Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs[1].
IC50 & Target
Ligand for Target Protein for PROTAC[1]
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
546.51
Formula
C27H26F4N4O4
CAS 号
2407458-49-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use. WO2019246570A1.
Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs[1].
IC50 & Target
Ligand for Target Protein for PROTAC[1]
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
546.51
Formula
C27H26F4N4O4
CAS 号
2407458-49-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use. WO2019246570A1.
Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs[1].
IC50 & Target
Ligand for Target Protein for PROTAC[1]
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
546.51
Formula
C27H26F4N4O4
CAS 号
2407458-49-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use. WO2019246570A1.
Asterriquinol D dimethyl ether 是一种真菌代谢物，可抑制小鼠骨髓瘤 NS-1 细胞系，IC50 为 28 μg/mL。Asterriquinol D dimethyl ether 还抑制胎儿三毛滴虫。
Asterriquinol D dimethyl ether Chemical Structure
CAS No. : 287117-66-2
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC50 of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits Tritrichomonas foetus[1].
IC50 & Target
Microbial Metabolite
分子量
428.48
Formula
C26H24N2O4
CAS 号
287117-66-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Heather J. Lacey, et al. Kumbicins A–D: Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius. Australian Journal of Chemistry 69(2) 152-160.
Asterriquinol D dimethyl ether 是一种真菌代谢物，可抑制小鼠骨髓瘤 NS-1 细胞系，IC50 为 28 μg/mL。Asterriquinol D dimethyl ether 还抑制胎儿三毛滴虫。
Asterriquinol D dimethyl ether Chemical Structure
CAS No. : 287117-66-2
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC50 of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits Tritrichomonas foetus[1].
IC50 & Target
Microbial Metabolite
分子量
428.48
Formula
C26H24N2O4
CAS 号
287117-66-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Heather J. Lacey, et al. Kumbicins A–D: Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius. Australian Journal of Chemistry 69(2) 152-160.
Asterriquinol D dimethyl ether 是一种真菌代谢物，可抑制小鼠骨髓瘤 NS-1 细胞系，IC50 为 28 μg/mL。Asterriquinol D dimethyl ether 还抑制胎儿三毛滴虫。
Asterriquinol D dimethyl ether Chemical Structure
CAS No. : 287117-66-2
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC50 of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits Tritrichomonas foetus[1].
IC50 & Target
Microbial Metabolite
分子量
428.48
Formula
C26H24N2O4
CAS 号
287117-66-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Heather J. Lacey, et al. Kumbicins A–D: Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius. Australian Journal of Chemistry 69(2) 152-160.
N-(m-PEG4)-3,3-Dimethyl-3H-indole-N’-(acid-PEG3)-benzothiazole Chemical Structure
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
N-(m-PEG4)-3,3-Dimethyl-3H-indole-N’-(acid-PEG3)-benzothiazole is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC50 & Target
PEGs
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
775.39
Formula
C40H55ClN2O9S
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
N-(m-PEG4)-3,3-Dimethyl-3H-indole-N’-(acid-PEG3)-benzothiazole Chemical Structure
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
N-(m-PEG4)-3,3-Dimethyl-3H-indole-N’-(acid-PEG3)-benzothiazole is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC50 & Target
PEGs
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
775.39
Formula
C40H55ClN2O9S
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
N-(m-PEG4)-3,3-Dimethyl-3H-indole-N’-(acid-PEG3)-benzothiazole Chemical Structure
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
N-(m-PEG4)-3,3-Dimethyl-3H-indole-N’-(acid-PEG3)-benzothiazole is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC50 & Target
PEGs
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
775.39
Formula
C40H55ClN2O9S
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Dimethyl-bisphenol A (DMBPA) 是一种有效的 HIF-1α 抑制剂。Dimethyl-bisphenol A 可降低 Vegfa mRNA 表达。
Dimethyl-bisphenol A Chemical Structure
CAS No. : 1568-83-8
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Dimethyl-bisphenol A (DMBPA) is a potent HIF-1α inhibitor. Dimethyl-bisphenol A can decrease Vegfa mRNA expression[1].
