标签归档：antipain

Antipain

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antipain 

Antipain 是一种从 Actinomycetes 分离的蛋白酶 (protease) 抑制剂。Antipain 抑制 N-甲基-N’-硝基-N-亚硝基胍 (MNNG) 诱导的转化，增加染色体畸变。Antipain 限制小鼠中子宫 DNA 合成和功能。

Antipain

Antipain Chemical Structure

CAS No. : 37691-11-5

规格 是否有货
250 μg 询价
500 μg 询价

* Please select Quantity before adding items.

生物活性

Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain restricts uterine DNA synthesis and function in mice[1][2][3][4].

体内研究
(In Vivo)

The intact, cycling female mice received subcutaneous injections of Antipain (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4].
Antipain (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

604.70

Formula

C27H44N10O6
CAS 号

37691-11-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. DiPaolo JA, et al. Antipain inhibits N-methyl-N’-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53.

    [2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6.

    [3]. Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76.

    [4]. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626.

    [5]. Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Antipain dihydrochloride

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antipain dihydrochloride  纯度: ≥95.0%

Antipain dihydrochloride是一种从 Actinomycetes 分离的蛋白酶 (protease) 抑制剂。Antipain dihydrochloride 抑制 N-甲基-N’-硝基-N-亚硝基胍 (MNNG) 诱导的转化，增加染色体畸变。Antipain dihydrochloride 限制小鼠中子宫 DNA 合成和功能。

Antipain dihydrochloride

Antipain dihydrochloride Chemical Structure

CAS No. : 37682-72-7

规格 价格 是否有货 数量
5 mg ￥2900 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4].

体内研究
(In Vivo)

The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4].
Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

677.62

Formula

C27H46Cl2N10O6
CAS 号

37682-72-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. DiPaolo JA, et al. Antipain inhibits N-methyl-N’-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53.

    [2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6.

    [3]. Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76.

    [4]. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626.

    [5]. Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务