SQNF-psi[CH2NH]PIVQ represents a competitive inhibitor of the HIV-1 protease (Ki = 1 碌M). The coupling of this affinity ligand to agarose resin enabled the rapid purification of HIV-1 protease.
溶解度
分子量
2313.72
化学式
C99H173N29O32S1
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference
J.V.Fecondo et al., AIDS Res. Human Retroviruses, 9, 733 (1993)
DABCYL-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)-EDANS
编码
别名
DABCYL-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)-EDANS
纯度
80%,90%,95%,98%,99%
重量
1mg,5mg,10mg,50mg,100mg,1g
序列(单字母缩写)
Dabcyl-SEVNLDAEF-Edans
序列(三字母缩写)
DABCYL-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-EDANS
基本描述
Substrate that can be cleaved by the HIV-1 protease at the Tyr-Pro position, thus resulting in a time-dependent increase in the intensity of fluorescence.
溶解度
分子量
1522.7
化学式
C71H91N15O21S1
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
Ala-Ala-Asn-PAB is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs)[1].
IC50 & Target
Cleavable
分子量
379.41
Formula
C17H25N5O5
CAS 号
2149584-00-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Cheng X, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675.
iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research[1].
IC50 & Target
Ki: 0.22 μM (Hck)[1]
体外研究 (In Vitro)
iHCK-37 (5.0-20 μM; 24 hours) exhibits a potent in vitro antiproliferative activity. The dose (μM) for growth inhibition (GI50) is 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562)[2].iHCK-37 (3-9 μM; plus Erythropoietin) leads to a decrease in ERK, AKT and P70S6K phosphorylation of in lentivirus HCK silenced K562 and U937 cell lines[2].iHCK-37 (3-9 μM) results in a decrease of p-HCK, p-ERK, p-AKT, p-70S6 in the cell line KG1a (AML/CD34+), in a dose-dependent manner[2].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay[1]
Cell Line:
U937, HL60, KG1a, HEL and K562 cells
Concentration:
5.0-20 μM
Incubation Time:
24 hours
Result:
Exhibited a reduction of growth in a dose-dependent manner.
分子量
544.73
Formula
C30H32N4O2S2
CAS 号
516478-09-4
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Cristina Tintori, et al. Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. ChemMedChem. 2013 Aug;8(8):1353-60.
[2]. Fernanda Marconi Roversi, et al. Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):450-461.
This IGF-I peptide analog was able to inhibit the autophosphorylation of the IGF-I receptor by IGF-I as well as the growth of several different cell types, including prostate carcinoma cells and SV40-transformed cells. Such analogs might be useful in treating abnormal cell growth.
溶解度
分子量
601.51
化学式
C23H32N5O12P1
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
Human T lymphotropic virus type 1 HTLV-1 Tax (11-19) is an immunodominant HLA-A2-restricted epitope. It is recognized by a high number of CD8+ cytotoxic T lymphocytes (CTLs) in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a demyelinating inflammatory neurologic disease associated with HTLV-1 infection. H-6096 therefore represents a useful tool to elucidate the role of antigen-specific CD8+ CTLs in HAM/TSP.
溶解度
分子量
918.06
化学式
C42H67N11O12
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference
J.C.Heimbach et al., Biochem. Biophys. Res. Commun., 164, 955 (1989)
Fluorogenic substrate for pro-memapsin-2 containing the b-secretase site of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 4.5 碌M and kcat = 0.25 min-1.
溶解度
分子量
1533.5
化学式
C68H88N14O27
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference
J.Ermolieff et al., Biochemistry, 39, 16263 (2000) J.Ermolieff et al., Biochemistry, 39, 12450 (2000)