标签归档：acid

cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

cis-Vaccenic acid (Synonyms: 顺-十八碳烯酸) 纯度: ≥98.0%

cis-Vaccenic acid 是来自 Rhodopseudomonas capsulate 的抗病毒提取物，是 Rhodopseudomonas capsulate 的主要活性成分，cis-Vaccenic acid 可用作潜在的胎儿血红蛋白诱导剂。

cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

cis-Vaccenic acid Chemical Structure

CAS No. : 506-17-2

规格 价格 是否有货 数量
25mg（1.77 M * 0.05 mL in Ethanol） ￥700 In-stock
50mg（1.77 M * 0.1 mL in Ethanol） ￥1100 In-stock
100mg（1.77 M * 0.2 mL in Ethanol） ￥1800 In-stock

* Please select Quantity before adding items.

生物活性

cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].

体外研究
(In Vitro)

cis-Vaccenic acid (CVA) (50 μM, 70 μM and 100 μM) induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells[2]. cis-Vaccenic acid (50 μM) also increased the percentage of benzidine positive JK-1 cell[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[2]

Cell Line: K562 cells
Concentration: 50 μM, 70 μM and 100 μM
Incubation Time: 48 and 120 hours
Result: Induced differentiation appeared to be concentration dependent in K562 cells with 50 μM CVA being the most effective concentration with more than 20% of the K562 cells showing positive for Benzidine stain after 48 h of incubation with CVA.

分子量

282.46

Formula

C18H34O2
CAS 号

506-17-2
中文名称

顺-十八碳烯酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
参考文献

  • [1]. H Hirotani, et al. Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols. FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7.

    [2]. Idowu A Aimola, et al. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016 Apr 5;776:9-18.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

cis-Vaccenic acid (Synonyms: 顺-十八碳烯酸) 纯度: ≥98.0%

cis-Vaccenic acid 是来自 Rhodopseudomonas capsulate 的抗病毒提取物，是 Rhodopseudomonas capsulate 的主要活性成分，cis-Vaccenic acid 可用作潜在的胎儿血红蛋白诱导剂。

cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

cis-Vaccenic acid Chemical Structure

CAS No. : 506-17-2

规格 价格 是否有货 数量
25mg（1.77 M * 0.05 mL in Ethanol） ￥700 In-stock
50mg（1.77 M * 0.1 mL in Ethanol） ￥1100 In-stock
100mg（1.77 M * 0.2 mL in Ethanol） ￥1800 In-stock

* Please select Quantity before adding items.

生物活性

cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].

体外研究
(In Vitro)

cis-Vaccenic acid (CVA) (50 μM, 70 μM and 100 μM) induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells[2]. cis-Vaccenic acid (50 μM) also increased the percentage of benzidine positive JK-1 cell[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[2]

Cell Line: K562 cells
Concentration: 50 μM, 70 μM and 100 μM
Incubation Time: 48 and 120 hours
Result: Induced differentiation appeared to be concentration dependent in K562 cells with 50 μM CVA being the most effective concentration with more than 20% of the K562 cells showing positive for Benzidine stain after 48 h of incubation with CVA.

分子量

282.46

Formula

C18H34O2
CAS 号

506-17-2
中文名称

顺-十八碳烯酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
参考文献

  • [1]. H Hirotani, et al. Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols. FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7.

    [2]. Idowu A Aimola, et al. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016 Apr 5;776:9-18.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

cis-Vaccenic acid (Synonyms: 顺-十八碳烯酸) 纯度: ≥98.0%

cis-Vaccenic acid 是来自 Rhodopseudomonas capsulate 的抗病毒提取物，是 Rhodopseudomonas capsulate 的主要活性成分，cis-Vaccenic acid 可用作潜在的胎儿血红蛋白诱导剂。

cis-Vaccenic acid(Synonyms: 顺-十八碳烯酸)

cis-Vaccenic acid Chemical Structure

CAS No. : 506-17-2

规格 价格 是否有货 数量
25mg（1.77 M * 0.05 mL in Ethanol） ￥700 In-stock
50mg（1.77 M * 0.1 mL in Ethanol） ￥1100 In-stock
100mg（1.77 M * 0.2 mL in Ethanol） ￥1800 In-stock

* Please select Quantity before adding items.

生物活性

cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].

