Cathepsin L-IN-2 (Z-Phe-Phe-FMK) 是一种有效且不可逆的组织蛋白酶 L (cathepsin L) 和组织蛋白酶 B (cathepsin B) 抑制剂。
Cathepsin L-IN-2 Chemical Structure
CAS No. : 108005-94-3
规格
是否有货
5 mg
询价
10 mg
询价
50 mg
询价
100 mg
询价
* Please select Quantity before adding items.
生物活性
Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor[1][2].
分子量
462.51
Formula
C27H27FN2O4
CAS 号
108005-94-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15(1):21.
[2]. Kirsi Ravanko, et al. Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts. Cancer Res. 2004 Dec 15;64(24):8831-8.
Cathepsin L-IN-2 (Z-Phe-Phe-FMK) 是一种有效且不可逆的组织蛋白酶 L (cathepsin L) 和组织蛋白酶 B (cathepsin B) 抑制剂。
Cathepsin L-IN-2 Chemical Structure
CAS No. : 108005-94-3
规格
是否有货
5 mg
询价
10 mg
询价
50 mg
询价
100 mg
询价
* Please select Quantity before adding items.
生物活性
Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor[1][2].
分子量
462.51
Formula
C27H27FN2O4
CAS 号
108005-94-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15(1):21.
[2]. Kirsi Ravanko, et al. Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts. Cancer Res. 2004 Dec 15;64(24):8831-8.
Cathepsin L-IN-2 (Z-Phe-Phe-FMK) 是一种有效且不可逆的组织蛋白酶 L (cathepsin L) 和组织蛋白酶 B (cathepsin B) 抑制剂。
Cathepsin L-IN-2 Chemical Structure
CAS No. : 108005-94-3
规格
是否有货
5 mg
询价
10 mg
询价
50 mg
询价
100 mg
询价
* Please select Quantity before adding items.
生物活性
Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor[1][2].
分子量
462.51
Formula
C27H27FN2O4
CAS 号
108005-94-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15(1):21.
[2]. Kirsi Ravanko, et al. Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts. Cancer Res. 2004 Dec 15;64(24):8831-8.
Cathepsin inhibitor 1 (compound 25) is a potent and selective inhibitor of Cathepsin, with pIC50s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively[1].
分子量
401.89
Formula
C20H24ClN5O2
CAS 号
225120-65-0
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Asaad N, et, al. Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4280-3.
Cathepsin D and E FRET Substrate acetate 纯度: 99.06%
Cathepsin D and E FRET Substrate acetate 为 cathepins D 和 E 的荧光底物 (fluorogenic substrate)，而不是 B、H 或 I 的荧光底物，它的裂解发生在 Phe-Phe 酰胺键处。Cathepsin D and E FRET Substrate 是用于组织蛋白酶 D 和组织蛋白酶 E 的常规检测和机制研究的有用工具。(激发波长:328 nm; 发射波长:393 nm)
Cathepsin D and E FRET Substrate acetate Chemical Structure
规格
价格
是否有货
数量
5 mg
￥2800
In-stock
10 mg
￥4500
In-stock
25 mg
￥8900
In-stock
50 mg
询价
100 mg
询价
* Please select Quantity before adding items.
Cathepsin D and E FRET Substrate acetate 相关产品
•相关化合物库:
Bioactive Compound Library Plus
Peptide Library
生物活性
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D[1].
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC50 of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic[1].
IC50 & Target
IC50: 7.13 µM (Cathepsin X)[1]
分子量
315.35
Formula
C15H13N3O3S
CAS 号
2418577-51-0
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Fonović UP, et al. Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X. Eur J Med Chem. 2020 May 1;193:112218.
