GSD-11

发表于2024年11月18日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

GSD-11

GSD-11 是一种有效的选择性抗紧缩剂。GSD-11 抑制 PANC-1 细胞的迁移和集落形成。GSD-11 抑制 Akt/mTOR 信号通路。GSD-11 具有研究胰腺癌的潜力。

GSD-11 Chemical Structure

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生物活性

GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer^[1].

体外研究
(In Vitro)

GSD-11 (0,1, 10, 100, 1000 µM) shows potent cytotoxicity against PANC-1 cells with PC₅₀ value of 0.72 µM in nutrient-deprived medium (NDM), and IC₅₀ value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM)^[1].
GSD-11 (10 µM, 24 h) induces morphological change in PANC-1 cells^[1].
GSD-11 (3, 5 µM, 24 h) inhibits the migration of PANC-1 tumor cells^[1].
GSD-11 (1, 3, 5 µM, 24 h) shows strong colony formation inhibitory effect in PANC-1 tumor cells^[1].
GSD-11 (2.5, 5, 10 µM) inhibits the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	PANC-1 cells
Concentration:	0,1, 10, 100, 1000 µM
Incubation Time:
Result:	Showed preferential cytotoxicity against PANC-1 cells with PC₅₀ of 0.72 µM in nutrient-deprived medium (NDM), and IC₅₀ value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM).

Western Blot Analysis^[1]

Cell Line:	PANC-1 cells
Concentration:	2.5, 5, 10 µM
Incubation Time:
Result:	Inhibited the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions.

分子量

300.44

Formula

C₂₀H₂₈O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kohyama A, et al. Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate. Bioorg Med Chem. 2022; 54:116563.

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TU-6D/TU-6型手持式紫外分析仪（用于电泳观察）

发表于2024年11月18日由上海金畔生物科技有限公司

【简单介绍】

TU-6D/TU-6型手持式紫外分析仪（用于电泳观察），采用超亮的长寿命LED灯作为光源，可以观察拍摄多种染料。光照强且对样品无伤害，寿命超长，体积小，便携。

【详细说明】

TU-6D/TU-6型手持式紫外分析仪（用于电泳观察）

产品简述：

TU-6D/TU-6型手持式紫外分析仪（用于电泳观察）采用超亮的长寿命LED灯作为光源，可以观察拍摄多种染料。光照强且对样品无伤害，寿命超长，体积小，便携。

技术特点：

1、外观设计简洁流畅，操作简单便携，符合人机工学，波长一键切换十分方便。

2、具有单波和双波两种系列可供选择，365nm和254nm或双254与双365组合

3、带有蓄电池可以长时间断电使用。满足更多使用需求。

4、可选配支架固定手持紫外分析仪，满足特殊操作需求。

5、TU-6D单波为470nm，LED寿命超长为10万小时。

技术参数：

产品型号	TU-6 手持紫外分析仪	TU-6D手持紫外分析仪
光源波长	365nm和254nm	470nm
外形尺寸	440×75×51（mm）
输入电源	AC110-220V，50/60Hz
紫外窗口	150x50mm
功率	≤6W
重量	1100g

注意事项：

1、紫外滤色片不能和金属物体磁擦、不能受力、表面应保持干燥清洁，每次使用完毕要用干净纱布擦净；

2、紫外线辐射对人体有害，所以不使用本仪器时请将紫外线灯关闭，在使用时也尽可能的不要对着人（TU-6D对人体无伤害，使用更加安全）。

Sarcosine-d3(Synonyms: N-Methylglycine-d3; Sarcosin-d3)

发表于2024年11月18日由上海金畔生物科技有限公司

Sarcosine-d3 (Synonyms: N-Methylglycine-d3; Sarcosin-d3)

Sarcosine-d3 (N-Methylglycine-d3) 是 Sarcosine 的氘代物。Sarcosine (N-Methylglycine) 是一种內源性氨基酸，是竞争性的甘氨酸转运蛋白-1 (GlyT1) 抑制剂和甘氨酸受体协同激动剂。Sarcosine 通过增加甘氨酸的浓度增强 NMDA 受体的功能。Sarcosine 通常用于精神分裂症的研究。

Sarcosine-d3 Chemical Structure

CAS No. : 118685-91-9

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生物活性	Sarcosine-d3 (N-Methylglycine-d3) is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	92.11
Formula	C₃H₄D₃NO₂
CAS 号	118685-91-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [3]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7. [4]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [5]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7.

