Caxii | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CAIX/CAXII-IN-1

化合物9对肿瘤特异性CA IX/CA XII（KI=29.1和8.8 nM）最有效，因此有可能在体外评估其对HepG-2、HCT-116和MCF-7癌细胞系的细胞毒性和选择性，而其对肿瘤细胞的IC₅₀值分别为1.78、1.94和3.07μM，表明其有明显的细胞毒性。

CAIX/CAXII-IN-1 Chemical Structure

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生物活性	Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC₅₀ values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.
分子量	620.48
Formula	C₂₄H₂₁IN₄O₄S₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Soliman AM,et al. Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity. Eur J Med Chem. 2020 Aug 15;200:112449.

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CAXII-IN-1

CAXII-IN-1 (Compound 17) 是一种选择性的 CA XII 抑制剂，对 hCA XII 和 hCA IX 的 K_i 值分别为 3.8 nM 和 56.0 nM。CAXII-IN-1 具有抗肿瘤活性。

CAXII-IN-1 Chemical Structure

CAS No. : 2479918-59-5

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生物活性	CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with K_i values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity^[1].
IC₅₀ & Target	IC₅₀: 3.8 nM (hCA XII), 56.0 nM (hCA IX)^[1]
体外研究 (In Vitro)	CAXII-IN-1 (Compound 17) shows cytotoxicity with IC₅₀ values of 20±1, 4.8±0.03 and 14±2 µM against MCF-7, HeLa and A549 cells, respectively^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	328.17
Formula	C₁₃H₇Cl₂NO₃S
CAS 号	2479918-59-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Grandāne A, et al. Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. Eur J Med Chem. 2020 Aug 15;200:112300.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

whatman (沃特曼)