Estradiol-d5(Synonyms: β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol-d5 (Synonyms: β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5)

Estradiol-d5 是 Estradiol 氘代物。Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达

Estradiol-d5(Synonyms: β-Estradiol-d5;  17β-Estradiol-d5;  17β-Oestradiol-d5)

Estradiol-d5 Chemical Structure

CAS No. : 221093-45-4

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生物活性

Estradiol-d5 is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

277.41

Formula

C18H19D5O2

CAS 号

221093-45-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

    [2]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604.

    [3]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.

    [4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [5]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.

    [6]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.

    [7]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

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Estradiol valerianate-d9

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol valerianate-d9 

Estradiol valerianate-d9 是 Estradiol valerianate 的氘代物。Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

Estradiol valerianate-d9

Estradiol valerianate-d9 Chemical Structure

CAS No. : 1316648-98-2

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生物活性

Estradiol valerianate-d9 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

365.55

Formula

C23H23D9O3

CAS 号

1316648-98-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

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Estradiol(Synonyms: 雌二醇; β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol (Synonyms: 雌二醇; β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol) 纯度: 99.99%

Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达。

Estradiol(Synonyms: 雌二醇; β-Estradiol;  E2;  17β-Estradiol;  17β-Oestradiol)

Estradiol Chemical Structure

CAS No. : 50-28-2

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥500 In-stock
500 mg ¥400 In-stock
1 g ¥500 In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

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生物活性

Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Estradiol causes new dendritic spines and synapses in hippocampal CA1 pyramidal cells. Estradiol increases NMDA receptor binding by 46% in parallel with dendritic spine and synapse density. Estradiol also elevates sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and such an effect is correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells[1]. Estradiol reduces Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. Estradiol also reduces Ba2+ currents but is significantly less effective than Estradiol in rat neostriatal neurons[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Estradiol functions in hippocampal synapse density during the estrous cycle in the adult rat[4].
Estradiol reverses the ovariectomy-induced decrease in spine density. Estradiol in combination with progesterone enhances spine density for 2 to 6 h but decreases following estradiol alone[5].
Estradiol (0.2 mg/kg; i.p.; C57BL/6 female mice) plus 10 or 20 mg/kg progesterone, enhances memory consolidation in young ovariectomized mice[6].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 female mice[6]
Dosage: 0.2 mg/kg
Administration: I.p.
Result: Post-training treatment with either effective progesterone dose (10 or 20 mg/kg) combined with an effective estradiol dose (0.2 mg/kg) significantly enhanced object recognition after a 48-hr delay.

Clinical Trial

分子量

272.38

Formula

C18H24O2

CAS 号

50-28-2

中文名称

雌二醇;强力求偶素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 50 mg/mL (183.57 mM)

Ethanol : 20 mg/mL (73.43 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6713 mL 18.3567 mL 36.7134 mL
5 mM 0.7343 mL 3.6713 mL 7.3427 mL
10 mM 0.3671 mL 1.8357 mL 3.6713 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: corn oil

    Solubility: 12.5 mg/mL (45.89 mM); Suspended solution; Need ultrasonic

  • 2.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.18 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.18 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 4.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.18 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

  • 5.

    请依序添加每种溶剂: 5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: 2.5 mg/mL (9.18 mM); Suspended solution; Need ultrasonic

  • 6.

    请依序添加每种溶剂: 5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.

    [2]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604.

    [3]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.

    [4]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.

    [5]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

    [6]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

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Estradiol (cypionate)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol (cypionate)  纯度: ≥98.0%

Estradiol cypionate 是Estradiol的 17β-环戊丙酸酯, 通过作用于雌激素受体而抑制ET-1合成。

Estradiol (cypionate)

Estradiol (cypionate) Chemical Structure

CAS No. : 313-06-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥550 In-stock
500 mg ¥500 In-stock
1 g ¥800 In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

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生物活性

Estradiol cypionate is a 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor IC50 value: Target: estrogen receptor Estradiol cypionate is a synthetic ester, is a estrogen. Compared to other commonly used estradiol esters, via the intramuscular route, Estradiol cypionate is found to have the longest duration of action with a duration of ~11 days,

分子量

396.56

Formula

C26H36O3

CAS 号

313-06-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO : ≥ 30 mg/mL (75.65 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5217 mL 12.6084 mL 25.2169 mL
5 mM 0.5043 mL 2.5217 mL 5.0434 mL
10 mM 0.2522 mL 1.2608 mL 2.5217 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.67 mg/mL (6.73 mM); Clear solution

    此方案可获得 ≥ 2.67 mg/mL (6.73 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 26.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.67 mg/mL (6.73 mM); Clear solution

    此方案可获得 ≥ 2.67 mg/mL (6.73 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 26.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Feng X, et al. NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer. Cell Death Dis. 2017 May 11;8(5):e2783.

