标签归档：baza

BAZ1A-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BAZ1A-IN-1  纯度: 99.84%

BAZ1A-IN-1 是一种有效的 BAZ1A（含溴结构域蛋白）抑制剂。 BAZ1A-IN-1 对 BAZ1A 溴结构域的 KD 值为 0.52 μM。BAZ1A-IN-1 对高表达 BAZ1A 的癌细胞系显示出良好的抗生存活性，但对低表达 BAZ1A 的癌细胞表现出弱活性或无活性。

BAZ1A-IN-1

BAZ1A-IN-1 Chemical Structure

CAS No. : 941521-45-5

规格 价格 是否有货 数量
5 mg ￥3000 In-stock
10 mg ￥4800 In-stock
50 mg ￥14500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

BAZ1A-IN-1 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Epigenetics Compound Library
  • Histone Modification Research Compound Library
  • Anti-Cancer Compound Library
  • Reprogramming Compound Library
  • Anti-Blood Cancer Compound Library

生物活性

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].

IC50 & Target

BAZ1A[1]
体外研究
(In Vitro)

BAZ1A-IN-1 (Cpd-2) (0.015-100  μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells
Concentration: 0.015-100  μM
Incubation Time: 96 hours
Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A.

分子量

340.36

Formula

C16H12N4O3S
CAS 号

941521-45-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 25 mg/mL (73.45 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9381 mL 14.6903 mL 29.3807 mL
5 mM 0.5876 mL 2.9381 mL 5.8761 mL
10 mM 0.2938 mL 1.4690 mL 2.9381 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

BAZ1A-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BAZ1A-IN-1  纯度: 99.84%

BAZ1A-IN-1 是一种有效的 BAZ1A（含溴结构域蛋白）抑制剂。 BAZ1A-IN-1 对 BAZ1A 溴结构域的 KD 值为 0.52 μM。BAZ1A-IN-1 对高表达 BAZ1A 的癌细胞系显示出良好的抗生存活性，但对低表达 BAZ1A 的癌细胞表现出弱活性或无活性。

BAZ1A-IN-1

BAZ1A-IN-1 Chemical Structure

CAS No. : 941521-45-5

规格 价格 是否有货 数量
5 mg ￥3000 In-stock
10 mg ￥4800 In-stock
50 mg ￥14500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

BAZ1A-IN-1 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Epigenetics Compound Library
  • Histone Modification Research Compound Library
  • Anti-Cancer Compound Library
  • Reprogramming Compound Library
  • Anti-Blood Cancer Compound Library

生物活性

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].

IC50 & Target

BAZ1A[1]
体外研究
(In Vitro)

BAZ1A-IN-1 (Cpd-2) (0.015-100  μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells
Concentration: 0.015-100  μM
Incubation Time: 96 hours
Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A.

分子量

340.36

Formula

C16H12N4O3S
CAS 号

941521-45-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 25 mg/mL (73.45 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9381 mL 14.6903 mL 29.3807 mL
5 mM 0.5876 mL 2.9381 mL 5.8761 mL
10 mM 0.2938 mL 1.4690 mL 2.9381 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

BAZ1A-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BAZ1A-IN-1  纯度: 99.84%

BAZ1A-IN-1 是一种有效的 BAZ1A（含溴结构域蛋白）抑制剂。 BAZ1A-IN-1 对 BAZ1A 溴结构域的 KD 值为 0.52 μM。BAZ1A-IN-1 对高表达 BAZ1A 的癌细胞系显示出良好的抗生存活性，但对低表达 BAZ1A 的癌细胞表现出弱活性或无活性。

BAZ1A-IN-1

BAZ1A-IN-1 Chemical Structure

CAS No. : 941521-45-5

规格 价格 是否有货 数量
5 mg ￥3000 In-stock
10 mg ￥4800 In-stock
50 mg ￥14500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

BAZ1A-IN-1 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Epigenetics Compound Library
  • Histone Modification Research Compound Library
  • Anti-Cancer Compound Library
  • Reprogramming Compound Library
  • Anti-Blood Cancer Compound Library

生物活性

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].

IC50 & Target

BAZ1A[1]
体外研究
(In Vitro)

BAZ1A-IN-1 (Cpd-2) (0.015-100  μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells
Concentration: 0.015-100  μM
Incubation Time: 96 hours
Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A.

分子量

340.36

Formula

C16H12N4O3S
CAS 号

941521-45-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 25 mg/mL (73.45 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9381 mL 14.6903 mL 29.3807 mL
5 mM 0.5876 mL 2.9381 mL 5.8761 mL
10 mM 0.2938 mL 1.4690 mL 2.9381 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务