标签归档：anhydrase

Carbonic anhydrase inhibitor 13

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 13 

Carbonic anhydrase inhibitor 13 (化合物 7) 是一种有效的碳酸酐酶 (CA) 抑制剂，其特征是 3- 甲基噻唑 [3,2-a] 苯并咪唑部分(作为尾部)通过脲基连接剂与锌锚定苯磺酰胺部分连接。

Carbonic anhydrase inhibitor 13

Carbonic anhydrase inhibitor 13 Chemical Structure

CAS No. : 2488872-31-5

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生物活性

Carbonic anhydrase inhibitor 13 (compound 7) is a potent carbonic anhydrase (CA) inhibitor, which features 3-methylthiazolo[3,2-a]benzimidazole moiety (as a tail) connected to the zinc anchoring benzenesulfonamide moiety via ureido linker[1].

分子量

401.46

Formula

C17H15N5O3S2
CAS 号

2488872-31-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Alkhaldi AAM, et al. 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies. Eur J Med Chem. 2020 Dec 1;207:112745.

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Carbonic anhydrase inhibitor 11

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 11 

Carbonic anhydrase inhibitor 11 (compound VI) 是一种有效的选择性碳酸酐酶抑制剂。Carbonic anhydrase inhibitor 11 对 CA II、IX 和 XII 的 Ki 值分别为 40、39、200 和 900 nM。

Carbonic anhydrase inhibitor 11

Carbonic anhydrase inhibitor 11 Chemical Structure

CAS No. : 2411059-71-5

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生物活性

Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 11 shows Ki values of 40, 39, 200 and 900 nM against CA II, IX, and XII, respectively[1].

分子量

468.47

Formula

C19H15F3N4O3S2
CAS 号

2411059-71-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Abdel-Mohsen HT, et al. Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. Eur J Med Chem. 2022;228:114004.

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Carbonic anhydrase inhibitor 11

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 11 

Carbonic anhydrase inhibitor 11 (compound VI) 是一种有效的选择性碳酸酐酶抑制剂。Carbonic anhydrase inhibitor 11 对 CA II、IX 和 XII 的 Ki 值分别为 40、39、200 和 900 nM。

Carbonic anhydrase inhibitor 11

Carbonic anhydrase inhibitor 11 Chemical Structure

CAS No. : 2411059-71-5

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250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 11 shows Ki values of 40, 39, 200 and 900 nM against CA II, IX, and XII, respectively[1].

分子量

468.47

Formula

C19H15F3N4O3S2
CAS 号

2411059-71-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Abdel-Mohsen HT, et al. Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. Eur J Med Chem. 2022;228:114004.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 11

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 11 

Carbonic anhydrase inhibitor 11 (compound VI) 是一种有效的选择性碳酸酐酶抑制剂。Carbonic anhydrase inhibitor 11 对 CA II、IX 和 XII 的 Ki 值分别为 40、39、200 和 900 nM。

Carbonic anhydrase inhibitor 11

Carbonic anhydrase inhibitor 11 Chemical Structure

CAS No. : 2411059-71-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 11 shows Ki values of 40, 39, 200 and 900 nM against CA II, IX, and XII, respectively[1].

分子量

468.47

Formula

C19H15F3N4O3S2
CAS 号

2411059-71-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Abdel-Mohsen HT, et al. Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. Eur J Med Chem. 2022;228:114004.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 9 

Carbonic anhydrase inhibitor 9 是一种有效的碳酸酐酶 (CA) 抑制剂，对 hCA II 和 IX 的 Ki 分别为 56.4 和 56.9 nM。 具有抗增殖活性。

Carbonic anhydrase inhibitor 9

Carbonic anhydrase inhibitor 9 Chemical Structure

规格 是否有货
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250 mg   询价  
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生物活性

Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with Kis of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity[1].

体外研究
(In Vitro)

Carbonic anhydrase inhibitor 9 (compound 3c) exerts only cytotoxic activity against A549 cell line with IC50=5.90 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

530.39

Formula

C22H20BrN5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Said MF, et al. Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity. J Enzyme Inhib Med Chem. 2022;37(1):701-717.

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Carbonic anhydrase inhibitor 9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 9 

Carbonic anhydrase inhibitor 9 是一种有效的碳酸酐酶 (CA) 抑制剂，对 hCA II 和 IX 的 Ki 分别为 56.4 和 56.9 nM。 具有抗增殖活性。

Carbonic anhydrase inhibitor 9

Carbonic anhydrase inhibitor 9 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with Kis of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity[1].

体外研究
(In Vitro)

Carbonic anhydrase inhibitor 9 (compound 3c) exerts only cytotoxic activity against A549 cell line with IC50=5.90 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

530.39

Formula

C22H20BrN5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Said MF, et al. Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity. J Enzyme Inhib Med Chem. 2022;37(1):701-717.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 9 

Carbonic anhydrase inhibitor 9 是一种有效的碳酸酐酶 (CA) 抑制剂，对 hCA II 和 IX 的 Ki 分别为 56.4 和 56.9 nM。 具有抗增殖活性。

Carbonic anhydrase inhibitor 9

Carbonic anhydrase inhibitor 9 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with Kis of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity[1].

