Leachianone A

发表于2024年3月14日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Leachianone A

Leachianone A 从槐花中分离，具有抗疟疾，抗炎和细胞毒性作用。 Leachianone A 诱导细胞凋亡 (apoptosis)。

Leachianone A Chemical Structure

CAS No. : 97938-31-3

规格	价格	是否有货
1 mg	￥1600	询问价格 & 货期
5 mg	￥3500	询问价格 & 货期
10 mg	￥6000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Leachianone A, isolated from Radix Sophorae, has anti-malarial, anti-inflammatory, and cytotoxic potent^[1]. Leachianone A induces apoptosis involved both extrinsic and intrinsic pathways^[2].

体外研究
(In Vitro)

Leachianone A (0-20 μg/ml; 24-72 hours) exhibits a marked inhibition on the survival of HepG2 cells time- and dose-dependently manner, IC₅₀ values are 6.9 μg/ml, 3.4 μg/ml and 2.8 μg/ml in cells with 24-, 48- and 72-hours treatment, respectively^[1].
Leachianone A (10-30 μg/ml; 48 hours) indicates that at low concentration of LA (10 μg/ml), a substantial amount of cells is primarily in the early phase of apoptosis, at higher concentrations, induces a shift of the cell population to late apoptotic/ necrotic stage^[1].
Leachianone A (10-30 μg/ml; 48 hours) decreases the precursor of caspase-3 in a dose-dependent manner, reduces the protein level of the pro-forms of upstream initiator caspases, caspases-8 and -9, decreases two downstream substrates, namely inhibitor of caspase-activated DNase(ICAD) and poly-ADP-ribose polymerase (PARP) in HepG2 cells^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HepG2 cells
Concentration:	0 μg/ml, 2 μg/ml, 4 μg/ml, 6 μg/ml, 8 μg/ml, 10 μg/ml, 12 μg/ml, 14 μg/ml, 16 μg/ml, 18 μg/ml, 20 μg/ml
Incubation Time:	24-72 hours
Result:	Inhibited HepG2 cells survival.

Apoptosis Analysis^[1]

Cell Line:	HepG2 cells
Concentration:	48 hours
Incubation Time:	10, 20, and 30 μg/ml
Result:	Induced the proportion of annexin V-stained cells in both the early and late apoptotic stage.

Western Blot Analysis^[1]

Cell Line:	HepG2 cells
Concentration:	48 hours
Incubation Time:	10, 20, and 30 μg/ml
Result:	Decreased the protein expression of caspase-3, caspases-8 and -9, reduced ICAD and PARP protein expression.

体内研究
(In Vivo)

Leachianone A (intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days) significantly diminishes the tumor volume by 17-54% in LA-treated nude mice, when compared with those solely given the vehicle^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male nude mice with human hepatoma HepG2 cells^[1]
Dosage:	20 mg/kg; 30 mg/kg
Administration:	Intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days
Result:	Suppressed the tumor growth in vivo.

分子量

438.51

Formula

C₂₆H₃₀O₆

CAS 号

97938-31-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Jeong GS, et al. Lavandulyl flavanones from Sophora flavescens protect mouse hippocampal cells against glutamate-induced neurotoxicity via the induction of heme oxygenase-1. Biol Pharm Bull. 2008 Oct;31(10):1964-7.

[2]. Cheung CS, et al. Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells. Cancer Lett. 2007 Aug 18;253(2):224-35. Epub 2007 Mar 26.

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Uvarigrin(Synonyms: 大花紫玉盘素)

发表于2024年3月13日由上海金畔生物科技有限公司

Uvarigrin (Synonyms: 大花紫玉盘素)

Uvarigrin 可从Uvaria calamistrata 根部分离得到，可诱导肿瘤多药耐药细胞凋亡和 Caspase-9 的激活。

Uvarigrin Chemical Structure

CAS No. : 200563-11-7

规格	价格	是否有货
500 μg	￥3950	询问价格 & 货期
1 mg	￥6720	询问价格 & 货期
2 mg	￥11430	询问价格 & 货期

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生物活性	Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation^[1]^[2].
分子量	608.93
Formula	C₃₇H₆₈O₆
CAS 号	200563-11-7
中文名称	大花紫玉盘素
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhou GX, et al. Calamistrins A and B, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Uvaria calamistrata. J Nat Prod. 1999 Feb;62(2):261-4. [2]. Li YF, et al. Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism. Yao Xue Xue Bao. 2006 Mar;41(3):252-6.