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Ethynyl Estradiol(Synonyms: 乙炔基雌二醇; 17α-Ethynylestradiol; Ethynylestradiol)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ethynyl Estradiol (Synonyms: 乙炔基雌二醇; 17α-Ethynylestradiol; Ethynylestradiol) 纯度: 99.76%

Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) 是生物活性雌激素。

Ethynyl Estradiol(Synonyms: 乙炔基雌二醇; 17α-Ethynylestradiol;  Ethynylestradiol)

Ethynyl Estradiol Chemical Structure

CAS No. : 57-63-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥500 In-stock
100 mg ¥420 In-stock
500 mg ¥800 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

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生物活性

Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Target: Estrogen Receptor Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol), also sometimes written as ethinylestradiol, ethynyl estradiol, or ethinyl estradiol, is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose. Transdermal ethinyl estradiol carries a greater risk of clot formation and venous thromboembolism than 17 beta estradiol, which some have theorized to be related to different amounts of hepatic metabolism after absorption. The same contraindications and precautions apply for EE as with other estrogen medications. Ethynyl Estradiol was a preparation of Ethynyl Estradiol alone that was used for the management of menopausal symptoms and female hypogonadism. Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication. The major concern with unopposed estrogen is of endometrial cancer. As such, the medication is generally prescribed with progesterone in the setting of birth control. The first orally active semisynthetic steroidal estrogen, Ethynyl Estradiol, the 17α-ethynyl analog of E2, was synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering AG in Berlin.

IC50 & Target

Human Endogenous Metabolite

 

分子量

296.40

Formula

C20H24O2

CAS 号

57-63-6

中文名称

乙炔基雌二醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (843.45 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3738 mL 16.8691 mL 33.7382 mL
5 mM 0.6748 mL 3.3738 mL 6.7476 mL
10 mM 0.3374 mL 1.6869 mL 3.3738 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.02 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.02 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.02 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.02 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Djerassi C. Chemical birth of the pill. 1992. Am J Obstet Gynecol. 2006 Jan;194(1):290-8.

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Estradiol valerianate(Synonyms: β-Estradiol 17-valerate)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol valerianate (Synonyms: β-Estradiol 17-valerate) 纯度: 99.43%

Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

Estradiol valerianate(Synonyms: β-Estradiol 17-valerate)

Estradiol valerianate Chemical Structure

CAS No. : 979-32-8

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥715 In-stock
500 mg ¥650 In-stock
1 g ¥1070 In-stock
5 g ¥3766 In-stock
10 g   询价  
50 g   询价  

* Please select Quantity before adding items.

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生物活性

Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

IC50 & Target

Estrogen Receptor/ERR

体外研究
(In Vitro)

β-estradiol 17-valerate (EV) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs and is detected in natural waters. EV is a reproductive toxicant and estrogenic chemical in both male and female fish [1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

356.50

Formula

C23H32O3

CAS 号

979-32-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 50 mg/mL (140.25 mM)

H2O : < 0.1 mg/mL (insoluble)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8050 mL 14.0252 mL 28.0505 mL
5 mM 0.5610 mL 2.8050 mL 5.6101 mL
10 mM 0.2805 mL 1.4025 mL 2.8050 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.67 mg/mL (7.49 mM); Clear solution

    此方案可获得 ≥ 2.67 mg/mL (7.49 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 26.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.67 mg/mL (7.49 mM); Clear solution

    此方案可获得 ≥ 2.67 mg/mL (7.49 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 26.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.67 mg/mL (7.49 mM); Clear solution

    此方案可获得 ≥ 2.67 mg/mL (7.49 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 26.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

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Estradiol benzoate(Synonyms: 苯甲酸雌二醇; β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol benzoate (Synonyms: 苯甲酸雌二醇; β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate) 纯度: 99.89%

