标签归档：alkylc

Thalidomide 4′-ether-alkylC2-amine hydrochloride

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thalidomide 4′-ether-alkylC2-amine hydrochloride 

Thalidomide 4′-ether-alkylC2-amine hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 linker，应用于 PROTAC 技术。

Thalidomide 4

Thalidomide 4′-ether-alkylC2-amine hydrochloride Chemical Structure

CAS No. : 2341840-99-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thalidomide 4′-ether-alkylC2-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

353.76

Formula

C15H16ClN3O5
CAS 号

2341840-99-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Turk BE, et al. Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci U S A. 1996;93(15):7552‐7556.

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(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride(Synonyms: VH032 phenol-alkylC6-amine dihydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride (Synonyms: VH032 phenol-alkylC6-amine dihydrochloride)

(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride 是一种合成的 E3 连接酶配体连接缀合物，包含基于 VH032 的 VHL 配体和 PROTAC 降解用的 linker。

(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride(Synonyms: VH032 phenol-alkylC6-amine dihydrochloride)

(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride Chemical Structure

CAS No. : 2376990-28-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and an alkyl linker used for PROTAC degrader[1].

分子量

660.70

Formula

C30H47Cl2N5O5S
CAS 号

2376990-28-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pomalidomide 4′-alkylC5-acid

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pomalidomide 4′-alkylC5-acid  纯度: 98.78%

Pomalidomide 4′-alkylC5-acid 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker。

Pomalidomide 4

Pomalidomide 4′-alkylC5-acid Chemical Structure

CAS No. : 2225940-49-6

规格 价格 是否有货 数量
25 mg ￥1300 In-stock
50 mg ￥2200 In-stock
100 mg ￥3700 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pomalidomide 4′-alkylC5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.

IC50 & Target

Cereblon

 

分子量

387.39

Formula

C19H21N3O6
CAS 号

2225940-49-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Boc-A 410099.1 amide-alkylC4-amine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Boc-A 410099.1 amide-alkylC4-amine 

Boc-A 410099.1 amide-alkylC4-amine 是用于 PROTAC 的功能化 IAP 配体，其结合了 IAP 配体和末端带有酰胺的 amide-alkylC4 linker，可与目标蛋白配体结合。

Boc-A 410099.1 amide-alkylC4-amine

Boc-A 410099.1 amide-alkylC4-amine Chemical Structure

CAS No. : 2415256-18-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Boc-A 410099.1 amide-alkylC4-amine is a functionalized IAP ligand for PROTACs that incorporates an IAP ligand and an amide-alkylC4 linker with terminal amine. Boc-A 410099.1 amide-alkylC4-amine can conjugates with target protein ligands.

IC50 & Target

cIAP1

 

分子量

682.89

Formula

C37H58N6O6
CAS 号

2415256-18-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Boc-A 410099.1 amide-alkylC4-amine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Boc-A 410099.1 amide-alkylC4-amine 

Boc-A 410099.1 amide-alkylC4-amine 是用于 PROTAC 的功能化 IAP 配体，其结合了 IAP 配体和末端带有酰胺的 amide-alkylC4 linker，可与目标蛋白配体结合。

Boc-A 410099.1 amide-alkylC4-amine

Boc-A 410099.1 amide-alkylC4-amine Chemical Structure

CAS No. : 2415256-18-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Boc-A 410099.1 amide-alkylC4-amine is a functionalized IAP ligand for PROTACs that incorporates an IAP ligand and an amide-alkylC4 linker with terminal amine. Boc-A 410099.1 amide-alkylC4-amine can conjugates with target protein ligands.

IC50 & Target

cIAP1

 

分子量

682.89

Formula

C37H58N6O6
CAS 号

2415256-18-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Boc-A 410099.1 amide-alkylC4-amine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Boc-A 410099.1 amide-alkylC4-amine 

Boc-A 410099.1 amide-alkylC4-amine 是用于 PROTAC 的功能化 IAP 配体，其结合了 IAP 配体和末端带有酰胺的 amide-alkylC4 linker，可与目标蛋白配体结合。

Boc-A 410099.1 amide-alkylC4-amine

Boc-A 410099.1 amide-alkylC4-amine Chemical Structure

CAS No. : 2415256-18-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Boc-A 410099.1 amide-alkylC4-amine is a functionalized IAP ligand for PROTACs that incorporates an IAP ligand and an amide-alkylC4 linker with terminal amine. Boc-A 410099.1 amide-alkylC4-amine can conjugates with target protein ligands.

IC50 & Target

cIAP1

 

分子量

682.89

Formula

C37H58N6O6
CAS 号

2415256-18-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Thalidomide 4′-ether-alkylC2-amine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thalidomide 4′-ether-alkylC2-amine 

Thalidomide 4′-ether-alkylC2-amine 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，可用于合成 PROTAC。

Thalidomide 4

Thalidomide 4′-ether-alkylC2-amine Chemical Structure

CAS No. : 390367-50-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thalidomide 4′-ether-alkylC2-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

317.30

Formula

C15H15N3O5
CAS 号

390367-50-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Thalidomide 4′-ether-alkylC2-amine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thalidomide 4′-ether-alkylC2-amine 

Thalidomide 4′-ether-alkylC2-amine 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，可用于合成 PROTAC。

Thalidomide 4

Thalidomide 4′-ether-alkylC2-amine Chemical Structure

CAS No. : 390367-50-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thalidomide 4′-ether-alkylC2-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

317.30

Formula

C15H15N3O5
CAS 号

390367-50-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Thalidomide 4′-ether-alkylC2-amine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thalidomide 4′-ether-alkylC2-amine 

Thalidomide 4′-ether-alkylC2-amine 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，可用于合成 PROTAC。

Thalidomide 4

Thalidomide 4′-ether-alkylC2-amine Chemical Structure

CAS No. : 390367-50-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thalidomide 4′-ether-alkylC2-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

317.30

Formula

C15H15N3O5
CAS 号

390367-50-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务