体外研究
(In Vitro)

cis-Vaccenic acid (CVA) (50 μM, 70 μM and 100 μM) induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells[2]. cis-Vaccenic acid (50 μM) also increased the percentage of benzidine positive JK-1 cell[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[2]

Cell Line: K562 cells
Concentration: 50 μM, 70 μM and 100 μM
Incubation Time: 48 and 120 hours
Result: Induced differentiation appeared to be concentration dependent in K562 cells with 50 μM CVA being the most effective concentration with more than 20% of the K562 cells showing positive for Benzidine stain after 48 h of incubation with CVA.

分子量

282.46

Formula

C18H34O2
CAS 号

506-17-2
中文名称

顺-十八碳烯酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
参考文献

  • [1]. H Hirotani, et al. Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols. FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7.

    [2]. Idowu A Aimola, et al. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016 Apr 5;776:9-18.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Heptelidic acid(Synonyms: 萜烯七脂酸; Koningic acid)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Heptelidic acid (Synonyms: 萜烯七脂酸; Koningic acid)

Heptelidic acid (Koningic acid) 是一种倍半萜类抗生素 (antibiotic)。Heptelidic acid 通过下调 caspase 从而抑制 Etoposide 诱导的细胞凋亡。Koningic acid (KA) 是一种特异性 GAPDH 抑制剂，IC50 为 90 μM。

Heptelidic acid(Synonyms: 萜烯七脂酸; Koningic acid)

Heptelidic acid Chemical Structure

CAS No. : 57710-57-3

规格 是否有货
1 mg 询价

* Please select Quantity before adding items.

生物活性

Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3].

IC50 & Target[2]

Caspase-3

 

体外研究
(In Vitro)

Heptelidic acid is a sesquiterpene antibiotic, found in the culture filtrate of three different strains of fungi isolated from soil samples. Heptelidic acid produces organisms, fermentation, isolation and characterization[1].
Heptelidic acid inhibits Etoposide-induced apoptosis in human leukemia U937 cells[2].Heptelidic acid inhibits caspase- 3 induction in U937 cells with an IC50 value of 40 μM after 8 h of Etoposide treatment[2].
Heptelidic acid (Koningic acid; KA), a natural product obtained from the Trichoderma fungus, can directly bind to the active site of human GAPDH. The expression of T. koningii KAr-GAPDH successfully rescued cell viability in human cells treated with Heptelidic acid. HEK293T cells expressing T. koningii KAr-GAPDH exhibited complete cell viability after treatment with 0-200 μM Heptelidic acid with the IC50=5 μM[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: HEK293T cells expressing KAr-GAPDH or EV (top left)
Concentration: 0.1, 1, 10, 100, 1000 μM
Incubation Time: 24 hours
Result: IC50=5 μM.

体内研究
(In Vivo)

Heptelidic acid (Koningic acid; KA) is bioavailable and induces dynamic changes to glycolysis in vivo[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week old female Foxn1nu mice bearing BT-474 tumor[3]
Dosage: 1, 2.5, 5, and 10 mg/kg
Administration: Daily intraperitoneal (IP) injections, 24 hours
Result: 1 mg/kg was determined to be the maximum tolerated dose (MTD) based upon behavioral monitoring and adverse events at higher doses (hemolysis, hematuria, and anemia).

分子量

280.32

Formula

C15H20O5
CAS 号

57710-57-3
中文名称

萜烯七脂酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo). 1980 May;33(5):468-73.

    [2]. Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19(8):787-91.

    [3]. Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26(4):648-659.e8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Heptelidic acid(Synonyms: 萜烯七脂酸; Koningic acid)

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Heptelidic acid (Synonyms: 萜烯七脂酸; Koningic acid)

Heptelidic acid (Koningic acid) 是一种倍半萜类抗生素 (antibiotic)。Heptelidic acid 通过下调 caspase 从而抑制 Etoposide 诱导的细胞凋亡。Koningic acid (KA) 是一种特异性 GAPDH 抑制剂，IC50 为 90 μM。

Heptelidic acid(Synonyms: 萜烯七脂酸; Koningic acid)

Heptelidic acid Chemical Structure

CAS No. : 57710-57-3

规格 是否有货
1 mg 询价

* Please select Quantity before adding items.

生物活性

Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3].