Estradiol Benzoate (β-Estradiol 3-benzoate) 是雌二醇的前体药物,是一种类固醇性激素。Estradiol Benzoate表现出轻微的合成代谢特性,增加血液凝固性。

Estradiol benzoate(Synonyms: 苯甲酸雌二醇; β-Estradiol 3-benzoate;  17β-Estradiol 3-benzoate)

Estradiol benzoate Chemical Structure

CAS No. : 50-50-0

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥500 In-stock
500 mg ¥400 In-stock
1 g ¥500 In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

Estradiol benzoate 相关产品

相关化合物库:

  • Drug Repurposing Compound Library Plus
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  • Bioactive Compound Library Plus
  • FDA-Approved Drug Library
  • Anti-Cancer Compound Library
  • Drug Repurposing Compound Library
  • Lipid Compound Library
  • Endocrinology Compound Library
  • NMPA-Approved Drug Library
  • FDA Approved & Pharmacopeial Drug Library

生物活性

Estradiol Benzoate (β-Estradiol 3-benzoate), a prodrug of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3].

分子量

376.49

Formula

C25H28O3

CAS 号

50-50-0

中文名称

苯甲酸雌二醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (265.61 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6561 mL 13.2806 mL 26.5611 mL
5 mM 0.5312 mL 2.6561 mL 5.3122 mL
10 mM 0.2656 mL 1.3281 mL 2.6561 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.64 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.64 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Zovko M, et al. Macromolecular prodrugs XI. Synthesis and characterization of polymer-estradiol conjugate. Int J Pharm. 2004 Nov 5;285(1-2):35-41.

    [2]. García-Gómez E, et al. Role of sex steroid hormones in bacterial-host interactions. Biomed Res Int. 2013;2013:928290.

    [3]. Estradiol benzoate

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol-d2(Synonyms: β-Estradiol-d2; 17β-Estradiol-d2; 17β-Oestradiol-d2)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol-d2 (Synonyms: β-Estradiol-d2; 17β-Estradiol-d2; 17β-Oestradiol-d2)

Estradiol-d2 (β-Estradiol-d2) 是 Estradiol 的氘代物。Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达。

Estradiol-d2(Synonyms: β-Estradiol-d2;  17β-Estradiol-d2;  17β-Oestradiol-d2)

Estradiol-d2 Chemical Structure

CAS No. : 53866-33-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol-d2 (β-Estradiol-d2) is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

274.39

Formula

C18H22D2O2

CAS 号

53866-33-4

中文名称

雌二醇 d2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.

    [3]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604.

    [4]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.

    [5]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.

    [6]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

    [7]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

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Estradiol 3-sulfamate(Synonyms: 雌二醇 3-氨基磺酸; BLE 00084; E2MATE; ES-J 995)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol 3-sulfamate (Synonyms: 雌二醇 3-氨基磺酸; BLE 00084; E2MATE; ES-J 995) 纯度: 99.74%

Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) 是一种长效和有口服活性的类固醇硫酸酯酶 (steroid sulfatase) 抑制剂;抑制雌酮硫酸酯酶的 IC50 值为251 nM,Ki 值为133 nM。

Estradiol 3-sulfamate(Synonyms: 雌二醇 3-氨基磺酸; BLE 00084;  E2MATE;  ES-J 995)

Estradiol 3-sulfamate Chemical Structure

CAS No. : 172377-52-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥3093 In-stock
1 mg ¥2000 In-stock
5 mg ¥4000 In-stock
10 mg ¥6800 In-stock
20 mg ¥12000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Estradiol 3-sulfamate 相关产品

相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.

IC50 & Target

IC50: 251 nM (estrone sulfatase)[1]

Ki: 133 nM (estrone sulfatase)[1]

体外研究
(In Vitro)

Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

351.46

Formula

C18H25NO4S

CAS 号

172377-52-5

中文名称

雌二醇 3-氨基磺酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL (177.83 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8453 mL 14.2264 mL 28.4527 mL
5 mM 0.5691 mL 2.8453 mL 5.6905 mL
10 mM 0.2845 mL 1.4226 mL 2.8453 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.92 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (5.92 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.92 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (5.92 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.92 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (5.92 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Numazawa M, et al. Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates. Steroids. 2006 May;71(5):371-9.

    [2]. Pohl O, et al. Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21(10):1256-65.