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Sarcosine-d3(Synonyms: N-Methylglycine-d3; Sarcosin-d3)

发表于2024年11月18日由上海金畔生物科技有限公司

Sarcosine-d3 (Synonyms: N-Methylglycine-d3; Sarcosin-d3)

Sarcosine-d3 Chemical Structure

CAS No. : 118685-91-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Sarcosine-d3 (N-Methylglycine-d3) is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	92.11
Formula	C₃H₄D₃NO₂
CAS 号	118685-91-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [3]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7. [4]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [5]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7.

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L-Norleucine-d9(Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

发表于2024年11月18日由上海金畔生物科技有限公司

L-Norleucine-d9 (Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) 是 L-Norleucine 的氘代物。L-Norleucine ((S)-2-Aminohexanoic acid) 是亮氨酸的异构体，能够影响骨骼肌中蛋白质的合成。

L-Norleucine-d9 Chemical Structure

CAS No. : 1331889-36-1

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250 mg		询价
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生物活性	L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	140.23
Formula	C₆H₄D₉NO₂
CAS 号	1331889-36-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37. [3]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.

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Sarcosine-d3(Synonyms: N-Methylglycine-d3; Sarcosin-d3)

发表于2024年11月18日由上海金畔生物科技有限公司

Sarcosine-d3 (Synonyms: N-Methylglycine-d3; Sarcosin-d3)

Sarcosine-d3 Chemical Structure

CAS No. : 118685-91-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Sarcosine-d3 (N-Methylglycine-d3) is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	92.11
Formula	C₃H₄D₃NO₂
CAS 号	118685-91-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [3]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7. [4]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [5]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7.

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L-Norleucine-d9(Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

发表于2024年11月18日由上海金畔生物科技有限公司

L-Norleucine-d9 (Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) 是 L-Norleucine 的氘代物。L-Norleucine ((S)-2-Aminohexanoic acid) 是亮氨酸的异构体，能够影响骨骼肌中蛋白质的合成。

L-Norleucine-d9 Chemical Structure

CAS No. : 1331889-36-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	140.23
Formula	C₆H₄D₉NO₂
CAS 号	1331889-36-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37. [3]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.

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L-Norleucine-d9(Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

发表于2024年11月18日由上海金畔生物科技有限公司

L-Norleucine-d9 (Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) 是 L-Norleucine 的氘代物。L-Norleucine ((S)-2-Aminohexanoic acid) 是亮氨酸的异构体，能够影响骨骼肌中蛋白质的合成。

L-Norleucine-d9 Chemical Structure

CAS No. : 1331889-36-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	L-Norleucine-d9 ((S)-2-Aminohexanoic acid-d9) is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	140.23
Formula	C₆H₄D₉NO₂
CAS 号	1331889-36-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37. [3]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.