体外研究
(In Vitro)

Carbonic anhydrase inhibitor 9 (compound 3c) exerts only cytotoxic activity against A549 cell line with IC50=5.90 μM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

530.39

Formula

C22H20BrN5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Said MF, et al. Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity. J Enzyme Inhib Med Chem. 2022;37(1):701-717.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 4

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 4 

Carbonic anhydrase inhibitor 4 is carbonic anhydrase photoprobe/inhibitor. Carbonic anhydrase inhibitor 4 is against human carbonic anhydrases (hCA I-XIV) with Ki values of 640-1166 nM.

Carbonic anhydrase inhibitor 4

Carbonic anhydrase inhibitor 4 Chemical Structure

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250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 4 is carbonic anhydrase photoprobe/inhibitor. Carbonic anhydrase inhibitor 4 is against human carbonic anhydrases (hCA I-XIV) with Ki values of 640-1166 nM[1].

分子量

394.44

Formula

C21H18N2O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Daniela Pagnozzi, et al. Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches. ACS Med. Chem. Lett. 2022, 13, 2, 271–277

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Carbonic anhydrase inhibitor 10

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 10 

Carbonic anhydrase inhibitor 10 是一种有效的 hCA IX 抑制剂，其 hCA IX 值为 6.2 nM。Carbonic anhydrase inhibitor 10 对 MCF-7 癌细胞具有抑制增殖活性，其 IC50 为 11.9 μM。Carbonic anhydrase inhibitor 10 可用于癌症研究。

Carbonic anhydrase inhibitor 10

Carbonic anhydrase inhibitor 10 Chemical Structure

规格 是否有货
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250 mg   询价  
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生物活性

Carbonic anhydrase inhibitor 10 is a potent hCA IX inhibitor with a Ki value of 6.2 nM. Carbonic anhydrase inhibitor 10 exhibits anti-proliferative activity against MCF-7 cancer cell line with an IC50 of 11.9 μM. Carbonic anhydrase inhibitor 10 can be used for cancer research[1].

分子量

335.38

Formula

C14H17N5O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Diaaeldin M Elimam, et al. Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Jan 15;228:114008.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 4

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 4 

Carbonic anhydrase inhibitor 4 is carbonic anhydrase photoprobe/inhibitor. Carbonic anhydrase inhibitor 4 is against human carbonic anhydrases (hCA I-XIV) with Ki values of 640-1166 nM.

Carbonic anhydrase inhibitor 4

Carbonic anhydrase inhibitor 4 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 4 is carbonic anhydrase photoprobe/inhibitor. Carbonic anhydrase inhibitor 4 is against human carbonic anhydrases (hCA I-XIV) with Ki values of 640-1166 nM[1].

分子量

394.44

Formula

C21H18N2O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Daniela Pagnozzi, et al. Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches. ACS Med. Chem. Lett. 2022, 13, 2, 271–277

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 4

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 4 

Carbonic anhydrase inhibitor 4 is carbonic anhydrase photoprobe/inhibitor. Carbonic anhydrase inhibitor 4 is against human carbonic anhydrases (hCA I-XIV) with Ki values of 640-1166 nM.

Carbonic anhydrase inhibitor 4

Carbonic anhydrase inhibitor 4 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 4 is carbonic anhydrase photoprobe/inhibitor. Carbonic anhydrase inhibitor 4 is against human carbonic anhydrases (hCA I-XIV) with Ki values of 640-1166 nM[1].

分子量

394.44

Formula

C21H18N2O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Daniela Pagnozzi, et al. Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches. ACS Med. Chem. Lett. 2022, 13, 2, 271–277

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 10

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 10 

Carbonic anhydrase inhibitor 10 是一种有效的 hCA IX 抑制剂，其 hCA IX 值为 6.2 nM。Carbonic anhydrase inhibitor 10 对 MCF-7 癌细胞具有抑制增殖活性，其 IC50 为 11.9 μM。Carbonic anhydrase inhibitor 10 可用于癌症研究。

Carbonic anhydrase inhibitor 10

Carbonic anhydrase inhibitor 10 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 10 is a potent hCA IX inhibitor with a Ki value of 6.2 nM. Carbonic anhydrase inhibitor 10 exhibits anti-proliferative activity against MCF-7 cancer cell line with an IC50 of 11.9 μM. Carbonic anhydrase inhibitor 10 can be used for cancer research[1].

分子量

335.38

Formula

C14H17N5O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Diaaeldin M Elimam, et al. Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Jan 15;228:114008.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 10

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 10 

Carbonic anhydrase inhibitor 10 是一种有效的 hCA IX 抑制剂，其 hCA IX 值为 6.2 nM。Carbonic anhydrase inhibitor 10 对 MCF-7 癌细胞具有抑制增殖活性，其 IC50 为 11.9 μM。Carbonic anhydrase inhibitor 10 可用于癌症研究。

Carbonic anhydrase inhibitor 10

Carbonic anhydrase inhibitor 10 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 10 is a potent hCA IX inhibitor with a Ki value of 6.2 nM. Carbonic anhydrase inhibitor 10 exhibits anti-proliferative activity against MCF-7 cancer cell line with an IC50 of 11.9 μM. Carbonic anhydrase inhibitor 10 can be used for cancer research[1].

