长川霉素
基本信息
| 产品名称 | 长川霉素 |
|---|---|
| 英文名称 | Ascomycin |
| 别名 | 长川霉素；子囊霉素 |
| 英文别名 | Immunomycin;FK 520;FR 900520;FR-900520;FR900520;FK-520;FK520 |
| 规格或纯度 | ≥97.0% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | When we used either CD4+CD8+ thymocytes or peripheral T cells activated by phorbol ester and ionomycin, the cell surface induction of CD5 was also partially blocked by CsA, FK-520 and rapamycin . Ascomycinalso had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition.Calcineurin/PP2B inhibitor (IC 50 = 49 nM). Forms a FK-506 binding protein 12 (FKBP12) – Ascomycin -Calcineurin complex. Immunosuppressant and antifungal activity in vitro and in vivo . |
一般描述
Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物，具有很强的免疫抑制剂。A potent immunosuppressive agent
Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
A potent immunosuppressive agent
application：
Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.
相关属性
| CAS编号 | 104987-12-4 |
|---|---|
| 沸点 | 868℃ |
| 溶解性 | Soluble in DMSO (65 mg/ml), ethanol (50 mg/ml), and water (10-50 μM). |
| 储存温度 | -20°C储存 |
| RTECS | KD4185000 |
| 分子量 | 792.01 |
| 分子式 | C43H69NO12 |
| EC号 | 200-835-2 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 关联CAS | 11011-38-4 |
| PubChem CID | 5282071 |