标签归档：cdk

PROTAC CDK9 degrader-4

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PROTAC CDK9 degrader-4 

PROTAC CDK9 degrader-4 是一种高效、靶向转录调控的 CDK9 降解物。

PROTAC CDK9 degrader-4

PROTAC CDK9 degrader-4 Chemical Structure

CAS No. : 2411021-01-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC CDK9 degrader-4 is a highly potent and efficacious CDK9 degrader for targeting transcription regulation.

分子量

792.97

Formula

C43H56N10O5
CAS 号

2411021-01-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14822-14847.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PROTAC CDK9 ligand-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PROTAC CDK9 ligand-1 

PROTAC CDK9 ligand-1 是一种可用于合成 PROTAC 的 CDK9 配体。

PROTAC CDK9 ligand-1

PROTAC CDK9 ligand-1 Chemical Structure

CAS No. : 2411021-95-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

分子量

368.48

Formula

C20H28N6O
CAS 号

2411021-95-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14822-14847.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PROTAC CDK9 degrader-4

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PROTAC CDK9 degrader-4 

PROTAC CDK9 degrader-4 是一种高效、靶向转录调控的 CDK9 降解物。

PROTAC CDK9 degrader-4

PROTAC CDK9 degrader-4 Chemical Structure

CAS No. : 2411021-01-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC CDK9 degrader-4 is a highly potent and efficacious CDK9 degrader for targeting transcription regulation.

分子量

792.97

Formula

C43H56N10O5
CAS 号

2411021-01-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14822-14847.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PROTAC CDK9 ligand-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PROTAC CDK9 ligand-1 

PROTAC CDK9 ligand-1 是一种可用于合成 PROTAC 的 CDK9 配体。

PROTAC CDK9 ligand-1

PROTAC CDK9 ligand-1 Chemical Structure

CAS No. : 2411021-95-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

分子量

368.48

Formula

C20H28N6O
CAS 号

2411021-95-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14822-14847.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK/HDAC-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK/HDAC-IN-1 

CDK/HDAC-IN-1 显示出显著的 CDK2/4/6 和 HDAC6 抑制活性（IC50 = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, 和 128.6 ± 0.4 nM）。

CDK/HDAC-IN-1

CDK/HDAC-IN-1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK/HDAC-IN-1 shows remarkable CDK2/4/6 and HDAC6 inhibitory activity of IC50 = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, and 128.6 ± 0.4 nM, respectively.

分子量

378.38

Formula

C20H18N4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Cao Z, et al. Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer. J Med Chem. 2021 Oct 28;64(20):15280-15296.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PROTAC CDK9 degrader-4

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PROTAC CDK9 degrader-4 

PROTAC CDK9 degrader-4 是一种高效、靶向转录调控的 CDK9 降解物。

PROTAC CDK9 degrader-4

PROTAC CDK9 degrader-4 Chemical Structure

CAS No. : 2411021-01-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC CDK9 degrader-4 is a highly potent and efficacious CDK9 degrader for targeting transcription regulation.

分子量

792.97

Formula

C43H56N10O5
CAS 号

2411021-01-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14822-14847.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PROTAC CDK9 ligand-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PROTAC CDK9 ligand-1 

PROTAC CDK9 ligand-1 是一种可用于合成 PROTAC 的 CDK9 配体。

PROTAC CDK9 ligand-1

PROTAC CDK9 ligand-1 Chemical Structure

CAS No. : 2411021-95-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

分子量

368.48

Formula

C20H28N6O
CAS 号

2411021-95-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wei D, et al. Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14822-14847.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK/HDAC-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK/HDAC-IN-1 

CDK/HDAC-IN-1 显示出显著的 CDK2/4/6 和 HDAC6 抑制活性（IC50 = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, 和 128.6 ± 0.4 nM）。

CDK/HDAC-IN-1

CDK/HDAC-IN-1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK/HDAC-IN-1 shows remarkable CDK2/4/6 and HDAC6 inhibitory activity of IC50 = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, and 128.6 ± 0.4 nM, respectively.

分子量

378.38

Formula

C20H18N4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Cao Z, et al. Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer. J Med Chem. 2021 Oct 28;64(20):15280-15296.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK/HDAC-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK/HDAC-IN-1 

CDK/HDAC-IN-1 显示出显著的 CDK2/4/6 和 HDAC6 抑制活性（IC50 = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, 和 128.6 ± 0.4 nM）。

CDK/HDAC-IN-1

CDK/HDAC-IN-1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK/HDAC-IN-1 shows remarkable CDK2/4/6 and HDAC6 inhibitory activity of IC50 = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, and 128.6 ± 0.4 nM, respectively.

