标签归档：bh

Bak BH3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Bak BH3 

Bak BH3 是一种多肽，源于 Bak 蛋白的 BH3 结构域，在细胞中，能够抑制 Bcl-xL 的活性。

Bak BH3

Bak BH3 Chemical Structure

规格 价格 是否有货
1 mg ￥1100 询问价格 & 货期
5 mg ￥3300 询问价格 & 货期
10 mg ￥5500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

IC50 & Target[1]

Bcl-xL

 

体外研究
(In Vitro)

Bak BH3 peptide antagonize the protective effects of microinjected Bcl-xL in α-Fas-treated HeLa cells, whereas a mutant Bak BH3 peptide that no longer binds Bcl-xL is inactive[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1724.90

Formula

C72H125N25O24
Sequence

Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg
Sequence Shortening

GQVGRQLAIIGDDINR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Holinger EP, et al. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 7;274(19):13298-304.
Cell Assay
[1]

Cells are plated in complete DMEM in 96-well tissue culture plates at 4×103/well. After 24 h, cells are washed with PBS and treated with peptides (50 μM) in SF-DMEM. Cell viability is determined by staining unfixed cells with calcein AM/ethidium homodimer, followed by microscopic analysis of cell staining and cellular morphology on a Nikon Diaphot 300 inverted microscope equipped with a fluorescence module.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Holinger EP, et al. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 7;274(19):13298-304.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

英国Stuart-双模块干式加热器BH-200D-2-HT

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【简单介绍】

品牌 金畔 加工定制 否

双模块干式加热器BH-200D-2-HT可用于精确加热试管、微管、透明容器和微滴定板。

自2022年6月起，型号为SBH200D的Stuart Digital 2-Block Heater现已更名为Cole-Parmer，型号为BH-200D-2-HT。所有相同的伟大功能和规格，只是有一个新的和改进的外观。

【详细说明】

双模块干式加热器BH-200D-2-HT

产品描述：数字2块加热器，200⁰C，230V

产品介绍

干式加热器设计用于试管、微量离心管、比色皿和微量滴定板的精确加热。铝块的大热质量提供了非常精确和稳定的温度控制。“接受的块数”表示每个加热器接受的单宽度块数。接受两个单宽度块的加热器也将接受一个双宽度块。请注意:自2022年6月起，型号为SBH200D的Stuart Digital 2-Block Heater现已更名为Cole-Parmer，型号为BH-200D-2-HT。所有相同的伟大功能和规格，只是有一个新的和改进的外观。

产品特点：

提供试管和微孔板的精确加热

当气缸体温度高于50°C时，热警示灯会发出指示

接受两个单宽加热块或一个双宽灵活加热块

高达200°C的数字控制

230伏交流电运行

提供完全匹配的模块抽出工具，但是模块需另外订购。

双模块干式加热器BH-200D-2-HT

技术参数

产品型号 BH-200D-2-HT
控制方式 数字控温
温度范围 200°C
温度稳定性（37℃） ±0.1℃
温度均一性（37℃） ±0.1℃
温度均一性（130℃） ±1℃
温度显示器 LED显示±0.1℃
重量 2.3Kg
规格（宽×D×Hmm） 235×280×115mm
电率 230V/50Hz
功率 300W
加热模块数量 2

多肽定制Bak-BH3 编码

发表于由

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Bak-BH3
编码
别名 Bak-BH3
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） GQVGRQLAIIGDDINR
序列（三字母缩写） Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg
基本描述
溶解度
分子量 1724.95
化学式 C72H125N25O24
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Bak-BH3 编码
Figures Bak-BH3 编码
Reference
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化学桥

多肽定制Bax-BH3 编码

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Bax-BH3
编码
别名 Bax-BH3
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） KKLSECLKRIGDELDS
序列（三字母缩写） Lys-Lys-Leu-Ser-Glu-Cys-Leu-Lys-Arg-Ile-Gly-Asp-Glu-Leu-Asp-Ser
基本描述
溶解度
分子量 1834.13
化学式 C77H136N22O27S
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Bax-BH3 编码
Figures Bax-BH3 编码
Reference
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化学桥