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Isocucurbitacin B

发表于2024年3月9日由上海金畔生物科技有限公司

Isocucurbitacin B

Isocucurbitacin B 是从Helicteres rswa L. (Sterculiaceae) 分离得到的一种毒性化合物。具有抗肿瘤活性。

Isocucurbitacin B Chemical Structure

CAS No. : 17278-28-3

规格	价格	是否有货
5 mg	￥4030	询问价格 & 货期
10 mg	￥6860	询问价格 & 货期

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生物活性	Isocucurbitacin B is a potent cytotoxic compound isolated from Helicteres rswa L. (Sterculiaceae). Isocucurbitacin B possesses anti-tumor acticity^[1]^[2].
分子量	558.70
Formula	C₃₂H₄₆O₈
CAS 号	17278-28-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. MF Bean, et al. Cucurbitacin B and isocucurbitacin B: cytotoxic components of Helicteres isora. Journal of Natural Products. 1985. [2]. SM Kupchan, et al. Tumor Inhibitors. XXIII.1 The Cytotoxic Principles of Marah oreganus.H. Cytotoxic principles of Marah oreganus H. 1976.

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Primin

发表于2024年3月9日由上海金畔生物科技有限公司

Primin

Primin 是存在 Primula obconica 的叶和茎毛状体中的天然产物，具有抗菌和抗癌特性。

Primin Chemical Structure

CAS No. : 15121-94-5

规格	价格	是否有货
1 mg	￥1300	询问价格 & 货期
5 mg	￥3200	询问价格 & 货期

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生物活性	Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimicrobial and antitumour properties^[1]^[2].
分子量	208.25
Formula	C₁₂H₁₆O₃
CAS 号	15121-94-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Horper, W., et al. Biosynthesis of primin and miconidin and its derivatives. Phytochemistry, 1996;41(2), 451–456. [2]. Brondani DJ, et al. Synthesis and antitumour activity of the Primin (2-methoxy-6-n-pentyl-1,4-benzoquinone) and analogues. Med Chem. 2007 Jul;3(4):369-72.

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Nortanshinone

发表于2024年3月9日由上海金畔生物科技有限公司

Nortanshinone

Nortanshinone 是一种从丹参中提取的色素。

Nortanshinone Chemical Structure

CAS No. : 97399-70-7

规格	价格	是否有货
1 mg	￥2290	询问价格 & 货期
5 mg	￥6860	询问价格 & 货期

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生物活性	Nortanshinone is a pigment isolated from Dan-Shen^[1].
分子量	280.27
Formula	C₁₇H₁₂O₄
CAS 号	97399-70-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Hou-WeiLuo, et al.Pigments from Salvia miltiorrhiza. Phytochemistry.Volume 24, Issue 4, 1985, Pages 815-817.

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Styraxlignolide F

发表于2024年3月9日由上海金畔生物科技有限公司

Styraxlignolide F

Styraxlignolide F 是从Styrax japonica 分离得到的一种天然产物。

Styraxlignolide F Chemical Structure

CAS No. : 823214-06-8

规格	价格	是否有货
1 mg	￥1900	询问价格 & 货期
5 mg	￥5710	询问价格 & 货期

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生物活性	Styraxlignolide F is a natural compoundisolated from Styrax japonica.
分子量	534.55
Formula	C₂₇H₃₄O₁₁
CAS 号	823214-06-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Min BS, et al. New furofuran and butyrolactone lignans with antioxidant activity from the stem bark of Styrax japonica. J Nat Prod. 2004 Dec;67(12):1980-4.