IC50 & Target[2]

Caspase-3

 

体外研究
(In Vitro)

Heptelidic acid is a sesquiterpene antibiotic, found in the culture filtrate of three different strains of fungi isolated from soil samples. Heptelidic acid produces organisms, fermentation, isolation and characterization[1].
Heptelidic acid inhibits Etoposide-induced apoptosis in human leukemia U937 cells[2].Heptelidic acid inhibits caspase- 3 induction in U937 cells with an IC50 value of 40 μM after 8 h of Etoposide treatment[2].
Heptelidic acid (Koningic acid; KA), a natural product obtained from the Trichoderma fungus, can directly bind to the active site of human GAPDH. The expression of T. koningii KAr-GAPDH successfully rescued cell viability in human cells treated with Heptelidic acid. HEK293T cells expressing T. koningii KAr-GAPDH exhibited complete cell viability after treatment with 0-200 μM Heptelidic acid with the IC50=5 μM[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: HEK293T cells expressing KAr-GAPDH or EV (top left)
Concentration: 0.1, 1, 10, 100, 1000 μM
Incubation Time: 24 hours
Result: IC50=5 μM.

体内研究
(In Vivo)

Heptelidic acid (Koningic acid; KA) is bioavailable and induces dynamic changes to glycolysis in vivo[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week old female Foxn1nu mice bearing BT-474 tumor[3]
Dosage: 1, 2.5, 5, and 10 mg/kg
Administration: Daily intraperitoneal (IP) injections, 24 hours
Result: 1 mg/kg was determined to be the maximum tolerated dose (MTD) based upon behavioral monitoring and adverse events at higher doses (hemolysis, hematuria, and anemia).

分子量

280.32

Formula

C15H20O5
CAS 号

57710-57-3
中文名称

萜烯七脂酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo). 1980 May;33(5):468-73.

    [2]. Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19(8):787-91.

    [3]. Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26(4):648-659.e8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Heptelidic acid(Synonyms: 萜烯七脂酸; Koningic acid)

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Heptelidic acid (Synonyms: 萜烯七脂酸; Koningic acid)

Heptelidic acid (Koningic acid) 是一种倍半萜类抗生素 (antibiotic)。Heptelidic acid 通过下调 caspase 从而抑制 Etoposide 诱导的细胞凋亡。Koningic acid (KA) 是一种特异性 GAPDH 抑制剂，IC50 为 90 μM。

Heptelidic acid(Synonyms: 萜烯七脂酸; Koningic acid)

Heptelidic acid Chemical Structure

CAS No. : 57710-57-3

规格 是否有货
1 mg 询价

* Please select Quantity before adding items.

生物活性

Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3].

IC50 & Target[2]

Caspase-3

 

体外研究
(In Vitro)

Heptelidic acid is a sesquiterpene antibiotic, found in the culture filtrate of three different strains of fungi isolated from soil samples. Heptelidic acid produces organisms, fermentation, isolation and characterization[1].
Heptelidic acid inhibits Etoposide-induced apoptosis in human leukemia U937 cells[2].Heptelidic acid inhibits caspase- 3 induction in U937 cells with an IC50 value of 40 μM after 8 h of Etoposide treatment[2].
Heptelidic acid (Koningic acid; KA), a natural product obtained from the Trichoderma fungus, can directly bind to the active site of human GAPDH. The expression of T. koningii KAr-GAPDH successfully rescued cell viability in human cells treated with Heptelidic acid. HEK293T cells expressing T. koningii KAr-GAPDH exhibited complete cell viability after treatment with 0-200 μM Heptelidic acid with the IC50=5 μM[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: HEK293T cells expressing KAr-GAPDH or EV (top left)
Concentration: 0.1, 1, 10, 100, 1000 μM
Incubation Time: 24 hours
Result: IC50=5 μM.

体内研究
(In Vivo)

Heptelidic acid (Koningic acid; KA) is bioavailable and induces dynamic changes to glycolysis in vivo[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week old female Foxn1nu mice bearing BT-474 tumor[3]
Dosage: 1, 2.5, 5, and 10 mg/kg
Administration: Daily intraperitoneal (IP) injections, 24 hours
Result: 1 mg/kg was determined to be the maximum tolerated dose (MTD) based upon behavioral monitoring and adverse events at higher doses (hemolysis, hematuria, and anemia).

分子量

280.32

Formula

C15H20O5
CAS 号

57710-57-3
中文名称

萜烯七脂酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Y Itoh, et al. A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization. J Antibiot (Tokyo). 1980 May;33(5):468-73.