多肽定制Bid BH3 编码

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Bid BH3
编码
别名 Bid BH3
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） RNIARHLAQVGDSMDR
序列（三字母缩写） Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg
基本描述
溶解度
分子量 1839.08
化学式 C74H127N29O24S
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Bid BH3 编码
Figures Bid BH3 编码
Reference
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化学桥

多肽定制Bid BH3 Peptide 编码

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Bid BH3 Peptide
编码
别名 Bid BH3 Peptide
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） EDIIRNIARHLAQVGDSMDR
序列（三字母缩写） Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg
基本描述
溶解度
分子量 2309.61
化学式 C95H161N33O32S
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Bid BH3 Peptide 编码
Figures Bid BH3 Peptide 编码
Reference
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化学桥

多肽定制Bid BH3-r8; R8BIDH3 编码

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Bid BH3-r8; R8BIDH3
编码
别名 Bid BH3-r8; R8BIDH3
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） rrrrrrrrGEDIIRNIAR HLAQVGDSMDR
序列（三字母缩写） D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-Gly-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg- His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg
基本描述
溶解度
分子量 3616.17
化学式 C145H260N66O41S
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Bid BH3-r8; R8BIDH3 编码
Figures Bid BH3-r8; R8BIDH3 编码
Reference
C端
N端
化学桥

多肽定制Bid BH3-r9; R9BIDH3 编码

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Bid BH3-r9; R9BIDH3
编码
别名 Bid BH3-r9; R9BIDH3
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） RRRRRRRRRGEDIIRNIARHLAQVGDSMDR
序列（三字母缩写） Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg
基本描述
溶解度
分子量 3772.36
化学式 C151H272N70O42S
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Bid BH3-r9; R9BIDH3 编码
Figures Bid BH3-r9; R9BIDH3 编码
Reference
C端
N端
化学桥

兰格一体式实验室注射泵LSP01-1BH

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兰格一体式实验室注射泵LSP01-1BH

  • 品牌 兰格|LONGER
  • 型号 LSP01-1BH
  • 商品详情

    适用场所：

    生物实验室使用

    产品特性：

    高压注射泵LSP01-1BH可装卡10ul-100ml规格的注射器(进样器)，该高压注射泵的超大推力适合粘稠液体的传输以及化学反应堆实验。

    功能特点

    LSP01-1BH高压注射泵可从列表中选择注射器或者直接输入注射器内径确定注射器
    大屏幕液晶显示、数码旋钮与薄膜按键操作直观、简便、快捷
    工作模式：5种工作模式(灌注/抽取/先灌注后抽取/先抽取后灌注/连续工作)
    掉电记忆功能: 1.EEPROM保存设置参数,重新上电后,无需重新设置 2.流量模式下运行时断电,恢复上电后可根据设置参数继续运行或停止
    堵车保护功能: 当工作过程中注射泵的推进机构被堵死,注射泵会停止推进机构的工作并发出鸣笛报警
    采用485通讯总线可与上位机相连,通过后台对其进行控制
    外控接口:输入/输出控制功能
    液量校准功能：通过校准程序可得到更精确的流量
    注射器保护功能: 通过调整限位块位置,可以保护注射器免受损伤

    技术指标

    高压注射泵工作模式：注射、抽取、先注射后抽取、先抽取后注射、连续
    通道数量：1
    最大行程：140mm
    行程分辨率：0.156μm
    线速度范围：5μm/min-130mm/min
    线速度调节分辨率：5μm/min
    行程控制精度：误差≤±0.5%(行程≥最大行程的30%时)
    高压注射泵额定线性推力：＞450N
    注射器选择：内置主要厂家、主要型号注射器供选择
    注射器自定义：可直接输入注射器内经
    流量校正：通过校正程序获得更为精确的液量
    运行参数设置：注射液量、注射时间、抽取时间等
    显示参数选择：液量、流量或线速度
    掉电记忆：重新上电后保持掉电前的参数设置
    状态信号输出：2路OC门信号输出，用于指示启/停和方向状态
    控制信号输入：2路启停控制输入端，1路下降沿触发信号控制启停；1路TTL电平信号控制启停
    通信接口：RS485
    外形尺寸：280×250×140(mm)
    重量：6.3kg
    使用电源：AC 90V-260V/25W
    工作环境温度：0℃-40℃
    工作环境相对湿度：＜80%

