制霉菌素水溶性
基本信息
| 产品名称 | 制霉菌素水溶性 |
|---|---|
| 英文名称 | Nystatin water soluble |
| 规格或纯度 | 适用于细胞培养 |
| 运输条件 | 超低温冰袋运输 |
一般描述
Description
Nystatin water soluble is a Nystatin derivate with fungistatic and fungicidal activity in resemblance to Nystatin. However, as opposed to the poor solubility of Nystatin the water soluble derivate can be dissolved in concentration of up to 100mg/ml. Nystatin binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active againstCandidaspecies. However, it is also reported to be effective againstAspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin toSaccharomyces cerevisiaewas reported to be 3μg/ml while for clinical isolates ofCandida albicansthe MIC was reported to be 4-16μg/ml.Nystatin is a polyene, broad-spectrum antibiotic. It can modify the microstructure of lipid rafts and sequestrate cholesterol present on the cell membrane of eukaryotes. Thus, nystatin can modulate immune responses. This is carried out through cytokine signaling, activation of lymphocytes and pathogen recognition.
Description
Nystatin water soluble is a Nystatin derivate with fungistatic and fungicidal activity in resemblance to Nystatin. However, as opposed to the poor solubility of Nystatin the water soluble derivate can be dissolved in concentration of up to 100mg/ml. Nystatin binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active againstCandidaspecies. However, it is also reported to be effective againstAspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin toSaccharomyces cerevisiaewas reported to be 3μg/ml while for clinical isolates ofCandida albicansthe MIC was reported to be 4-16μg/ml.Nystatin is a polyene, broad-spectrum antibiotic. It can modify the microstructure of lipid rafts and sequestrate cholesterol present on the cell membrane of eukaryotes. Thus, nystatin can modulate immune responses. This is carried out through cytokine signaling, activation of lymphocytes and pathogen recognition.
相关属性
| 溶解性 | 100毫克/毫升 |
|---|---|
| 储存温度 | -20°C储存 |
| 品牌 | Jinpan |