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SN-38-d3(Synonyms: NK012-d3)

发表于2024年11月17日由上海金畔生物科技有限公司

SN-38-d3 (Synonyms: NK012-d3)

SN-38-d3 是 SN-38 的氘代物。SN-38 (NK012) 是拓扑异构酶 I (Topoisomerase I) 抑制剂伊立替康的活性代谢产物。SN-38 (NK012) 抑制 DNA 合成和 RNA 合成的 IC₅₀ 分别为 0.077 和 1.3 μM。

SN-38-d3 Chemical Structure

CAS No. : 718612-49-8

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively^[1]^[2]^[3]^[4].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	395.42
Formula	C₂₂H₁₇D₃N₂O₅
CAS 号	718612-49-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19(6):1493-8. [3]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56. [4]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

郑州长城科工贸直流无级调速搅拌器D971-60

发表于2024年11月16日由上海金畔生物科技有限公司

郑州长城科工贸直流无级调速搅拌器D971-60

品牌长城科工贸|Greatwall

型号 D971-60

商品详情

D-971-30/60/90/120型，本机在同类产品的基础上改进而成的，它设计合理、结构新颖，采用直流输出、无级调速，装有稳压系统，转速显示稳定，具有功率大噪音低、操作安全等特点，为各大专院校科研单位、工厂等实验室搅拌各种液相化学反应提供一项不可缺少的基本设备。
1.AC调速，无火花；
2.宽调速，恒转矩，恒转速；
3.系统稳定，电网电压在180-250V变化，转速不变。

格型号	功率W	工作电压 V/HZ	轴转速r/m	速度显示	机型尺寸	全机重量
D-971	60	220/50	40-1400	–	350×350×750	14

D5261

发表于2024年11月14日由上海金畔生物科技有限公司

D5261

D5261 是一个有效的、类型III变构的 tropomyosin-related kinase A (TrkA) 抑制剂。

D5261 Chemical Structure

CAS No. : 1574574-57-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

D5261 is a potent, type III allosteric tropomyosin-related kinase A (TrkA) inhibitor^[1].

IC₅₀ & Target

TrkA

体外研究
(In Vitro)

D5261 (0-10 µM, 72 h) displays favorable anti-proliferative activity in Ba/F3-MPRIP-TrkA cells (IC₅₀ = 3.32 µM) and Ba/F3 CD74-TrkA cells (IC₅₀ = 2.91 µM) ^[1].
D5261 exhibits cellular selectivity over TrkB/C to some extent (Ba/F3 IC₅₀ > 10 µM, Ba/F3-QKI-TrkB IC₅₀ = 6.17 µM and Ba/F3-EML4-TrkC IC₅₀ > 10 µM)^[1].
D5261 (0-50 µM) inhibits the TrkA autophosphorylation and downstream signaling in a concentration-dependent manner^[1].
D5261 shows inhibitory activity against Ba/F3 cells harboring TrkA mutants (G667C, G667S, G667A, G595R and V573 M)^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Ba/F3-MPRIP-TrkA, Ba/F3 CD74-TrkA cells
Concentration:	0-10 µM
Incubation Time:	72 h
Result:	Displayed favorable anti-proliferative activity with an IC₅₀ of 3.32 and 2.91 µM against Ba/F3-MPRIP-TrkA and Ba/F3 CD74-TrkA cells, respectively.

Western Blot Analysis^[1]

Cell Line:	Ba/F3 CD74-TrkA cells
Concentration:	0.08, 0.4, 2, 10, and 50 µM
Incubation Time:
Result:	Inhibited the TrkA autophosphorylation and phosphorylation of downstream PLCγ1, AKT and ERK in a concentration-dependent manner.

分子量

447.53

Formula

C₂₅H₂₉N₅O₃

CAS 号

1574574-57-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Jing Guo, et al. Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies. Eur J Med Chem. 2022 Jan 15;228:114022.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D5261

发表于2024年11月14日由上海金畔生物科技有限公司

D5261

D5261 是一个有效的、类型III变构的 tropomyosin-related kinase A (TrkA) 抑制剂。

D5261 Chemical Structure

CAS No. : 1574574-57-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

D5261 is a potent, type III allosteric tropomyosin-related kinase A (TrkA) inhibitor^[1].