    注射泵型号

    产品编号

    适用注射器规格(ml)

    注射器内经(mm)

    参考流量范围(μl/min-ml/min)  

    最大出口压强(Mpa)

    LSP01-1BH

    05.03.43A

    2.5

    4.79

    0.0901-2.3426

    19.48

    8

    9.53

    0.3567-9.2730

    5.05

    20

    19.13

    1.4371-37.3648

    1.25

    50

    28.6

    3.2121-83.5152

    0.56

    100

    34.9

    4.7831-124.361

    0.37

    • BH3 hydrochloride

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    BH3 hydrochloride 

    BH3 hydrochloride 是能透过血脑屏障的多肽，通过直接激活促凋亡 Bax/Bak 或通过中和抗凋亡 Bcl-2 蛋白 (Bcl-2、Bcl-XL、Bcl-w、mcl1和A-1)来诱导细胞凋亡，通过与BH3 结构域结合。

    BH3 hydrochloride

    BH3 hydrochloride Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian[1][2].

    分子量

    2677.45

    Formula

    C120H183ClN36O32
    Sequence

    Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg
    Sequence Shortening

    IWIAQELRRIGDEFNAYYARR
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Guang Yang, et al. Modulating Protein-Protein Interactions In Vivo via Peptide-Lanthanide-Derived Nanoparticles for Hazard-Free Cancer Therapy. J Biomed Nanotechnol. 2019 Sep 1;15(9):1937-1947.

      [2]. Shatrunajay Shukla, et al. BH3-only Protein BIM: An Emerging Target in Chemotherapy. Eur J Cell Biol. 2017 Dec;96(8):728-738.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    BH3 hydrochloride

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    BH3 hydrochloride 

    BH3 hydrochloride 是能透过血脑屏障的多肽，通过直接激活促凋亡 Bax/Bak 或通过中和抗凋亡 Bcl-2 蛋白 (Bcl-2、Bcl-XL、Bcl-w、mcl1和A-1)来诱导细胞凋亡，通过与BH3 结构域结合。

    BH3 hydrochloride

    BH3 hydrochloride Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian[1][2].

    分子量

    2677.45

    Formula

    C120H183ClN36O32
    Sequence

    Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg
    Sequence Shortening

    IWIAQELRRIGDEFNAYYARR
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Guang Yang, et al. Modulating Protein-Protein Interactions In Vivo via Peptide-Lanthanide-Derived Nanoparticles for Hazard-Free Cancer Therapy. J Biomed Nanotechnol. 2019 Sep 1;15(9):1937-1947.

      [2]. Shatrunajay Shukla, et al. BH3-only Protein BIM: An Emerging Target in Chemotherapy. Eur J Cell Biol. 2017 Dec;96(8):728-738.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    BH3 hydrochloride

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    BH3 hydrochloride 

    BH3 hydrochloride 是能透过血脑屏障的多肽，通过直接激活促凋亡 Bax/Bak 或通过中和抗凋亡 Bcl-2 蛋白 (Bcl-2、Bcl-XL、Bcl-w、mcl1和A-1)来诱导细胞凋亡，通过与BH3 结构域结合。

    BH3 hydrochloride

    BH3 hydrochloride Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian[1][2].

    分子量

    2677.45

    Formula

    C120H183ClN36O32
    Sequence

    Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg
    Sequence Shortening

    IWIAQELRRIGDEFNAYYARR
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Guang Yang, et al. Modulating Protein-Protein Interactions In Vivo via Peptide-Lanthanide-Derived Nanoparticles for Hazard-Free Cancer Therapy. J Biomed Nanotechnol. 2019 Sep 1;15(9):1937-1947.

