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NSC745885 纯度: ≥98.0%
NSC745885 是一种有效的抗肿瘤 (anti-tumor) 试剂，对多种癌细胞株有选择性毒性，但对正常细胞没有毒性。NSC745885 是一种有效的 EZH2 的下调因子通过蛋白酶体降解途径。NSC745885 为晚期膀胱癌和口腔鳞癌的研究提供了可能性。
NSC745885 Chemical Structure
CAS No. : 4219-52-7
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| Free Sample (0.1-0.5 mg) | Apply now | ||
| 5 mg | ￥2500 | In-stock | |
| 10 mg | ￥4500 | In-stock | |
| 50 mg | ￥13000 | In-stock | |
| 100 mg | ￥18000 | In-stock | |
| 200 mg | 询价 | ||
| 500 mg | 询价 |
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NSC745885 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
| 生物活性 |
NSC745885 an effective anti-tumor agent, shows selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 provides possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers[1][2]. |
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| IC50 & Target[2] |
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| 体外研究 (In Vitro) |
NSC745885 (0.5-4 μM; 24, 48 or 72 hours) has a growth inhibitory or death-promoting effect on the SAS cells, it significantly decreases the densities of cultured cells when compared with untreated cells. The IC50 of NSC745885 is 0.85 μM after 72 hours’ treatment[1].NSC745885 (0.5-4 μM; 24 hours) increases annexin V positive cells in a dose-dependent manner, and the differences appears as a dose-dependent manner[1].NSC745885 (0.5-2 μM; 24 or 48 hours) decreases XIAP protein levels and increases protein levels both as a dose-dependent manner in SAS cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
Apoptosis Analysis[1]
Western Blot Analysis[1]
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| 体内研究 (In Vivo) |
NSC745885 (intraperitoneal injection; 2 mg/kg; once daily; 10 days) treatment significantly reduces tumor size when compared with the vehicle control, and exhibits a higher safety than doxorubicin[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
266.27 |
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| Formula |
C14H6N2O2S |
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| CAS 号 |
4219-52-7 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
DMSO : < 1 mg/mL (insoluble or slightly soluble) *NSC745885 is usually formulated as a suspension. |
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| 参考文献 |
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