    [2]. Jin Hee Kim, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug;19(8):787-91.

    [3]. Maria V Liberti, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 3;26(4):648-659.e8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sparfosic acid

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sparfosic acid 

Sparfosic acid 是 DNA 抗代谢剂和天门冬氨酸氨甲酰转移酶 (aspartate transcarbamoyl transferase) 的有效抑制剂。Sparfosic acid 具有抗肿瘤活性。天冬氨酸氨甲酰转移酶催化第二步 de novo 嘧啶生物合成。Sparfosic acid 协同增强 5-氟尿嘧啶 (5-FU) 和干扰素-α (IFN) 对人结肠癌细胞系的细胞毒性。

Sparfosic acid

Sparfosic acid Chemical Structure

CAS No. : 51321-79-0

规格 价格 是否有货
5 mg ￥3800 询问价格 & 货期
10 mg ￥6000 询问价格 & 货期
50 mg ￥19800 询问价格 & 货期
100 mg ￥29500 询问价格 & 货期

* Please select Quantity before adding items.

Sparfosic acid 的其他形式现货产品:

Sparfosic acid trisodium

生物活性

Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3].

体外研究
(In Vitro)

Sparfosic acid (N-(Phosphonacetyl)-L-aspartate, PALA) causes apoptosis in the resistant Br1 cells[1].
Sparfosic acid (300 µM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Br-l and L-2 cell lines established from metastasis in nude mouse injected with the human tumor cell line MDA-MB-435
Concentration: 300 µM
Incubation Time: 12, 24 and 48 hours
Result: Cells were predominantly in S phase in both the cell lines, although slightly higher proportion of cells in S phase were noted in L-2 than Brl-3prl cells.

Western Blot Analysis[1]

Cell Line: Br-l and L-2 cell lines
Concentration: 300 µM
Incubation Time: 4, 10 and 24 hours
Result: There was moderate difference in the level of phosphorylated Rb proteins seen in the two cell types. Marked increase in the amount of cyclin A protein was detected in the L-2 cells undergoing apoptosis with the highest level detected at 10 h post-drug treatment. In contrast, there was no increase in the level of cyclin A seen in the Brl-3prl cells. Cyclin E protein was found elevated in the L-2 cells and Brl-3prl cells compared to their respective controls.

体内研究
(In Vivo)

Sparfosic acid (490 mg/kg; i.p.; on days 1, 5, and 9; mice bearing B16 melanoma) shows the life-span is increased survives 77 to 86% longer than controls. Lewis lung carcinoma is highly sensitive to Sparfosic acid. Treatment on days 1, 5, and 9 following s.c. implantation of Lewis lung carcinoma is curative to 50% of the mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

255.12

Formula

C6H10NO8P
CAS 号

51321-79-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

H2O : 125 mg/mL (489.97 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9197 mL 19.5986 mL 39.1972 mL
5 mM 0.7839 mL 3.9197 mL 7.8394 mL
10 mM 0.3920 mL 1.9599 mL 3.9197 mL

参考文献

  • [1]. Wang J, et al. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol. 2015 Aug;47(2):782-90.

    [2]. Angela D. Morris, et al. A New, Efficient, Two Step Procedure for the Preparation of the Antineoplastic Agent Sparfosic Acid.

    [3]. Johnson RK, et al. Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase. Cancer Res. 1976;36(8):2720-2725.

    [4]. Wadler S, et al. Phase II trial of N-(phosphonacetyl)-L-aspartate (PALA), 5-fluorouracil and recombinant interferon-alpha-2b in patients with advanced gastric carcinoma. Eur J Cancer. 1996;32A(7):1254-1256.

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Sparfosic acid

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sparfosic acid 

Sparfosic acid 是 DNA 抗代谢剂和天门冬氨酸氨甲酰转移酶 (aspartate transcarbamoyl transferase) 的有效抑制剂。Sparfosic acid 具有抗肿瘤活性。天冬氨酸氨甲酰转移酶催化第二步 de novo 嘧啶生物合成。Sparfosic acid 协同增强 5-氟尿嘧啶 (5-FU) 和干扰素-α (IFN) 对人结肠癌细胞系的细胞毒性。

Sparfosic acid

Sparfosic acid Chemical Structure

CAS No. : 51321-79-0

规格 价格 是否有货
5 mg ￥3800 询问价格 & 货期
10 mg ￥6000 询问价格 & 货期
50 mg ￥19800 询问价格 & 货期
100 mg ￥29500 询问价格 & 货期

* Please select Quantity before adding items.