分子量

378.38

Formula

C20H18N4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Cao Z, et al. Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer. J Med Chem. 2021 Oct 28;64(20):15280-15296.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK1/Cyc B-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK1/Cyc B-IN-1 

CDK1/Cyc B-IN-1 (Compound 5) 是一种选择性的 CDK1/Cyc B 复合体抑制剂，IC50 为 97 nM。CDK1/Cyc B-IN-1 诱导细胞凋亡 (apoptosis) 和 G2/M 细胞期阻滞。CDK1/Cyc B-IN-1 对癌细胞具有广谱的细胞毒性。

CDK1/Cyc B-IN-1

CDK1/Cyc B-IN-1 Chemical Structure

CAS No. : 2459916-56-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines[1].

IC50 & Target

CDK1-Cyclin B

97 nM (IC50)

体外研究
(In Vitro)

CDK1/Cyc B-IN-1 (Compound 5) shows cytotoxic activity with IC50 values of 5.33 ± 0.69 µM and 21.69 ± 1.04 µM against HCT-116 and WI-38, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

353.85

Formula

C14H12ClN3O2S2
CAS 号

2459916-56-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):115633.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7-IN-5

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7-IN-5 

CDK7-IN-5 是一种 CDK7 抑制剂，IC50 值 <100 nM。CDK7-IN-5 具有抗癌作用。(WO2015154022A1 (Compound 104))。

CDK7-IN-5

CDK7-IN-5 Chemical Structure

CAS No. : 1817006-50-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-5 is a CDK7 inhibitor with an IC50 value <100 nm. cdk7-in-5 has anticancer effects. (wo2015154022a1 (compound 104))[1].

IC50 & Target[1]

CDK7

<100 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-5 (Comp 104; 72 hours) inhibits the proliferation of A673 cells with an IC50 <500 nm[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

611.78

Formula

C34H45N9O2
CAS 号

1817006-50-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jason J. MARINEAU, et al. Inhibitors of cyclin-dependent kinase 7 (cdk7). WO2015154022A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7-IN-5

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7-IN-5 

CDK7-IN-5 是一种 CDK7 抑制剂，IC50 值 <100 nM。CDK7-IN-5 具有抗癌作用。(WO2015154022A1 (Compound 104))。

CDK7-IN-5

CDK7-IN-5 Chemical Structure

CAS No. : 1817006-50-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-5 is a CDK7 inhibitor with an IC50 value <100 nm. cdk7-in-5 has anticancer effects. (wo2015154022a1 (compound 104))[1].

IC50 & Target[1]

CDK7

<100 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-5 (Comp 104; 72 hours) inhibits the proliferation of A673 cells with an IC50 <500 nm[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

611.78

Formula

C34H45N9O2
CAS 号

1817006-50-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jason J. MARINEAU, et al. Inhibitors of cyclin-dependent kinase 7 (cdk7). WO2015154022A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK2-IN-8

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK2-IN-8 

CDK2-IN-8 是一种有效的 CDK2 抑制剂，IC50 为 1.74 µM。CDK2-IN-8 显示出抗增殖活性。CDK2-IN-8 具有研究黑色素瘤的潜力。

CDK2-IN-8

CDK2-IN-8 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK2-IN-8 is a potent CDK2 inhibitor with an IC50 of 1.74 µM. CDK2-IN-8 shows antiproliferative activity. CDK2-IN-8 has the potential for the research of melanoma[1].

IC50 & Target[1]

CDK2

1.74 μM (IC50)

体外研究
(In Vitro)

CDK2-IN-8 (compound 8a) shows antiproliferative activity with IC50s of 6.22, 37.24 µM for MDA-MB-435, WI-38 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

407.47

Formula

C22H25N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mohammed ER, et al. Development of newly synthesised quinazolinone-based CDK2 inhibitors with potent efficacy against melanoma. J Enzyme Inhib Med Chem. 2022 Dec;37(1):686-700.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7-IN-5

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7-IN-5 

CDK7-IN-5 是一种 CDK7 抑制剂，IC50 值 <100 nM。CDK7-IN-5 具有抗癌作用。(WO2015154022A1 (Compound 104))。

CDK7-IN-5

CDK7-IN-5 Chemical Structure

CAS No. : 1817006-50-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-5 is a CDK7 inhibitor with an IC50 value <100 nm. cdk7-in-5 has anticancer effects. (wo2015154022a1 (compound 104))[1].

