AR antagonist 3

发表于2024年11月25日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

AR antagonist 3

AR antagonist 3 是一种有效的选择性 androgen receptor (AR) 拮抗剂，IC₅₀ 为 0.47 µM。AR antagonist 3 呈剂量依赖性降低 FRET 信号 (IC₅₀= 18.05 μM)。当瘤内给药时，AR antagonist 3 可有效抑制肿瘤生长。

AR antagonist 3 Chemical Structure

CAS No. : 349573-58-6

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生物活性

AR antagonist 3 is a potent and selective androgen receptor (AR) antagonist with an IC₅₀ of 0.47 µM. AR antagonist 3 exhibits a dose-dependent decrease of the FRET signal (IC₅₀= 18.05 μM). AR antagonist 3 shows effective inhibition on tumor growth when administered intratumorally^[1].

IC₅₀ & Target

IC₅₀: 0.47 µM (AR)^[1]

体外研究
(In Vitro)

AR antagonist 3 (compound T1-12) (0.01, 0.1, 1, 10, 100 µM) shows excellent AR antagonistic activity (eGFP IC₅₀= 0.47 μM; PSA IC₅₀= 1.42 μM)^[1].
AR antagonist 3 (0.01, 0.1, 1, 10, 100 µM) inhibits the proliferation of LNCaP cells^[1].
AR antagonist 3 (0.1, 1, 10 µM; 48 h) reduces the protein expression levels of c-Myc and KLK3^[1].
AR antagonist 3 (0.01, 0.1, 1, 10, 100 µM) exhibits a dose-dependent decrease of the FRET signal (IC₅₀= 18.05 μM)^[1].
AR antagonist 3 (10 µM; 2 h) reduces the DHT-mediated translocation of the AR into the nucleus in LNCaP cells^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	LNCaP-ARR2PB-eGFP cells
Concentration:	0.01, 0.1, 1, 10, 100 µM
Incubation Time:
Result:	Showed excellent AR antagonistic activity (eGFP IC₅₀= 0.47 μM; PSA IC₅₀= 1.42 μM).

Cell Proliferation Assay^[1]

Cell Line:	LNCaP, 22Rv1, C4-2, PC3, DU145 cells
Concentration:	0.01, 0.1, 1, 10, 100 µM
Incubation Time:	3 days
Result:	Inhibited the proliferation of LNCaP cells.

体内研究
(In Vivo)

AR antagonist 3 (intratumorally injected; 2.5 mg/kg; every week for 25 days) inhibits tumor growth and the final tumor growth inhibition is 65%^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6 weeks-old male CB17 SCID mice (specificpathogen-free grade), 18-24 g^[1]
Dosage:	2.5 mg/kg
Administration:	intratumorally injected; week; 25 days
Result:	Inhibited tumor growth and the final tumor growth inhibition is 65%.

分子量

306.38

Formula

C₁₅H₁₈N₂O₃S

CAS 号

349573-58-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Chai X, et al. Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2. J Med Chem. 2022, 65(3):2507-2521.

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GRPR antagonist-1

发表于2024年11月25日由上海金畔生物科技有限公司

GRPR antagonist-1

GRPR antagonist-1 是一种有效的胃泌素释放肽受体 (GRPR) 拮抗剂，对某些癌细胞具有细胞毒性 (在PC3、Pan02、HGC-27 细胞中的 IC₅₀ 分别是 4.97、4.36、3.40 μM)。GRPR antagonist-1 通过降低 Bcl-2 水平、增加 Bax 水平，来抑制 HGC-27 细胞活力，引起细胞凋亡。具有抗癌活性。

GRPR antagonist-1 Chemical Structure

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生物活性

GRPR antagonist-1 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC₅₀ of 4.97, 4.36 and 3.40 μM in PC3, Pan02 and HGC-27 cells, respectively). GRPR antagonist-1 inhibits HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis. Anticancer activity^[1].

