标签归档：多菌灵

Carbendazim-d4(Synonyms: 多菌灵 d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbendazim-d4 (Synonyms: 多菌灵 d4)

Carbendazim-d4 是 Carbendazim 的氘代物。Carbendazim 是一种有效的，具有口服活性的口服广谱苯并咪唑杀菌剂 (fungicide)，可作为真菌疾病研究的杀虫剂，如孢霉病、镰刀菌病和菌核病。Carbendazim 是一种具有抗肿瘤活性的苯并咪唑 (HY-Y1825) 衍生物，用于癌症研究，特别是晚期实体肿瘤和淋巴瘤。

Carbendazim-d4(Synonyms: 多菌灵 d4)

Carbendazim-d4 Chemical Structure

CAS No. : 291765-95-2

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生物活性

Carbendazim-d4 is the deuterium labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina[1][3]. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

195.21

Formula

C9H5D4N3O2
CAS 号

291765-95-2
中文名称

多菌灵 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Carbendazim

    [3]. Yuanxiang Jin, et al. Oral Exposure of Mice to Carbendazim Induces Hepatic Lipid Metabolism Disorder and Gut Microbiota Dysbiosis. Toxicol Sci. 2015 Sep;147(1):116-26

    [4]. Bilge G. Tuna, et al. Enhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled release. RSC Advances

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多菌灵-d4

发表于由

多菌灵-d4

氘标记的杀真菌剂多菌灵衍生物
Isotopic purity: 98%

有货

多菌灵-d4

CAS编号 291765-95-2 | 品牌：Jinpan
Carbendazim-d4

MSDS

质检证书(CoA)

相似产品

  • 分子式 C₉H₅D₄N₃O₂
  • 分子量195.21
  • PubChem编号 10584007

货号 (SKU) 包装规格 是否现货 价格 数量
C355386-1mg 1mg 期货 多菌灵-d4  
C355386-10mg 10mg 期货 多菌灵-d4  

基本信息

产品名称 多菌灵-d4
英文名称 Carbendazim-d4
英文别名 N-1H-(Benzimidazol-d4)-2-yl-carbamic Acid Methyl Ester
规格或纯度 Isotopic purity: 98%
运输条件 常规运输

一般描述

多菌灵-d4是一种杀菌剂和氘标记的多菌灵。

Carbendazim-d4 is a fungicide and deuterium labeled Carbendazim.

相关属性

CAS编号 291765-95-2
折光率 n20D1.71 (Predicted)
熔点 302-307° C
溶解性 Soluble in water, DMSO, acetone, chloroform, and ethanol.
储存温度 室温
密度 1.45 g/cm3(Predicted)
分子量 195.21
分子式 C₉H₅D₄N₃O₂
品牌 Jinpan
Smiles [2H]C1=C([2H])C2=C(N=C(NC(=O)OC)N2)C([2H])=C1[2H]
PubChem CID 10584007

Carbendazim(Synonyms: 多菌灵)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbendazim (Synonyms: 多菌灵) 纯度: 99.81%

Carbendazim 是一种有效的，具有口服活性的口服广谱苯并咪唑杀菌剂 (fungicide)，可作为真菌疾病研究的杀虫剂，如孢霉病、镰刀菌病和菌核病。Carbendazim 是一种具有抗肿瘤活性的苯并咪唑 (HY-Y1825) 衍生物，用于癌症研究，特别是晚期实体肿瘤和淋巴瘤。

Carbendazim(Synonyms: 多菌灵)

Carbendazim Chemical Structure

CAS No. : 10605-21-7

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
500 mg ￥700 In-stock
1 g ￥900 In-stock
5 g ￥2700 In-stock
10 g   询价  
50 g   询价  

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Carbendazim 相关产品

•相关化合物库:

  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Antifungal Compound Library
  • Anti-Blood Cancer Compound Library

生物活性

Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina[1][3]. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma[3].

体外研究
(In Vitro)

Carbendazim (4-60 µM; 24 hours) has no effects on viability of HeLa cells in a CCK-8 assay[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Carbendazim (oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days) induces hepatic lipid metabolism disorder, it results in a significant increase of hepatic lipid accumulation and triglyceride (TG) levels in mice[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male ICR mice[2]
Dosage: 100 and 500 mg/kg
Administration: Oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days
Result: Increased the relative mRNA levels of some key genes related to lipogenesis and TG synthesis.
Up-regulated mRNA levels of IL-1b and IL-6 in the liver in mice.
Increased the serum concentrations of 2 proinflammatory cytokines IL-1b and IL-6 at 500 mg/kg. However, in the fat tissues, onlyIL-1b in the CBZ-500-treated group increased significantly as compared with the control group.

Clinical Trial

分子量

191.19

Formula

C9H9N3O2
CAS 号

10605-21-7
中文名称

多菌灵
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 6.8 mg/mL (35.57 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2304 mL 26.1520 mL 52.3040 mL
5 mM 1.0461 mL 5.2304 mL 10.4608 mL
10 mM 0.5230 mL 2.6152 mL 5.2304 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (2.62 mM); Clear solution

    此方案可获得 ≥ 0.5 mg/mL (2.62 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (2.62 mM); Clear solution

    此方案可获得 ≥ 0.5 mg/mL (2.62 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Carbendazim

    [2]. Yuanxiang Jin, et al. Oral Exposure of Mice to Carbendazim Induces Hepatic Lipid Metabolism Disorder and Gut Microbiota Dysbiosis. Toxicol Sci. 2015 Sep;147(1):116-26

    [3]. Bilge G. Tuna, et al. Enhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled release. RSC Advances

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务