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KIF18A-IN-1

发表于2024年3月4日由上海金畔生物科技有限公司

KIF18A-IN-1

KIF18A-IN-1 是一种有丝分裂驱动蛋白 KIF18A 的抑制剂，具有抗肿瘤活性。详细信息请参考专利文献 WO2021026098A1 中的化合物 100-13。

KIF18A-IN-1 Chemical Structure

CAS No. : 2600559-12-2

规格	价格	是否有货
5 mg	￥3900	询问价格 & 货期
10 mg	￥6250	询问价格 & 货期
25 mg	￥12500	询问价格 & 货期

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生物活性	KIF18A-IN-1 is a mitotic kinesin KIF18A inhibitor extracted from patent WO2021026098A1 example 100-13. KIF18A-IN-1 exhibits anti-tumor activity^[1].
IC₅₀ & Target	mitotic kinesin KIF18A^[1]
分子量	576.77
Formula	C₂₈H₄₀N₄O₅S₂
CAS 号	2600559-12-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Tamayo NA, et, al. Kif18a inhibitors. WO2021026098A1.

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Deltasonamide 2

发表于2024年2月26日由上海金畔生物科技有限公司

Deltasonamide 2

Deltasonamide 2 是一种竞争性的，高亲和力的 PDEδ 抑制剂，K_d 值约为 385 pM。

Deltasonamide 2 Chemical Structure

CAS No. : 2088485-34-9

规格	价格	是否有货
5 mg	￥3500	询问价格 & 货期
10 mg	￥5500	询问价格 & 货期
50 mg	￥16500	询问价格 & 货期

* Please select Quantity before adding items.

Deltasonamide 2 的其他形式现货产品:

Deltasonamide 2 (TFA) Deltasonamide 2 hydrochloride

生物活性	Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a K_d of ~385 pM^[1].
IC₅₀ & Target	Kd: ~385 pM (PDEδ)^[1]
分子量	647.25
Formula	C₃₀H₃₉ClN₆O₄S₂
CAS 号	2088485-34-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Klein CH, et al. PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell linesharboring oncogenic KRas. Int J Cancer. 2019 Feb 15;144(4):767-776.

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D-Erythro-dihydrosphingosine

发表于2024年2月19日由上海金畔生物科技有限公司

D-Erythro-dihydrosphingosine

D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A₂α (cPLA₂α) 活性。

D-Erythro-dihydrosphingosine Chemical Structure

CAS No. : 764-22-7

规格	价格	是否有货
5 mg	￥1400	询问价格 & 货期
10 mg	￥2400	询问价格 & 货期
25 mg	￥4600	询问价格 & 货期
50 mg	￥7700	询问价格 & 货期

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D-Erythro-dihydrosphingosine 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Natural Product Library
Anti-Cancer Compound Library
Human Endogenous Metabolite Compound Library
Lipid Compound Library
Lipid Metabolism Compound Library
Food-Sourced Compound Library

生物活性

D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na₃VO₄-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [³H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA₂α activity^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

301.51

Formula

C₁₈H₃₉NO₂

CAS 号

764-22-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 10 mg/mL (33.17 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3166 mL	16.5832 mL	33.1664 mL
5 mM	0.6633 mL	3.3166 mL	6.6333 mL
10 mM	0.3317 mL	1.6583 mL	3.3166 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

此方案可获得 ≥ 1 mg/mL (3.32 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

此方案可获得 ≥ 1 mg/mL (3.32 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

此方案可获得 ≥ 1 mg/mL (3.32 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17.

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CDK8-IN-1

发表于2024年2月11日由上海金畔生物科技有限公司

CDK8-IN-1

CDK8-IN-1 是一个有效的、CDK8 的选择性抑制剂，其 IC₅₀ 值为 3 nM。

CDK8-IN-1 Chemical Structure

CAS No. : 1629633-48-2

规格	价格	是否有货
5 mg	￥3500	询问价格 & 货期
10 mg	￥5500	询问价格 & 货期
25 mg	￥9900	询问价格 & 货期
50 mg	￥16500	询问价格 & 货期
100 mg	￥22500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC₅₀ of 3 nM.

