Carvedilol-d5(Synonyms: BM 14190-d5)

发表于2024年10月29日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Carvedilol-d5 (Synonyms: BM 14190-d5)

Carvedilol-d5 是 Carvedilol 氘代物。Carvedilol (BM 14190) 是一种非选择性 β/α-1 受体阻断剂。Carvedilol 抑制脂质过氧化，IC₅₀ 为 5 μM。Carvedilol 是一种多用途降压剂，有潜力用于心绞痛和充血性心力衰竭的研究。Carvedilol是一种自噬 (autophagy) 诱导剂，可抑制 NLRP3 炎性体。

Carvedilol-d5 Chemical Structure

CAS No. : 929106-58-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Carvedilol-d5 is deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker^[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure^[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome^[3].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	411.51
Formula	C₂₄H₂₁D₅N₂O₄
CAS 号	929106-58-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22. [3]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8. [4]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol(Synonyms: 卡维地洛; BM 14190)

发表于2024年9月8日由上海金畔生物科技有限公司

Carvedilol (Synonyms: 卡维地洛; BM 14190) 纯度: 99.87%

Carvedilol (BM 14190) 是一种非选择性 β/α-1 受体阻断剂。Carvedilol 抑制脂质过氧化，IC₅₀ 为 5 μM。Carvedilol 是一种多用途降压剂，有潜力用于心绞痛和充血性心力衰竭的研究。Carvedilol是一种自噬 (autophagy) 诱导剂，可抑制 NLRP3 炎性体。

Carvedilol Chemical Structure

CAS No. : 72956-09-3

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥550	In-stock
100 mg	￥500	In-stock
500 mg	￥1000	In-stock
1 g		询价
5 g		询价

* Please select Quantity before adding items.

Carvedilol 相关产品

•相关化合物库:

Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
FDA-Approved Drug Library Mini
Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Immunology/Inflammation Compound Library
Neuronal Signaling Compound Library
FDA-Approved Drug Library
Anti-Cancer Compound Library
Autophagy Compound Library
Drug Repurposing Compound Library
Anti-Cardiovascular Disease Compound Library
Ferroptosis Compound Library
Anti-COVID-19 Compound Library
NMPA-Approved Drug Library
Orally Active Compound Library
Neurotransmitter Receptor Compound Library
FDA Approved & Pharmacopeial Drug Library
Anti-Alzheimer’s Disease Compound Library
Drug-Induced Liver Injury (DILI) Compound Library
Neurodegenerative Disease-related Compound Library
Rare Diseases Drug Library

生物活性

Carvedilol (BM 14190) is a non-selective β/α-1 blocker^[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure^[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome^[3].

IC₅₀ & Target

β/α-1 adrenergic receptor^[1]
IC50: 5 μM (lipid peroxidation)^[2]
Autophagy^[3]

体外研究
(In Vitro)

Superoxide generation by activated human neutrophils in vitro is inhibited by Carvedilol with an IC₅₀ of 28 μM. Carvedilol is shown to scavenge oxygen free radicals in a cell-free system with an IC₅₀ of 25 μM^[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

406.47

Formula

C₂₄H₂₆N₂O₄

CAS 号

72956-09-3

中文名称

卡维地洛；卡维地罗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (246.02 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4602 mL	12.3010 mL	24.6021 mL
5 mM	0.4920 mL	2.4602 mL	4.9204 mL
10 mM	0.2460 mL	1.2301 mL	2.4602 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.15 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (6.15 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (6.15 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.15 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22.

[2]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8.

[3]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

4-Hydroxyphenyl Carvedilol-d5(Synonyms: 4-Hydroxycarvedilol-d5)

发表于2024年4月13日由上海金畔生物科技有限公司

4-Hydroxyphenyl Carvedilol-d5 (Synonyms: 4-Hydroxycarvedilol-d5)

4-Hydroxyphenyl Carvedilol D5 是 4-Hydroxyphenyl Carvedilol 的氘代物。

4-Hydroxyphenyl Carvedilol-d5 Chemical Structure

CAS No. : 1261395-96-3

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	4-Hydroxyphenyl Carvedilol D5 is the deuterium labeled 4-Hydroxyphenyl Carvedilol.
分子量	427.50
Formula	C₂₄H₂₁D₅N₂O₅
CAS 号	1261395-96-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol-d4(Synonyms: BM 14190-d4)

发表于2024年4月11日由上海金畔生物科技有限公司

Carvedilol-d4 (Synonyms: BM 14190-d4)

Carvedilol-d4 (BM 14190-d4) 是 Carvedilol 的氘代物。Carvedilol (BM 14190) 是一种非选择性 β/α-1 受体阻断剂。Carvedilol 抑制脂质过氧化，IC₅₀ 为 5 μM。Carvedilol 是一种多用途降压剂，有潜力用于心绞痛和充血性心力衰竭的研究。Carvedilol是一种自噬 (autophagy) 诱导剂，可抑制 NLRP3 炎性体。

Carvedilol-d4 Chemical Structure

CAS No. : 1133705-56-2

规格	价格	是否有货
1 mg	￥2900	询问价格 & 货期
5 mg	￥8800	询问价格 & 货期
10 mg	￥14500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Carvedilol-d4 (BM 14190-d4) is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker^[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure^[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome^[3].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	410.50
Formula	C₂₄H₂₂D₄N₂O₄
CAS 号	1133705-56-2
中文名称	卡维地洛 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22. [3]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8. [4]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol-d3(Synonyms: 卡维地洛 d3)

发表于2024年4月10日由上海金畔生物科技有限公司

Carvedilol-d3 (Synonyms: 卡维地洛 d3)

AA 是 Carvedilol 的氘代物。Carvedilol (BM 14190) 是一种非选择性 β/α-1 受体阻断剂。Carvedilol 抑制脂质过氧化，IC₅₀ 为 5 μM。Carvedilol 是一种多用途降压剂，有潜力用于心绞痛和充血性心力衰竭的研究。Carvedilol是一种自噬 (autophagy) 诱导剂，可抑制 NLRP3 炎性体。

Carvedilol-d3 Chemical Structure

CAS No. : 1020719-25-8

规格		是否有货
1 mg		Check price and availability
10 mg		Check price and availability

* Please select Quantity before adding items.

