH (trifluoroacetate salt)
    基本描述 Leptin administration produces fragments of rat inhibition of food intake.
    溶解度
    分子量 1765.1
    化学式 C80H137N19O25
    存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
    注释
    Documents Tyr-Leptin (26-39), human          编码
    Figures Tyr-Leptin (26-39), human          编码
    Reference Y. Zhang et al., Nature, 372, 425 (1994) M.A. Pelleymounter et al., Science 269, 541 (1995)
    C端
    N端
    化学桥

    科进KIRGEN琼脂糖(Agarose)KG8220/KG8221

    【简单介绍】

    科进KIRGEN琼脂糖(Agarose)KG8220/KG8221,是高纯度低电渗(Low EEO)多用途琼脂糖, 适用于凝胶电泳,采用绿色环保的原创工艺,生产过程中不 使用有机溶剂,从而减少环境污染,同时也减少对操作者和 样品影响。
    KG8220:100g/瓶

    KG8221:500g/瓶

    【详细说明】

    科进KIRGEN琼脂糖(Agarose)KG8220/KG8221

    产品描述

       科进KIRGEN琼脂糖(Agarose)KG8220/KG8221是高纯度低电渗(Low EEO)多用途琼脂糖, 适用于凝胶电泳,采用绿色环保的原创工艺,生产过程中不 使用有机溶剂,从而减少环境污染,同时也减少对操作者和 样品影响。 
    技术参数:     
    外观:    白色粉末                  
    级别:    分子生物学级                 
    产品线:  生物试剂                  
    杂质:   含水量≤10%           
    EEO:  ≤0.13                       
    凝胶温度:36 °C (1.5% gel, ± 1.5 °C) 
    凝胶强度:  ≥1200 g/cm2 (1% gel)      
    其   他:   DNA酶,RNA酶不得检出 
    贮   存:   室温  
    产品特点:    
    绿色环保,绿色选择;高强度凝胶让您操作轻松自如;高分辨率让您一目了然;低电渗加快条带移动为您节约实验时间;极低背景给您清新视野;稳定品质使您的实验结果良好重现。

    KG8220:100g/瓶

    KG8221:500g/瓶


    产品特点

    1、KIRGEN酵母浸粉以纯培养的酿酒酵母为原料,经过酶解、 过滤、浓缩、喷粉等工艺生产而成,产品呈浅黄色粉状, 富含肽类、游离氨基酸、核苷酸、维生素、微量元素等营 养成分。
    2、KIRGEN琼脂糖是高纯度低电渗(Low EEO)多用途琼脂糖, 适用于凝胶电泳,采用绿色环保的原创工艺,生产过程中不 使用有机溶剂,从而减少环境污染,同时也减少对操作者和 样品影响。 
    3、KIRGEN胰蛋白胨采用优质乳酪蛋白,进行胰酶酶解生成的蛋白胨产物。 
    4、水浴锅除菌剂:用于清除和抑制水浴锅中/培养箱的水盘中的细菌、真菌。 
    5、培养箱/细胞房除菌剂:用于细胞房和细胞培养箱中细菌、真菌的清除。


    技术规格

    产品型号 产品描述 包装规格
    KG8216 酵母粉 Yeast Extrat(搭配KG8217) 500g/瓶
    KG8217 蛋白胨 Peptone(搭配KG8216) 500g/瓶
    KG8218 超滤级酵母粉 Yeast Extrat(搭配KG8219) 500g/瓶
    KG8219 超滤级胰蛋白胨 Tryptone(搭配KG8218) 500g/瓶
    KG8220 琼脂糖 Agarose 100g/瓶
    KG8221 琼脂糖 Agarose 500g/瓶
    KG8230 Bath Cleaner 水浴锅除菌剂 100ml/瓶
    KG8231 Incubator Cleaner 培养箱除菌剂 500ml/瓶
    KG8232 Room Cleaner 细胞房除菌剂 500ml/瓶