Sparfosic acid 的其他形式现货产品:

Sparfosic acid trisodium

生物活性

Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3].

体外研究
(In Vitro)

Sparfosic acid (N-(Phosphonacetyl)-L-aspartate, PALA) causes apoptosis in the resistant Br1 cells[1].
Sparfosic acid (300 µM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Br-l and L-2 cell lines established from metastasis in nude mouse injected with the human tumor cell line MDA-MB-435
Concentration: 300 µM
Incubation Time: 12, 24 and 48 hours
Result: Cells were predominantly in S phase in both the cell lines, although slightly higher proportion of cells in S phase were noted in L-2 than Brl-3prl cells.

Western Blot Analysis[1]

Cell Line: Br-l and L-2 cell lines
Concentration: 300 µM
Incubation Time: 4, 10 and 24 hours
Result: There was moderate difference in the level of phosphorylated Rb proteins seen in the two cell types. Marked increase in the amount of cyclin A protein was detected in the L-2 cells undergoing apoptosis with the highest level detected at 10 h post-drug treatment. In contrast, there was no increase in the level of cyclin A seen in the Brl-3prl cells. Cyclin E protein was found elevated in the L-2 cells and Brl-3prl cells compared to their respective controls.

体内研究
(In Vivo)

Sparfosic acid (490 mg/kg; i.p.; on days 1, 5, and 9; mice bearing B16 melanoma) shows the life-span is increased survives 77 to 86% longer than controls. Lewis lung carcinoma is highly sensitive to Sparfosic acid. Treatment on days 1, 5, and 9 following s.c. implantation of Lewis lung carcinoma is curative to 50% of the mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

255.12

Formula

C6H10NO8P
CAS 号

51321-79-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

H2O : 125 mg/mL (489.97 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9197 mL 19.5986 mL 39.1972 mL
5 mM 0.7839 mL 3.9197 mL 7.8394 mL
10 mM 0.3920 mL 1.9599 mL 3.9197 mL

参考文献

  • [1]. Wang J, et al. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol. 2015 Aug;47(2):782-90.

    [2]. Angela D. Morris, et al. A New, Efficient, Two Step Procedure for the Preparation of the Antineoplastic Agent Sparfosic Acid.

    [3]. Johnson RK, et al. Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase. Cancer Res. 1976;36(8):2720-2725.

    [4]. Wadler S, et al. Phase II trial of N-(phosphonacetyl)-L-aspartate (PALA), 5-fluorouracil and recombinant interferon-alpha-2b in patients with advanced gastric carcinoma. Eur J Cancer. 1996;32A(7):1254-1256.

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Lipoic acid PEG Hydrazide Cat. No. PG2-HZLA-5k 5000 Da 25 mg修饰性聚乙二醇

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Lipoic acid PEG Hydrazide

Cat. No. PG2-HZLA-5k
Specification 5000 Da
Unit Size 25 mg
Price $385.00

Qty Add to Cart

Synonym: Hydrazide PEG Lipoic acid,  Lipoic acid-PEG-CONHNH2, LPA-PEG-CONHNH2.

Description:

Lipoic acid PEG Hydrazide (Lipoic acid-PEG-CONHNH2) is one of Nanocs carbonyl reactive PEG derivatives that have a lipoic acid group on one end of PEG and a hydrazide group (-NHNH2) on the other terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. Hydrazide group (-NHNH2), on the other hand, can react with aldehyde or ketone groups derived from polysaccarides or glycoproteins. Reaction between hydrazide and ketone group results in a stable hydrazone bond, which is more stable than the schiff base formed between amine and ketone group. 