IC₅₀ & Target^[1]

CDK8

3 nM (IC₅₀)

体内研究
(In Vivo)

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The t_max is 0.25 h by PO. The mean values of C_max are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

255.20

Formula

C₁₁H₈F₃N₃O

CAS 号

1629633-48-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

Animal Administration ^[1]	Mice^[1] CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

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Vinflunine Tartrate

发表于2024年2月11日由上海金畔生物科技有限公司

Vinflunine Tartrate

Vinflunine Tartrate 是种独特的长春花生物碱，能干扰微管蛋白和有丝分裂。

Vinflunine Tartrate Chemical Structure

CAS No. : 1201898-17-0

规格	价格	是否有货
1 mg	￥900	询问价格 & 货期
5 mg	￥2600	询问价格 & 货期
10 mg	￥4300	询问价格 & 货期
25 mg	￥8500	询问价格 & 货期
50 mg	￥14000	询问价格 & 货期
100 mg	￥23000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Vinflunine Tartrat is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity^[1].

分子量

967.02

Formula

C₄₉H₆₀F₂N₄O₁₄

CAS 号

1201898-17-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : ≥ 45 mg/mL (46.53 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0341 mL	5.1705 mL	10.3410 mL
5 mM	0.2068 mL	1.0341 mL	2.0682 mL
10 mM	0.1034 mL	0.5171 mL	1.0341 mL

参考文献

[1]. Ngan, V.K., et al., Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res, 2000. 60(18): p. 5045-51.

[2]. Lobert, S., et al., Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line. Biochemistry, 2000. 39(39): p. 12053-62.

[3]. Kruczynski, A., et al., Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer, 2006. 42(16): p. 2821-32.

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Hirsutenone

发表于2024年1月30日由上海金畔生物科技有限公司

Hirsutenone

Hirsutenone 是桤木中含有的一种活性二庚酮，具有抗炎、抗肿瘤和抗特应性皮炎等多种生物活性。Hirsutenone 减弱脂肪形成，可以直接与 PI3K 和 ERK1 以非 ATP 竞争的方式结合。Hirsutenone 可用于肥胖的研究。

Hirsutenone Chemical Structure

CAS No. : 41137-87-5

规格	价格	是否有货
1 mg	￥3300	询问价格 & 货期
5 mg	￥13000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity^[1].
体外研究 (In Vitro)	Hirsutenone (0-100 μM; 48 hours) inhibits adipogenesis in 3T3-L1 preadipocytes and exhibits non-toxicity at 20-100 μM^[1]. Hirsutenone (0-100 μM; 48 hours) attenuates MDI-induced lipid accumulation in 3T3-L1 preadipocytes in a dose-dependent manner. In particular, HST at 40 and 80 μM significantly reduces MDI-induced adipogenesis in 3T3-L1 preadipocytes^[1]. Hirsutenone (0-100 μM; 48 hours) reduces the protein expression levels of PPARg, C/EBPa, and FAS in a dose-dependent manner in 3T3-L1 preadipocytes^[1]. Hirsutenone (80 μM; 20-24 hours) suppresses the cell cycle entry to S and G2/M phases occurrs at 20 hours when compares with at 20 hours. At 24 h, more cells are arrested in G1 phase (53% of total cells) when compares with the MDI-induced group which contains the majority of cells (56% of total cells) in G2/M phase^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	328.36
Formula	C₁₉H₂₀O₅
CAS 号	41137-87-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Lai Yee Cheong, et al. Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes.J Cell Biochem

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Hirsutenone

发表于2024年1月29日由上海金畔生物科技有限公司

Hirsutenone

Hirsutenone Chemical Structure

CAS No. : 41137-87-5

规格	价格	是否有货
1 mg	￥3300	询问价格 & 货期
5 mg	￥13000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity^[1].
体外研究 (In Vitro)	Hirsutenone (0-100 μM; 48 hours) inhibits adipogenesis in 3T3-L1 preadipocytes and exhibits non-toxicity at 20-100 μM^[1]. Hirsutenone (0-100 μM; 48 hours) attenuates MDI-induced lipid accumulation in 3T3-L1 preadipocytes in a dose-dependent manner. In particular, HST at 40 and 80 μM significantly reduces MDI-induced adipogenesis in 3T3-L1 preadipocytes^[1]. Hirsutenone (0-100 μM; 48 hours) reduces the protein expression levels of PPARg, C/EBPa, and FAS in a dose-dependent manner in 3T3-L1 preadipocytes^[1]. Hirsutenone (80 μM; 20-24 hours) suppresses the cell cycle entry to S and G2/M phases occurrs at 20 hours when compares with at 20 hours. At 24 h, more cells are arrested in G1 phase (53% of total cells) when compares with the MDI-induced group which contains the majority of cells (56% of total cells) in G2/M phase^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	328.36
Formula	C₁₉H₂₀O₅
CAS 号	41137-87-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Lai Yee Cheong, et al. Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes.J Cell Biochem

