根赤壳菌素
基本信息
| 产品名称 | 根赤壳菌素 |
|---|---|
| 英文名称 | Radicicol |
| 别名 | 根赤壳霉素 |
| 英文别名 | Monorden [1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione;Monorden |
| 应用 | A potent inhibitor of Hsp90, SRC, and Cox-2 |
| 规格或纯度 | 98% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.Heat shock protein 90 inhibitor and antifungal antibiotic. Binds to the N-terminal ATP/ADP-binding domain suppressing cell transformation induced by src, ras and mos. Induces cell cycle arrest at G 1 -S phase. Shows antiangiogenic effects in vivo . |
一般描述
Radicicol, a microbial cell differentiation modulator originally extracted from Neocosmospora tenuicristata, has been shown to inhibit proliferation and plasminogen activator production by vascular endothelial cells. Radicicol inhibits the expression of Cox-2 (IC50 = 27 nM) without affecting Cox-1 expression in LPS-stimulated macrophages. It is also a potent inhibitor of Hsp90. Experiments sμggest that radicicol reduces the intracellular level of autophosphorylation of p60v-src as well as other tyrosine-phosphorylated proteins via inhibition of SRC kinases. In addition, radicicol has demonstrated the ability to inhibit K-ras signaling pathway which includes phosphorylation of Raf-1, MAPKK, and MAPK.A potent inhibitor of Hsp90, SRC, and Cox-2
Radicicol, a microbial cell differentiation modulator originally extracted from Neocosmospora tenuicristata, has been shown to inhibit proliferation and plasminogen activator production by vascular endothelial cells. Radicicol inhibits the expression of Cox-2 (IC50 = 27 nM) without affecting Cox-1 expression in LPS-stimulated macrophages. It is also a potent inhibitor of Hsp90. Experiments suggest that radicicol reduces the intracellular level of autophosphorylation of p60v-src as well as other tyrosine-phosphorylated proteins via inhibition of SRC kinases. In addition, radicicol has demonstrated the ability to inhibit K-ras signaling pathway which includes phosphorylation of Raf-1, MAPKK, and MAPK.
A potent inhibitor of Hsp90, SRC, and Cox-2
相关属性
| CAS编号 | 12772-57-5 |
|---|---|
| 敏感性 | 对热、光和空气敏感 |
| 溶解性 | Soluble in DMSO and ethanol (10mg/mL) |
| 储存温度 | -20°C储存,充氩 |
| MDL号 | MFCD06795865 |
| 密度 | 1.364 |
| 分子量 | 364.78 |
| 分子式 | C18H17ClO6 |
| 品牌 | Jinpan |
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| PubChem CID | 6323491 |