Product Specification:

  • Form: Solid powder or semi-solid depends on PEG length
  • Color: Yellow to pale yellow
  • Reactive group: Hydrazide (-CONHNH2)
  • Reactive to: Aldehyde/ketone
  • Solubility: Soluble in water

Storage Conditions:

  • Store at -20 0C. 
Related Products
PG2-CALA-5k , Lipoic acid PEG acid, LA-PEG-COOH
PG2-LANS-5k , Lipoic acid PEG NHS, LA-PEG-NHS
PG2-BNLA-5k , Lipoic acid PEG Biotin, LA-PEG-Biotin
PG2-AZLA-5k , Lipoic acid PEG azide, LA-PEG-N3
PG2-LAML-3k , Lipoic acid PEG Maleimide, LA-PEG-Mal

Lipoic acid PEG Alkyne Cat. No. PG2-AKLA-5k 5000 Da 25 mg修饰性聚乙二醇

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Lipoic acid PEG Alkyne

Cat. No. PG2-AKLA-5k
Specification 5000 Da
Unit Size 25 mg
Price $385.00

Qty Add to Cart

Synonym: Alkyne PEG Lipoic acid,  Lipoic acid-PEG-Alkyne, LPA-PEG-Alkyne.

Description:

Lipoic acid PEG Alkyne (LPA-PEG-Alkyne) is one of Nanocs click chemistry reactive PEG derivatives that have a lipoic acid group on one end of PEG and an alkynde on the other terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. Alkyne, on the other hand, can react with azide group in aqueous solution via so called Click Chemistry.  Reaction between alkyne and azide results in a stable conjugation of Lipoic acid PEG to targeted substrates.

Product Specification:

  • Form: Solid powder or semi-solid depends on PEG length
  • Color: Yellow to pale yellow
  • Reactive group: Alkyne
  • Reactive to: Azide
  • Solubility: Soluble in water

Storage Conditions:

  • Store at -20 0C. 
Related Products
PG2-LANS-5k , Lipoic acid PEG NHS, LA-PEG-NHS

Lipoic acid PEG DBCO Cat. No. PG2-DBLA-5k 5000 Da 10 mg修饰性聚乙二醇

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Lipoic acid PEG DBCO

Cat. No. PG2-DBLA-5k
Specification 5000 Da
Unit Size 10 mg
Price $385.00

Qty Add to Cart

Synonym: DBCO PEG Lipoic acid, LPA-PEG-DBCO.

Description:

Lipoic acid PEG DBCO is one of Nanocs Click Chemistry reactive PEG derivatives that have a lipoic acid group on one end of PEG chain and a DBCO group (Dibenzocyclooctyne) on the other PEG terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. DBCO, on the other hand, is able to react with azide group via so called copper-free click chemistry reaction. Reaction between DBCO and azide allows efficient conjugation of Lipoic acid to targeted molecules quickly and easily. 

Product Specification:

  • Form: Solid powder or semi-solid depends on PEG length
  • Color: Yellow to pale yellow
  • Reactive group: DBCO
  • Reactive to: Azide/Azido
  • Solubility: Soluble in water

Storage Conditions:

  • Store at -20 0C. 
Related Products
PG2-BNLA-5k , Lipoic acid PEG Biotin, LA-PEG-Biotin
PG2-AZLA-5k , Lipoic acid PEG azide, LA-PEG-N3
PG2-LAML-3k , Lipoic acid PEG Maleimide, LA-PEG-Mal

Sparfosic acid

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sparfosic acid 

Sparfosic acid 是 DNA 抗代谢剂和天门冬氨酸氨甲酰转移酶 (aspartate transcarbamoyl transferase) 的有效抑制剂。Sparfosic acid 具有抗肿瘤活性。天冬氨酸氨甲酰转移酶催化第二步 de novo 嘧啶生物合成。Sparfosic acid 协同增强 5-氟尿嘧啶 (5-FU) 和干扰素-α (IFN) 对人结肠癌细胞系的细胞毒性。

Sparfosic acid

Sparfosic acid Chemical Structure

CAS No. : 51321-79-0

规格 价格 是否有货
5 mg ￥3800 询问价格 & 货期
10 mg ￥6000 询问价格 & 货期
50 mg ￥19800 询问价格 & 货期
100 mg ￥29500 询问价格 & 货期

* Please select Quantity before adding items.

Sparfosic acid 的其他形式现货产品:

Sparfosic acid trisodium

生物活性

Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3].

体外研究
(In Vitro)

Sparfosic acid (N-(Phosphonacetyl)-L-aspartate, PALA) causes apoptosis in the resistant Br1 cells[1].
Sparfosic acid (300 µM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Br-l and L-2 cell lines established from metastasis in nude mouse injected with the human tumor cell line MDA-MB-435
Concentration: 300 µM
Incubation Time: 12, 24 and 48 hours
Result: Cells were predominantly in S phase in both the cell lines, although slightly higher proportion of cells in S phase were noted in L-2 than Brl-3prl cells.

