标签归档：抗菌肽

Cecropin A TFA(Synonyms: 抗菌肽三氟醋酸盐)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cecropin A TFA (Synonyms: 抗菌肽三氟醋酸盐) 纯度: 98.96%

Cecropin A TFA 是由 37 个氨基酸残基构成的线性抗菌肽，从 Hyalaphora cecropia pupae 得到，具有抗菌、抗炎和抗癌作用。

Cecropin A TFA(Synonyms: 抗菌肽三氟醋酸盐)

Cecropin A TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1900 In-stock
5 mg ￥4900 In-stock
10 mg ￥7400 In-stock
50 mg   询价  
100 mg   询价  

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Cecropin A TFA 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. Cecropin A TFA exhibits anti-bacterial, anti-inflammatory[1] and anti-cancer activity[2].

体外研究
(In Vitro)

Cecropin A (10, 20, 30, 40 and 50 μM) induces cytotoxicity on HL-60 cells in a dose-dependent manner. Cecropin A induces apoptosis independent of caspase activation[1].
Cecropin A shows good antibacterial activity against both multidrug-resistant Gram-negative bacteria such as A. baumanii (MDRAB) and multidrug-resistant P. aeruginosa (MDRPA) with IC50s of 0.5-1 μM.
Cecropin A (0.1, 0.25 μM) exhibits anti-inflammatory activities. Cecropin A (25 μM) effectively suppresses the expression of mTNF-α, mIL-1β, and mMIP-2 mRNA and slightly inhibits the expression of mMIP-1 mRNA. Cecropin A also effectively inhibits LPS-induced phosphorylation of ERK, JNK, p38 MAPK, and reduced the expression of COX-2[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4117.80

Formula

C186H314N53O48F3
中文名称

抗菌肽三氟醋酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : ≥ 50 mg/mL (12.14 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2428 mL 1.2142 mL 2.4285 mL
5 mM 0.0486 mL 0.2428 mL 0.4857 mL
10 mM 0.0243 mL 0.1214 mL 0.2428 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Cerón JM, et al. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides. 2010 Aug;31(8):1494-503.

    [2]. Lee E, et al. Anti-inflammatory activities of cecropin A and its mechanism of action. Arch Insect Biochem Physiol. 2015 Jan;88(1):31-44.

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Bactenecin, 牛〔白細胞〕抗菌肽,Bactenecin,

发表于由

细菌素

≥95% (HPLC)

有货

Bactenecin, 牛〔白細胞〕抗菌肽,Bactenecin,

品牌：Jinpan
Bactenecin

MSDS

质检证书(CoA)

相似产品

  • MDL号 MFCD00236810

货号 (SKU) 包装规格 是否现货 价格 数量
B118769-1mg 1mg 现货 Bactenecin, 牛〔白細胞〕抗菌肽,Bactenecin,  
B118769-5mg 5mg 现货 Bactenecin, 牛〔白細胞〕抗菌肽,Bactenecin,  

基本信息

产品名称 细菌素
英文名称 Bactenecin
别名 牛〔白細胞〕抗菌肽
规格或纯度 ≥95% (HPLC)
运输条件 超低温冰袋运输
生化机理 Bactenecin is a 12-amino acid cationic antimicrobial peptide from bovine neutrophils. It strongly binds to LPS and perturbs the structure, fluidity and permeability of the inner membrane. This results in the leakage of cytosol and subsequent death of the bacteria.

一般描述

氨基酸序列 Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg-OH (Disulfide bridge: 3-11)Bactenecin′s activity has been studied as a cyclic molecule as well as in a linear form.It was used to study the functional role of Trk1p in the mechanism of other antifungal peptides. It has been used to study chemokine and cytokine production, alteration of gene expression in host cells, and inhibition of proinflammatory responses of host cells to bacterial components.

Amino Acid Sequence Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg-OH (Disulfide bridge: 3-11)
Bactenecin is a 12-amino acid cationic antimicrobial peptide from bovine neutrophils. Bactenecin′s activity has been studied as a cyclic molecule as well as in a linear form . It is used to study the functional role of Trk1p in the mechanism of other antifungal peptides . It has been used to study chemokine and cytokine production, alteration of gene expression in host cells, and inhibition of proinflammatory responses of host cells to bacterial components

相关属性

溶解性 1 mg/mL (in 1% TFA in H20)
储存温度 -20°C储存
MDL号 MFCD00236810
品牌 Jinpan
备注 1mg卖完停产，不再备货

天蚕丝抗菌肽对照品

发表于由
天蚕丝抗菌肽对照品

  【编号】：PRPG016

  【产品名称】：天蚕丝抗菌肽对照品

  【规格】：10mg

  【用途】：

　　天蚕丝抗菌肽对照品

　　编号：PRPG016
　　英文名称：Cecropin B
　　英文别名：H-Lys-Trp-Lys-Val-Phe-Lys-lle-Glu-Lys-Met-Gly-Arg-Asn-Gly-lle-Val-Lys-Ala-Gly-Pro-Ala-lle-Ala-Val-Leu-Gly-Glu-Ala-Lys-Ala-Leu-NH2
　　Cas 号: 80451-05-4
　　分 子 式：C176H302N52O41S
　　分 子 量：3834.72
　　物理性状: White to Off-white Powder
　　化合物类型: Polypeptide
　　纯度: 95%~99%
　　分析方法: HPLC-DAD
　　包装: 棕色小玻璃瓶，标准包装10mg，20mg，50mg；可以按客户需求包装。
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。