标签归档：catecholestrone

2-Hydroxyestrone-d4(Synonyms: Catecholestrone-d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxyestrone-d4 (Synonyms: Catecholestrone-d4)

2-Hydroxyestrone-d4 (Catecholestrone-d4) 是 2-Hydroxyestrone 的氘代物。2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

2-Hydroxyestrone-d4(Synonyms: Catecholestrone-d4)

2-Hydroxyestrone-d4 Chemical Structure

CAS No. : 81586-97-2

规格 是否有货
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生物活性

2-Hydroxyestrone-d4 (Catecholestrone-d4) is the deuterium labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

290.39

Formula

C18H18D4O3
CAS 号

81586-97-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. H L Bradlow, et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.

    [3]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.

    [4]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

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2-Hydroxyestrone(Synonyms: Catecholestrone)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxyestrone (Synonyms: Catecholestrone)

2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

2-Hydroxyestrone(Synonyms: Catecholestrone)

2-Hydroxyestrone Chemical Structure

CAS No. : 362-06-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

Estrogen receptor

 

体外研究
(In Vitro)

2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-330
Concentration: 1-1000 nM
Incubation Time: 6 days
Result: 10 and 100 nM markedly suppressed the growth and proliferation of the cells in the presence of quinalizarin. The tumor cell growth-inhibitory action of the catechol estrogen was neutralized by the presence of 1 nM estradiol.

体内研究
(In Vivo)

Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.) and  2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1 4SR) in rats treated with 2-Hydroxyestrone were significantly different between the induced and noninduced groups[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male Sprague-Dawley rats (6 weeks old)[3]
Dosage: 2 mg/kg
Administration: Administered i.p.
Result: Levels of both 2-OHE1 and  2-OHE1 4SR in rats treated with 2-OHE1 were significantly different between the induced and noninduced groups.

分子量

286.37

Formula

C18H22O3
CAS 号

362-06-1
中文名称

2-羟雌甾酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vivo:
  • 1.

    2-Hydroxyestrone is suspended in corn oil by sonication[3].
参考文献

  • [1]. H L Bradlow, et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.

    [2]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.

    [3]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-Hydroxyestrone(Synonyms: Catecholestrone)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxyestrone (Synonyms: Catecholestrone)

2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

2-Hydroxyestrone(Synonyms: Catecholestrone)

2-Hydroxyestrone Chemical Structure

CAS No. : 362-06-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

Estrogen receptor

 

体外研究
(In Vitro)

2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-330
Concentration: 1-1000 nM
Incubation Time: 6 days
Result: 10 and 100 nM markedly suppressed the growth and proliferation of the cells in the presence of quinalizarin. The tumor cell growth-inhibitory action of the catechol estrogen was neutralized by the presence of 1 nM estradiol.

体内研究
(In Vivo)

Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.) and  2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1 4SR) in rats treated with 2-Hydroxyestrone were significantly different between the induced and noninduced groups[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male Sprague-Dawley rats (6 weeks old)[3]
Dosage: 2 mg/kg
Administration: Administered i.p.
Result: Levels of both 2-OHE1 and  2-OHE1 4SR in rats treated with 2-OHE1 were significantly different between the induced and noninduced groups.

分子量

286.37

Formula

C18H22O3
CAS 号

362-06-1
中文名称

2-羟雌甾酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vivo:
  • 1.

    2-Hydroxyestrone is suspended in corn oil by sonication[3].
参考文献

  • [1]. H L Bradlow, et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.

    [2]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.

    [3]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-Hydroxyestrone(Synonyms: Catecholestrone)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxyestrone (Synonyms: Catecholestrone)

2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

2-Hydroxyestrone(Synonyms: Catecholestrone)

2-Hydroxyestrone Chemical Structure

CAS No. : 362-06-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

Estrogen receptor

 

体外研究
(In Vitro)

2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-330
Concentration: 1-1000 nM
Incubation Time: 6 days
Result: 10 and 100 nM markedly suppressed the growth and proliferation of the cells in the presence of quinalizarin. The tumor cell growth-inhibitory action of the catechol estrogen was neutralized by the presence of 1 nM estradiol.

体内研究
(In Vivo)

Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.) and  2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1 4SR) in rats treated with 2-Hydroxyestrone were significantly different between the induced and noninduced groups[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male Sprague-Dawley rats (6 weeks old)[3]
Dosage: 2 mg/kg
Administration: Administered i.p.
Result: Levels of both 2-OHE1 and  2-OHE1 4SR in rats treated with 2-OHE1 were significantly different between the induced and noninduced groups.

分子量

286.37

Formula

C18H22O3
CAS 号

362-06-1
中文名称

2-羟雌甾酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vivo:
  • 1.

    2-Hydroxyestrone is suspended in corn oil by sonication[3].
参考文献

  • [1]. H L Bradlow, et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.

    [2]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.

    [3]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-Hydroxyestrone-13C6(Synonyms: Catecholestrone-13C6)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxyestrone-13C6 (Synonyms: Catecholestrone-13C6)

2-Hydroxyestrone-13C6 (Catecholestrone-13C6) 是一种 13C 标记的 2-Hydroxyestrone。2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

2-Hydroxyestrone-13C6(Synonyms: Catecholestrone-13C6)

2-Hydroxyestrone-13C6 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-Hydroxyestrone-13C6 (Catecholestrone-13C6) is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

292.32

Formula

C1213C6H22O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. H L Bradlow, et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.

    [3]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.

    [4]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-Hydroxyestrone-13C6(Synonyms: Catecholestrone-13C6)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxyestrone-13C6 (Synonyms: Catecholestrone-13C6)

2-Hydroxyestrone-13C6 (Catecholestrone-13C6) 是一种 13C 标记的 2-Hydroxyestrone。2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

2-Hydroxyestrone-13C6(Synonyms: Catecholestrone-13C6)

2-Hydroxyestrone-13C6 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-Hydroxyestrone-13C6 (Catecholestrone-13C6) is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

292.32

Formula

C1213C6H22O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. H L Bradlow, et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.

    [3]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.

    [4]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-Hydroxyestrone-13C6(Synonyms: Catecholestrone-13C6)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxyestrone-13C6 (Synonyms: Catecholestrone-13C6)

2-Hydroxyestrone-13C6 (Catecholestrone-13C6) 是一种 13C 标记的 2-Hydroxyestrone。2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

2-Hydroxyestrone-13C6(Synonyms: Catecholestrone-13C6)

2-Hydroxyestrone-13C6 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-Hydroxyestrone-13C6 (Catecholestrone-13C6) is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

292.32

Formula

C1213C6H22O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. H L Bradlow, et al. 2-Hydroxyestrone: the ‘good’ estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65.

    [3]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5.

    [4]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务