上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Bryostatin 1 (Synonyms: 苔藓抑素1) 纯度: ≥99.0%
Bryostatin 1 是一种天然的大环内酯类化合物,从苔藓虫 Bugula neritina 中分离出来,也是一种有效的中枢神经系统 (CNS) 渗透性的 PKC 调节剂。Bryostatin 1 以 Ki 值为 8.07 nM 和 0.45 nM 分别结合到分离的 Munc13-1 的 C1 域和全长的 Munc13-1 蛋白。Bryostatin 1 具有抗癌,抗炎,神经保护,抗 HIV-1 感染的特性。
Bryostatin 1 Chemical Structure
CAS No. : 83314-01-6
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
10 μg | ¥6200 | In-stock |
* Please select Quantity before adding items.
生物活性 |
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties[1][2][3][4]. |
IC50 & Target |
PKC[1] |
|||||||
---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
Bryostatin 1 (1 µM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation [1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
|
|||||||||
体内研究 (In Vivo) |
Bryostatin 1 (30 μg/kg; intraperitoneal injection; 3 d per week; for 2 weeks; C57BL/6J mice) treatment abolishes the onset of EAE[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
|
|||||||||
Clinical Trial |
|
|||||||||
分子量 |
905.03 |
|||||||||
Formula |
C47H68O17 |
|||||||||
CAS 号 |
83314-01-6 |
|||||||||
中文名称 |
苔藓抑素1 |
|||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
|||||||||
储存方式 |
|
|||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务