Vancomycin 盐酸盐
基本信息
| 产品名称 |
Vancomycin 盐酸盐 |
| 英文名称 |
Vancomycin hydrochloride |
| 规格或纯度 |
现成溶液，100 mg/mL in DMSO |
| 生化机理 |
Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP- N -acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme. It is a frequently used antibiotic for the treatment of peritonitis caused by gram-positive bacteria in patients with continuous ambulatory peritoneal dialysis. In patients with cirrhosis, it is used to control portal systemic encephalopathy. Mice with Clostridium difficile infection (CDI) had better clinical outcome when treated with vancomycin as opposed to the outcome on treatment with metronidazole. |
一般描述
General Description
Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis . It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus ). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.
Application
Vancomycin hydrochloride may be used- for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions for the estimation of biomass in a culture of various strains of bacteria as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
General Description
Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis . It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus ). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.
Application
Vancomycin hydrochloride may be used- for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions for the estimation of biomass in a culture of various strains of bacteria as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
相关属性
| CAS编号 |
1404-93-9 |
| 储存温度 |
干燥 |
| RTECS |
YW4380000 |
| 分子量 |
1485.71 |
| 分子式 |
C66H76Cl3N9O24 |
| 品牌 |
Jinpan |
| PubChem CID |
6420023 |