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Estradiol hemihydrate(Synonyms: β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol hemihydrate (Synonyms: β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate)

Estradiol (β-Estradiol) hemihydrate 是一种类固醇激素和主要的女性性激素。Estradiol (β-Estradiol) hemihydrate 可上调人子宫内膜干细胞(hEnSCs)神经标志物的表达并促进其神经分化。Estradiol (β-Estradiol) hemihydrate 可用于癌症、神经退行性疾病和神经组织工程的相关研究。

Estradiol hemihydrate(Synonyms: β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate)

Estradiol hemihydrate Chemical Structure

CAS No. : 35380-71-3

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250 mg   询价  
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Estradiol hemihydrate 的其他形式现货产品:

Estradiol

生物活性

Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].

体外研究
(In Vitro)

Estradiol hemihydrate (10 nM, 7 days) induces neural differentiation and increased neurite branching of human endometrial stem cells (hEnSCs)[1].
Estradiol hemihydrate (17β-estradiol, 10 nM, 7 days) increases the expression of neuron-like cell markers (Tuj-1, nestin and NF-H) in neural-like cells differentiated from hEnSCs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[1]

Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue
Concentration: 10 nM
Incubation Time: 7 days
Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.

Immunofluorescence[1]

Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue
Concentration: 10 nM
Incubation Time: 7 days
Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.

体内研究
(In Vivo)

Estradiol hemihydrate (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1].
Estradiol hemihydrate (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FBN-ARO-KO Mice[2]
Dosage: 1 nM
Administration: Treated for the hippocampal slices
Result: Rescued long-term potentiation (LTP) amplitude of both male and female mice.
Animal Model: FBN-ARO-KO Mice[2]
Dosage: 0.0167 mg
Administration: Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.
Result: Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain.
Rescued the spatial learning and memory defects.

分子量

281.39

Formula

C18H26O3

CAS 号

35380-71-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Elham Hasanzadeh. Defining the role of 17β-estradiol in human endometrial stem cells differentiation into neuron-like cells. Cell Biol Int. 2021 Jan;45(1):140-153.

    [2]. Yujiao Lu, et al. Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory. J Neurosci. 2019 Apr 10;39(15):2792-2809.

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Estradiol-d4(Synonyms: β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol-d4 (Synonyms: β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4) 纯度: 99.85%

Estradiol-D4 (β-Estradiol-D4) 是 Estradiol 的氘代物。Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达。

Estradiol-d4(Synonyms: β-Estradiol-d4;  17β-Estradiol-d4;  17β-Oestradiol-d4)

Estradiol-d4 Chemical Structure

CAS No. : 66789-03-5

规格 价格 是否有货 数量
1 mg ¥1300 In-stock
5 mg ¥5500 In-stock
10 mg ¥9800 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol-D4 (β-Estradiol-D4) is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

276.41

Formula

C18H20D4O2

CAS 号

66789-03-5

中文名称

雌二醇 d4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (904.45 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6178 mL 18.0891 mL 36.1781 mL
5 mM 0.7236 mL 3.6178 mL 7.2356 mL
10 mM 0.3618 mL 1.8089 mL 3.6178 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.53 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.53 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.53 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.53 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.;Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604.;Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.;Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.;Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.;Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol-d3(Synonyms: β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol-d3 (Synonyms: β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3)

Estradiol-d3 (β-Estradiol-d3) 是 Estradiol 的氘代物。Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达。

Estradiol-d3(Synonyms: β-Estradiol-d3;  17β-Estradiol-d3;  17β-Oestradiol-d3)

Estradiol-d3 Chemical Structure

CAS No. : 79037-37-9

规格 是否有货
100 mg Check price and availability
1 mg Check price and availability
5 mg Check price and availability
10 mg Check price and availability

* Please select Quantity before adding items.

生物活性

Estradiol-d3 (β-Estradiol-d3) is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

275.40

Formula

C18H21D3O2

CAS 号

79037-37-9

中文名称

雌二醇 D3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.

    [3]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604.

    [4]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.

    [5]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.