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Hirsutenone

发表于2024年1月29日由上海金畔生物科技有限公司

Hirsutenone

Hirsutenone Chemical Structure

CAS No. : 41137-87-5

规格	价格	是否有货
1 mg	￥3300	询问价格 & 货期
5 mg	￥13000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity^[1].
体外研究 (In Vitro)	Hirsutenone (0-100 μM; 48 hours) inhibits adipogenesis in 3T3-L1 preadipocytes and exhibits non-toxicity at 20-100 μM^[1]. Hirsutenone (0-100 μM; 48 hours) attenuates MDI-induced lipid accumulation in 3T3-L1 preadipocytes in a dose-dependent manner. In particular, HST at 40 and 80 μM significantly reduces MDI-induced adipogenesis in 3T3-L1 preadipocytes^[1]. Hirsutenone (0-100 μM; 48 hours) reduces the protein expression levels of PPARg, C/EBPa, and FAS in a dose-dependent manner in 3T3-L1 preadipocytes^[1]. Hirsutenone (80 μM; 20-24 hours) suppresses the cell cycle entry to S and G2/M phases occurrs at 20 hours when compares with at 20 hours. At 24 h, more cells are arrested in G1 phase (53% of total cells) when compares with the MDI-induced group which contains the majority of cells (56% of total cells) in G2/M phase^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	328.36
Formula	C₁₉H₂₀O₅
CAS 号	41137-87-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Lai Yee Cheong, et al. Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes.J Cell Biochem

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Pilloin

发表于2024年1月28日由上海金畔生物科技有限公司

Pilloin

Pilloinc 是可从Marrubium cylleneum 中分离得到的一种黄酮类化合物，具有抗炎和抗癌生物活性。

Pilloin Chemical Structure

CAS No. : 32174-62-2

规格	价格	是否有货
1 mg	￥2000	询问价格 & 货期
5 mg	￥5000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity^[1].
分子量	314.29
Formula	C₁₇H₁₄O₆
CAS 号	32174-62-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Fotios Michelis, et al. Effects of the Flavonoid Pilloin Isolated from Marrubium cylleneum on Mitogen-Induced Lymphocyte Transformation. Journal Pharmaceutical Biology. 2002. [2]. Yun-Chen Tsai, et al. Pilloin, A Flavonoid Isolated From Aquilaria sinensis, Exhibits Anti-Inflammatory Activity In Vitro and In Vivo. Molecules. 2018 Dec 2;23(12):3177.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lusianthridin

发表于2024年1月28日由上海金畔生物科技有限公司

Lusianthridin

Lusianthridin 是来自 Dendrobium venustum 的天然化合物，具有抗迁移作用。Lusianthridin 通过抑制Src-STAT3 信号，促进c-Myc 的降解。

Lusianthridin Chemical Structure

CAS No. : 87530-30-1

规格	价格	是否有货
5 mg	￥11500	询问价格 & 货期
10 mg	￥18500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling^[1].

体外研究
(In Vitro)

Lusianthridin (0-100 μM) inhibits cell viability at concentrations greater than 50 μM in both H460 and H292 cells^[1].
Lusianthridin significantly reduces the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentration 5, 10, and 20 μM Lusianthridin, respectively^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells^[1]. 0-100 μM.
Concentration:	0-100 μM.
Incubation Time:	24 h.
Result:	Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.

