来自聚合链霉菌的离子霉素

应用

离子霉素是一种由链霉菌产生的离子载体。 研究表明，它可诱导中央脱髓鞘，抑制肾上腺牛 TREK-1 通道，并调节成熟的人 B 细胞的细胞分裂。它用于研究钙通量对内质网（ER）应激、线粒体应激和内在凋亡机制的影响。 它也通常与 PMA 一起用于刺激细胞因子、干扰素、穿孔素、IL-2 和 IL-4 的细胞内产生。

Description

Ionomycin is an ionophore produced by the bacteriumStreptomyces conglobatus. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.