标签归档：butoxycarbonyl

Butoxycarbonyl-PEG5-sulfonic acid

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Butoxycarbonyl-PEG5-sulfonic acid 

Butoxycarbonyl-PEG5-sulfonic acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Butoxycarbonyl-PEG5-sulfonic acid

Butoxycarbonyl-PEG5-sulfonic acid Chemical Structure

CAS No. : 1817735-28-6

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生物活性

Butoxycarbonyl-PEG5-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

430.51

Formula

C17H34O10S
CAS 号

1817735-28-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 是一种可降解 (cleavable) 的 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 也是一种 PROTAC linker，属于 PEG 和 Alkyl/ether 类，可用于合成 PROTAC 分子。

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Chemical Structure

CAS No. : 175724-30-8

规格 价格 是否有货 数量
50 mg ￥500 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

Cleavable

 

Alkyl/ether

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

505.64

Formula

C25H47NO9
CAS 号

175724-30-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Kostiainen MA, et al. Optically degradable dendrons for temporary adhesion of proteins to DNA. Chemistry. 2010 Jun 18;16(23):6912-8.

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N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline Chemical Structure

CAS No. : 147266-92-0

规格 价格 是否有货 数量
1 g ￥400 In-stock
5 g ￥560 In-stock
10 g   询价  
50 g   询价  

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生物活性

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

IC50 & Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

231.25

Formula

C10H17NO5
CAS 号

147266-92-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid_143527-70-2

发表于由
3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

  【编号】：VIP(XL)80371

  【产品名称】：3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

  【规格】：5mg；98%

  【用途】：

　　3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid对照品

　　编号：VIP(XL)80371
　　英文：3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid
　　CAS号：143527-70-2
　　分子式：C17H23NO5
3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid_143527-70-2
　　规格：可定做：10mg；20mg；50mg；100mg
　　声明：此对照品、标准品由上海金畔生物科技有限公司提供网站查询购买服务
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