IC₅₀ & Target

IC₅₀: 4.97 μM (GRPR) in PC3, 4.36 μM (GRPR) in Pan02, 3.40 μM (GRPR) in HGC-27^[1]

体外研究
(In Vitro)

GRPR antagonist-1 (compound 5a) (0.032-100 μM; 48 hours) has the cytotoxicity against certain cancer cells, also reduces PC3, Pan02, HGC-27, and HepG2 cell viability combined with HDAC inhibitor (1 μM)^[1].
GRPR antagonist-1 (1, 2, 8 μM; 24 hours) increases the rate of late apoptosis/necrosis, inducing apoptosis of HGC-27 cells^[1].
GRPR antagonist-1 (0.8, 4 μM; 24 hours) inhibits HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	PC3, HepG2, HGC-27, Pan02, and HK2 cells^[1]
Concentration:	0.032-100 μM
Incubation Time:	48 hours
Result:	Showed the cytotoxicity against these cancer cells, also reduced PC3, Pan02, HGC-27, and HepG2 cell viability combined with HDAC inhibitor (1 μM).

Apoptosis Analysis

Cell Line:	HGC-27^[1]
Concentration:	1, 2, 8 μM
Incubation Time:	24 hours
Result:	Increased the rate of late apoptosis/necrosis, inducing apoptosis of HGC-27 cells.

Western Blot Analysis

Cell Line:	HGC-27^[1]
Concentration:	0.8, 4 μM
Incubation Time:	24 hours
Result:	Inhibited HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis.

分子量

558.59

Formula

C₂₉H₃₃F₃N₄O₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Yu, Mj., et al. Structure–activity relationship studies on Pd176252 derivatives leading to discovery of novel GRP receptor antagonist with potent anticancer activity. Med Chem Res 30, 2069–2089 (2021).

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GRPR antagonist-2

发表于2024年11月25日由上海金畔生物科技有限公司

GRPR antagonist-2

GRPR antagonist-2 是一种有效的胃泌素释放肽受体 (GRPR) 拮抗剂，对某些癌细胞具有细胞毒性 (在 HGC-27 和 Pan02 细胞中的 IC₅₀ 分别是 0.77 和 2.5 μM)。具有抗癌活性。

GRPR antagonist-2 Chemical Structure

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生物活性

GRPR antagonist-2 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC₅₀ of 0.77 and 2.5 μM in HGC-27 and Pan02 cells, respectively). Anticancer activity^[1].

IC₅₀ & Target

IC₅₀: 0.77 μM (GRPR) in HGC-27, 2.5 μM (GRPR) in Pan02^[1]

体外研究
(In Vitro)

GRPR antagonist-2 (compound 6e) (0.032-100 μM; 48 hours) has the cytotoxicity against certain cancer cells, also reduces PC3, Pan02, HGC-27, and HepG2 cell viability combined with HDAC inhibitor (1 μM)^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	PC3, HepG2, HGC-27, Pan02, and HK2 cells^[1]
Concentration:	0.032-100 μM
Incubation Time:	48 hours
Result:	Showed the cytotoxicity against these cancer cells, also reduced PC3, Pan02, HGC-27, and HepG2 cell viability combined with HDAC inhibitor (1 μM).

分子量

559.58

Formula

C₂₈H₃₂F₃N₅O₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Yu, Mj., et al. Structure–activity relationship studies on Pd176252 derivatives leading to discovery of novel GRP receptor antagonist with potent anticancer activity. Med Chem Res 30, 2069–2089 (2021).

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AR antagonist 3

发表于2024年11月25日由上海金畔生物科技有限公司

AR antagonist 3

AR antagonist 3 Chemical Structure

CAS No. : 349573-58-6

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

IC₅₀ & Target

IC₅₀: 0.47 µM (AR)^[1]

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	LNCaP-ARR2PB-eGFP cells
Concentration:	0.01, 0.1, 1, 10, 100 µM
Incubation Time:
Result:	Showed excellent AR antagonistic activity (eGFP IC₅₀= 0.47 μM; PSA IC₅₀= 1.42 μM).

Cell Proliferation Assay^[1]

Cell Line:	LNCaP, 22Rv1, C4-2, PC3, DU145 cells
Concentration:	0.01, 0.1, 1, 10, 100 µM
Incubation Time:	3 days
Result:	Inhibited the proliferation of LNCaP cells.

体内研究
(In Vivo)

AR antagonist 3 (intratumorally injected; 2.5 mg/kg; every week for 25 days) inhibits tumor growth and the final tumor growth inhibition is 65%^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6 weeks-old male CB17 SCID mice (specificpathogen-free grade), 18-24 g^[1]
Dosage:	2.5 mg/kg
Administration:	intratumorally injected; week; 25 days
Result:	Inhibited tumor growth and the final tumor growth inhibition is 65%.

