标签归档：ascomycin

Cas(104987-12-4,11011-38-4), Ascomycin, 长川霉素,Ascomycin,

发表于由

长川霉素

钙调神经磷酸酶/ PP2B抑制剂。免疫抑制剂和抗真菌活性。
≥97.0%

有货

Cas(104987-12-4,11011-38-4), Ascomycin, 长川霉素,Ascomycin,

CAS编号 104987-12-4 | 品牌：Jinpan
Ascomycin

MSDS

质检证书(CoA)

相似产品

  • 分子式 C43H69NO12
  • 分子量792.01
  • EC号 200-835-2
  • PubChem编号 5282071

货号 (SKU) 包装规格 是否现货 价格 数量
A127632-25mg 25mg 现货 Cas(104987-12-4,11011-38-4), Ascomycin, 长川霉素,Ascomycin,  
A127632-100mg 100mg 现货 Cas(104987-12-4,11011-38-4), Ascomycin, 长川霉素,Ascomycin,  
A127632-500mg 500mg 现货 Cas(104987-12-4,11011-38-4), Ascomycin, 长川霉素,Ascomycin,  
A127632-1g 1g 现货 Cas(104987-12-4,11011-38-4), Ascomycin, 长川霉素,Ascomycin,  

基本信息

产品名称 长川霉素
英文名称 Ascomycin
别名 长川霉素；子囊霉素
英文别名 Immunomycin;FK 520;FR 900520;FR-900520;FR900520;FK-520;FK520
规格或纯度 ≥97.0%
运输条件 超低温冰袋运输
生化机理 When we used either CD4+CD8+ thymocytes or peripheral T cells activated by phorbol ester and ionomycin, the cell surface induction of CD5 was also partially blocked by CsA, FK-520 and rapamycin . Ascomycinalso had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition.Calcineurin/PP2B inhibitor (IC 50 = 49 nM). Forms a FK-506 binding protein 12 (FKBP12) – Ascomycin -Calcineurin complex. Immunosuppressant and antifungal activity in vitro and in vivo .

一般描述

Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物，具有很强的免疫抑制剂。A potent immunosuppressive agent

Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
A potent immunosuppressive agent

application：

Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.

相关属性

CAS编号 104987-12-4
沸点 868℃
溶解性 Soluble in DMSO (65 mg/ml), ethanol (50 mg/ml), and water (10-50 μM).
储存温度 -20°C储存
RTECS KD4185000
分子量 792.01
分子式 C43H69NO12
EC号 200-835-2
品牌 Jinpan
备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
关联CAS 11011-38-4
PubChem CID 5282071