生物活性	AA is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker^[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure^[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome^[3].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	409.49
Formula	C₂₄H₂₃D₃N₂O₄
CAS 号	1020719-25-8
中文名称	卡维地洛 d3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22. [3]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8. [4]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol(Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

发表于2023年11月15日由上海金畔生物科技有限公司

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol (Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

4-Hydroxyphenyl Carvedilol是Carvedilol的代谢物。

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol Chemical Structure

CAS No. : 142227-49-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker.

分子量

422.47

Formula

C₂₄H₂₆N₂O₅

CAS 号

142227-49-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol(Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

发表于2023年11月15日由上海金畔生物科技有限公司

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol (Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

4-Hydroxyphenyl Carvedilol是Carvedilol的代谢物。

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol Chemical Structure

CAS No. : 142227-49-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker.

分子量

422.47

Formula

C₂₄H₂₆N₂O₅

CAS 号

142227-49-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol(Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

发表于2023年11月15日由上海金畔生物科技有限公司

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol (Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

4-Hydroxyphenyl Carvedilol是Carvedilol的代谢物。

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol Chemical Structure

CAS No. : 142227-49-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker.

分子量

422.47

Formula

C₂₄H₂₆N₂O₅

CAS 号

142227-49-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol phosphate hemihydrate(Synonyms: BM 14190 phosphate hemihydrate)

发表于2023年11月15日由上海金畔生物科技有限公司

Carvedilol phosphate hemihydrate (Synonyms: BM 14190 phosphate hemihydrate)

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种非选择性 β/α-1 受体阻断剂。Carvedilol 抑制脂质过氧化，IC₅₀ 为 5 μM。Carvedilol 是一种多用途降压剂，有潜力用于心绞痛和充血性心力衰竭的研究。Carvedilol是一种自噬 (autophagy) 诱导剂，可抑制 NLRP3 炎性体。

Carvedilol phosphate hemihydrate Chemical Structure

CAS No. : 610309-89-2

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Carvedilol phosphate hemihydrate 的其他形式现货产品:

Carvedilol (S)-Carvedilol (R)-Carvedilol

生物活性

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker^[1]. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC₅₀ of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure^[2]. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome^[3].

IC₅₀ & Target

β/α-1 adrenergic receptor^[1]
IC50: 5 μM (lipid peroxidation)^[2]
Autophagy^[3]

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

513.48

Formula

C₂₄H₃₀N₂O_8.5P

CAS 号

610309-89-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22.

[2]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8.

[3]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol phosphate hemihydrate(Synonyms: BM 14190 phosphate hemihydrate)

发表于2023年11月15日由上海金畔生物科技有限公司

Carvedilol phosphate hemihydrate (Synonyms: BM 14190 phosphate hemihydrate)

Carvedilol phosphate hemihydrate Chemical Structure

CAS No. : 610309-89-2

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Carvedilol phosphate hemihydrate 的其他形式现货产品:

Carvedilol (S)-Carvedilol (R)-Carvedilol

生物活性

IC₅₀ & Target

β/α-1 adrenergic receptor^[1]
IC50: 5 μM (lipid peroxidation)^[2]
Autophagy^[3]

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

513.48

Formula

C₂₄H₃₀N₂O_8.5P

CAS 号

610309-89-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22.

[2]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8.

[3]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carvedilol phosphate hemihydrate(Synonyms: BM 14190 phosphate hemihydrate)

发表于2023年11月15日由上海金畔生物科技有限公司

Carvedilol phosphate hemihydrate (Synonyms: BM 14190 phosphate hemihydrate)

Carvedilol phosphate hemihydrate Chemical Structure

CAS No. : 610309-89-2

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Carvedilol phosphate hemihydrate 的其他形式现货产品:

Carvedilol (S)-Carvedilol (R)-Carvedilol

生物活性

IC₅₀ & Target

β/α-1 adrenergic receptor^[1]
IC50: 5 μM (lipid peroxidation)^[2]
Autophagy^[3]

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

513.48

Formula

C₂₄H₃₀N₂O_8.5P

CAS 号

610309-89-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22.

[2]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8.

[3]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

whatman (沃特曼)

英国沃特曼 Millipore PALL中国代理商金畔官网

标签归档：carvedilol

Carvedilol-d5(Synonyms: BM 14190-d5)

Carvedilol(Synonyms: 卡维地洛; BM 14190)

Carvedilol 相关产品

•相关化合物库:

4-Hydroxyphenyl Carvedilol-d5(Synonyms: 4-Hydroxycarvedilol-d5)

Carvedilol-d4(Synonyms: BM 14190-d4)

Carvedilol-d3(Synonyms: 卡维地洛 d3)

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol(Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol(Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol(Synonyms: 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol)

Carvedilol phosphate hemihydrate(Synonyms: BM 14190 phosphate hemihydrate)

Carvedilol phosphate hemihydrate(Synonyms: BM 14190 phosphate hemihydrate)

Carvedilol phosphate hemihydrate(Synonyms: BM 14190 phosphate hemihydrate)

2024年 11月
一	二	三	四	五	六	日
				1	2	3
4	5	6	7	8	9	10
11	12	13	14	15	16	17
18	19	20	21	22	23	24
25	26	27	28	29	30