体外研究 (In Vitro)
Dimethyl-bisphenol A (DMBPA; 50 μM; 30 min) significantly inhibits Vegfa120 and Vegfa164 expression in large osteoclasts (OCs)[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
256.34
Formula
C17H20O2
CAS 号
1568-83-8
中文名称
双酚A二甲醚
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Diana P Trebec-Reynolds, et al. VEGF-A expression in osteoclasts is regulated by NF-kappaB induction of HIF-1alpha. J Cell Biochem. 2010 May 15;110(2):343-51.
O,O-Dimethyl-cannabigerol is a natural product from Cannabis sativa. O,O-Dimethyl-cannabigerol has an antibacterial effect on drug-resistant strains of Staphylococcus aureus (MIC ranging from 1 to 2 µg/mL)[1]. O,O-Dimethyl-cannabigerol is a nonpsychoactive constituent[2][3].
体外研究 (In Vitro)
O,O-Dimethyl-cannabigerol (compound 1) inhibits KB cells growth with IC50s of 44.55 μM (MTT assay) and 69.4 μM (SRB assay)[2]. O,O-Dimethyl-cannabigerol (0-100 μM; 48 hours) induces cell cytotoxic in NIH 3T3 fibroblasts, with CD50s of 60.46 μM (MTT assay) and 82.98 μM (SRB assay)[2]. O,O-Dimethyl-cannabigerol shows antitumor efficacy against melanoma cells of a mouse’s skin with an IC50 of 31.3 μM[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay[2]
Cell Line:
NIH 3T3 fibroblasts
Concentration:
0, 1, 25, 50, 100 μM
Incubation Time:
48 hours
Result:
Induced cell cytotoxic with CD50s of 60.46 μM (MTT assay) and 82.98 μM (SRB assay)
分子量
344.53
Formula
C23H36O2
CAS 号
29106-16-9
运输条件
Room temperature in continental US; may vary elsewhere.
Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[1][2].
IC50 & Target
Human Endogenous Metabolite
体外研究 (In Vitro)
Dimethyl fumarate (DMF; 20-200 μM; 24 hours) treatment dose-dependently reduces the viability of SGC-7901, HT29, HCT116 and CT26 cancer cells[1]. Dimethyl fumarate (DMF; 100 μM; 3-24 hours) significantly activates JNK, p38 and ERK in CT26 cells[1]. Dimethyl fumarate induces necroptosis in colon cancer cells and the mechanism involves GSH depletion, an increase in ROS and activation of MAPKs-mediated signalling[1]. Dimethyl fumarate inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl fumarate impairs NF-κB signaling via reduced p65 nuclear translocalization and phosphorylation. Dimethyl fumarate inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling[2]. Dimethyl fumarate (DMF), an immune modulator and inducer of the antioxidant response, suppresses HIV replication and neurotoxin release[3].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay[1]
Cell Line:
SGC-7901, HT29, HCT116 and CT26 cells
Concentration:
20 μM, 50 μM, 100 μM, 200 μM
Incubation Time:
24 hours
Result:
Reduced cell viability in SGC-7901, HT29, HCT116 and CT26 cancer cells.
Western Blot Analysis[1]
Cell Line:
CT26 cancer cells
Concentration:
100 μM
Incubation Time:
3 hours, 6 hours, 12 hours, 24 hours
Result:
Significantly activated JNK, p38 and ERK in CT26 cells after treatment from 3 to 24 h.
体内研究 (In Vivo)
Dimethyl fumarate (DMF; 50 mg/kg; oral gavage; daily; for 7 days) treatment is shown to upregulate the mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice[4].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Male C57BL/6 mice (8-week-old)[4]
Dosage:
50 mg/kg
Administration:
Oral gavage; daily; for 7 days
Result:
Was shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes.
