标签归档：crolibulin

Crolibulin(Synonyms: EPC2407)

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Crolibulin (Synonyms: EPC2407) 纯度: 98.99%

Crolibulin (EPC2407) 是一种微管 (tubulin) 蛋白聚合抑制剂，具有诱导凋亡 (apoptosis) 和抑制细胞生长的作用。Crolibulin 有抗肿瘤活性。Crolibulin 还具有心血管毒性和神经毒性。

Crolibulin(Synonyms: EPC2407)

Crolibulin Chemical Structure

CAS No. : 1000852-17-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥2200 In-stock
5 mg ￥2000 In-stock
10 mg ￥3600 In-stock
25 mg ￥7500 In-stock
50 mg ￥13000 In-stock
100 mg   询价  
200 mg   询价  

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Crolibulin 相关产品

•相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Cell Cycle/DNA Damage Compound Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Anti-Aging Compound Library
  • Drug Repurposing Compound Library
  • Cytoskeleton Compound Library
  • Anti-Lung Cancer Compound Library

生物活性

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity[1][2][3].

IC50 & Target

Tubulin polymerization[1]
体外研究
(In Vitro)

Crolibulin shows significant cytotoxic activity against HT-29 cells, with an IC50 of 0.52 μM[2].
Crolibulin is active against various experimental tumors and exhibit potent inhibition of mitosis at the G2/M stage[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

417.26

Formula

C18H17BrN4O3
CAS 号

1000852-17-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (299.57 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3966 mL 11.9829 mL 23.9659 mL
5 mM 0.4793 mL 2.3966 mL 4.7932 mL
10 mM 0.2397 mL 1.1983 mL 2.3966 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kalmuk J, et al. Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer. Oncotarget. 2015 Sep 15;6(27):24376-92.

    [2]. Zhai X, et al. Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site. Sci Rep. 2017 Feb 27;7:43398.

    [3]. S. P. Anthony, et al. EPC2407, a new beta-tubulin vascular disrupting agent with potent apoptosis and cell growth inhibition. Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007) 14043-14043.

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