Cibisatamab (CEA-TCB) 是一种 T 细胞双特异性抗体,与癌细胞上的癌胚抗原 (CEA) 和 T 细胞上的 CD3 结合。Cibisatamab (CEA-TCB) 对细胞表面表达中到高水平 CEA 的癌细胞系触发 T 细胞杀伤。Cibisatamab (CEA-TCB) 可用于结直肠癌研究。
Cibisatamab Chemical Structure
CAS No. : 1855925-27-7
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
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生物活性
Cibisatamab (CEA-TCB), a T cell bispecific antibody, binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab (CEA-TCB) triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cell surface. Cibisatamab (CEA-TCB) can be used for colorectal cancer research[1].
CAS 号
1855925-27-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Reyes Gonzalez-Exposito, et al. CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. J Immunother Cancer. 2019 Apr 15;7(1):101.
Carcinoembryonic Antigen (CEA) is a tumor marker in lung cancer.
体外研究 (In Vitro)
Carcinoembryonic Antigen (CEA) as tumor marker in lung cancer. The use of CEA as a prognostic and predictive marker. CEA is a glycoprotein involved in cell adhesion, and is normally produced during fetal development but the production stops before birth. CEA is a glycosyl phosphatidyl inositol (GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
965.08
Formula
C43H68N10O15
CAS 号
168635-85-6
Sequence
Tyr-Leu-Ser-Gly-Ala-Asn-Leu-Asn-Leu
Sequence Shortening
YLSGANLNL
中文名称
癌胚抗原
运输条件
Room temperature in continental US; may vary elsewhere.