      [2]. Shatrunajay Shukla, et al. BH3-only Protein BIM: An Emerging Target in Chemotherapy. Eur J Cell Biol. 2017 Dec;96(8):728-738.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Bax BH3 peptide (55-74), wild type

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Bax BH3 peptide (55-74), wild type 

    Bax BH3 peptide (55-74), wild type 是一种含 20 个氨基酸的 Bax BH3 肽 (Bax 1)，能够在多种细胞系模型中诱导细胞凋亡。

    Bax BH3 peptide (55-74), wild type

    Bax BH3 peptide (55-74), wild type Chemical Structure

    CAS No. : 299946-20-6

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models[1].

    体外研究
    (In Vitro)

    In addition to disrupting Bax/Bcl-2 and Bax/Bcl-XL, Bax BH3 peptide (55-74), wild type can promote cytochrome c release from isolated mitochondria. Bax BH3 belongs to the Bcl-2 protein family which consists of both pro-apoptotic and anti-apoptotic members. Bax BH3 acts to regulate apoptosis via governance of the ‘intrinsic’ pathway of cell death[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    2267.60

    Formula

    C93H163N27O34S2
    CAS 号

    299946-20-6
    Sequence

    Ser-Thr-Lys-Lys-Leu-Ser-Glu-Cys-Leu-Lys-Arg-Ile-Gly-Asp-Glu-Leu-Asp-Ser-Asn-Met
    Sequence Shortening

    STKKLSECLKRIGDELDSNM
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    H2O

    Peptide Solubility and Storage Guidelines:

    1.  Calculate the length of the peptide.

    2.  Calculate the overall charge of the entire peptide according to the following table:

      Contents Assign value
    Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
    Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
    Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

    3.  Recommended solution:

    Overall charge of peptide Details
    Negative (<0) 1.  Try to dissolve the peptide in water first.
    2.  If water fails, add NH4OH (<50 μL).
    3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
    Positive (>0) 1.  Try to dissolve the peptide in water first.
    2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
    3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
    Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
    2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
    参考文献

    • [1]. Peter E Czabotar, et al. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem. 2011 Mar 4;286(9):7123-31.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Bax BH3 peptide (55-74), wild type

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Bax BH3 peptide (55-74), wild type 

    Bax BH3 peptide (55-74), wild type 是一种含 20 个氨基酸的 Bax BH3 肽 (Bax 1)，能够在多种细胞系模型中诱导细胞凋亡。

    Bax BH3 peptide (55-74), wild type

    Bax BH3 peptide (55-74), wild type Chemical Structure

    CAS No. : 299946-20-6

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models[1].

    体外研究
    (In Vitro)

    In addition to disrupting Bax/Bcl-2 and Bax/Bcl-XL, Bax BH3 peptide (55-74), wild type can promote cytochrome c release from isolated mitochondria. Bax BH3 belongs to the Bcl-2 protein family which consists of both pro-apoptotic and anti-apoptotic members. Bax BH3 acts to regulate apoptosis via governance of the ‘intrinsic’ pathway of cell death[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    2267.60

    Formula

    C93H163N27O34S2
    CAS 号

    299946-20-6
    Sequence

    Ser-Thr-Lys-Lys-Leu-Ser-Glu-Cys-Leu-Lys-Arg-Ile-Gly-Asp-Glu-Leu-Asp-Ser-Asn-Met
    Sequence Shortening

    STKKLSECLKRIGDELDSNM
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    H2O

    Peptide Solubility and Storage Guidelines:

    1.  Calculate the length of the peptide.

    2.  Calculate the overall charge of the entire peptide according to the following table:

      Contents Assign value
    Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
    Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
    Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

    3.  Recommended solution:

    Overall charge of peptide Details
    Negative (<0) 1.  Try to dissolve the peptide in water first.
    2.  If water fails, add NH4OH (<50 μL).
    3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
    Positive (>0) 1.  Try to dissolve the peptide in water first.
    2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
    3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
    Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
    2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
    参考文献

    • [1]. Peter E Czabotar, et al. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem. 2011 Mar 4;286(9):7123-31.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Bax BH3 peptide (55-74), wild type

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Bax BH3 peptide (55-74), wild type 

    Bax BH3 peptide (55-74), wild type 是一种含 20 个氨基酸的 Bax BH3 肽 (Bax 1)，能够在多种细胞系模型中诱导细胞凋亡。

    Bax BH3 peptide (55-74), wild type

    Bax BH3 peptide (55-74), wild type Chemical Structure

    CAS No. : 299946-20-6

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models[1].

