标签归档：cobomarsen

Cobomarsen(Synonyms: MRG-106)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cobomarsen (Synonyms: MRG-106)

Cobomarsen (MRG-106) 是 miR-155 的寡核苷酸抑制剂。 Cobomarsen 抑制与细胞存活相关的多种基因通路 (JAK/STAT，MAPK/ERK 和 PI3K/AKT)。Cobomarsen 可用于 B 细胞淋巴瘤的研究。

Cobomarsen(Synonyms: MRG-106)

Cobomarsen Chemical Structure

CAS No. : 1848257-52-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma[1][2].

体外研究
(In Vitro)

Cobomarsen (10 μM; 48-96 h) reduces cell proliferation and induces apoptosis in U2932, OCI-LY3, and RCK8 cells[2].
Cobomarsen (10 μM; 72 h) significantly increases the expression of the four direct targets in the cell lines that overexpress miR-155[1].
Cobomarsen (10 μM; 12 days) reduces cellular proliferation and induces apoptosis in MF and HTLV-1+ CTCL cells[1].
Cobomarsen (10-50 μM; 7 days) reduces phosphorylation of the downstream signalling proteins AKT, ERK1/2, and STAT-3 in primary human activated T cells or MF cell lines[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 48, 72, 96 hours
Result: Concentration-dependently inhibited cell phosphorylation.

Apoptosis Analysis[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 96 hours
Result: Triggered a significant induction of late apoptosis in all cell lines.

体内研究
(In Vivo)

Cobomarsen (1 mg/kg; i.v. on days 0, 2, 4, and 7) inhibits tumor growth in mice carrying U2932 cells xenografts[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-to-six weeks old female NSG mice injected with U2932 cells
Dosage: 1 mg/kg
Administration: I.v. on days 0, 2, 4, and 7
Result: Reduced tumor growth most significantly at day 7 and day 10.

CAS 号

1848257-52-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183(3):428-444.

    [2]. Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27(4):1139-1149.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cobomarsen(Synonyms: MRG-106)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cobomarsen (Synonyms: MRG-106)

Cobomarsen (MRG-106) 是 miR-155 的寡核苷酸抑制剂。 Cobomarsen 抑制与细胞存活相关的多种基因通路 (JAK/STAT，MAPK/ERK 和 PI3K/AKT)。Cobomarsen 可用于 B 细胞淋巴瘤的研究。

Cobomarsen(Synonyms: MRG-106)

Cobomarsen Chemical Structure

CAS No. : 1848257-52-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma[1][2].

体外研究
(In Vitro)

Cobomarsen (10 μM; 48-96 h) reduces cell proliferation and induces apoptosis in U2932, OCI-LY3, and RCK8 cells[2].
Cobomarsen (10 μM; 72 h) significantly increases the expression of the four direct targets in the cell lines that overexpress miR-155[1].
Cobomarsen (10 μM; 12 days) reduces cellular proliferation and induces apoptosis in MF and HTLV-1+ CTCL cells[1].
Cobomarsen (10-50 μM; 7 days) reduces phosphorylation of the downstream signalling proteins AKT, ERK1/2, and STAT-3 in primary human activated T cells or MF cell lines[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 48, 72, 96 hours
Result: Concentration-dependently inhibited cell phosphorylation.

Apoptosis Analysis[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 96 hours
Result: Triggered a significant induction of late apoptosis in all cell lines.

体内研究
(In Vivo)

Cobomarsen (1 mg/kg; i.v. on days 0, 2, 4, and 7) inhibits tumor growth in mice carrying U2932 cells xenografts[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-to-six weeks old female NSG mice injected with U2932 cells
Dosage: 1 mg/kg
Administration: I.v. on days 0, 2, 4, and 7
Result: Reduced tumor growth most significantly at day 7 and day 10.

CAS 号

1848257-52-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183(3):428-444.

    [2]. Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27(4):1139-1149.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cobomarsen(Synonyms: MRG-106)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cobomarsen (Synonyms: MRG-106)

Cobomarsen (MRG-106) 是 miR-155 的寡核苷酸抑制剂。 Cobomarsen 抑制与细胞存活相关的多种基因通路 (JAK/STAT，MAPK/ERK 和 PI3K/AKT)。Cobomarsen 可用于 B 细胞淋巴瘤的研究。

Cobomarsen(Synonyms: MRG-106)

Cobomarsen Chemical Structure

CAS No. : 1848257-52-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma[1][2].

体外研究
(In Vitro)

Cobomarsen (10 μM; 48-96 h) reduces cell proliferation and induces apoptosis in U2932, OCI-LY3, and RCK8 cells[2].
Cobomarsen (10 μM; 72 h) significantly increases the expression of the four direct targets in the cell lines that overexpress miR-155[1].
Cobomarsen (10 μM; 12 days) reduces cellular proliferation and induces apoptosis in MF and HTLV-1+ CTCL cells[1].
Cobomarsen (10-50 μM; 7 days) reduces phosphorylation of the downstream signalling proteins AKT, ERK1/2, and STAT-3 in primary human activated T cells or MF cell lines[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 48, 72, 96 hours
Result: Concentration-dependently inhibited cell phosphorylation.

Apoptosis Analysis[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 96 hours
Result: Triggered a significant induction of late apoptosis in all cell lines.

体内研究
(In Vivo)

Cobomarsen (1 mg/kg; i.v. on days 0, 2, 4, and 7) inhibits tumor growth in mice carrying U2932 cells xenografts[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-to-six weeks old female NSG mice injected with U2932 cells
Dosage: 1 mg/kg
Administration: I.v. on days 0, 2, 4, and 7
Result: Reduced tumor growth most significantly at day 7 and day 10.

CAS 号

1848257-52-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183(3):428-444.

    [2]. Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27(4):1139-1149.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务