     

    m-PEG16-NH2

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    m-PEG16-NH2 

    m-PEG16-NH2 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    m-PEG16-NH2

    m-PEG16-NH2 Chemical Structure

    CAS No. : 907577-50-8

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    m-PEG16-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    735.90

    Formula

    C33H69NO16

    CAS 号

    907577-50-8

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Thiol-PEG4-alcohol(Synonyms: HS-PEG4-OH)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Thiol-PEG4-alcohol (Synonyms: HS-PEG4-OH)

    Thiol-PEG4-alcohol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    Thiol-PEG4-alcohol(Synonyms: HS-PEG4-OH)

    Thiol-PEG4-alcohol Chemical Structure

    CAS No. : 90952-27-5

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    210.29

    Formula

    C8H18O4S

    CAS 号

    90952-27-5

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    上海一恒旋转蒸发器RV-211A

    上海一恒旋转蒸发器RV-211A

  • 品牌 一恒|yiheng
  • 型号 RV-211A
  • 可选配件及服务

    上海一恒旋转蒸发器RV-211A

    上海一恒旋转蒸发器RV-211A

    上海一恒循环水真空泵BSH-3A

    ¥2090.00

    上海一恒冷却循环器BWR-03A

    ¥7900.00

    上海一恒旋转蒸发器RV-211A

    请询价

    商品详情

    旋转蒸发仪 

    实验室仪器旋转蒸发仪主要用于在减压条件下连续蒸馏大量易挥发性溶剂。尤其对萃取液的浓缩和色谱分离时的接收液的蒸馏,可以分离和纯化反应产物。旋转蒸发仪的基本原理就是减压蒸馏,也就是在减压情况下,当溶剂蒸馏时,蒸馏烧瓶在连续转动。

    产品特点:

    ●  手动 / 自动升降,结构简单、稳定,单手可轻松操作;

    ●  独特的密封系统设计,PTFE+FKM 材料高弹性密封圈,耐高温、耐腐蚀、经久耐用;

    ●  斜式双层蛇形盘管 冷却面积 0.15m 2 , 蒸发能力可达 Max.18ml/min;

    ●  水浴 / 油浴双重加热模式,温度 LCD 数显,可进行定时操作;

    ●  水浴锅高安全等级设计,具有防干烧断电功能;

    ●  高效双重冷凝管,防止蒸发冷凝液倒流设计;

    ●  PID 控制 , 转速 LCD 数显操作简单快捷;

    ●  可选精确的进口真空表;

    ●  本产品采用宽电压,可满足 110V/220V 的电源上使用。

    技术参数

    型号

    RV-211M

    RV-211A

    性能

    旋转速度

    20-180rpm

    水浴温度范围

    RT+5~180℃

    蒸发能力

    22ml/min

    极限真空度

    8mbar

    功能

    转速设定

    旋钮设定液晶显示

    升降方式

    手动

    自动

    电机功能

    直流无刷电机

    结构组成

    主电机

    直流无刷

    冷凝器

    蛇形冷凝管冷凝面积0.15㎡、1L旋转瓶、1L收集瓶、TS29/38瓶夹、球磨口S35/20

    真空密封圈

    PTFE+特氟龙涂层

    加热浴

    水浴锅尺寸(内)

    D230mm*H130mm

    水浴锅材质

    不锈钢耐腐蚀涂层

    加热功率

    1000W

    使用温度范围

    5~35℃

    外形尺寸

    H230mm*D150mm

    电源输入

    110V~220V  50/60HZ

  • Hydroxy-PEG2-acid

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Hydroxy-PEG2-acid 

    Hydroxy-PEG2-acid 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

    Hydroxy-PEG2-acid

    Hydroxy-PEG2-acid Chemical Structure

    CAS No. : 1334286-77-9

    规格 价格 是否有货 数量
    100 mg ¥1200 In-stock
    250 mg ¥2100 In-stock
    500 mg ¥3300 In-stock
    1 g   询价  
    5 g   询价  

    * Please select Quantity before adding items.

    生物活性

    Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    178.18

    Formula

    C7H14O5

    CAS 号

    1334286-77-9

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    参考文献
    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务