标签归档：diphyllin

Diphyllin(Synonyms: 二叶草素)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Diphyllin (Synonyms: 二叶草素) 纯度: 99.85%

Diphyllin 是一种从 Justicia procumbens 中分离出的芳基萘木脂素，是一种有效的 HIV-1 抑制剂，IC50 为 0.38 μM。Diphyllin 还具有抗水泡性口炎病毒 (VSV) 和流感病毒的活性。Diphyllin 是 V-ATPase 的抑制剂，IC50 值为 17 nM，可抑制人破骨细胞中的溶酶体酸化。Diphyllin 以 IC50 值为 50 μM 来抑制 NO 产生，并具有抗癌和抗炎活性。

Diphyllin(Synonyms: 二叶草素)

Diphyllin Chemical Structure

CAS No. : 22055-22-7

规格 价格 是否有货 数量
10 mg ￥6500 In-stock
25 mg ￥9500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Diphyllin 相关产品

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生物活性

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus[1]. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts[2]. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities[3].

IC50 & Target[1][2]

HIV-1

0.38 μM (IC50)

Vesicular stomatitis virus (VSV)

 

Vacuolar type H+-ATPase

17 nM (IC50)

分子量

380.35

Formula

C21H16O7
CAS 号

22055-22-7
中文名称

二叶草素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 14.29 mg/mL (37.57 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6292 mL 13.1458 mL 26.2916 mL
5 mM 0.5258 mL 2.6292 mL 5.2583 mL
10 mM 0.2629 mL 1.3146 mL 2.6292 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution

    此方案可获得 ≥ 1.43 mg/mL (3.76 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 14.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution

    此方案可获得 ≥ 1.43 mg/mL (3.76 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 14.3 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Xin-Ya Xu, et al. Anti-HIV Lignans From Justicia Procumbens. Chin J Nat Med. 2019 Dec;17(12):945-952.

    [2]. Mette G Sørensen, et al. Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption. J Bone Miner Res. 2007 Oct;22(10):1640-8.

    [3]. Yerra Koteswara Rao, et al. Anti-inflammatory Activities of Constituents Isolated From Phyllanthus Polyphyllus. J Ethnopharmacol. 2006 Jan 16;103(2):181-6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cleistanthin B(Synonyms: Diphyllin O-glucoside)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cleistanthin B (Synonyms: Diphyllin O-glucoside) 纯度: ≥99.0%

Cleistanthin B (Diphyllin O-glucoside) 是一种具有口服活性的芳基萘木酚素内酯糖苷。Cleistanthin B 在 Vero 细胞中表现出抗 SARS-CoV-2 作用，EC50 值为 6.51 µM。Cleistanthin B 在体内具有抗肿瘤、利尿和抗高血压的作用。

Cleistanthin B(Synonyms: Diphyllin O-glucoside)

Cleistanthin B Chemical Structure

CAS No. : 30021-77-3

规格 价格 是否有货 数量
1 mg ￥6400 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

生物活性

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

IC50 & Target

IC50: 6.51 µM (SARS-CoV-2)[1]
体外研究
(In Vitro)

Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1].
Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

542.49

Formula

C27H26O12
CAS 号

30021-77-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471.

    [2]. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388.

    [3]. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7.

    [4]. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cleistanthin B(Synonyms: Diphyllin O-glucoside)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cleistanthin B (Synonyms: Diphyllin O-glucoside) 纯度: ≥99.0%

Cleistanthin B (Diphyllin O-glucoside) 是一种具有口服活性的芳基萘木酚素内酯糖苷。Cleistanthin B 在 Vero 细胞中表现出抗 SARS-CoV-2 作用，EC50 值为 6.51 µM。Cleistanthin B 在体内具有抗肿瘤、利尿和抗高血压的作用。

Cleistanthin B(Synonyms: Diphyllin O-glucoside)

Cleistanthin B Chemical Structure

CAS No. : 30021-77-3

规格 价格 是否有货 数量
1 mg ￥6400 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

生物活性

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

IC50 & Target

IC50: 6.51 µM (SARS-CoV-2)[1]
体外研究
(In Vitro)

Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1].
Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

542.49

Formula

C27H26O12
CAS 号

30021-77-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471.

    [2]. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388.

    [3]. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7.

    [4]. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cleistanthin B(Synonyms: Diphyllin O-glucoside)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cleistanthin B (Synonyms: Diphyllin O-glucoside) 纯度: ≥99.0%

Cleistanthin B (Diphyllin O-glucoside) 是一种具有口服活性的芳基萘木酚素内酯糖苷。Cleistanthin B 在 Vero 细胞中表现出抗 SARS-CoV-2 作用，EC50 值为 6.51 µM。Cleistanthin B 在体内具有抗肿瘤、利尿和抗高血压的作用。

Cleistanthin B(Synonyms: Diphyllin O-glucoside)

Cleistanthin B Chemical Structure

CAS No. : 30021-77-3

规格 价格 是否有货 数量
1 mg ￥6400 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

生物活性

Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

IC50 & Target

IC50: 6.51 µM (SARS-CoV-2)[1]
体外研究
(In Vitro)

Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM[1].
Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

542.49

Formula

C27H26O12
CAS 号

30021-77-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471.

    [2]. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388.

    [3]. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7.

    [4]. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务