Western Blot Analysis[1]

Cell Line: Br-l and L-2 cell lines
Concentration: 300 µM
Incubation Time: 4, 10 and 24 hours
Result: There was moderate difference in the level of phosphorylated Rb proteins seen in the two cell types. Marked increase in the amount of cyclin A protein was detected in the L-2 cells undergoing apoptosis with the highest level detected at 10 h post-drug treatment. In contrast, there was no increase in the level of cyclin A seen in the Brl-3prl cells. Cyclin E protein was found elevated in the L-2 cells and Brl-3prl cells compared to their respective controls.

体内研究
(In Vivo)

Sparfosic acid (490 mg/kg; i.p.; on days 1, 5, and 9; mice bearing B16 melanoma) shows the life-span is increased survives 77 to 86% longer than controls. Lewis lung carcinoma is highly sensitive to Sparfosic acid. Treatment on days 1, 5, and 9 following s.c. implantation of Lewis lung carcinoma is curative to 50% of the mice[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

255.12

Formula

C6H10NO8P
CAS 号

51321-79-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro: 

H2O : 125 mg/mL (489.97 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9197 mL 19.5986 mL 39.1972 mL
5 mM 0.7839 mL 3.9197 mL 7.8394 mL
10 mM 0.3920 mL 1.9599 mL 3.9197 mL

参考文献

  • [1]. Wang J, et al. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol. 2015 Aug;47(2):782-90.

    [2]. Angela D. Morris, et al. A New, Efficient, Two Step Procedure for the Preparation of the Antineoplastic Agent Sparfosic Acid.

    [3]. Johnson RK, et al. Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase. Cancer Res. 1976;36(8):2720-2725.

    [4]. Wadler S, et al. Phase II trial of N-(phosphonacetyl)-L-aspartate (PALA), 5-fluorouracil and recombinant interferon-alpha-2b in patients with advanced gastric carcinoma. Eur J Cancer. 1996;32A(7):1254-1256.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lipoic acid PEG Cy5 Cat. No. PG2-LAS5-1 5000 Da 5 mg修饰性聚乙二醇

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Lipoic acid PEG Cy5

Cat. No. PG2-LAS5-1
Specification 5000 Da
Unit Size 5 mg
Price $385.00

Qty Add to Cart

Synonym: Thioctic acid PEG Cy5, Cy5 PEG Lipoic acid, LPA-PEG-Cy5.

Similar products: Lipoic acid PEG SF650, Alexa Fluor 647 PEG Lipoic acid

Description:

Lipoic acid PEG Cy5 is one of Nanocs fluorescent PEG derivatives that have a lipoic acid group on one end of PEG chain and a Cy5 fluorescent dye on the other PEG terminus. Lipoic acid, also known as thioctic acid, contains a disufide bond that can bind to gold and other metal surface. It is also an important molecule parting in various biological processes. Cy5, on the other hand, is a bright cyanine dye that has excitation/emission wavelength at 650 nm/670 nm. Cy5 labeled lipoic acid PEG can be easily detected with common fluorescent instruments.

Product Specification:

  • Form: Solid powder or semi-solid depends on PEG length
  • Color: Blue or dark blue
  • Fluorescent dye: Cy5
  • Ex/Em: 650 nm/670 nm
  • Solubility: Soluble in water

Storage Conditions:

  • Store at -20 0C. Protect from light.
Related Products
PG2-BNLA-5k , Lipoic acid PEG Biotin, LA-PEG-Biotin
PG2-AZLA-5k , Lipoic acid PEG azide, LA-PEG-N3
PG2-FCLA-5k , Lipoic acid PEG FITC, LA-PEG-FITC

Norbornene PEG Acid Cat. No. PG2-CANB-5k 5000 Da 25 mg修饰性聚乙二醇

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Norbornene PEG Acid

Cat. No. PG2-CANB-5k
Specification 5000 Da
Unit Size 25 mg
Price $325.00

Qty Add to Cart

Synonym: COOH PEG Norbornene, Norbornene PEG5000 Acid, Norbornene PEG COOH

Description:

Norbornene PEG Acid (Norbornene PEG COOH) is one of Nanocs Click Chemistry PEG Reagents that have a Norbornene group on one end of PEG chain and a carboxylic acid group (-COOH) on the other PEG terminus. Norbornene is a strain-promoted dienophile that has been used in thiol-ene click chemistry to react with thiols. It also an excellent Click Chemistry reagent used in tetrazine-norbornene cycloaddition.  Meanwhile, COOH group  allows conjugation of Norbornene group to various molecules via their amine groups. Resulted Norbornene group thus can participate various Click Chemistry reactions.  PEG linker between Norbornene and COOH offers good water solubility, better stability or flexible linker structure.