    体外研究
    (In Vitro)

    In addition to disrupting Bax/Bcl-2 and Bax/Bcl-XL, Bax BH3 peptide (55-74), wild type can promote cytochrome c release from isolated mitochondria. Bax BH3 belongs to the Bcl-2 protein family which consists of both pro-apoptotic and anti-apoptotic members. Bax BH3 acts to regulate apoptosis via governance of the ‘intrinsic’ pathway of cell death[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    2267.60

    Formula

    C93H163N27O34S2
    CAS 号

    299946-20-6
    Sequence

    Ser-Thr-Lys-Lys-Leu-Ser-Glu-Cys-Leu-Lys-Arg-Ile-Gly-Asp-Glu-Leu-Asp-Ser-Asn-Met
    Sequence Shortening

    STKKLSECLKRIGDELDSNM
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    H2O

    Peptide Solubility and Storage Guidelines:

    1.  Calculate the length of the peptide.

    2.  Calculate the overall charge of the entire peptide according to the following table:

      Contents Assign value
    Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
    Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
    Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

    3.  Recommended solution:

    Overall charge of peptide Details
    Negative (<0) 1.  Try to dissolve the peptide in water first.
    2.  If water fails, add NH4OH (<50 μL).
    3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
    Positive (>0) 1.  Try to dissolve the peptide in water first.
    2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
    3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
    Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
    2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
    参考文献

    • [1]. Peter E Czabotar, et al. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem. 2011 Mar 4;286(9):7123-31.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    PUMA BH3 TFA

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    PUMA BH3 TFA 

    PUMA BH3 (TFA) 是一种 p53 正向凋亡调控因子 (PUMA) BH3 结构域多肽，作为 Bak 的直接激活剂，Kd 值为 26 nM。

    PUMA BH3 TFA

    PUMA BH3 TFA Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    PUMA BH3 (TFA) is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM[1].

    IC50 & Target[1]

    Bak

    26 nM (Kd)

    分子量

    3163.32

    Formula

    C130H203F3N42O45S
    Sequence Shortening

    EEQWAREIGAQLRRMADDLNAQYER
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Dai H, et al. Evaluation of the BH3-only protein Puma as a direct Bak activator. J Biol Chem. 2014 Jan 3;289(1):89-99.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    PUMA BH3 TFA

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    PUMA BH3 TFA 

    PUMA BH3 (TFA) 是一种 p53 正向凋亡调控因子 (PUMA) BH3 结构域多肽，作为 Bak 的直接激活剂，Kd 值为 26 nM。

    PUMA BH3 TFA

    PUMA BH3 TFA Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    PUMA BH3 (TFA) is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM[1].

    IC50 & Target[1]

    Bak

    26 nM (Kd)

    分子量

    3163.32

    Formula

    C130H203F3N42O45S
    Sequence Shortening

    EEQWAREIGAQLRRMADDLNAQYER
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Dai H, et al. Evaluation of the BH3-only protein Puma as a direct Bak activator. J Biol Chem. 2014 Jan 3;289(1):89-99.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    PUMA BH3 TFA

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    PUMA BH3 TFA 

    PUMA BH3 (TFA) 是一种 p53 正向凋亡调控因子 (PUMA) BH3 结构域多肽，作为 Bak 的直接激活剂，Kd 值为 26 nM。

    PUMA BH3 TFA

    PUMA BH3 TFA Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    PUMA BH3 (TFA) is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM[1].

    IC50 & Target[1]

    Bak

    26 nM (Kd)

    分子量

    3163.32

    Formula

    C130H203F3N42O45S
    Sequence Shortening

    EEQWAREIGAQLRRMADDLNAQYER
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Dai H, et al. Evaluation of the BH3-only protein Puma as a direct Bak activator. J Biol Chem. 2014 Jan 3;289(1):89-99.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务