IC50 & Target[1]

CDK7

<100 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-5 (Comp 104; 72 hours) inhibits the proliferation of A673 cells with an IC50 <500 nm[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

611.78

Formula

C34H45N9O2
CAS 号

1817006-50-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jason J. MARINEAU, et al. Inhibitors of cyclin-dependent kinase 7 (cdk7). WO2015154022A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7/9-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7/9-IN-1 

CDK7/9-IN-1 是一种细胞周期蛋白依赖性激酶 7/9 (CDK7/9) 抑制剂。CDK7/9-IN-1 选择性抑制 CDK7。CDK7/9-IN-1 在非预孵育和预孵育 3 小时后抑制 CDK7，IC50 分别为 0.0656 μM 和 0.00574 μM。 CDK7/9-IN-1 在预孵育 3 小时后抑制 CDK9，IC50 为 2.14 μM。 CDK7/9-IN-1可用于癌症研究。

CDK7/9-IN-1

CDK7/9-IN-1 Chemical Structure

CAS No. : 2747919-19-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer[1].

IC50 & Target[1]

CDK7

5.74-65.6 nM (IC50)

CDK9

2.14 μM (IC50)

体外研究
(In Vitro)

CDK7/9-IN-1 (example 8; 0.001-20 μM; 4 h) inhibits CDK7 with an relative IC50 of 0.0262 μM for phospho-carboxyl terminal domain (Rbp2) (Ser5) in HCT116 cells[1].
CDK7/9-IN-1 (0.001-20 μM; 4 h) inhibits CDK9 with an IC50 of 2.59 μM for phospho-carboxyl terminal domain (Rbp2) (Ser2) in HCT116 cells[1].
CDK7/9-IN-1 (0.001-20 μM; 4 h) inhibits cMyc with an relative IC50 of 0.0138 μM in HCT116 cells[1].
CDK7/9-IN-1 (20 μΜ, 2 μΜ, and 0.2 μΜ; 1 h) shows excellent selectivity against the 468 protein kinases panel. CDK7/9-IN-1 shows approximately 96% inhibition against CDK7[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

479.54

Formula

C24H32F3N5O2
CAS 号

2747919-19-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Maria Carmen FERNANDEZ FIGUEROA, et al. Compounds useful for inhibiting cdk7. WO2021242602 A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7/9-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7/9-IN-1 

CDK7/9-IN-1 是一种细胞周期蛋白依赖性激酶 7/9 (CDK7/9) 抑制剂。CDK7/9-IN-1 选择性抑制 CDK7。CDK7/9-IN-1 在非预孵育和预孵育 3 小时后抑制 CDK7，IC50 分别为 0.0656 μM 和 0.00574 μM。 CDK7/9-IN-1 在预孵育 3 小时后抑制 CDK9，IC50 为 2.14 μM。 CDK7/9-IN-1可用于癌症研究。

CDK7/9-IN-1

CDK7/9-IN-1 Chemical Structure

CAS No. : 2747919-19-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer[1].

IC50 & Target[1]

CDK7

5.74-65.6 nM (IC50)

CDK9

2.14 μM (IC50)

体外研究
(In Vitro)

CDK7/9-IN-1 (example 8; 0.001-20 μM; 4 h) inhibits CDK7 with an relative IC50 of 0.0262 μM for phospho-carboxyl terminal domain (Rbp2) (Ser5) in HCT116 cells[1].
CDK7/9-IN-1 (0.001-20 μM; 4 h) inhibits CDK9 with an IC50 of 2.59 μM for phospho-carboxyl terminal domain (Rbp2) (Ser2) in HCT116 cells[1].
CDK7/9-IN-1 (0.001-20 μM; 4 h) inhibits cMyc with an relative IC50 of 0.0138 μM in HCT116 cells[1].
CDK7/9-IN-1 (20 μΜ, 2 μΜ, and 0.2 μΜ; 1 h) shows excellent selectivity against the 468 protein kinases panel. CDK7/9-IN-1 shows approximately 96% inhibition against CDK7[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

479.54

Formula

C24H32F3N5O2
CAS 号

2747919-19-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Maria Carmen FERNANDEZ FIGUEROA, et al. Compounds useful for inhibiting cdk7. WO2021242602 A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7/9-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7/9-IN-1 

CDK7/9-IN-1 是一种细胞周期蛋白依赖性激酶 7/9 (CDK7/9) 抑制剂。CDK7/9-IN-1 选择性抑制 CDK7。CDK7/9-IN-1 在非预孵育和预孵育 3 小时后抑制 CDK7，IC50 分别为 0.0656 μM 和 0.00574 μM。 CDK7/9-IN-1 在预孵育 3 小时后抑制 CDK9，IC50 为 2.14 μM。 CDK7/9-IN-1可用于癌症研究。

CDK7/9-IN-1

CDK7/9-IN-1 Chemical Structure

CAS No. : 2747919-19-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer[1].