分子量

306.38

Formula

C₁₅H₁₈N₂O₃S

CAS 号

349573-58-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Chai X, et al. Discovery of N-(4-(Benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of the Human Androgen Receptor Targeting the Activation Function 2. J Med Chem. 2022, 65(3):2507-2521.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Estrogen receptor antagonist 5

发表于2024年11月22日由上海金畔生物科技有限公司

Estrogen receptor antagonist 5

Estrogen receptor antagonist 5 是一种有效的 Estrogen receptor 拮抗剂。雌激素受体是一种配体激活的转录调节蛋白，它通过与内源性雌激素的相互作用介导多种生物效应的诱导。Estrogen receptor antagonist 5 具有研究转移性疾病的潜力 (摘自专利 WO2017174757A1，化合物 165)。

Estrogen receptor antagonist 5 Chemical Structure

CAS No. : 2136600-69-4

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生物活性	Estrogen receptor antagonist 5 is a potent antagonist of Estrogen receptor. The estrogen receptor is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 5 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 165)^[1].
分子量	464.52
Formula	C₂₅H₃₁F₃N₂O₃
CAS 号	2136600-69-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Sharada Labadie, et al. Tetrahydroisoquinoline estrogen receptor modulators and uses thereof. Patent WO2017174757A1.

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Estrogen receptor antagonist 5

发表于2024年11月22日由上海金畔生物科技有限公司

Estrogen receptor antagonist 5

Estrogen receptor antagonist 5 Chemical Structure

CAS No. : 2136600-69-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	Estrogen receptor antagonist 5 is a potent antagonist of Estrogen receptor. The estrogen receptor is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 5 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 165)^[1].
分子量	464.52
Formula	C₂₅H₃₁F₃N₂O₃
CAS 号	2136600-69-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Sharada Labadie, et al. Tetrahydroisoquinoline estrogen receptor modulators and uses thereof. Patent WO2017174757A1.

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Estrogen receptor antagonist 5

发表于2024年11月22日由上海金畔生物科技有限公司

Estrogen receptor antagonist 5

Estrogen receptor antagonist 5 Chemical Structure

CAS No. : 2136600-69-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Estrogen receptor antagonist 5 is a potent antagonist of Estrogen receptor. The estrogen receptor is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 5 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 165)^[1].
分子量	464.52
Formula	C₂₅H₃₁F₃N₂O₃
CAS 号	2136600-69-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Sharada Labadie, et al. Tetrahydroisoquinoline estrogen receptor modulators and uses thereof. Patent WO2017174757A1.

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CCR8 antagonist 2

发表于2024年11月21日由上海金畔生物科技有限公司

CCR8 antagonist 2

CCR8 antagonist 2 是一种有效的 CCR8 拮抗剂。CCR8 (C-C Motif 趋化因子受体 8) 主要在 Treg 细胞和 Th2 细胞上表达，但不在 Th1 细胞上表达。CCR8 antagonist 2 抑制 CCR8 活性，可用于治疗由 CCR8 介导的疾病，如癌症和/或神经性疼痛 (摘自专利 WO2022000443A1，化合物 220)。

CCR8 antagonist 2 Chemical Structure

CAS No. : 2756350-98-6

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生物活性	CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the treatment of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220)^[1].
分子量	464.02
Formula	C₂₃H₃₀ClN₃O₃S
CAS 号	2756350-98-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Guohuang FAN, et al. Methods and compositions for targeting tregs using ccr8 inhibitors.

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CCR8 antagonist 2

发表于2024年11月21日由上海金畔生物科技有限公司

CCR8 antagonist 2

CCR8 antagonist 2 Chemical Structure

CAS No. : 2756350-98-6

规格		是否有货
100 mg		询价
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生物活性	CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the treatment of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220)^[1].
分子量	464.02
Formula	C₂₃H₃₀ClN₃O₃S
CAS 号	2756350-98-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Guohuang FAN, et al. Methods and compositions for targeting tregs using ccr8 inhibitors.