Product Specifications:

  • Form: Solid powder
  • Color: White
  • Solubility: Soluble in water
  • Reactive groups: Norbornene, COOH
  • Reactive to: Thiol, tetrazine, amine
  • Purity: >95%
  • Applications: Thiol-ene and tetrazine-norbornene  click chemistry

Storage:

  • Store at -20 0C. Desiccate.
Related Products
PG4A-NB-10k , 4 arm Norbornene PEG

Palmitic acid-13C sodium

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Palmitic acid-13C sodium 

Palmitic acid-13C sodium 是一种 13C 标记的 Palmitic acid sodium。Palmitic acid sodium 一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid sodium 以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。

Palmitic acid-13C sodium

Palmitic acid-13C sodium Chemical Structure

CAS No. : 201612-54-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Palmitic acid-13C sodium is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

分子量

279.40

Formula

C1513CH31NaO2
CAS 号

201612-54-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

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Palmitic acid-13C16 sodium

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Palmitic acid-13C16 sodium 

Palmitic acid-13C16 sodium 是一种 13C 标记的 Palmitic acid sodium。Palmitic acid sodium 一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid sodium 以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。

Palmitic acid-13C16 sodium

Palmitic acid-13C16 sodium Chemical Structure

CAS No. : 2483736-17-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Palmitic acid-13C16 sodium is the 13C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

分子量

294.29

Formula

13C16H31NaO2
CAS 号

2483736-17-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

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Palmitic acid-1,2,3,4-13C4(Synonyms: 棕榈酸 13C4)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Palmitic acid-1,2,3,4-13C4 (Synonyms: 棕榈酸 13C4)

Palmitic acid-1,2,3,4-13C4 是一种 13C 标记的 Palmitic acid。Palmitic acid 一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid 以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。

Palmitic acid-1,2,3,4-13C4(Synonyms: 棕榈酸 13C4)

Palmitic acid-1,2,3,4-13C4 Chemical Structure

CAS No. : 287100-89-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Palmitic acid-1,2,3,4-13C4 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

分子量

260.39

Formula

C1213C4H32O2
CAS 号

287100-89-4
中文名称

棕榈酸 13C4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Palmitic acid-13C sodium

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Palmitic acid-13C sodium 

Palmitic acid-13C sodium 是一种 13C 标记的 Palmitic acid sodium。Palmitic acid sodium 一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid sodium 以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。

Palmitic acid-13C sodium

Palmitic acid-13C sodium Chemical Structure

CAS No. : 201612-54-6

规格 是否有货
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生物活性

Palmitic acid-13C sodium is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

分子量

279.40

Formula

C1513CH31NaO2
CAS 号

201612-54-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

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Palmitic acid-13C2(Synonyms: 棕榈酸 13C2)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Palmitic acid-13C2 (Synonyms: 棕榈酸 13C2)

Palmitic acid-13C2 是一种 13C 标记的 Palmitic acid。Palmitic acid 一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid 以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。

Palmitic acid-13C2(Synonyms: 棕榈酸 13C2)

Palmitic acid-13C2 Chemical Structure

CAS No. : 86683-25-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

分子量

258.41

Formula

C1413C2H32O2
CAS 号

86683-25-2
中文名称

棕榈酸 13C2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Palmitic acid-13C16 sodium

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Palmitic acid-13C16 sodium 

Palmitic acid-13C16 sodium 是一种 13C 标记的 Palmitic acid sodium。Palmitic acid sodium 一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid sodium 以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。

Palmitic acid-13C16 sodium

Palmitic acid-13C16 sodium Chemical Structure

CAS No. : 2483736-17-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Palmitic acid-13C16 sodium is the 13C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

分子量

294.29

Formula

13C16H31NaO2
CAS 号

2483736-17-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务