IC₅₀ & Target

TrkA

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Ba/F3-MPRIP-TrkA, Ba/F3 CD74-TrkA cells
Concentration:	0-10 µM
Incubation Time:	72 h
Result:	Displayed favorable anti-proliferative activity with an IC₅₀ of 3.32 and 2.91 µM against Ba/F3-MPRIP-TrkA and Ba/F3 CD74-TrkA cells, respectively.

Western Blot Analysis^[1]

Cell Line:	Ba/F3 CD74-TrkA cells
Concentration:	0.08, 0.4, 2, 10, and 50 µM
Incubation Time:
Result:	Inhibited the TrkA autophosphorylation and phosphorylation of downstream PLCγ1, AKT and ERK in a concentration-dependent manner.

分子量

447.53

Formula

C₂₅H₂₉N₅O₃

CAS 号

1574574-57-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Jing Guo, et al. Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies. Eur J Med Chem. 2022 Jan 15;228:114022.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D5261

发表于2024年11月13日由上海金畔生物科技有限公司

D5261

D5261 是一个有效的、类型III变构的 tropomyosin-related kinase A (TrkA) 抑制剂。

D5261 Chemical Structure

CAS No. : 1574574-57-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

D5261 is a potent, type III allosteric tropomyosin-related kinase A (TrkA) inhibitor^[1].

IC₅₀ & Target

TrkA

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Ba/F3-MPRIP-TrkA, Ba/F3 CD74-TrkA cells
Concentration:	0-10 µM
Incubation Time:	72 h
Result:	Displayed favorable anti-proliferative activity with an IC₅₀ of 3.32 and 2.91 µM against Ba/F3-MPRIP-TrkA and Ba/F3 CD74-TrkA cells, respectively.

Western Blot Analysis^[1]

Cell Line:	Ba/F3 CD74-TrkA cells
Concentration:	0.08, 0.4, 2, 10, and 50 µM
Incubation Time:
Result:	Inhibited the TrkA autophosphorylation and phosphorylation of downstream PLCγ1, AKT and ERK in a concentration-dependent manner.

分子量

447.53

Formula

C₂₅H₂₉N₅O₃

CAS 号

1574574-57-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Jing Guo, et al. Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies. Eur J Med Chem. 2022 Jan 15;228:114022.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sphingosine (d14:1)(Synonyms: Tetradecasphing-4-enine)

发表于2024年11月13日由上海金畔生物科技有限公司

Sphingosine (d14:1) (Synonyms: Tetradecasphing-4-enine)

Sphingosine (d14:1) (Tetradecasphing-4-enine) 是一种鞘脂，是一种有效的蛋白激酶 C (PKC) 抑制剂。Sphingosine (d14:1) 可防止其与 sn-1,2-二酰基甘油 (DAG)/佛波酯相互作用。

Sphingosine (d14:1) Chemical Structure

CAS No. : 24558-60-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters^[1].

IC₅₀ & Target^[1]

PKC

分子量

243.39

Formula

C₁₄H₂₉NO₂

CAS 号

24558-60-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Y A Hannun, et al. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15;185(3):333-45.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sphingosine (d14:1)(Synonyms: Tetradecasphing-4-enine)

发表于2024年11月13日由上海金畔生物科技有限公司

Sphingosine (d14:1) (Synonyms: Tetradecasphing-4-enine)

Sphingosine (d14:1) Chemical Structure

CAS No. : 24558-60-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

IC₅₀ & Target^[1]

PKC

分子量

243.39

Formula

C₁₄H₂₉NO₂

CAS 号

24558-60-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Y A Hannun, et al. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15;185(3):333-45.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sphingosine (d14:1)(Synonyms: Tetradecasphing-4-enine)

发表于2024年11月13日由上海金畔生物科技有限公司

Sphingosine (d14:1) (Synonyms: Tetradecasphing-4-enine)

Sphingosine (d14:1) Chemical Structure

CAS No. : 24558-60-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

IC₅₀ & Target^[1]