分子量

242.27

Formula

C₁₅H₁₄O₃

CAS 号

87530-30-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Narumol Bhummaphan, et al. Targeting of Lung Cancer Stem Cells via Src-STAT3 Suppression. Phytomedicine. 2019 Sep;62:152932.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pilloin

发表于2024年1月27日由上海金畔生物科技有限公司

Pilloin

Pilloinc 是可从Marrubium cylleneum 中分离得到的一种黄酮类化合物，具有抗炎和抗癌生物活性。

Pilloin Chemical Structure

CAS No. : 32174-62-2

规格	价格	是否有货
1 mg	￥2000	询问价格 & 货期
5 mg	￥5000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity^[1].
分子量	314.29
Formula	C₁₇H₁₄O₆
CAS 号	32174-62-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Fotios Michelis, et al. Effects of the Flavonoid Pilloin Isolated from Marrubium cylleneum on Mitogen-Induced Lymphocyte Transformation. Journal Pharmaceutical Biology. 2002. [2]. Yun-Chen Tsai, et al. Pilloin, A Flavonoid Isolated From Aquilaria sinensis, Exhibits Anti-Inflammatory Activity In Vitro and In Vivo. Molecules. 2018 Dec 2;23(12):3177.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pilloin

发表于2024年1月27日由上海金畔生物科技有限公司

Pilloin

Pilloinc 是可从Marrubium cylleneum 中分离得到的一种黄酮类化合物，具有抗炎和抗癌生物活性。

Pilloin Chemical Structure

CAS No. : 32174-62-2

规格	价格	是否有货
1 mg	￥2000	询问价格 & 货期
5 mg	￥5000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity^[1].
分子量	314.29
Formula	C₁₇H₁₄O₆
CAS 号	32174-62-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Fotios Michelis, et al. Effects of the Flavonoid Pilloin Isolated from Marrubium cylleneum on Mitogen-Induced Lymphocyte Transformation. Journal Pharmaceutical Biology. 2002. [2]. Yun-Chen Tsai, et al. Pilloin, A Flavonoid Isolated From Aquilaria sinensis, Exhibits Anti-Inflammatory Activity In Vitro and In Vivo. Molecules. 2018 Dec 2;23(12):3177.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lusianthridin

发表于2024年1月27日由上海金畔生物科技有限公司

Lusianthridin

Lusianthridin 是来自 Dendrobium venustum 的天然化合物，具有抗迁移作用。Lusianthridin 通过抑制Src-STAT3 信号，促进c-Myc 的降解。

Lusianthridin Chemical Structure

CAS No. : 87530-30-1

规格	价格	是否有货
5 mg	￥11500	询问价格 & 货期
10 mg	￥18500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling^[1].

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells^[1]. 0-100 μM.
Concentration:	0-100 μM.
Incubation Time:	24 h.
Result:	Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.

分子量

242.27

Formula

C₁₅H₁₄O₃

CAS 号

87530-30-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Narumol Bhummaphan, et al. Targeting of Lung Cancer Stem Cells via Src-STAT3 Suppression. Phytomedicine. 2019 Sep;62:152932.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lusianthridin

发表于2024年1月27日由上海金畔生物科技有限公司

Lusianthridin

Lusianthridin 是来自 Dendrobium venustum 的天然化合物，具有抗迁移作用。Lusianthridin 通过抑制Src-STAT3 信号，促进c-Myc 的降解。

Lusianthridin Chemical Structure

CAS No. : 87530-30-1

规格	价格	是否有货
5 mg	￥11500	询问价格 & 货期
10 mg	￥18500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling^[1].

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells^[1]. 0-100 μM.
Concentration:	0-100 μM.
Incubation Time:	24 h.
Result:	Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.

分子量

242.27

Formula

C₁₅H₁₄O₃

CAS 号

87530-30-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Narumol Bhummaphan, et al. Targeting of Lung Cancer Stem Cells via Src-STAT3 Suppression. Phytomedicine. 2019 Sep;62:152932.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

whatman (沃特曼)

英国沃特曼 Millipore PALL中国代理商金畔官网

标签归档：货期

Leachianone A

Uvarigrin(Synonyms: 大花紫玉盘素)

Isocucurbitacin B

Primin

Nortanshinone

Styraxlignolide F

KIF18A-IN-1

Deltasonamide 2

D-Erythro-dihydrosphingosine

D-Erythro-dihydrosphingosine 相关产品

•相关化合物库:

CDK8-IN-1

Vinflunine Tartrate

Hirsutenone

Hirsutenone

Hirsutenone

Pilloin

Lusianthridin

Pilloin

Pilloin

Lusianthridin

Lusianthridin