标签归档：ansatrienin

Ansatrienin B

发表于由

Ansatrienin B

含有三烯结构的安沙霉素抗生素

有货

Ansatrienin B

CAS编号 82189-04-6 | 品牌：Jinpan
Ansatrienin B

MSDS

质检证书(CoA)

相似产品

  • 分子式 C36H50N2O8
  • 分子量638.79
  • PubChem编号 6440888

货号 (SKU) 包装规格 是否现货 价格 数量
A329588-1mg 1mg 期货 Ansatrienin B  

基本信息

产品名称 Ansatrienin B
英文名称 Ansatrienin B
英文别名 Mycotrienin II
运输条件 超低温冰袋运输

一般描述

Ansatrienin B是从链霉菌|中分离出的安沙霉素抗生素，具有三烯结构。它具有抗肿瘤抗生素活性，可显着增强许多临床抗肿瘤药物的作用。它还显示有效的抗癌活性。据报道，Ansatrienin B以浓度依赖的方式抑制甲状旁腺激素刺激的骨吸收。

Ansatrienin B is an ansamycin antibiotic isolated from|Streptomyces|, and contains a triene structure. It displays antitumor antibiotic activity, potentiating significantly the action of many clinical antitumor agents. It also displays potent anticancer activities. Ansatrienin B has been reported to inhibit parathyroid hormone-stimulated bone resorption in a concentration-dependent manner.

相关属性

CAS编号 82189-04-6
溶解性 Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
储存温度 -20°C储存
分子量 638.79
分子式 C36H50N2O8
品牌 Jinpan
Smiles C[C@@H]1[C@H](C/C=C/C=C/C=C/[C@@H](CC(=O)NC2=C(C(=CC(=C2)O)CC/C=C(/[C@@H]1O)\\C)O)OC)OC(=O)[C@@H](C)NC(=O)C3CCCCC3
PubChem CID 6440888

Ansatrienin B(Synonyms: Mycotrienin II)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Ansatrienin B (Synonyms: Mycotrienin II)

Ansatrienin B (Mycotrienin II) 是从链霉菌中分离得到的一种抗生素 (antibiotic)。Ansatrienin B 对真菌和酵母有活性，但对细菌无活性。Ansatrienin B 具有抗肿瘤活性，可作为 ADC 毒素分子。

Ansatrienin B(Synonyms: Mycotrienin II)

Ansatrienin B Chemical Structure

CAS No. : 82189-04-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].

体外研究
(In Vitro)

Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively[1].
Ansatrienin B inhibits the release of 45calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC50) value of 21 nM[2].
Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC50 of 300 nM[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

638.79

Formula

C36H50N2O8
CAS 号

82189-04-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. M Sugita, et al. Studies on Mycotrienin Antibiotics, a Novel Class of Ansamycins. I. Taxonomy, Fermentation, Isolation and Properties of Mycotrienins I and II. J Antibiot (Tokyo). 1982 Nov;35(11):1460-6.

    [2]. D Feuerbach, et al. Mycotrienins. A New Class of Potent Inhibitors of Osteoclastic Bone Resorption. J Biol Chem. 1995 Oct 27;270(43):25949-55.

    [3]. Yuriko Yamada, et al.Mycotrienin II, a Translation Inhibitor That Prevents ICAM-1 Expression Induced by Pro-Inflammatory Cytokines. J Antibiot (Tokyo). 2011 May;64(5):361-6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ansatrienin B(Synonyms: Mycotrienin II)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Ansatrienin B (Synonyms: Mycotrienin II)

Ansatrienin B (Mycotrienin II) 是从链霉菌中分离得到的一种抗生素 (antibiotic)。Ansatrienin B 对真菌和酵母有活性，但对细菌无活性。Ansatrienin B 具有抗肿瘤活性，可作为 ADC 毒素分子。

Ansatrienin B(Synonyms: Mycotrienin II)

Ansatrienin B Chemical Structure

CAS No. : 82189-04-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].

体外研究
(In Vitro)

Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively[1].
Ansatrienin B inhibits the release of 45calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC50) value of 21 nM[2].
Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC50 of 300 nM[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

638.79

Formula

C36H50N2O8
CAS 号

82189-04-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. M Sugita, et al. Studies on Mycotrienin Antibiotics, a Novel Class of Ansamycins. I. Taxonomy, Fermentation, Isolation and Properties of Mycotrienins I and II. J Antibiot (Tokyo). 1982 Nov;35(11):1460-6.

    [2]. D Feuerbach, et al. Mycotrienins. A New Class of Potent Inhibitors of Osteoclastic Bone Resorption. J Biol Chem. 1995 Oct 27;270(43):25949-55.

    [3]. Yuriko Yamada, et al.Mycotrienin II, a Translation Inhibitor That Prevents ICAM-1 Expression Induced by Pro-Inflammatory Cytokines. J Antibiot (Tokyo). 2011 May;64(5):361-6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ansatrienin B(Synonyms: Mycotrienin II)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Ansatrienin B (Synonyms: Mycotrienin II)

Ansatrienin B (Mycotrienin II) 是从链霉菌中分离得到的一种抗生素 (antibiotic)。Ansatrienin B 对真菌和酵母有活性，但对细菌无活性。Ansatrienin B 具有抗肿瘤活性，可作为 ADC 毒素分子。

Ansatrienin B(Synonyms: Mycotrienin II)

Ansatrienin B Chemical Structure

CAS No. : 82189-04-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].

体外研究
(In Vitro)

Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively[1].
Ansatrienin B inhibits the release of 45calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC50) value of 21 nM[2].
Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC50 of 300 nM[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

638.79

Formula

C36H50N2O8
CAS 号

82189-04-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. M Sugita, et al. Studies on Mycotrienin Antibiotics, a Novel Class of Ansamycins. I. Taxonomy, Fermentation, Isolation and Properties of Mycotrienins I and II. J Antibiot (Tokyo). 1982 Nov;35(11):1460-6.

    [2]. D Feuerbach, et al. Mycotrienins. A New Class of Potent Inhibitors of Osteoclastic Bone Resorption. J Biol Chem. 1995 Oct 27;270(43):25949-55.

    [3]. Yuriko Yamada, et al.Mycotrienin II, a Translation Inhibitor That Prevents ICAM-1 Expression Induced by Pro-Inflammatory Cytokines. J Antibiot (Tokyo). 2011 May;64(5):361-6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务