    [6]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

    [7]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol valerianate-d12

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol valerianate-d12 

Estradiol valerianate-d12 是 Estradiol valerianate 的氘代物。Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

Estradiol valerianate-d12

Estradiol valerianate-d12 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol valerianate-d12 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

368.57

Formula

C23H20D12O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol valerianate-d12

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol valerianate-d12 

Estradiol valerianate-d12 是 Estradiol valerianate 的氘代物。Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

Estradiol valerianate-d12

Estradiol valerianate-d12 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol valerianate-d12 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

368.57

Formula

C23H20D12O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol valerianate-d12

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol valerianate-d12 

Estradiol valerianate-d12 是 Estradiol valerianate 的氘代物。Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

Estradiol valerianate-d12

Estradiol valerianate-d12 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol valerianate-d12 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

368.57

Formula

C23H20D12O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol valerianate-d4(Synonyms: β-Estradiol 17-valerate-d4)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol valerianate-d4 (Synonyms: β-Estradiol 17-valerate-d4)

Estradiol valerianate-d4 (β-Estradiol 17-valerate-d4) 是 Estradiol valerianate 的氘代物。Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

Estradiol valerianate-d4(Synonyms: β-Estradiol 17-valerate-d4)

Estradiol valerianate-d4 Chemical Structure

CAS No. : 2673269-82-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol valerianate-d4 (β-Estradiol 17-valerate-d4) is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

360.52

Formula

C23H28D4O3

CAS 号

2673269-82-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

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Estradiol valerianate-d4(Synonyms: β-Estradiol 17-valerate-d4)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol valerianate-d4 (Synonyms: β-Estradiol 17-valerate-d4)

Estradiol valerianate-d4 (β-Estradiol 17-valerate-d4) 是 Estradiol valerianate 的氘代物。Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

Estradiol valerianate-d4(Synonyms: β-Estradiol 17-valerate-d4)

Estradiol valerianate-d4 Chemical Structure

CAS No. : 2673269-82-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol valerianate-d4 (β-Estradiol 17-valerate-d4) is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

360.52

Formula

C23H28D4O3

CAS 号

2673269-82-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol valerianate-d4(Synonyms: β-Estradiol 17-valerate-d4)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol valerianate-d4 (Synonyms: β-Estradiol 17-valerate-d4)

Estradiol valerianate-d4 (β-Estradiol 17-valerate-d4) 是 Estradiol valerianate 的氘代物。Estradiol valerianate (β-estradiol 17-valerate) 是合成的雌性激素,可与其它甾类激素联用。

Estradiol valerianate-d4(Synonyms: β-Estradiol 17-valerate-d4)

Estradiol valerianate-d4 Chemical Structure

CAS No. : 2673269-82-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol valerianate-d4 (β-Estradiol 17-valerate-d4) is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

360.52

Formula

C23H28D4O3

CAS 号

2673269-82-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Lei, B., et al., beta-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat Toxicol, 2013. 134-135: p. 128-34.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol-13C6(Synonyms: β-Estradiol-13C6; E2-13C6; 17β-Estradiol-13C6; 17β-Oestradiol-13C6)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol-13C6 (Synonyms: β-Estradiol-13C6; E2-13C6; 17β-Estradiol-13C6; 17β-Oestradiol-13C6)

Estradiol-13C6 (β-Estradiol-13C6) 是一种 13C 标记的 Estradiol。Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达。

Estradiol-13C6(Synonyms: β-Estradiol-13C6;  E2-13C6;  17β-Estradiol-13C6;  17β-Oestradiol-13C6)

Estradiol-13C6 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol-13C6 (β-Estradiol-13C6) is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

278.34

Formula

C1213C6H24O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.

    [3]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604.

    [4]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.

    [5]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.

    [6]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

    [7]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Estradiol-13C2(Synonyms: β-Estradiol-13C2; E2-13C2; 17β-Estradiol-13C2; 17β-Oestradiol-13C2)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Estradiol-13C2 (Synonyms: β-Estradiol-13C2; E2-13C2; 17β-Estradiol-13C2; 17β-Oestradiol-13C2)

Estradiol-13C2 (β-Estradiol-13C2) 是一种 13C 标记的 Estradiol。Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。Estradiol 通过雌激素受体 β (ERβ) 途径上调 IL-6 表达。

Estradiol-13C2(Synonyms: β-Estradiol-13C2;  E2-13C2;  17β-Estradiol-13C2;  17β-Oestradiol-13C2)

Estradiol-13C2 Chemical Structure

CAS No. : 82938-05-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Estradiol-13C2 (β-Estradiol-13C2) is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

274.37

Formula

C1613C2H24O2

CAS 号

82938-05-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59.

    [3]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604.

    [4]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133.

    [5]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.

    [6]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

    [7]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务