Clinical Trial
分子量
144.13
Formula
C6H8O4
CAS 号
624-49-7
中文名称
富马酸二甲酯
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 62.5 mg/mL (433.64 mM; Need ultrasonic)
H2O : 8.33 mg/mL (57.80 mM; ultrasonic and warming and heat to 60°C)
[1]. Xin Xie, et al. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015 Aug;172(15):3929-43.
[2]. Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26.
[3]. Cross SA, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15;187(10):5015-25.
[4]. Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson’s disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40
4,4-Dimethyl-2-cyclopenten-1-one Chemical Structure
CAS No. : 22748-16-9
规格
价格
是否有货
10 mg
￥500
询问价格 & 货期
* Please select Quantity before adding items.
生物活性
4,4-Dimethyl-2-cyclopenten-1-one, a natural compound from Apocyniveneti Folium, displays higher tumor-specific cytotoxicity[1].
体外研究 (In Vitro)
4,4-Dimethyl-2-cyclopenten-1-one selectively kills the tumor cells (HSC-2, HL-60). 4,4-Dimethyl-2-cyclopenten-1-one exhibits CC50 (50% cytotoxic concentration) values of 43.8 μg/mL, 152 μg/mL, 118 μg/mL, 14.0 μg/mL, 177 μg/mL and 123 μg/mL in HSC-2, HSC-3, HSG, HL-60, HGF and normal cells (HPC), respectively[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
110.15
Formula
C7H10O
CAS 号
22748-16-9
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Tohru Nakayachi, et al. Structure-activity relationships of alpha, beta-unsaturated ketones as assessed by their cytotoxicity against oral tumor cells. Anticancer Res. Mar-Apr 2004;24(2B):737-42.
[2]. Wei-WeiZhu, et al. Cornstalk liquefaction in methanol/water mixed solvents. Fuel Processing Technology Volume 117, January 2014, Pages 1-7.
2-Bromo-2,2-dimethyl-acetamido-PEG3-acid Chemical Structure
CAS No. : 2279944-67-9
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
2-Bromo-22-dimethyl-acetamido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC50 & Target
PEGs
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
370.24
Formula
C13H24BrNO6
CAS 号
2279944-67-9
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂，能抑制 DNA 复制。
Dimethyl-SGD-1882 Chemical Structure
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].
IC50 & Target[1]
Pyrrolobenzodiazepines
体外研究 (In Vitro)
The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
753.84
Formula
C44H43N5O7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂，能抑制 DNA 复制。
Dimethyl-SGD-1882 Chemical Structure
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].
IC50 & Target[1]
Pyrrolobenzodiazepines
体外研究 (In Vitro)
The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
753.84
Formula
C44H43N5O7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂，能抑制 DNA 复制。
Dimethyl-SGD-1882 Chemical Structure
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].
IC50 & Target[1]
Pyrrolobenzodiazepines
体外研究 (In Vitro)
The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible and the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity and antibacterial activity compared to PBD monomers, and one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer and leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
753.84
Formula
C44H43N5O7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.
Hexaethylene glycol dimethyl ether Chemical Structure
CAS No. : 1072-40-8
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Hexaethylene glycol dimethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC50 & Target
PEGs
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
310.38
Formula
C14H30O7
CAS 号
1072-40-8
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Hexaethylene glycol dimethyl ether Chemical Structure
CAS No. : 1072-40-8
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Hexaethylene glycol dimethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC50 & Target
PEGs
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
310.38
Formula
C14H30O7
CAS 号
1072-40-8
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Hexaethylene glycol dimethyl ether Chemical Structure
CAS No. : 1072-40-8
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
Hexaethylene glycol dimethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC50 & Target
PEGs
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
310.38
Formula
C14H30O7
CAS 号
1072-40-8
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