PKC

分子量

243.39

Formula

C₁₄H₂₉NO₂

CAS 号

24558-60-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Y A Hannun, et al. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15;185(3):333-45.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Fluvastatin D6 sodium(Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

发表于2024年11月11日由上海金畔生物科技有限公司

Fluvastatin D6 sodium (Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

Fluvastatin D6 sodium (XU 62-320 D6) 是 Fluvastatin sodium (HY-14664A) 的氘代标记化合物。Fluvastatin sodium (XU 62320) 是第一个完全合成的，竞争性的 HMG-CoA 还原酶 抑制剂，IC₅₀ 为 8 nM。

Fluvastatin D6 sodium Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

Fluvastatin D6 sodium (XU 62-320 D6) is deuterium labeled Fluvastatin sodium. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM.

Clinical Trial

分子量

439.48

Formula

C₂₄H₁₉D₆FNNaO₄

中文名称

氟伐他汀钠D6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Fluvastatin D6 sodium(Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

发表于2024年11月11日由上海金畔生物科技有限公司

Fluvastatin D6 sodium (Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

Fluvastatin D6 sodium Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

Clinical Trial

分子量

439.48

Formula

C₂₄H₁₉D₆FNNaO₄

中文名称

氟伐他汀钠D6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Fluvastatin D6 sodium(Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

发表于2024年11月11日由上海金畔生物科技有限公司

Fluvastatin D6 sodium (Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

Fluvastatin D6 sodium Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

Clinical Trial

分子量

439.48

Formula

C₂₄H₁₉D₆FNNaO₄

中文名称

氟伐他汀钠D6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Losartan (D4 Carboxylic Acid)(Synonyms: 氯沙坦羧酸 D4; E-3174 D4; EXP-3174 D4)

发表于2024年11月10日由上海金畔生物科技有限公司

Losartan (D4 Carboxylic Acid) (Synonyms: 氯沙坦羧酸 D4; E-3174 D4; EXP-3174 D4)

Losartan D4 Carboxylic Acid (E-3174 D4) 是 Losartan 的氘代物。

Losartan (D4 Carboxylic Acid) Chemical Structure

CAS No. : 1246820-62-1

规格	价格	是否有货
1 mg	￥2100	询问价格 & 货期
5 mg	￥9800	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	Losartan D4 Carboxylic Acid (E-3174 D4) is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist.
分子量	440.92
Formula	C₂₂H₁₇D₄ClN₆O₂
CAS 号	1246820-62-1
中文名称	氯沙坦羧酸 D4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

whatman (沃特曼)

英国沃特曼 Millipore PALL中国代理商金畔官网

标签归档：d

GSD-11

TU-6D/TU-6型手持式紫外分析仪（用于电泳观察）

Sarcosine-d3(Synonyms: N-Methylglycine-d3; Sarcosin-d3)

Sarcosine-d3(Synonyms: N-Methylglycine-d3; Sarcosin-d3)

L-Norleucine-d9(Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

Sarcosine-d3(Synonyms: N-Methylglycine-d3; Sarcosin-d3)

L-Norleucine-d9(Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

L-Norleucine-d9(Synonyms: (S)-2-Aminohexanoic acid-d9; (S)-Norleucine-d9)

SN-38-d3(Synonyms: NK012-d3)

郑州长城科工贸直流无级调速搅拌器D971-60

D5261

D5261

D5261

Sphingosine (d14:1)(Synonyms: Tetradecasphing-4-enine)

Sphingosine (d14:1)(Synonyms: Tetradecasphing-4-enine)

Sphingosine (d14:1)(Synonyms: Tetradecasphing-4-enine)

Fluvastatin D6 sodium(Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

Fluvastatin D6 sodium(Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

Fluvastatin D6 sodium(Synonyms: 氟伐他汀钠D6; XU 62-320 (D6))

Losartan (D4 Carboxylic Acid)(Synonyms: 氯沙坦羧酸 D4; E-3174 D4; EXP-3174 D4)