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CCR8 antagonist 2

发表于2024年11月21日由上海金畔生物科技有限公司

CCR8 antagonist 2

CCR8 antagonist 2 Chemical Structure

CAS No. : 2756350-98-6

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the treatment of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220)^[1].
分子量	464.02
Formula	C₂₃H₃₀ClN₃O₃S
CAS 号	2756350-98-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Guohuang FAN, et al. Methods and compositions for targeting tregs using ccr8 inhibitors.

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Estrogen receptor antagonist 3

发表于2024年11月21日由上海金畔生物科技有限公司

Estrogen receptor antagonist 3

Estrogen receptor antagonist 3 是一种有效的雌激素受体 (ER) 降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist 4 具有研究癌症疾病的潜力 (摘自专利 WO2021213358A1，化合物 7)。

Estrogen receptor antagonist 3 Chemical Structure

CAS No. : 2730011-50-2

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	Estrogen receptor antagonist 3 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 3 has the potential for the research of cancer diseases (extracted from patent WO2021213358A1, compound 7)^[1].
分子量	554.34
Formula	C₂₆H₂₉BF₆N₄O₂
CAS 号	2730011-50-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gu Peng, et al. Boron-containing compounds and their applications. Patent WO2021213358A1.

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Estrogen receptor antagonist 4

发表于2024年11月21日由上海金畔生物科技有限公司

Estrogen receptor antagonist 4

Estrogen receptor antagonist 4 是一种有效的雌激素受体 (ER) 降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist 4 具有研究癌症疾病的潜力 (摘自专利 WO2021213358A1，化合物 1)。

Estrogen receptor antagonist 4 Chemical Structure

规格		是否有货
100 mg		询价
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生物活性	Estrogen receptor antagonist 4 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 4 has the potential for the research of cancer diseases (extracted from patent WO2021213358A1, compound 1)^[1].
分子量	476.34
Formula	C₂₄H₃₂BF₃N₄O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gu Peng, et al. Boron-containing compounds and their applications. Patent WO2021213358A1.

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Estrogen receptor antagonist 3

发表于2024年11月21日由上海金畔生物科技有限公司

Estrogen receptor antagonist 3

Estrogen receptor antagonist 3 Chemical Structure

CAS No. : 2730011-50-2

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	Estrogen receptor antagonist 3 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 3 has the potential for the research of cancer diseases (extracted from patent WO2021213358A1, compound 7)^[1].
分子量	554.34
Formula	C₂₆H₂₉BF₆N₄O₂
CAS 号	2730011-50-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gu Peng, et al. Boron-containing compounds and their applications. Patent WO2021213358A1.

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Estrogen receptor antagonist 4

发表于2024年11月21日由上海金畔生物科技有限公司

Estrogen receptor antagonist 4

Estrogen receptor antagonist 4 Chemical Structure

规格		是否有货
100 mg		询价
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生物活性	Estrogen receptor antagonist 4 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 4 has the potential for the research of cancer diseases (extracted from patent WO2021213358A1, compound 1)^[1].
分子量	476.34
Formula	C₂₄H₃₂BF₃N₄O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gu Peng, et al. Boron-containing compounds and their applications. Patent WO2021213358A1.

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Estrogen receptor antagonist 3

发表于2024年11月20日由上海金畔生物科技有限公司

Estrogen receptor antagonist 3

Estrogen receptor antagonist 3 Chemical Structure

CAS No. : 2730011-50-2

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500 mg		询价

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生物活性	Estrogen receptor antagonist 3 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 3 has the potential for the research of cancer diseases (extracted from patent WO2021213358A1, compound 7)^[1].
分子量	554.34
Formula	C₂₆H₂₉BF₆N₄O₂
CAS 号	2730011-50-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gu Peng, et al. Boron-containing compounds and their applications. Patent WO2021213358A1.

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Estrogen receptor antagonist 4

发表于2024年11月20日由上海金畔生物科技有限公司

Estrogen receptor antagonist 4

Estrogen receptor antagonist 4 Chemical Structure

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生物活性	Estrogen receptor antagonist 4 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 4 has the potential for the research of cancer diseases (extracted from patent WO2021213358A1, compound 1)^[1].
分子量	476.34
Formula	C₂₄H₃₂BF₃N₄O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gu Peng, et al. Boron-containing compounds and their applications. Patent WO2021213358A1.