分子量

335.38

Formula

C14H17N5O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Diaaeldin M Elimam, et al. Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Jan 15;228:114008.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 8

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 8 

Carbonic anhydrase inhibitor 8 (compound R-13) 是一种苄基衍生物，一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IV 的 Ki 值分别为 60.7 nM、320.7 nM、2298 nM。

Carbonic anhydrase inhibitor 8

Carbonic anhydrase inhibitor 8 Chemical Structure

规格 是否有货
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生物活性

Carbonic anhydrase inhibitor 8 (compound R-13), a benzyl-derivative, is a potent human carbonic anhydrase (hCA) inhibitor with Ki values of 60.7 nM, 320.7 nM, 2298 nM for hCA I, hCA II, hCA IV, respectively[1].

分子量

403.50

Formula

C20H25N3O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Niccolò Chiaramonte, et al. 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022 Jan 15;228:114026.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 7

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 7 

Carbonic anhydrase inhibitor 7 (化合物 5b) 是一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA IX，hCA II，hCA XII 和 hCA I 的 Ki 值分别为 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM。

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 7 Chemical Structure

CAS No. : 546105-61-7

规格 是否有货
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生物活性

Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively[1].

分子量

447.46

Formula

C23H17N3O5S
CAS 号

546105-61-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

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Carbonic anhydrase inhibitor 5

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 5 

Carbonic anhydrase inhibitor 5 是一种有效且具有选择性的的人碳酸酐酶 (hCA) 抑制剂，hCA II、hCA IX 和 hCA XII 的 IC50s 分别为42.9 nM、47.6 nM 和 6.7 nM。

Carbonic anhydrase inhibitor 5

Carbonic anhydrase inhibitor 5 Chemical Structure

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生物活性

Carbonic anhydrase inhibitor 5 is a potent and selective human carbonic anhydrase (hCA) inhibitor with IC50s of 42.9, 47,6 and 6.7 nM for hCA II, hCA IX and hCA XII, respectively[1].

IC50 & Target

IC50: 42.9 nM (hCA II), 47.6 nM (hCA IX), 6.7 nM (hCA XII)[1]
分子量

465.95

Formula

C24H20ClN3O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Swain B, et al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022;234:114247.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 8

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 8 

Carbonic anhydrase inhibitor 8 (compound R-13) 是一种苄基衍生物，一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IV 的 Ki 值分别为 60.7 nM、320.7 nM、2298 nM。

Carbonic anhydrase inhibitor 8

Carbonic anhydrase inhibitor 8 Chemical Structure

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250 mg   询价  
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生物活性

Carbonic anhydrase inhibitor 8 (compound R-13), a benzyl-derivative, is a potent human carbonic anhydrase (hCA) inhibitor with Ki values of 60.7 nM, 320.7 nM, 2298 nM for hCA I, hCA II, hCA IV, respectively[1].

分子量

403.50

Formula

C20H25N3O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Niccolò Chiaramonte, et al. 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022 Jan 15;228:114026.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 8

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 8 

Carbonic anhydrase inhibitor 8 (compound R-13) 是一种苄基衍生物，一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IV 的 Ki 值分别为 60.7 nM、320.7 nM、2298 nM。

Carbonic anhydrase inhibitor 8

Carbonic anhydrase inhibitor 8 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Carbonic anhydrase inhibitor 8 (compound R-13), a benzyl-derivative, is a potent human carbonic anhydrase (hCA) inhibitor with Ki values of 60.7 nM, 320.7 nM, 2298 nM for hCA I, hCA II, hCA IV, respectively[1].

分子量

403.50

Formula

C20H25N3O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Niccolò Chiaramonte, et al. 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022 Jan 15;228:114026.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 6

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 6 

Carbonic anhydrase inhibitor 6 (化合物 9b) 是一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA IX，hCA II，hCA XII 和 hCA I 的 Ki 值分别为 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM。

Carbonic anhydrase inhibitor 6

Carbonic anhydrase inhibitor 6 Chemical Structure

CAS No. : 1013213-84-7

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250 mg   询价  
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生物活性

Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively[1].

分子量

491.56

Formula

C26H25N3O5S
CAS 号

1013213-84-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carbonic anhydrase inhibitor 7

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carbonic anhydrase inhibitor 7 

Carbonic anhydrase inhibitor 7 (化合物 5b) 是一种有效的人碳酸酐酶 (hCA) 抑制剂，对 hCA IX，hCA II，hCA XII 和 hCA I 的 Ki 值分别为 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM。

Carbonic anhydrase inhibitor 7

Carbonic anhydrase inhibitor 7 Chemical Structure

CAS No. : 546105-61-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively[1].

分子量

447.46

Formula

C23H17N3O5S
CAS 号

546105-61-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务