上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Sabizabulin (Synonyms: VERU-111; ABI-231) 纯度: 98.02%
VERU-111 (ABI-231) 是一种高效、口服可利用 α/β 微管蛋白 (tubulin) 抑制剂，具有很强的抗增殖活性，对黑素瘤和前列腺癌细胞系作用的平均 IC50 值为 5.2 nM。VERU-111 (ABI-231) 通过靶向 HPV E6 和 E7 抑制肿瘤生长和转移表型，有潜力用于前列腺癌的研究。
Sabizabulin Chemical Structure
CAS No. : 1332881-26-1
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 5 mg | ￥3800 | In-stock | |
| 10 mg | ￥6000 | In-stock | |
| 25 mg | ￥11500 | In-stock | |
| 50 mg | ￥18000 | In-stock | |
| 100 mg | ￥28500 | In-stock | |
| 200 mg | 询价 | ||
| 500 mg | 询价 |
* Please select Quantity before adding items.
Sabizabulin 相关产品
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| 生物活性 |
VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC50 of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer[1][2][3]. |
IC50 & Target |
tubulin[1] |
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| 体外研究 (In Vitro) |
VERU-111 (2.5-80 nM; 24-48 hours) inhibits Panc-1, AsPC-1 and HPAF-II cells growth in a dose and time-dependent manner (24 hours: IC50s of 25, 35 and 35 nM, respectively; 48 hours: IC50s of 11.8, 15.5, and 25 nM, respectively)[4]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[4]
Apoptosis Analysis[4]
Western Blot Analysis[4]
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| 体内研究 (In Vivo) |
VERU-111 (50 μg/mouse; intra-tumorally; 3 times per week for 3 weeks) effectively inhibits tumor growth as compared to vehicle-treated group. None of the mouse showed any apparent toxicity as constant increase of body weight in VERU-111 treated mice[4]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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| Clinical Trial |
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| 分子量 |
377.39 |
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| Formula |
C21H19N3O4 |
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| CAS 号 |
1332881-26-1 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| 溶解性数据 |
In Vitro:
DMSO : 20 mg/mL (53.00 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂： ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
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| 参考文献 |
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