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AR antagonist 2

发表于2024年11月19日由上海金畔生物科技有限公司

AR antagonist 2

AR antagonist 2 (compound 58) 是一种有效的雄激素受体 (AR) 抑制剂，IC₅₀ 为 0.95 μM。AR antagonist 2 具有用于癌症研究的潜力。

AR antagonist 2 Chemical Structure

CAS No. : 2275752-15-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	AR antagonist 2 (compound 58) is a potent androgen receptor (AR) inhibitor with an IC₅₀ of 0.95 μM. AR antagonist 2 has the potential for cancer research^[1].
分子量	469.92
Formula	C₂₂H₁₇ClFN₅O₂S
CAS 号	2275752-15-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Chenli Shen, et al. Diaryl thiohydantoins as androgen receptor antagonists. WO2019029521A1

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AR antagonist 2

发表于2024年11月19日由上海金畔生物科技有限公司

AR antagonist 2

AR antagonist 2 (compound 58) 是一种有效的雄激素受体 (AR) 抑制剂，IC₅₀ 为 0.95 μM。AR antagonist 2 具有用于癌症研究的潜力。

AR antagonist 2 Chemical Structure

CAS No. : 2275752-15-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	AR antagonist 2 (compound 58) is a potent androgen receptor (AR) inhibitor with an IC₅₀ of 0.95 μM. AR antagonist 2 has the potential for cancer research^[1].
分子量	469.92
Formula	C₂₂H₁₇ClFN₅O₂S
CAS 号	2275752-15-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Chenli Shen, et al. Diaryl thiohydantoins as androgen receptor antagonists. WO2019029521A1

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AR antagonist 2

发表于2024年11月19日由上海金畔生物科技有限公司

AR antagonist 2

AR antagonist 2 (compound 58) 是一种有效的雄激素受体 (AR) 抑制剂，IC₅₀ 为 0.95 μM。AR antagonist 2 具有用于癌症研究的潜力。

AR antagonist 2 Chemical Structure

CAS No. : 2275752-15-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	AR antagonist 2 (compound 58) is a potent androgen receptor (AR) inhibitor with an IC₅₀ of 0.95 μM. AR antagonist 2 has the potential for cancer research^[1].
分子量	469.92
Formula	C₂₂H₁₇ClFN₅O₂S
CAS 号	2275752-15-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Chenli Shen, et al. Diaryl thiohydantoins as androgen receptor antagonists. WO2019029521A1

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Estrogen receptor antagonist 1

发表于2024年11月18日由上海金畔生物科技有限公司

Estrogen receptor antagonist 1

Estrogen receptor antagonist 1 是一种选择性的 estrogen receptor 拮抗剂。雌激素 (E2) 和雌激素α受体 (ERα) 是乳腺癌发展的重要驱动因素。Estrogen receptor antagonist 1 具有研究乳腺癌疾病的潜力 (摘自专利 WO2021249533A1，化合物 4)。

Estrogen receptor antagonist 1 Chemical Structure

CAS No. : 2751609-45-5

规格		是否有货
100 mg		询价
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生物活性	Estrogen receptor antagonist 1 is a selective estrogen receptor antagonist. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. Estrogen receptor antagonist 1 has the potential for the research of breast cancer diseases (extracted from patent WO2021249533A1, compound 4)^[1].
分子量	515.59
Formula	C₂₈H₃₃F₄N₅
CAS 号	2751609-45-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhang Yan, et al. Estrogen receptor modulator compounds and their uses. Patent WO2021249533A1.

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whatman (沃特曼)

英国沃特曼 Millipore PALL中国代理商金畔官网

标签归档：antagonist

AR antagonist 3

GRPR antagonist-1

GRPR antagonist-2

AR antagonist 3

Estrogen receptor antagonist 5

Estrogen receptor antagonist 5

Estrogen receptor antagonist 5

CCR8 antagonist 2

CCR8 antagonist 2

CCR8 antagonist 2

Estrogen receptor antagonist 3

Estrogen receptor antagonist 4

Estrogen receptor antagonist 3

Estrogen receptor antagonist 4

Estrogen receptor antagonist 3

Estrogen receptor antagonist 4

AR antagonist 2

AR antagonist 2

AR antagonist 2

Estrogen receptor antagonist 1