标签归档：cycleanine

Cycleanine(Synonyms: 轮环藤碱)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cycleanine (Synonyms: 轮环藤碱) 纯度: 99.80%

Cycleanine 是一种高效的血管选择性 Ca– 拮抗剂。Cycleanine 具有缓解疼痛、肌肉松弛和抗炎作用。Cycleanine 具有通过凋亡通路发挥抗卵巢癌作用的潜力。

Cycleanine(Synonyms: 轮环藤碱)

Cycleanine Chemical Structure

CAS No. : 518-94-5

规格 价格 是否有货 数量
5 mg ￥2300 In-stock
10 mg ￥3600 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Cycleanine 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Membrane Transporter/Ion Channel Compound Library
  • Neuronal Signaling Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Macrocyclic Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Neuroprotective Compound Library
  • Alkaloids Library

生物活性

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].

IC50 & Target

L-type calcium channel

 

体外研究
(In Vitro)

Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1].
Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2].
Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2].
Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2].
Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively.

Western Blot Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin.

Apoptosis Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Caused a significant increase of the population of both early and late apoptotic cells.

Cell Cycle Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Increased the percentage of Ovcar-8 cells in subG1.

体内研究
(In Vivo)

Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

622.75

Formula

C38H42N2O6
CAS 号

518-94-5
中文名称

轮环藤碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Martínez JA, et al. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. Fundam Clin Pharmacol. 1998;12(2):182-7.

    [2]. Uche FI, et al. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res. 2016 Sep;30(9):1533-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cycleanine(Synonyms: 轮环藤碱)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cycleanine (Synonyms: 轮环藤碱) 纯度: 99.80%

Cycleanine 是一种高效的血管选择性 Ca– 拮抗剂。Cycleanine 具有缓解疼痛、肌肉松弛和抗炎作用。Cycleanine 具有通过凋亡通路发挥抗卵巢癌作用的潜力。

Cycleanine(Synonyms: 轮环藤碱)

Cycleanine Chemical Structure

CAS No. : 518-94-5

规格 价格 是否有货 数量
5 mg ￥2300 In-stock
10 mg ￥3600 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Cycleanine 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Membrane Transporter/Ion Channel Compound Library
  • Neuronal Signaling Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Macrocyclic Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Neuroprotective Compound Library
  • Alkaloids Library

生物活性

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].

IC50 & Target

L-type calcium channel

 

体外研究
(In Vitro)

Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1].
Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2].
Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2].
Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2].
Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively.

Western Blot Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin.

Apoptosis Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Caused a significant increase of the population of both early and late apoptotic cells.

Cell Cycle Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Increased the percentage of Ovcar-8 cells in subG1.

体内研究
(In Vivo)

Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

622.75

Formula

C38H42N2O6
CAS 号

518-94-5
中文名称

轮环藤碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Martínez JA, et al. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. Fundam Clin Pharmacol. 1998;12(2):182-7.

    [2]. Uche FI, et al. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res. 2016 Sep;30(9):1533-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cycleanine(Synonyms: 轮环藤碱)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cycleanine (Synonyms: 轮环藤碱) 纯度: 99.80%

Cycleanine 是一种高效的血管选择性 Ca– 拮抗剂。Cycleanine 具有缓解疼痛、肌肉松弛和抗炎作用。Cycleanine 具有通过凋亡通路发挥抗卵巢癌作用的潜力。

Cycleanine(Synonyms: 轮环藤碱)

Cycleanine Chemical Structure

CAS No. : 518-94-5

规格 价格 是否有货 数量
5 mg ￥2300 In-stock
10 mg ￥3600 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Cycleanine 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Membrane Transporter/Ion Channel Compound Library
  • Neuronal Signaling Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Macrocyclic Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Neuroprotective Compound Library
  • Alkaloids Library

生物活性

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].

IC50 & Target

L-type calcium channel

 

体外研究
(In Vitro)

Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1].
Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2].
Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2].
Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2].
Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively.

Western Blot Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin.

Apoptosis Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Caused a significant increase of the population of both early and late apoptotic cells.

Cell Cycle Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Increased the percentage of Ovcar-8 cells in subG1.

体内研究
(In Vivo)

Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

622.75

Formula

C38H42N2O6
CAS 号

518-94-5
中文名称

轮环藤碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Martínez JA, et al. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. Fundam Clin Pharmacol. 1998;12(2):182-7.

    [2]. Uche FI, et al. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res. 2016 Sep;30(9):1533-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务