标签归档：adenosyl

S-Adenosyl-L-methionine tosylate(Synonyms: S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

S-Adenosyl-L-methionine tosylate (Synonyms: S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate) 纯度: ≥98.0%

S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的具有口服活性的甲基供体。S-Adenosyl-L-methionine tosylate 是一种具有有效的抗抑郁作用的膳食补充剂，可用于缓解疼痛的研究，并可用于肝病和骨关节炎的研究。

S-Adenosyl-L-methionine tosylate(Synonyms: S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate)

S-Adenosyl-L-methionine tosylate Chemical Structure

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥825 In-stock
50 mg ￥750 In-stock
100 mg ￥1300 In-stock
500 mg ￥3900 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

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生物活性

S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine[2].
In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

570.64

Formula

C22H30N6O8S2
中文名称

腺苷蛋氨酸甲苯磺酸盐；丁二磺酸腺苷蛋氨酸甲苯磺酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

H2O : 250 mg/mL (438.10 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7524 mL 8.7621 mL 17.5242 mL
5 mM 0.3505 mL 1.7524 mL 3.5048 mL
10 mM 0.1752 mL 0.8762 mL 1.7524 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. G M Bressa. et al. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

    [3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

S-Adenosyl-L-methionine(Synonyms: S-Adenosyl methionine; Ademetionine; AdoMet)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

S-Adenosyl-L-methionine (Synonyms: S-Adenosyl methionine; Ademetionine; AdoMet)

S-Adenosyl-L-methionine (S-Adenosyl methionine) 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的具有口服活性的甲基供体。S-Adenosyl-L-methionine 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂，并可用于肝病和骨关节炎的研究。

S-Adenosyl-L-methionine(Synonyms: S-Adenosyl methionine; Ademetionine; AdoMet)

S-Adenosyl-L-methionine Chemical Structure

CAS No. : 29908-03-0

规格 价格 是否有货
100 mg ￥4500 询问价格 & 货期

* Please select Quantity before adding items.

S-Adenosyl-L-methionine 的其他形式现货产品:

S-Adenosyl-L-methionine tosylate S-Adenosyl-L-methionine disulfate tosylate

生物活性

S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[1][2][3].

体外研究
(In Vitro)

S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine[2].
In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

398.44

Formula

C15H22N6O5S
CAS 号

29908-03-0
中文名称

S-腺苷-L-蛋氨酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (250.98 mM; Need ultrasonic)

H2O : ≥ 43 mg/mL (107.92 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5098 mL 12.5489 mL 25.0979 mL
5 mM 0.5020 mL 2.5098 mL 5.0196 mL
10 mM 0.2510 mL 1.2549 mL 2.5098 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

    [3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

S-Adenosyl-L-methionine-d3 (Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) 是S-Adenosyl-L-methionine 的氘代物。S-Adenosyl-L-methionine 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的具有口服活性的甲基供体。

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine-d3 Chemical Structure

CAS No. : 68684-40-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) is a deuterium labeled S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor[1][2].

分子量

401.46

Formula

C15H19D3N6O5S
CAS 号

68684-40-2
中文名称

S-腺苷-L-蛋氨酸D3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

S-Adenosyl-L-methionine-d3 (Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) 是S-Adenosyl-L-methionine 的氘代物。S-Adenosyl-L-methionine 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的具有口服活性的甲基供体。

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine-d3 Chemical Structure

CAS No. : 68684-40-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) is a deuterium labeled S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor[1][2].

分子量

401.46

Formula

C15H19D3N6O5S
CAS 号

68684-40-2
中文名称

S-腺苷-L-蛋氨酸D3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

S-Adenosyl-L-methionine-d3 (Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) 是S-Adenosyl-L-methionine 的氘代物。S-Adenosyl-L-methionine 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的具有口服活性的甲基供体。

S-Adenosyl-L-methionine-d3(Synonyms: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3)

S-Adenosyl-L-methionine-d3 Chemical Structure

CAS No. : 68684-40-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) is a deuterium labeled S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor[1][2].

分子量

401.46

Formula

C15H19D3N6O5S
CAS 号

68684-40-2
中文名称

S-腺苷-L-蛋氨酸D3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

    [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务