IC50 & Target[1]

CDK7

5.74-65.6 nM (IC50)

CDK9

2.14 μM (IC50)

体外研究
(In Vitro)

CDK7/9-IN-1 (example 8; 0.001-20 μM; 4 h) inhibits CDK7 with an relative IC50 of 0.0262 μM for phospho-carboxyl terminal domain (Rbp2) (Ser5) in HCT116 cells[1].
CDK7/9-IN-1 (0.001-20 μM; 4 h) inhibits CDK9 with an IC50 of 2.59 μM for phospho-carboxyl terminal domain (Rbp2) (Ser2) in HCT116 cells[1].
CDK7/9-IN-1 (0.001-20 μM; 4 h) inhibits cMyc with an relative IC50 of 0.0138 μM in HCT116 cells[1].
CDK7/9-IN-1 (20 μΜ, 2 μΜ, and 0.2 μΜ; 1 h) shows excellent selectivity against the 468 protein kinases panel. CDK7/9-IN-1 shows approximately 96% inhibition against CDK7[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

479.54

Formula

C24H32F3N5O2
CAS 号

2747919-19-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Maria Carmen FERNANDEZ FIGUEROA, et al. Compounds useful for inhibiting cdk7. WO2021242602 A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7-IN-6

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7-IN-6 

CDK7-IN-6 是一种有效的选择性细胞周期蛋白依赖性激酶 (CDK7) 抑制剂 (IC50≤100 nM)，来自专利 WO2019197549 A1，compound 210。CDK7- IN-6 对 CDK7 的选择性比 CDK1、CDK2 和 CDK5 高 200 倍以上。CDK7-IN-6 可用于癌症研究。

CDK7-IN-6

CDK7-IN-6 Chemical Structure

CAS No. : 2378710-04-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC50≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5. CDK7-IN-6 can be used for the research of cancer[1].

IC50 & Target[1]

CDK7

≤100 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-6 inhibits the viability of HCT116, H460, MV4-11, A2780, and OVCAR cells (IC50≤1 μM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

524.06

Formula

C26H34ClN9O
CAS 号

2378710-04-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kiyean NAM, et al.Preparation of pyrazolotriazine and/or pyrazolopyrimidine derivatives as selective inhibitor of cyclin dependent kinase. WO2019197549 A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7-IN-7

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7-IN-7 

CDK7-IN-7 是一种有效的 CDK7 抑制剂，IC50 为 <50 nM. 详细信息可参考专利 CN112661745A, compound T-01。

CDK7-IN-7

CDK7-IN-7 Chemical Structure

CAS No. : 2640208-01-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-7 is a potent and selective CDK7 kinase inhibitor with an IC50 of <50 nm (patent cn112661745a, compound t-01)[1].

IC50 & Target[1]

CDK7

<50 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-7 shows inhibitory against MDA‑MB 231, MDA-MB453, OVCAR3, A2780, HCT-116, WiDr and Calu-6 cells (IC50 ranging from 12.21 to 144.9 nM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

513.31

Formula

C20H20BrF3N6O2
CAS 号

2640208-01-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Compounds useful as CDK7 kinase inhibitors and uses thereof. CN112661745A.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK7-IN-6

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CDK7-IN-6 

CDK7-IN-6 是一种有效的选择性细胞周期蛋白依赖性激酶 (CDK7) 抑制剂 (IC50≤100 nM)，来自专利 WO2019197549 A1，compound 210。CDK7- IN-6 对 CDK7 的选择性比 CDK1、CDK2 和 CDK5 高 200 倍以上。CDK7-IN-6 可用于癌症研究。

CDK7-IN-6

CDK7-IN-6 Chemical Structure

CAS No. : 2378710-04-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC50≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5. CDK7-IN-6 can be used for the research of cancer[1].

IC50 & Target[1]

CDK7

≤100 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-6 inhibits the viability of HCT116, H460, MV4-11, A2780, and OVCAR cells (IC50≤1 μM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

524.06

Formula

C26H34ClN9O
CAS 号

2378710-04-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kiyean NAM, et al.Preparation of pyrazolotriazine and/or pyrazolopyrimidine derivatives as selective inhibitor of cyclin dependent kinase. WO2019197549 A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务